Ozone TherapyNCT07728422
Effects of Ozone Therapy on Muscle Damage
A study testing Autohemotherapy, Ozone Sauna Therapy and Ozonated Lavender Oil Massage in people with Ozone Therapy and Muscle Damage, run by Inonu University at 1 site in Turkey (Türkiye).
Trial summary
The goal of this clinical trial is to determine the effectiveness of different ozone therapy methods in enhancing recovery after muscle-damaging exercise in healthy adults, and to evaluate their impact on biochemical markers of muscle damage and fatigue. Read more about this study
- Who is it for?
- Ages 18 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Ozone Therapy, Muscle Damage, Oxidative Stress
- What is being tested?
- Autohemotherapy, Ozone Sauna Therapy and Ozonated Lavender Oil Massage
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 4 Oct 2024to 20 Feb 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- male football players aged 18-30 years
- playing exclusively in the midfield position
- active participation in regional professional football leagues (non-top-tier)
- engagement in regular football training at least four sessions per week with a minimum duration of 90 minutes per session
- absence of acute or chronic musculoskeletal injuries within the preceding six months
- no use of anti-inflammatory medications or ergogenic supplements within the four weeks prior to the study
Who cannot join
- female football players
- diagnosed cardiovascular, metabolic, or neurological disorders
- known hypersensitivity to ozone exposure or lavender oil
- any surgical intervention within the past six months
- concurrent participation in alternative recovery or therapeutic interventions during the study period
- playing positions other than midfield
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Ozone Therapy Modalities on Biochemical Markers of Muscle Damage Following Eccentric Exercise
The goal of this clinical trial is to determine the effectiveness of different ozone therapy methods in enhancing recovery after muscle-damaging exercise in healthy adults, and to evaluate their impact on biochemical markers of muscle damage and fatigue.
The main questions it aims to answer are:
Read more
- Do ozone-based interventions accelerate recovery by reducing biochemical markers of muscle damage and fatigue following eccentric exercise?
- Which ozone therapy modality provides the greatest recovery benefit? Researchers will compare three intervention groups (autohemotherapy, ozone sauna therapy, and ozonated lavender oil massage) with a control group receiving no treatment.
Participants will:
- Complete a standardized eccentric exercise protocol designed to induce muscle damage
- Receive one of the assigned interventions or no treatment (control)
- Provide blood samples at multiple time points (baseline, post-exercise, post-intervention, and 24, 48, and 72 hours follow-up) to assess recovery- related biomarkers
Read the detailed description
This randomized controlled trial was designed to investigate the effects of different ozone therapy modalities on recovery following eccentric exercise-induced muscle damage in healthy male amateur collegiate football players aged 18-30 years.
Thirty-two participants were randomly assigned to one of four groups: autohemotherapy, ozone sauna therapy, ozonated lavender oil massage, or a no-intervention control group (n = 8 per group). All participants completed a standardized eccentric exercise protocol to induce muscle damage and fatigue.
Following exercise, participants in the intervention groups received a single session of their assigned treatment, while the control group remained at rest without any recovery intervention. Autohemotherapy involved withdrawal of venous blood, exposure to an oxygen-ozone mixture, and reinfusion. Ozone sauna therapy was applied in a sealed cabin under controlled conditions with measures to prevent inhalation. Ozonated lavender oil massage was administered to the lower extremities using standardized massage techniques.
Blood samples were collected at baseline, immediately post-exercise, post-intervention, and at 24, 48, and 72 hours after intervention. Serum levels of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and uric acid (UA) were analyzed as indicators of muscle damage and metabolic stress.
Statistical analysis was performed using two-way permutational multivariate analysis of variance (PERMANOVA) to assess group, time, and group × time interaction effects.
- Conditions
- Ozone Therapy, Muscle Damage, Oxidative Stress, Recovery
- Being tested
- Autohemotherapy, Ozone Sauna Therapy, Ozonated Lavender Oil Massage
- Keywords
- Ozone theraphy, Eccentric exercise, Muscle damage biomarkers, Oxidative stress
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AutohemotherapyOther
Autohemotherapy was performed by withdrawing 100 mL of venous blood, which was subsequently exposed to an oxygen-ozone gas mixture (5% ozone, 95% oxygen) for 5-10 minutes in an ozone-resistant, sterile container. The ozonated blood was then rein-fused intravenously over a 15-minute period in accordance with established clinical protocols
Ozone Sauna TherapyOther
Ozone sauna therapy was administered in a sealed cabin maintained at a tempera-ture of 45°C. Participants remained seated with the head positioned outside the cabin and the neck sealed using a polyethylene collar to prevent ozone inhalation. Each session lasted 20 minutes and was conducted at an ozone concentration of 20 µg·mL-¹
Ozonated Lavender Oil MassageOther
Massage with ozonated lavender oil was administered by a certified massage thera-pist and targeted the lower extremity muscle groups, including the quadriceps, ham-strings, and gluteal muscles. The intervention lasted 20 minutes in total (10 minutes per limb) and followed standardized techniques adapted from Braun and Simonson (2008).
| Study group | Role | What they receive |
|---|---|---|
| Autohemotherapy | Experimental | Participants underwent major autohemotherapy involving withdrawal of venous blood, exposure to an oxygen-ozone mixture, and subsequent intravenous reinfusion in accordance with established clinical protocols Receives: Other: Autohemotherapy |
| Ozone Sauna Therapy | Experimental | Participants underwent ozone sauna therapy administered in a sealed cabin system, with the head outside the chamber to avoid inhalation, under controlled temperature and ozone concentration conditions. Receives: Other: Ozone Sauna Therapy |
| Ozonated Lavender Oil Massage | Experimental | Participants underwent massage therapy with ozonated lavender oil targeting lower extremity muscles, delivered by a certified therapist according to standardized procedures. Receives: Other: Ozonated Lavender Oil Massage |
| Control | No intervention | Participants remained at rest without receiving any recovery intervention, serving as the control condition for comparison. |
What is being measured
The primary outcome is the main question the study is designed to answer.
CK
Serum Creatine Kinase level
Measured: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.
Secondary outcomes (4)
LDH
Serum lactate dehydrogenase level
Measured: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.
AST
Serum Aspartate Aminotransferase level
Measured: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.
UA
Serum Uric Acid level
Measured: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.
ALT
Serum Alanine Aminotransferase level
Measured: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jul 2026
- Study start4 Oct 2024
- Primary completion28 Nov 2024
- Study completion20 Feb 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (29)Papers the sponsor has linked to this study.
- Other trials for Ozone TherapyStudies of the same condition, open and under way.
- More trials run by Inonu UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- Inonu University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, SERKAN DÜZ, Inonu University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07728422
- Sponsor's protocol ID
- 2019/188
- Status last verified
- Jul 2026
- First submitted
- 14 Jul 2026
- Last updated
- 27 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Description of the variables, or types of data, collected for each individual
Publications
Dupuy O, Douzi W, Theurot D, Bosquet L, Dugue B. An Evidence-Based Approach for Choosing Post-exercise Recovery Techniques to Reduce Markers of Muscle Damage, Soreness, Fatigue, and Inflammation: A Systematic Review With Meta-Analysis. Front Physiol. 2018 Apr 26;9:403. doi: 10.3389/fphys.2018.00403. eCollection 2018.
PubMed 29755363Paoli A, Bianco A, Battaglia G, Bellafiore M, Grainer A, Marcolin G, Cardoso CC, Dall'aglio R, Palma A. Sports massage with ozonised oil or non-ozonised oil: Comparative effects on recovery parameters after maximal effort in cyclists. Phys Ther Sport. 2013 Nov;14(4):240-5. doi: 10.1016/j.ptsp.2012.11.004. Epub 2013 Apr 24.
PubMed 23623301Moreno-Fernandez A, Macias-Garcia L, Valverde-Moreno R, Ortiz T, Fernandez-Rodriguez A, Molini-Estrada A, De-Miguel M. Autohemotherapy with ozone as a possible effective treatment for Fibromyalgia. Acta Reumatol Port. 2019 Sep 29;44(3):244-249. Print 2019 Jul-Sep.
PubMed 31575841Lin PH, Lin YP, Chen KL, Yang SY, Shih YH, Wang PY. Effect of aromatherapy on autonomic nervous system regulation with treadmill exercise-induced stress among adolescents. PLoS One. 2021 Apr 13;16(4):e0249795. doi: 10.1371/journal.pone.0249795. eCollection 2021.
PubMed 33848307Pandur E, Balatinacz A, Micalizzi G, Mondello L, Horvath A, Sipos K, Horvath G. Anti-inflammatory effect of lavender (Lavandula angustifolia Mill.) essential oil prepared during different plant phenophases on THP-1 macrophages. BMC Complement Med Ther. 2021 Nov 24;21(1):287. doi: 10.1186/s12906-021-03461-5.
PubMed 34819075Yousefi B, Banihashemian SZ, Feyzabadi ZK, Hasanpour S, Kokhaei P, Abdolshahi A, Emadi A, Eslami M. Potential therapeutic effect of oxygen-ozone in controlling of COVID-19 disease. Med Gas Res. 2022 Apr-Jun;12(2):33-40. doi: 10.4103/2045-9912.325989.
PubMed 34677149Tartari APS, Moreira FF, Pereira MCDS, Carraro E, Cidral-Filho FJ, Salgado AI, Kerppers II. Anti-inflammatory Effect of Ozone Therapy in an Experimental Model of Rheumatoid Arthritis. Inflammation. 2020 Jun;43(3):985-993. doi: 10.1007/s10753-020-01184-2.
PubMed 32382842Fatouros IG, Jamurtas AZ. Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance. J Inflamm Res. 2016 Oct 21;9:175-186. doi: 10.2147/JIR.S114635. eCollection 2016.
PubMed 27799809Hody S, Croisier JL, Bury T, Rogister B, Leprince P. Eccentric Muscle Contractions: Risks and Benefits. Front Physiol. 2019 May 3;10:536. doi: 10.3389/fphys.2019.00536. eCollection 2019.
PubMed 31130877Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: Friend or foe? J Sport Health Sci. 2020 Sep;9(5):415-425. doi: 10.1016/j.jshs.2020.04.001. Epub 2020 May 4.
PubMed 32380253Davis HL, Alabed S, Chico TJA. Effect of sports massage on performance and recovery: a systematic review and meta-analysis. BMJ Open Sport Exerc Med. 2020 May 7;6(1):e000614. doi: 10.1136/bmjsem-2019-000614. eCollection 2020.
PubMed 32426160Clavo B, Rodriguez-Esparragon F, Rodriguez-Abreu D, Martinez-Sanchez G, Llontop P, Aguiar-Bujanda D, Fernandez-Perez L, Santana-Rodriguez N. Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects. Antioxidants (Basel). 2019 Nov 26;8(12):588. doi: 10.3390/antiox8120588.
PubMed 31779159Hidalgo-Tallon FJ, Pinto-Bonilla R, Baeza-Noci J, Menendez-Cepero S, Cabizosu A. Medical ozone on hamstring injury in a professional athlete assessed by thermography: a clinical case report. BJR Case Rep. 2023 Jun 13;9(4):20220078. doi: 10.1259/bjrcr.20220078. eCollection 2023 Aug.
PubMed 37576006Scassellati C, Galoforo AC, Bonvicini C, Esposito C, Ricevuti G. Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders. Ageing Res Rev. 2020 Nov;63:101138. doi: 10.1016/j.arr.2020.101138. Epub 2020 Aug 15.
PubMed 32810649Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res. 2006 May;37(4):425-35. doi: 10.1016/j.arcmed.2005.08.006.
PubMed 16624639
Study at a glance
From the registry record, last updated by the sponsor on 27 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Ozone Therapy Modalities on Biochemical Markers of Muscle Damage Following Eccentric Exercise
- ClinicalTrials.gov ID
- NCT07728422
- Acronym / sponsor ID
- 2019/188
- Conditions
- Ozone Therapy, Muscle Damage, Oxidative Stress, Recovery
- Keywords
- Ozone theraphy, Eccentric exercise, Muscle damage biomarkers, Oxidative stress
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- Inonu UniversityUniversity, hospital or other
- Study start
- 4 Oct 2024 (actual)
- Primary completion
- 28 Nov 2024 (actual)
- Study completion
- 20 Feb 2025 (actual)
- First posted
- 27 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to determine the effectiveness of different ozone therapy methods in enhancing recovery after muscle-damaging exercise in healthy adults, and to evaluate their impact on biochemical markers of muscle damage and fatigue.
The main questions it aims to answer are:
- Do ozone-based interventions accelerate recovery by reducing biochemical markers of muscle damage and fatigue following eccentric exercise?
- Which ozone therapy modality provides the greatest recovery benefit? Researchers will compare three intervention groups (autohemotherapy, ozone sauna therapy, and ozonated lavender oil massage) with a control group receiving no treatment.
Participants will:
- Complete a standardized eccentric exercise protocol designed to induce muscle damage
- Receive one of the assigned interventions or no treatment (control)
- Provide blood samples at multiple time points (baseline, post-exercise, post-intervention, and 24, 48, and 72 hours follow-up) to assess recovery- related biomarkers
Detailed description
This randomized controlled trial was designed to investigate the effects of different ozone therapy modalities on recovery following eccentric exercise-induced muscle damage in healthy male amateur collegiate football players aged 18-30 years.
Thirty-two participants were randomly assigned to one of four groups: autohemotherapy, ozone sauna therapy, ozonated lavender oil massage, or a no-intervention control group (n = 8 per group). All participants completed a standardized eccentric exercise protocol to induce muscle damage and fatigue.
Following exercise, participants in the intervention groups received a single session of their assigned treatment, while the control group remained at rest without any recovery intervention. Autohemotherapy involved withdrawal of venous blood, exposure to an oxygen-ozone mixture, and reinfusion. Ozone sauna therapy was applied in a sealed cabin under controlled conditions with measures to prevent inhalation. Ozonated lavender oil massage was administered to the lower extremities using standardized massage techniques.
Blood samples were collected at baseline, immediately post-exercise, post-intervention, and at 24, 48, and 72 hours after intervention. Serum levels of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and uric acid (UA) were analyzed as indicators of muscle damage and metabolic stress.
Statistical analysis was performed using two-way permutational multivariate analysis of variance (PERMANOVA) to assess group, time, and group × time interaction effects.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Autohemotherapy | Experimental | Other: AutohemotherapyParticipants underwent major autohemotherapy involving withdrawal of venous blood, exposure to an oxygen-ozone mixture, and subsequent intravenous reinfusion in accordance with established clinical protocols |
| Ozone Sauna Therapy | Experimental | Other: Ozone Sauna TherapyParticipants underwent ozone sauna therapy administered in a sealed cabin system, with the head outside the chamber to avoid inhalation, under controlled temperature and ozone concentration conditions. |
| Ozonated Lavender Oil Massage | Experimental | Other: Ozonated Lavender Oil MassageParticipants underwent massage therapy with ozonated lavender oil targeting lower extremity muscles, delivered by a certified therapist according to standardized procedures. |
| Control | No intervention | –Participants remained at rest without receiving any recovery intervention, serving as the control condition for comparison. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- male football players aged 18-30 years
- playing exclusively in the midfield position
- active participation in regional professional football leagues (non-top-tier)
- engagement in regular football training at least four sessions per week with a minimum duration of 90 minutes per session
- absence of acute or chronic musculoskeletal injuries within the preceding six months
Key exclusion criteria (6 listed)
- female football players
- diagnosed cardiovascular, metabolic, or neurological disorders
- known hypersensitivity to ozone exposure or lavender oil
- any surgical intervention within the past six months
- concurrent participation in alternative recovery or therapeutic interventions during the study period
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AutohemotherapyAutohemotherapy was performed by withdrawing 100 mL of venous blood, which was subsequently exposed to an oxygen-ozone gas mixture (5% ozone, 95% oxygen) for 5-10 minutes in an ozone-resistant, sterile container. The ozonated blood was then rein-fused intravenously over a 15-minute period in accordance with established clinical protocols | Other | Autohemotherapy |
| Ozone Sauna TherapyOzone sauna therapy was administered in a sealed cabin maintained at a tempera-ture of 45°C. Participants remained seated with the head positioned outside the cabin and the neck sealed using a polyethylene collar to prevent ozone inhalation. Each session lasted 20 minutes and was conducted at an ozone concentration of 20 µg·mL-¹ | Other | Ozone Sauna Therapy |
| Ozonated Lavender Oil MassageMassage with ozonated lavender oil was administered by a certified massage thera-pist and targeted the lower extremity muscle groups, including the quadriceps, ham-strings, and gluteal muscles. The intervention lasted 20 minutes in total (10 minutes per limb) and followed standardized techniques adapted from Braun and Simonson (2008). | Other | Ozonated Lavender Oil Massage |
Primary outcome
CK
Time frame: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.
Serum Creatine Kinase level
4 secondary outcomes
LDH
Time frame: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.
AST
Time frame: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.
UA
Time frame: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.
ALT
Time frame: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jul 2026.
- Background: PubMed 29755363Dupuy O, Douzi W, Theurot D, Bosquet L, Dugue B. An Evidence-Based Approach for Choosing Post-exercise Recovery Techniques to Reduce Markers of Muscle Damage, Soreness, Fatigue, and Inflammation: A Systematic Review With Meta-Analysis. Front Physiol. 2018 Apr 26;9:403. doi: 10.3389/fphys.2018.00403. eCollection 2018.
- Background: PubMed 23623301Paoli A, Bianco A, Battaglia G, Bellafiore M, Grainer A, Marcolin G, Cardoso CC, Dall'aglio R, Palma A. Sports massage with ozonised oil or non-ozonised oil: Comparative effects on recovery parameters after maximal effort in cyclists. Phys Ther Sport. 2013 Nov;14(4):240-5. doi: 10.1016/j.ptsp.2012.11.004. Epub 2013 Apr 24.
- Background: PubMed 31575841Moreno-Fernandez A, Macias-Garcia L, Valverde-Moreno R, Ortiz T, Fernandez-Rodriguez A, Molini-Estrada A, De-Miguel M. Autohemotherapy with ozone as a possible effective treatment for Fibromyalgia. Acta Reumatol Port. 2019 Sep 29;44(3):244-249. Print 2019 Jul-Sep.
- Background: PubMed 33848307Lin PH, Lin YP, Chen KL, Yang SY, Shih YH, Wang PY. Effect of aromatherapy on autonomic nervous system regulation with treadmill exercise-induced stress among adolescents. PLoS One. 2021 Apr 13;16(4):e0249795. doi: 10.1371/journal.pone.0249795. eCollection 2021.
- Background: PubMed 34819075Pandur E, Balatinacz A, Micalizzi G, Mondello L, Horvath A, Sipos K, Horvath G. Anti-inflammatory effect of lavender (Lavandula angustifolia Mill.) essential oil prepared during different plant phenophases on THP-1 macrophages. BMC Complement Med Ther. 2021 Nov 24;21(1):287. doi: 10.1186/s12906-021-03461-5.
- Background: PubMed 34677149Yousefi B, Banihashemian SZ, Feyzabadi ZK, Hasanpour S, Kokhaei P, Abdolshahi A, Emadi A, Eslami M. Potential therapeutic effect of oxygen-ozone in controlling of COVID-19 disease. Med Gas Res. 2022 Apr-Jun;12(2):33-40. doi: 10.4103/2045-9912.325989.
- Background: PubMed 32382842Tartari APS, Moreira FF, Pereira MCDS, Carraro E, Cidral-Filho FJ, Salgado AI, Kerppers II. Anti-inflammatory Effect of Ozone Therapy in an Experimental Model of Rheumatoid Arthritis. Inflammation. 2020 Jun;43(3):985-993. doi: 10.1007/s10753-020-01184-2.
- Background: PubMed 27799809Fatouros IG, Jamurtas AZ. Insights into the molecular etiology of exercise-induced inflammation: opportunities for optimizing performance. J Inflamm Res. 2016 Oct 21;9:175-186. doi: 10.2147/JIR.S114635. eCollection 2016.
- Background: PubMed 31130877Hody S, Croisier JL, Bury T, Rogister B, Leprince P. Eccentric Muscle Contractions: Risks and Benefits. Front Physiol. 2019 May 3;10:536. doi: 10.3389/fphys.2019.00536. eCollection 2019.
- Background: PubMed 32380253Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: Friend or foe? J Sport Health Sci. 2020 Sep;9(5):415-425. doi: 10.1016/j.jshs.2020.04.001. Epub 2020 May 4.
- Background: PubMed 32426160Davis HL, Alabed S, Chico TJA. Effect of sports massage on performance and recovery: a systematic review and meta-analysis. BMJ Open Sport Exerc Med. 2020 May 7;6(1):e000614. doi: 10.1136/bmjsem-2019-000614. eCollection 2020.
- Background: PubMed 31779159Clavo B, Rodriguez-Esparragon F, Rodriguez-Abreu D, Martinez-Sanchez G, Llontop P, Aguiar-Bujanda D, Fernandez-Perez L, Santana-Rodriguez N. Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects. Antioxidants (Basel). 2019 Nov 26;8(12):588. doi: 10.3390/antiox8120588.
- Individual participant dataSharing planned: Yes. Description of the variables, or types of data, collected for each individual
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Autohemotherapy, Ozone Sauna Therapy and Ozonated Lavender Oil Massage in people with Ozone Therapy and Muscle Damage, run by Inonu University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
CK (time frame: Baseline, immediately post-exercise, immediately after ozone sauna treatment, 24 hours after ozone sauna treatment, 48 hours after ozone sauna treatment and 72 hours after ozone sauna treatment.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07728422, which also lists 29 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jul 2026.