Postoperative PainEOIPB-ONNCT07726550
Modified External Oblique Intercostal Plane Block Versus Erector Spinae Plane Block for Open Nephrectomy
A study testing Erector Spinae Plane Block and Modified External Oblique Intercostal Plane Block in people with Postoperative Pain and Open Nephrectomy, run by Namik Kemal University at 1 site in Turkey (Türkiye).
Trial summary
This prospective, randomized, assessor-blinded clinical trial aims to compare the postoperative analgesic efficacy of ultrasound-guided Erector Spinae Plane Block (ESPB) and Modified External Oblique Intercostal Plane Block (EOIPB) in patients undergoing elective open nephrectomy under general anesthesia. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Postoperative Pain, Open Nephrectomy
- What is being tested?
- Erector Spinae Plane Block and Modified External Oblique Intercostal Plane Block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Aug 2026to 1 Feb 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age between 18 and 65 years.
- American Society of Anesthesiologists (ASA) physical status I or II.
- Scheduled for elective open nephrectomy.
- Able and willing to provide written informed consent.
- Willing to comply with study procedures.
Who cannot join
- Refusal to participate or inability to provide informed consent.
- Emergency surgery.
- Body mass index (BMI) greater than 35 kg/m².
- Known allergy or hypersensitivity to local anesthetics.
- Infection at the planned block insertion site.
- Coagulopathy or ongoing anticoagulant therapy.
- Pregnancy or breastfeeding.
- Prisoners or other vulnerable populations unable to provide independent consent.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Tekirdağ Namık Kemal University
Tekirdağ, Tekirdağ, 59000
Onur Baran, Associate Professor, +90 539 342 25 82, dronurbaran@hotmail.com
About this study
Official title: Comparison of Modified External Oblique Intercostal Plane Block and Erector Spinae Plane Block for Postoperative Analgesia in Patients Undergoing Open Nephrectomy: A Prospective Randomized Controlled Trial
This prospective, randomized, assessor-blinded clinical trial aims to compare the postoperative analgesic efficacy of ultrasound-guided Erector Spinae Plane Block (ESPB) and Modified External Oblique Intercostal Plane Block (EOIPB) in patients undergoing elective open nephrectomy under general anesthesia. Sixty adult patients will be randomized to receive either ESPB or EOIPB before surgical incision. All participants will receive standardized general anesthesia and postoperative multimodal analgesia. Postoperative pain scores, opioid consumption, rescue analgesic requirements, and postoperative nausea and vomiting will be assessed during the first 24 hours after surgery. The study aims to determine whether one fascial plane block technique provides superior postoperative pain control and recovery following open nephrectomy.
Read the detailed description
Open nephrectomy is associated with substantial postoperative pain that may impair recovery, delay mobilization, and increase opioid consumption. Regional anesthesia techniques have become important components of multimodal analgesia strategies aimed at improving postoperative outcomes while minimizing opioid-related adverse effects.
The erector spinae plane block (ESPB) and modified external oblique intercostal plane block (EOIPB) are ultrasound-guided fascial plane blocks that have demonstrated effectiveness in providing thoracoabdominal analgesia. However, evidence directly comparing these techniques in patients undergoing open nephrectomy remains limited.
This study is a prospective, randomized, controlled, assessor-blinded clinical trial conducted at a single tertiary academic center. Sixty patients aged 18 to 65 years with ASA physical status I-II who are scheduled for elective open nephrectomy will be enrolled and randomized in a 1:1 ratio to one of two study groups.
Participants assigned to the ESPB group will receive an ultrasound-guided erector spinae plane block with 30 mL of 0.25% bupivacaine after induction of general anesthesia and before surgical incision. Participants assigned to the EOIPB group will receive an ultrasound-guided modified external oblique intercostal plane block using the same volume and concentration of local anesthetic.
All patients will receive standardized general anesthesia, postoperative intravenous patient-controlled analgesia with tramadol, scheduled paracetamol, and rescue analgesics according to institutional protocols. Patients will be followed in the post-anesthesia care unit and at postoperative 2, 6, 12, and 24 hours.
The primary objective is to compare postoperative pain intensity between the two groups during the first 24 postoperative hours. Secondary objectives include comparison of opioid consumption, rescue analgesic requirements, postoperative nausea and vomiting, and perioperative hemodynamic parameters.
The results of this study may help identify the optimal regional analgesia technique for patients undergoing open nephrectomy and contribute to enhanced postoperative recovery.
- Conditions
- Postoperative Pain, Open Nephrectomy
- Being tested
- Erector Spinae Plane Block, Modified External Oblique Intercostal Plane Block
- Keywords
- Erector Spinae Plane Block, External Oblique Intercostal Plane Block, Regional Anesthesia, EOIPB, ESPB, Postoperative Analgesia, Open Nephrectomy, Multimodal Analgesia, Pain Management
- Medical subject headings
- Pain, Postoperative, Agnosia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Erector Spinae Plane BlockProcedure or surgery
Ultrasound-guided erector spinae plane block performed after induction of general anesthesia using 30 mL of 0.25% bupivacaine before surgical incision.
Modified External Oblique Intercostal Plane BlockProcedure or surgery
Ultrasound-guided modified external oblique intercostal plane block performed after induction of general anesthesia using 30 mL of 0.25% bupivacaine before surgical incision.
| Study group | Role | What they receive |
|---|---|---|
| ESPB Group | Experimental | Participants will receive an ultrasound-guided erector spinae plane block with 30 mL of 0.25% bupivacaine after induction of general anesthesia and before surgical incision. Standardized general anesthesia and postoperative multimodal analgesia will be provided to all participants. Receives: Procedure: Erector Spinae Plane Block |
| EOIPB Group | Experimental | Participants will receive an ultrasound-guided modified external oblique intercostal plane block with 30 mL of 0.25% bupivacaine after induction of general anesthesia and before surgical incision. Standardized general anesthesia and postoperative multimodal analgesia will be provided to all participants. Receives: Procedure: Modified External Oblique Intercostal Plane Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain intensity at rest
Postoperative pain intensity will be assessed at rest using the 11-point Numeric Rating Scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores indicate greater pain intensity.
Measured: 0, 2, 6, 12, and 24 hours after surgery
Secondary outcomes (6)
Pain intensity during movement
Postoperative pain intensity will be assessed during movement using the 11-point Numeric Rating Scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores indicate greater pain intensity.
Measured: 0, 2, 6, 12, and 24 hours after surgery
Total Opioid Consumption
Total postoperative tramadol consumption recorded from patient-controlled analgesia during the first 24 postoperative hours.
Measured: 24 hours after surgery
Rescue Analgesic Requirement
Number of patients requiring rescue analgesia during the first 24 postoperative hours.
Measured: 24 hours after surgery
Postoperative Nausea and Vomiting
Incidence of postoperative nausea and vomiting during the first 24 postoperative hours.
Measured: 24 hours after surgery
Heart Rate
Intraoperative heart rate measured in beats per minute at predefined intraoperative time points.
Measured: From induction of anesthesia until the end of surgery
Mean Arterial Pressure
Intraoperative mean arterial pressure measured in millimeters of mercury at predefined intraoperative time points.
Measured: From induction of anesthesia until the end of surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Jul 2026
- Study start1 Aug 2026
- Primary completion1 Feb 2027 (estimated)
- Study completion1 Feb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Postoperative PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomized in a 1:1 ratio to receive either ultrasound-guided erector spinae plane block (ESPB) or modified external oblique intercostal plane block (EOIPB) before surgical incision. Both groups will receive standardized general anesthesia and postoperative multimodal analgesia.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Namik Kemal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Onur Baran, Namik Kemal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07726550
- Sponsor's protocol ID
- TNKU-EOIPB003
- Acronym
- EOIPB-ON
- Status last verified
- Sep 2026
- First submitted
- 22 Jun 2026
- Last updated
- 25 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: De-identified individual participant data are not planned to be shared because no formal data-sharing infrastructure or approved data-sharing plan has been established for this study.
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Modified External Oblique Intercostal Plane Block and Erector Spinae Plane Block for Postoperative Analgesia in Patients Undergoing Open Nephrectomy: A Prospective Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07726550
- Acronym / sponsor ID
- EOIPB-ON / TNKU-EOIPB003
- Conditions
- Postoperative Pain, Open Nephrectomy
- Keywords
- Erector Spinae Plane Block, External Oblique Intercostal Plane Block, Regional Anesthesia, EOIPB, ESPB, Postoperative Analgesia, Open Nephrectomy, Multimodal Analgesia
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Namik Kemal UniversityUniversity, hospital or other
- Study start
- 1 Aug 2026 (actual)
- Primary completion
- 1 Feb 2027 (estimated)
- Study completion
- 1 Feb 2027 (estimated)
- First posted
- 24 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective, randomized, assessor-blinded clinical trial aims to compare the postoperative analgesic efficacy of ultrasound-guided Erector Spinae Plane Block (ESPB) and Modified External Oblique Intercostal Plane Block (EOIPB) in patients undergoing elective open nephrectomy under general anesthesia. Sixty adult patients will be randomized to receive either ESPB or EOIPB before surgical incision. All participants will receive standardized general anesthesia and postoperative multimodal analgesia. Postoperative pain scores, opioid consumption, rescue analgesic requirements, and postoperative nausea and vomiting will be assessed during the first 24 hours after surgery. The study aims to determine whether one fascial plane block technique provides superior postoperative pain control and recovery following open nephrectomy.
Detailed description
Open nephrectomy is associated with substantial postoperative pain that may impair recovery, delay mobilization, and increase opioid consumption. Regional anesthesia techniques have become important components of multimodal analgesia strategies aimed at improving postoperative outcomes while minimizing opioid-related adverse effects.
The erector spinae plane block (ESPB) and modified external oblique intercostal plane block (EOIPB) are ultrasound-guided fascial plane blocks that have demonstrated effectiveness in providing thoracoabdominal analgesia. However, evidence directly comparing these techniques in patients undergoing open nephrectomy remains limited.
This study is a prospective, randomized, controlled, assessor-blinded clinical trial conducted at a single tertiary academic center. Sixty patients aged 18 to 65 years with ASA physical status I-II who are scheduled for elective open nephrectomy will be enrolled and randomized in a 1:1 ratio to one of two study groups.
Participants assigned to the ESPB group will receive an ultrasound-guided erector spinae plane block with 30 mL of 0.25% bupivacaine after induction of general anesthesia and before surgical incision. Participants assigned to the EOIPB group will receive an ultrasound-guided modified external oblique intercostal plane block using the same volume and concentration of local anesthetic.
All patients will receive standardized general anesthesia, postoperative intravenous patient-controlled analgesia with tramadol, scheduled paracetamol, and rescue analgesics according to institutional protocols. Patients will be followed in the post-anesthesia care unit and at postoperative 2, 6, 12, and 24 hours.
The primary objective is to compare postoperative pain intensity between the two groups during the first 24 postoperative hours. Secondary objectives include comparison of opioid consumption, rescue analgesic requirements, postoperative nausea and vomiting, and perioperative hemodynamic parameters.
The results of this study may help identify the optimal regional analgesia technique for patients undergoing open nephrectomy and contribute to enhanced postoperative recovery.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Participants will be randomized in a 1:1 ratio to receive either ultrasound-guided erector spinae plane block (ESPB) or modified external oblique intercostal plane block (EOIPB) before surgical incision. Both groups will receive standardized general anesthesia and postoperative multimodal analgesia.
| Arm | Type | Receives |
|---|---|---|
| ESPB Group | Experimental | Procedure: Erector Spinae Plane BlockParticipants will receive an ultrasound-guided erector spinae plane block with 30 mL of 0.25% bupivacaine after induction of general anesthesia and before surgical incision. Standardized general anesthesia and postoperative multimodal analgesia will be provided to all participants. |
| EOIPB Group | Experimental | Procedure: Modified External Oblique Intercostal Plane BlockParticipants will receive an ultrasound-guided modified external oblique intercostal plane block with 30 mL of 0.25% bupivacaine after induction of general anesthesia and before surgical incision. Standardized general anesthesia and postoperative multimodal analgesia will be provided to all participants. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age between 18 and 65 years.
- American Society of Anesthesiologists (ASA) physical status I or II.
- Scheduled for elective open nephrectomy.
- Able and willing to provide written informed consent.
- Willing to comply with study procedures.
Key exclusion criteria (8 listed)
- Refusal to participate or inability to provide informed consent.
- Emergency surgery.
- Body mass index (BMI) greater than 35 kg/m².
- Known allergy or hypersensitivity to local anesthetics.
- Infection at the planned block insertion site.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Erector Spinae Plane BlockUltrasound-guided erector spinae plane block performed after induction of general anesthesia using 30 mL of 0.25% bupivacaine before surgical incision. | Procedure or surgery | ESPB Group |
| Modified External Oblique Intercostal Plane BlockUltrasound-guided modified external oblique intercostal plane block performed after induction of general anesthesia using 30 mL of 0.25% bupivacaine before surgical incision. | Procedure or surgery | EOIPB Group |
Primary outcome
Pain intensity at rest
Time frame: 0, 2, 6, 12, and 24 hours after surgery
Postoperative pain intensity will be assessed at rest using the 11-point Numeric Rating Scale, ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores indicate greater pain intensity.
6 secondary outcomes
Pain intensity during movement
Time frame: 0, 2, 6, 12, and 24 hours after surgery
Total Opioid Consumption
Time frame: 24 hours after surgery
Rescue Analgesic Requirement
Time frame: 24 hours after surgery
Postoperative Nausea and Vomiting
Time frame: 24 hours after surgery
Heart Rate
Time frame: From induction of anesthesia until the end of surgery
Mean Arterial Pressure
Time frame: From induction of anesthesia until the end of surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2026.
- Individual participant dataSharing planned: No. De-identified individual participant data are not planned to be shared because no formal data-sharing infrastructure or approved data-sharing plan has been established for this study.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Erector Spinae Plane Block and Modified External Oblique Intercostal Plane Block in people with Postoperative Pain and Open Nephrectomy, run by Namik Kemal University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 25 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Onur Baran, MD (+90 539 342 25 82, dronurbaran@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain intensity at rest (time frame: 0, 2, 6, 12, and 24 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2026.