StrokeNCT07724730
Effects of Task-Oriented Training With and Without Rhythmic Auditory Stimulation in Post-Stroke Patients
A study testing Task-Oriented Training + Rhythmic Auditory Stimulation and Task-Oriented Training Only in people with Stroke, run by Riphah International University at 1 site in Pakistan.
Trial summary
Stroke is one of the leading causes of long-term disability worldwide. Among survivors, limitations in lower limb motor function, balance, and proprioception significantly affect their independence and quality of life. Read more about this study
- Who is it for?
- Ages 40 to 60 years
- Conditions the study is for
- Stroke
- What is being tested?
- Task-Oriented Training + Rhythmic Auditory Stimulation and Task-Oriented Training Only
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 38 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Jun 2025to 5 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- • Age 40-60 years
- First-time ischemic or hemorrhagic stroke
- Subacute stroke (<6 months)
- Brunnstrom stage ≥ 3 (lower limb)
- Able to walk 10 meters independently or with minimal support
- Able to follow simple commands
Who cannot join
- • Severe aphasia
- Other neurological disorders (Parkinson's, TBI)
- Uncontrolled cardiovascular issues (BP > 180 mmHg, arrhythmias)
- Severe visual, auditory, or orthopedic impairments
- Musculoskeletal injuries or medical conditions limiting participation
- Diabetes, hypertension, fractures, surgeries, OA, RA
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Civil Hospital Daska, Pakistan
Daska Kalan
Dr. Jansher Mansoori, 03226613232, qaynatqaynat0@gmail.com
About this study
Official title: Effects of Task-Oriented Training With and Without Rhythmic Auditory Stimulation on Lower Limb Motor Function, Dynamic Balance, Proprioception, Motivation, and Adherence in Post-Stroke Patients
Stroke is one of the leading causes of long-term disability worldwide. Among survivors, limitations in lower limb motor function, balance, and proprioception significantly affect their independence and quality of life. There is a growing need for targeted rehabilitation strategies for stroke survivors, who often experience lower limb impairments that limit independence during a highly active stage of life. Task-oriented training (TOT) helps patients practice real-life movements, while rhythmic auditory stimulation (RAS), such as metronome beats, can guide and improve their timing and coordination.
Read the detailed description
It will be a single blinded randomized controlled trial. Non-probability convenience sampling technique will be used to recruit 38 participants aged 40 to 60 years, subacute stage post-stroke from hospitals of Daska and NLH Physio Clinic. Sealed opaque method will be used to randomly divide into two groups. Group A will receive TOT along with RAS, while Group B will receive only TOT. Both groups will participate in supervised 30-minute exercise sessions, including a 10-minute warm-up and cool-down period, five days a week for eight weeks, in addition to 30 minutes of baseline conventional physiotherapy program. The interventions will focus on lower limb function, balance, proprioceptive training, and motivational engagement. Tools used for outcome assessment include the Lower Extremity Functional Scale (LEFS) for motor function, Timed Up and Go (TUG) test for dynamic balance, Joint Position Sense (JPS) test for proprioception, Stroke Rehabilitation Motivation Scale (SRMS) for motivation, and the Rehabilitation Adherence Questionnaire (RAQ) for adherence. Data will be analyzed using SPSS version 25 to compare pre- and post-intervention effects. . After assessing the normality, if the p-value is greater than 0.05, a parametric test will be applied. If the p-value is less than 0.05 then a non-parametric test will be applied.
- Conditions
- Stroke
- Being tested
- Task-Oriented Training + Rhythmic Auditory Stimulation, Task-Oriented Training Only
- Keywords
- Rhythmic Auditory Stimulation, Task-Oriented Training, Balance, Proprioception, Lower Extremity Function, Motivation, Rehabilitation Adherence
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Task-Oriented Training + Rhythmic Auditory StimulationOther
- 30-minute TOT session + RAS (60-110 BPM progression)
- Functional gait tasks, obstacle walking, stair climbing, balance tasks
- 5 days/week for 8 weeks
- Plus 30-minute baseline physiotherapy
Task-Oriented Training OnlyOther
- Same TOT structure without rhythmic cues
- Functional lower limb tasks, balance training, gait practice
- 5 days/week for 8 weeks
- Plus 30-minute baseline physiotherapy
| Study group | Role | What they receive |
|---|---|---|
| Group A - Task-Oriented Training + Rhythmic Auditory Stimulation | Experimental | * 30-minute TOT session + RAS (60-110 BPM progression)
* Functional gait tasks, obstacle walking, stair climbing, balance tasks
* 5 days/week for 8 weeks
* Plus 30-minute baseline physiotherapy Receives: Other: Task-Oriented Training + Rhythmic Auditory Stimulation |
| Group B - Task-Oriented Training Only | Active comparator | * Same TOT structure without rhythmic cues
* Functional lower limb tasks, balance training, gait practice
* 5 days/week for 8 weeks
* Plus 30-minute baseline physiotherapy Receives: Other: Task-Oriented Training Only |
What is being measured
The primary outcome is the main question the study is designed to answer.
Lower Limb Motor Function
Lower Extremity Function (LEFS)
Measured: Baseline and Week 8
Dynamic Balance
Time up and Go Test
Measured: Baseline and Week 8
Proprioception
Joint Position Sense Test
Measured: Baseline and post 8 weeks
motivation
Stroke Rehabilitation Motivation Scale (SRMS)
Measured: Baseline and post 8 weeks
adherence
Rehabilitation Adherence Questionnaire (RAQ)
Measured: Baseline and post 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jul 2026
- Study start1 Jun 2025
- Primary completion30 Jul 2026 (estimated)
- Study completion5 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized Clinical Trial
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 38 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Aiza Yousaf, MS-OMPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07724730
- Sponsor's protocol ID
- REC/RCR & AHS/25/0240
- Status last verified
- Jul 2026
- First submitted
- 21 Jul 2026
- Last updated
- 24 Jul 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Task-Oriented Training With and Without Rhythmic Auditory Stimulation on Lower Limb Motor Function, Dynamic Balance, Proprioception, Motivation, and Adherence in Post-Stroke Patients
- ClinicalTrials.gov ID
- NCT07724730
- Acronym / sponsor ID
- REC/RCR & AHS/25/0240
- Conditions
- Stroke
- Keywords
- Rhythmic Auditory Stimulation, Task-Oriented Training, Balance, Proprioception, Lower Extremity Function, Motivation, Rehabilitation Adherence
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 38 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 1 Jun 2025 (actual)
- Primary completion
- 30 Jul 2026 (estimated)
- Study completion
- 5 Aug 2026 (estimated)
- First posted
- 24 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Stroke is one of the leading causes of long-term disability worldwide. Among survivors, limitations in lower limb motor function, balance, and proprioception significantly affect their independence and quality of life. There is a growing need for targeted rehabilitation strategies for stroke survivors, who often experience lower limb impairments that limit independence during a highly active stage of life. Task-oriented training (TOT) helps patients practice real-life movements, while rhythmic auditory stimulation (RAS), such as metronome beats, can guide and improve their timing and coordination.
Detailed description
It will be a single blinded randomized controlled trial. Non-probability convenience sampling technique will be used to recruit 38 participants aged 40 to 60 years, subacute stage post-stroke from hospitals of Daska and NLH Physio Clinic. Sealed opaque method will be used to randomly divide into two groups. Group A will receive TOT along with RAS, while Group B will receive only TOT. Both groups will participate in supervised 30-minute exercise sessions, including a 10-minute warm-up and cool-down period, five days a week for eight weeks, in addition to 30 minutes of baseline conventional physiotherapy program. The interventions will focus on lower limb function, balance, proprioceptive training, and motivational engagement. Tools used for outcome assessment include the Lower Extremity Functional Scale (LEFS) for motor function, Timed Up and Go (TUG) test for dynamic balance, Joint Position Sense (JPS) test for proprioception, Stroke Rehabilitation Motivation Scale (SRMS) for motivation, and the Rehabilitation Adherence Questionnaire (RAQ) for adherence. Data will be analyzed using SPSS version 25 to compare pre- and post-intervention effects. . After assessing the normality, if the p-value is greater than 0.05, a parametric test will be applied. If the p-value is less than 0.05 then a non-parametric test will be applied.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Randomized Clinical Trial
| Arm | Type | Receives |
|---|---|---|
| Group A - Task-Oriented Training + Rhythmic Auditory Stimulation | Experimental | Other: Task-Oriented Training + Rhythmic Auditory Stimulation* 30-minute TOT session + RAS (60-110 BPM progression) * Functional gait tasks, obstacle walking, stair climbing, balance tasks * 5 days/week for 8 weeks * Plus 30-minute baseline physiotherapy |
| Group B - Task-Oriented Training Only | Active comparator | Other: Task-Oriented Training Only* Same TOT structure without rhythmic cues * Functional lower limb tasks, balance training, gait practice * 5 days/week for 8 weeks * Plus 30-minute baseline physiotherapy |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- • Age 40-60 years
Key exclusion criteria (6 listed)
- • Severe aphasia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Task-Oriented Training + Rhythmic Auditory Stimulation* 30-minute TOT session + RAS (60-110 BPM progression) * Functional gait tasks, obstacle walking, stair climbing, balance tasks * 5 days/week for 8 weeks * Plus 30-minute baseline physiotherapy | Other | Group A - Task-Oriented Training + Rhythmic Auditory Stimulation |
| Task-Oriented Training Only* Same TOT structure without rhythmic cues * Functional lower limb tasks, balance training, gait practice * 5 days/week for 8 weeks * Plus 30-minute baseline physiotherapy | Other | Group B - Task-Oriented Training Only |
Primary outcome
Lower Limb Motor Function
Time frame: Baseline and Week 8
Lower Extremity Function (LEFS)
Dynamic Balance
Time frame: Baseline and Week 8
Time up and Go Test
Proprioception
Time frame: Baseline and post 8 weeks
Joint Position Sense Test
motivation
Time frame: Baseline and post 8 weeks
Stroke Rehabilitation Motivation Scale (SRMS)
adherence
Time frame: Baseline and post 8 weeks
Rehabilitation Adherence Questionnaire (RAQ)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jul 2026.
- Individual participant dataSharing planned: No
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Atrial Fibrillation (AF), Stroke Prevention in Patients With Atrial Fibrillation
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Metformin in Acute Ischemic Stroke
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Aiza Yousaf, MS-OMPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Task-Oriented Training + Rhythmic Auditory Stimulation and Task-Oriented Training Only in people with Stroke, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Imran Amjad, PhD (03324390125, imran.amjad@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Lower Limb Motor Function (time frame: Baseline and Week 8). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jul 2026.