CABGNCT07725887
Structured Inpatient Physiotherapy in High-Risk Coronary Artery Bypass Grafting Patients
A study testing Preoperative and Postoperative Structured Inpatient Physiotherapy and Postoperative Structured Inpatient Physiotherapy in people with CABG, run by Bezmialem Vakif University at 1 site in Turkey (Türkiye).
Trial summary
Coronary artery bypass grafting (CABG) may be associated with prolonged recovery, particularly in high-risk patients. Although preoperative rehabilitation has shown promising results, evidence remains limited because of heterogeneous intervention protocols and variations in postoperative care. Read more about this study
- Who is it for?
- Ages 18 to 90 years
- Conditions the study is for
- CABG
- What is being tested?
- Preoperative and Postoperative Structured Inpatient Physiotherapy and Postoperative Structured Inpatient Physiotherapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 22 Jul 2026to 3 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18 years or older.
- Scheduled to undergo elective coronary artery bypass grafting (CABG).
- High-risk patients meeting at least three of the following criteria:
- Left ventricular ejection fraction (LVEF) <40%. Three-vessel coronary artery disease. More than two comorbidities. History of smoking. Age >65 years.
- Able and willing to provide written informed consent.
Who cannot join
- Planned redo CABG surgery.
- Severe neurological or orthopedic conditions limiting mobilization.
- Severe cognitive impairment.
- Hemodynamic instability.
- Contraindications to mobilization or exercise.
- Inability to complete at least two days of the preoperative physiotherapy program.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Bezmialem Vakif University
Istanbul, Eyupsultan
Fuat Gokdemir, PT, MSc, +905543727084, fuat.gokdemir@bezmialem.edu.tr
Ayşe Sena Manzak Dursun, PT, PhD, +905356735150
About this study
Official title: Effect of a Preoperatively Initiated Structured Inpatient Physiotherapy Program on Postoperative Outcomes in High-Risk Coronary Artery Bypass Grafting Patients
Coronary artery bypass grafting (CABG) may be associated with prolonged recovery, particularly in high-risk patients. Although preoperative rehabilitation has shown promising results, evidence remains limited because of heterogeneous intervention protocols and variations in postoperative care. This study aims to investigate the effects of a structured inpatient physiotherapy program initiated at least two days before surgery and continued postoperatively, compared with the same structured physiotherapy program provided only during the postoperative period, in high-risk CABG patients. The primary outcome is hospital length of stay. Secondary outcomes include intensive care unit length of stay, C-reactive protein, neutrophil-to-lymphocyte ratio, hemoglobin, dyspnea, and fatigue.
Read the detailed description
Coronary artery bypass grafting (CABG) is commonly performed for the treatment of coronary artery disease. Postoperative recovery may be prolonged in patients with advanced age, reduced left ventricular ejection fraction, multivessel coronary artery disease, smoking history, and multiple comorbidities.
Preoperative rehabilitation has been proposed as a strategy to support postoperative recovery. However, previous studies have used heterogeneous intervention protocols and different postoperative care approaches.
This study will compare two physiotherapy strategies in high-risk CABG patients. Participants in the intervention group will receive a structured inpatient physiotherapy program initiated at least two days before surgery and continued postoperatively. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises. Before surgery, one supervised session will be provided daily, and participants will be instructed to repeat the program independently twice daily.
Participants in the control group will receive the same structured physiotherapy program only during the postoperative period.
The primary outcome is hospital length of stay. Secondary outcomes include intensive care unit length of stay, hemoglobin, C-reactive protein, neutrophil-to-lymphocyte ratio, dyspnea, and fatigue.
- Conditions
- CABG
- Being tested
- Preoperative and Postoperative Structured Inpatient Physiotherapy, Postoperative Structured Inpatient Physiotherapy
- Keywords
- CABG, preoperative rehabilitation, postoperative rehabilitation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Preoperative and Postoperative Structured Inpatient PhysiotherapyOther
Participants will receive a structured inpatient physiotherapy program initiated at least two days before CABG surgery and continued throughout postoperative hospitalization. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises. Before surgery, one supervised session will be provided daily, and participants will be instructed to repeat the program independently twice daily.
Postoperative Structured Inpatient PhysiotherapyOther
Participants will receive the same structured inpatient physiotherapy program only during the postoperative hospitalization. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises.
| Study group | Role | What they receive |
|---|---|---|
| Preoperative and Postoperative Structured Inpatient Physiotherapy | Experimental | Participants will receive a structured inpatient physiotherapy program initiated at least two days before CABG surgery and continued throughout the postoperative hospitalization. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises. One supervised session will be provided daily before surgery, and participants will be instructed to repeat the program independently twice daily. Receives: Other: Preoperative and Postoperative Structured Inpatient Physiotherapy |
| Postoperative Structured Inpatient Physiotherapy | Active comparator | Participants will receive the same structured inpatient physiotherapy program only during the postoperative hospitalization. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises. No preoperative physiotherapy will be provided. Receives: Other: Postoperative Structured Inpatient Physiotherapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hospital Length of Stay
Postoperative hospital length of stay, defined as the number of days from surgery until hospital discharge.
Measured: From surgery until hospital discharge (approximately 7-14 days)
Secondary outcomes (6)
Intensive Care Unit Length of Stay
Length of stay in the intensive care unit, measured in days from admission to discharge from the intensive care unit.
Measured: From surgery until discharge from the intensive care unit (approximately 1-5 days)
Hemoglobin
Hemoglobin concentration measured as part of routine clinical laboratory testing and expressed in grams per deciliter (g/dL).
Measured: Baseline (preoperative), through hospital discharge (up to approximately 30 days after surgery), and 7-10 days after hospital discharge.
C-Reactive Protein (CRP)
Serum C-reactive protein concentration measured as part of routine clinical laboratory testing and expressed in milligrams per liter (mg/L) to assess postoperative inflammatory response.
Measured: Baseline (preoperative), through hospital discharge (up to approximately 30 days after surgery), and 7-10 days after hospital discharge.
Neutrophil-to-Lymphocyte Ratio (NLR)
Neutrophil-to-lymphocyte ratio calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. The NLR is a unitless index used to assess systemic inflammatory response.
Measured: Baseline (preoperative), through hospital discharge (up to approximately 30 days after surgery), and 7-10 days after hospital discharge.
Dyspnea
Dyspnea assessed using the Modified Borg Dyspnea Scale (0-10), with higher scores indicating greater perceived breathlessness.
Measured: At the first postoperative physiotherapy session on the surgical ward and at the final physiotherapy session before hospital discharge.
Fatigue
Fatigue assessed using the Modified Borg Fatigue Scale (0-10), with higher scores indicating greater perceived fatigue.
Measured: At the first postoperative physiotherapy session on the surgical ward and at the final physiotherapy session before hospital discharge.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jul 2026
- Study start22 Jul 2026
- Primary completion2 Jan 2027 (estimated)
- Study completion3 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CABGStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to one of two parallel groups. The intervention group will receive a structured inpatient physiotherapy program initiated at least two days before coronary artery bypass grafting (CABG) and continued postoperatively. The control group will receive the same structured physiotherapy program only during the postoperative period.
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Bezmialem Vakif University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ayşe Sena Manzak, Bezmialem Vakif University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07725887
- Sponsor's protocol ID
- 2026/315
- Status last verified
- Jul 2026
- First submitted
- 20 Jul 2026
- Last updated
- 24 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of a Preoperatively Initiated Structured Inpatient Physiotherapy Program on Postoperative Outcomes in High-Risk Coronary Artery Bypass Grafting Patients
- ClinicalTrials.gov ID
- NCT07725887
- Acronym / sponsor ID
- 2026/315
- Conditions
- CABG
- Keywords
- CABG, preoperative rehabilitation, postoperative rehabilitation
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Bezmialem Vakif UniversityUniversity, hospital or other
- Study start
- 22 Jul 2026 (actual)
- Primary completion
- 2 Jan 2027 (estimated)
- Study completion
- 3 Jan 2027 (estimated)
- First posted
- 24 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Coronary artery bypass grafting (CABG) may be associated with prolonged recovery, particularly in high-risk patients. Although preoperative rehabilitation has shown promising results, evidence remains limited because of heterogeneous intervention protocols and variations in postoperative care. This study aims to investigate the effects of a structured inpatient physiotherapy program initiated at least two days before surgery and continued postoperatively, compared with the same structured physiotherapy program provided only during the postoperative period, in high-risk CABG patients. The primary outcome is hospital length of stay. Secondary outcomes include intensive care unit length of stay, C-reactive protein, neutrophil-to-lymphocyte ratio, hemoglobin, dyspnea, and fatigue.
Detailed description
Coronary artery bypass grafting (CABG) is commonly performed for the treatment of coronary artery disease. Postoperative recovery may be prolonged in patients with advanced age, reduced left ventricular ejection fraction, multivessel coronary artery disease, smoking history, and multiple comorbidities.
Preoperative rehabilitation has been proposed as a strategy to support postoperative recovery. However, previous studies have used heterogeneous intervention protocols and different postoperative care approaches.
This study will compare two physiotherapy strategies in high-risk CABG patients. Participants in the intervention group will receive a structured inpatient physiotherapy program initiated at least two days before surgery and continued postoperatively. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises. Before surgery, one supervised session will be provided daily, and participants will be instructed to repeat the program independently twice daily.
Participants in the control group will receive the same structured physiotherapy program only during the postoperative period.
The primary outcome is hospital length of stay. Secondary outcomes include intensive care unit length of stay, hemoglobin, C-reactive protein, neutrophil-to-lymphocyte ratio, dyspnea, and fatigue.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned to one of two parallel groups. The intervention group will receive a structured inpatient physiotherapy program initiated at least two days before coronary artery bypass grafting (CABG) and continued postoperatively. The control group will receive the same structured physiotherapy program only during the postoperative period.
| Arm | Type | Receives |
|---|---|---|
| Preoperative and Postoperative Structured Inpatient Physiotherapy | Experimental | Other: Preoperative and Postoperative Structured Inpatient PhysiotherapyParticipants will receive a structured inpatient physiotherapy program initiated at least two days before CABG surgery and continued throughout the postoperative hospitalization. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises. One supervised session will be provided daily before surgery, and participants will be instructed to repeat the program independently twice daily. |
| Postoperative Structured Inpatient Physiotherapy | Active comparator | Other: Postoperative Structured Inpatient PhysiotherapyParticipants will receive the same structured inpatient physiotherapy program only during the postoperative hospitalization. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises. No preoperative physiotherapy will be provided. |
Who may qualify
- Ages
- 18 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Adults aged 18 years or older.
- Scheduled to undergo elective coronary artery bypass grafting (CABG).
- High-risk patients meeting at least three of the following criteria:
- Left ventricular ejection fraction (LVEF) <40%. Three-vessel coronary artery disease. More than two comorbidities. History of smoking. Age >65 years.
- Able and willing to provide written informed consent.
Key exclusion criteria (6 listed)
- Planned redo CABG surgery.
- Severe neurological or orthopedic conditions limiting mobilization.
- Severe cognitive impairment.
- Hemodynamic instability.
- Contraindications to mobilization or exercise.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Preoperative and Postoperative Structured Inpatient PhysiotherapyParticipants will receive a structured inpatient physiotherapy program initiated at least two days before CABG surgery and continued throughout postoperative hospitalization. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises. Before surgery, one supervised session will be provided daily, and participants will be instructed to repeat the program independently twice daily. | Other | Preoperative and Postoperative Structured Inpatient Physiotherapy |
| Postoperative Structured Inpatient PhysiotherapyParticipants will receive the same structured inpatient physiotherapy program only during the postoperative hospitalization. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises. | Other | Postoperative Structured Inpatient Physiotherapy |
Primary outcome
Hospital Length of Stay
Time frame: From surgery until hospital discharge (approximately 7-14 days)
Postoperative hospital length of stay, defined as the number of days from surgery until hospital discharge.
6 secondary outcomes
Intensive Care Unit Length of Stay
Time frame: From surgery until discharge from the intensive care unit (approximately 1-5 days)
Hemoglobin
Time frame: Baseline (preoperative), through hospital discharge (up to approximately 30 days after surgery), and 7-10 days after hospital discharge.
C-Reactive Protein (CRP)
Time frame: Baseline (preoperative), through hospital discharge (up to approximately 30 days after surgery), and 7-10 days after hospital discharge.
Neutrophil-to-Lymphocyte Ratio (NLR)
Time frame: Baseline (preoperative), through hospital discharge (up to approximately 30 days after surgery), and 7-10 days after hospital discharge.
Dyspnea
Time frame: At the first postoperative physiotherapy session on the surgical ward and at the final physiotherapy session before hospital discharge.
Fatigue
Time frame: At the first postoperative physiotherapy session on the surgical ward and at the final physiotherapy session before hospital discharge.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Preoperative and Postoperative Structured Inpatient Physiotherapy and Postoperative Structured Inpatient Physiotherapy in people with CABG, run by Bezmialem Vakif University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Fuat Gökdemir, PT, MSc (+905543727084, fuat.gokdemir@bezmialem.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hospital Length of Stay (time frame: From surgery until hospital discharge (approximately 7-14 days)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jul 2026.