AsthmaNCT07728578
Effect of Pilates Training Versus High Intensity Interval Training on Cardiorespiratory Fitness in Asthmatic Patients
A study testing Pilates exercises, low-volume high-intensity interval training and diaphragmatic breathing exercise. in people with Asthma, run by Horus University at 1 site in Egypt.
Trial summary
To compare the effect of Pilates Training Versus High Intensity Interval Training on Cardiorespiratory Fitness in Asthmatic Patients. Read more about this study
- Who is it for?
- Ages 30 to 40 years
- Conditions the study is for
- Asthma
- What is being tested?
- Pilates exercises, low-volume high-intensity interval training and diaphragmatic breathing exercise.
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 51 participants
- Where
- 1 siteEgypt
- Study dates
- 25 Jul 2026to 30 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- 51 patients diagnosed with a clinical diagnosis of asthma and a history of respiratory illness, aged between 30 and 40 years.
- Medically stable and capable of performing physical exercise.
- All participants provided written informed consent before enrollment.
- body mass index 25.0 - 29.9 (overweight)
- Patients with partially controlled asthma according to the Asthma Control Questionnaire (ACQ) from 0 to 1.5.
Who cannot join
- Participants with musculoskeletal limitations, cardiovascular instability, or any contraindications to exercise were excluded.
- Uncontrolled hypertension.
- Cognitive impaired patients.
- Severe Anemic patients.
- Pregnancy.
- Recent cardiothoracic surgery.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
out-patient clinic, faculty of physical therapy, Horus university
Damietta
Ghidaa Elmahdi Eldomiaty, Assistant lecturer, +20 10 22143737, gelmahdi@horus.edu.eg
About this study
To compare the effect of Pilates Training Versus High Intensity Interval Training on Cardiorespiratory Fitness in Asthmatic Patients.
Read the detailed description
Asthma is a widespread chronic inflammatory disease affecting over 300 million people globally, leading to approximately 461,000 deaths annually. Exercise, particularly Pilates and high-intensity interval training, is critical for improving cardiorespiratory fitness and can enhance the quality of life for asthma patients, who often face reduced physical fitness and comorbidities like depression. Pilates improves respiratory control and strengthens respiratory muscles, while high-intensity interval training enhances aerobic and anaerobic capacities, reduces inflammation, and improves maximal oxygen uptake (VO₂ max). This study aims to establish guidelines comparing the effects of Pilates and high-intensity interval training on cardiorespiratory fitness in asthmatic patients.
- Conditions
- Asthma
- Being tested
- Pilates exercises, low-volume high-intensity interval training, diaphragmatic breathing exercise.
- Medical subject headings
- Asthma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Pilates exercisesOther
17 Patients will perform Pilates exercises 40-60 mins, three times per week, over 8weeks.
Pilates exercises include five movements: The Hundred, Single Leg Stretch, Side Kick, Toe Taps, and Leg Pull Front, all performed with structured breathing Patterns To Emphasize Respiratory Control And Core Stabilization
low-volume high-intensity interval trainingOther
17 patients will engage in low-volume high-intensity interval training complemented by diaphragmatic breathing exercises. Each session begins with a 5-10 minute warm-up on a treadmill at 40% of heart rate reserve. The targeted heart rate during high-intensity interval training is set at 85-90% of heart rate reserve plus resting heart rate. Participants will complete 3-minute high-intensity interval training intervals at the specified intensity, alternating with 2 minutes of moderate-intensity recovery at 60-70% heart rate reserve. Total exercise duration is 25-30 minutes, concluding with a 5-minute cool-down at 30% heart rate reserve.
diaphragmatic breathing exercise.Other
Breathing in slowly and deeply through the nose using the diaphragm with a minimum movement of the chest in a supine position with one hand placed on the chest and the other on the belly. During breathing, practitioners should be careful that chest remains as still as possible and stomach moves against the hand focusing on contracting the diaphragm. Generally, diaphragmatic breathing practitioners inhale and exhale for approximately six seconds, respectively
| Study group | Role | What they receive |
|---|---|---|
| Pilates exercises | Experimental | Patients will receive Pilates exercises administered to Group A include five movements: The Hundred, Single Leg Stretch, Side Kick, Toe Taps, and Leg Pull Front all performed with structured breathing patterns to emphasize respiratory control and core stabilization. Receives: Other: Pilates exercises; Other: diaphragmatic breathing exercise. |
| low-volume high-intensity interval training | Experimental | Patients will receive low-volume high-intensity interval training. Participants will perform 3-minute High Intensity Interval Training intervals on a treadmill at 85- 90% of heart rate reserve, each followed by 2 minutes of moderate-intensity active recovery at 60% -70% of eart rate reserve. The total time spent in the exercise session is 25-30 minutes. Receives: Other: low-volume high-intensity interval training; Other: diaphragmatic breathing exercise. |
| Diaphragmatic breathing exercises | Active comparator | Diaphragmatic breathing exercises involve inhaling slowly through the nose while keeping the chest still and allowing the diaphragm to move the stomach. This is performed in a supine position, with one hand on the chest and the other on the belly, ensuring minimal chest movement. Practitioners typically inhale and exhale over six seconds each. Receives: Other: diaphragmatic breathing exercise. |
What is being measured
The primary outcome is the main question the study is designed to answer.
assessment of maximum oxygen consumption
Cardiopulmonary exercise testing is essential for evaluating patient symptoms, disease severity, prognosis, and therapy responses. It assesses the interaction of cardiovascular and pulmonary systems with other bodily systems. maximum oxygen consumption is calculated using the Bruce protocol via the Ergo Spiro Device. This protocol involves a multi-stage treadmill test, starting at a 10% grade and increasing speed and grade every three minutes until exhaustion. Subjects must refrain from eating, smoking, and consuming caffeine before testing, and avoid intense exercise leading up to the test.
Measured: At baseline and after 8 weeks
Secondary outcomes (3)
assessment of Quality of Life
The Mini-Asthma Quality of Life Questionnaire is a shortened, 15-item version of the original questionnaire, designed to accurately assess the quality of life in asthmatic patients without consuming much time. It evaluates four domains: symptoms, activity limitation, emotional function, and environmental stimuli, based on the respondents' experiences over the past two weeks. it employs a 7-point Likert scale, where 7 indicates no impairment and 1 signifies significant impairment
Measured: At baseline and after 8 weeks
assessment of dyspnea
The Modified Borg Dyspnea Scale is a validated, numerical rating scale used to quantify the subjective perception of breathlessness during physical activity or exercise. The scale ranges from 0 to 10, where 0 indicates no breathlessness and 10 represents maximal or extremely severe breathlessness. Participants are instructed to rate their perceived level of dyspnea immediately after or during exercise, providing a simple, reliable, and clinically applicable measure of symptom intensity for monitoring exercise tolerance and evaluating treatment outcomes.
Measured: At baseline and after 8 weeks
assessment of asthma symptoms
Asthma Control Questionnaire (ACQ-6) is a six-item questionnaire designed to measure asthma symptoms. The questionnaire is scored by the mean of all items (0-6), with higher scores indicating poorer control.
Measured: At baseline and after 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jul 2026
- Study start25 Jul 2026 (estimated)
- Primary completion1 Nov 2026 (estimated)
- Study completion30 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AsthmaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 51 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Horus University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ghidaa Elmahdi Eldomiaty, Horus University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07728578
- Sponsor's protocol ID
- Ghidaa-PHD
- Status last verified
- Jul 2026
- First submitted
- 22 Jul 2026
- Last updated
- 27 Jul 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Pilates Training Versus High Intensity Interval Training on Cardiorespiratory Fitness in Asthmatic Patients
- ClinicalTrials.gov ID
- NCT07728578
- Acronym / sponsor ID
- Ghidaa-PHD
- Conditions
- Asthma
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 51 participants (estimated)
- Lead sponsor
- Horus UniversityUniversity, hospital or other
- Study start
- 25 Jul 2026 (estimated)
- Primary completion
- 1 Nov 2026 (estimated)
- Study completion
- 30 Nov 2026 (estimated)
- First posted
- 27 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To compare the effect of Pilates Training Versus High Intensity Interval Training on Cardiorespiratory Fitness in Asthmatic Patients.
Detailed description
Asthma is a widespread chronic inflammatory disease affecting over 300 million people globally, leading to approximately 461,000 deaths annually. Exercise, particularly Pilates and high-intensity interval training, is critical for improving cardiorespiratory fitness and can enhance the quality of life for asthma patients, who often face reduced physical fitness and comorbidities like depression. Pilates improves respiratory control and strengthens respiratory muscles, while high-intensity interval training enhances aerobic and anaerobic capacities, reduces inflammation, and improves maximal oxygen uptake (VO₂ max). This study aims to establish guidelines comparing the effects of Pilates and high-intensity interval training on cardiorespiratory fitness in asthmatic patients.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Pilates exercises | Experimental | Other: Pilates exercises, Other: diaphragmatic breathing exercise.Patients will receive Pilates exercises administered to Group A include five movements: The Hundred, Single Leg Stretch, Side Kick, Toe Taps, and Leg Pull Front all performed with structured breathing patterns to emphasize respiratory control and core stabilization. |
| low-volume high-intensity interval training | Experimental | Other: low-volume high-intensity interval training, Other: diaphragmatic breathing exercise.Patients will receive low-volume high-intensity interval training. Participants will perform 3-minute High Intensity Interval Training intervals on a treadmill at 85- 90% of heart rate reserve, each followed by 2 minutes of moderate-intensity active recovery at 60% -70% of eart rate reserve. The total time spent in the exercise session is 25-30 minutes. |
| Diaphragmatic breathing exercises | Active comparator | Other: diaphragmatic breathing exercise.Diaphragmatic breathing exercises involve inhaling slowly through the nose while keeping the chest still and allowing the diaphragm to move the stomach. This is performed in a supine position, with one hand on the chest and the other on the belly, ensuring minimal chest movement. Practitioners typically inhale and exhale over six seconds each. |
Who may qualify
- Ages
- 30 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- 51 patients diagnosed with a clinical diagnosis of asthma and a history of respiratory illness, aged between 30 and 40 years.
- Medically stable and capable of performing physical exercise.
- All participants provided written informed consent before enrollment.
- body mass index 25.0 - 29.9 (overweight)
- Patients with partially controlled asthma according to the Asthma Control Questionnaire (ACQ) from 0 to 1.5.
Key exclusion criteria (6 listed)
- Participants with musculoskeletal limitations, cardiovascular instability, or any contraindications to exercise were excluded.
- Uncontrolled hypertension.
- Cognitive impaired patients.
- Severe Anemic patients.
- Pregnancy.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Pilates exercises17 Patients will perform Pilates exercises 40-60 mins, three times per week, over 8weeks. Pilates exercises include five movements: The Hundred, Single Leg Stretch, Side Kick, Toe Taps, and Leg Pull Front, all performed with structured breathing Patterns To Emphasize Respiratory Control And Core Stabilization | Other | Pilates exercises |
| low-volume high-intensity interval training17 patients will engage in low-volume high-intensity interval training complemented by diaphragmatic breathing exercises. Each session begins with a 5-10 minute warm-up on a treadmill at 40% of heart rate reserve. The targeted heart rate during high-intensity interval training is set at 85-90% of heart rate reserve plus resting heart rate. Participants will complete 3-minute high-intensity interval training intervals at the specified intensity, alternating with 2 minutes of moderate-intensity recovery at 60-70% heart rate reserve. Total exercise duration is 25-30 minutes, concluding with a 5-minute cool-down at 30% heart rate reserve. | Other | low-volume high-intensity interval training |
| diaphragmatic breathing exercise.Breathing in slowly and deeply through the nose using the diaphragm with a minimum movement of the chest in a supine position with one hand placed on the chest and the other on the belly. During breathing, practitioners should be careful that chest remains as still as possible and stomach moves against the hand focusing on contracting the diaphragm. Generally, diaphragmatic breathing practitioners inhale and exhale for approximately six seconds, respectively | Other | Diaphragmatic breathing exercises, Pilates exercises, low-volume high-intensity interval training |
Primary outcome
assessment of maximum oxygen consumption
Time frame: At baseline and after 8 weeks
Cardiopulmonary exercise testing is essential for evaluating patient symptoms, disease severity, prognosis, and therapy responses. It assesses the interaction of cardiovascular and pulmonary systems with other bodily systems. maximum oxygen consumption is calculated using the Bruce protocol via the Ergo Spiro Device. This protocol involves a multi-stage treadmill test, starting at a 10% grade and increasing speed and grade every three minutes until exhaustion. Subjects must refrain from eating, smoking, and consuming caffeine before testing, and avoid intense exercise leading up to the test.
3 secondary outcomes
assessment of Quality of Life
Time frame: At baseline and after 8 weeks
assessment of dyspnea
Time frame: At baseline and after 8 weeks
assessment of asthma symptoms
Time frame: At baseline and after 8 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Pilates exercises, low-volume high-intensity interval training and diaphragmatic breathing exercise. in people with Asthma, run by Horus University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 27 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ghidaa Elmahdi Eldomiaty, Assistant lecturer (+20 10 22143737, gelmahdi@horus.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
assessment of maximum oxygen consumption (time frame: At baseline and after 8 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jul 2026.