Myocardial Infarction (MI)ECCENTRIC-MINCT07729410
Eccentric Exercise Rehabilitation After Myocardial Infarction
A study testing Standard Inpatient Cardiac Rehabilitation and Eccentric Cycling Exercise in people with Myocardial Infarction (MI) and Cardiac Rehabilitation, run by Medical University of Gdansk at 1 site in Poland.
Trial summary
This clinical trial will evaluate a two-week eccentric exercise program conducted as part of comprehensive cardiac rehabilitation in patients after a heart attack (myocardial infarction). Read more about this study
- Who is it for?
- Ages 50 to 75 years, men only
- Conditions the study is for
- Myocardial Infarction (MI), Cardiac Rehabilitation
- What is being tested?
- Standard Inpatient Cardiac Rehabilitation and Eccentric Cycling Exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 sitePoland
- Study dates
- 22 Jul 2026to 21 Jul 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 75 years
- Men only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Documented history of myocardial infarction confirmed by medical records.
- Qualification for stage I comprehensive inpatient cardiac rehabilitation.
- Clinically stable condition allowing participation in exercise-based cardiac rehabilitation.
- New York Heart Association functional class I or II.
- Moderate or good exercise tolerance, defined as an exercise capacity of at least 5 metabolic equivalents, assessed during an exercise test.
- No cardiovascular contraindications to exercise testing or participation in exercise-based cardiac rehabilitation.
- Ability to understand the study procedures and follow the instructions provided by the study personnel.
- Provision of written informed consent to participate in the study.
Who cannot join
- Any contraindication to exercise-based cardiac rehabilitation or exercise testing.
- Acute myocardial infarction within the first 4 days before planned initiation of exercise rehabilitation.
- Unstable angina.
- Significant left main coronary artery stenosis considered a contraindication to exercise by the treating cardiologist.
- Symptomatic cardiac arrhythmias.
- Symptomatic severe aortic stenosis.
Show all 18Show fewer
- Decompensated heart failure.
- Acute pulmonary embolism or pulmonary infarction.
- Deep vein thrombosis.
- Recent or mobile intracardiac thrombus.
- Acute myocarditis, endocarditis, or pericarditis.
- Aortic dissection.
- Symptomatic acquired second- or third-degree atrioventricular block without appropriate cardiac pacing.
- Poorly controlled arterial hypertension.
- Recent stroke or transient cerebral ischemic event.
- Any acute or uncontrolled non-cardiovascular condition that may interfere with exercise testing or worsen during exercise, including febrile illness, clinically significant electrolyte abnormalities, uncontrolled hyperthyroidism, or clinically significant anemia.
- Physical or cognitive impairment preventing safe completion of the study procedures, exercise testing, or training intervention.
- Inability or unwillingness to provide written informed consent.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Poland1 site
Florian Ceynowa Specialist Hospital in Wejherowo
Wejherowo, Pomeranian Voivodeship, 84-200
Joanna Jaworska, PhD, +48503864566, joanna.jaworska@awf.gda.pl
Tomasz Klinkosz, MD, +48729716689, tomaszklinkosz12@gmail.com
About this study
Official title: Effects of Two-Week Eccentric Exercise-Based Cardiac Rehabilitation on Myokines, Exerkines, and Physical Function in Patients After Myocardial Infarction
This clinical trial will evaluate a two-week eccentric exercise program conducted as part of comprehensive cardiac rehabilitation in patients after a heart attack (myocardial infarction). Eccentric exercise involves muscle contractions while the muscles are lengthening and may allow the muscles to work at a relatively high load with a lower cardiovascular and metabolic demand than traditional exercise.
The main aim of the study is to determine whether eccentric exercise affects blood levels of proteins released or regulated in response to physical activity, including musclin, interleukin-6, and myostatin. The study will also evaluate whether the program improves physical performance and functional capacity.
Participants will complete eccentric cycling exercise on a semi-recumbent cycle ergometer during a two-week cardiac rehabilitation program. Blood samples and physical-function measurements will be collected before and after the intervention.
Read the detailed description
Exercise-based cardiac rehabilitation is an important component of secondary prevention after myocardial infarction. However, some patients experience reduced exercise tolerance or fear of physical activity, which may limit participation in rehabilitation and contribute to physical deconditioning, loss of muscle mass, and reduced functional capacity.
Eccentric exercise is characterized by muscle contractions performed while the muscle is lengthening. Compared with traditional concentric exercise, eccentric exercise can provide a relatively high mechanical load to skeletal muscles while requiring lower oxygen consumption and imposing a lower metabolic demand. For this reason, eccentric training may be a useful rehabilitation strategy for patients who have limited exercise tolerance after myocardial infarction.
The intervention will consist of a two-week eccentric cycling program performed on a semi-recumbent cycle ergometer as part of comprehensive cardiac rehabilitation. The training is intended to provide controlled loading of the lower-limb muscles while limiting excessive cardiovascular strain.
The primary scientific objective is to evaluate changes in the molecular response to eccentric exercise, with particular emphasis on circulating myokines and exerkines. Blood concentrations of musclin, interleukin-6, and myostatin will be assessed before and after the rehabilitation period. The study will also evaluate changes in physical performance, muscle function, and functional exercise capacity using the assessments specified in the study protocol.
The findings may help determine whether eccentric exercise produces beneficial molecular and functional adaptations in patients undergoing cardiac rehabilitation after myocardial infarction.
- Conditions
- Myocardial Infarction (MI), Cardiac Rehabilitation
- Being tested
- Standard Inpatient Cardiac Rehabilitation, Eccentric Cycling Exercise
- Keywords
- Eccentric Exercise, Eccentric Cycling, Cardiac Rehabilitation, Post-Myocardial Infarction, Myokines, Exerkines, Functional Capacity, Kinesiophobia
- Medical subject headings
- Myocardial Infarction, Kinesiophobia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Standard Inpatient Cardiac RehabilitationBehavioural
Standard stage I inpatient cardiac rehabilitation provided after myocardial infarction and individualized according to each participant's clinical condition and exercise capacity. The program includes standard kinesitherapy and exercise-based rehabilitation procedures.
Eccentric Cycling ExerciseBehavioural
Supervised eccentric cycling exercise performed on a motor-driven semi-recumbent cycle ergometer in addition to standard inpatient cardiac rehabilitation. Sessions will last 10 to 30 minutes, with progressive adaptation during the first five sessions. Exercise workload will be individualized according to baseline exercise capacity. Perceived exertion and muscle soreness will be monitored during each session.
| Study group | Role | What they receive |
|---|---|---|
| Standard Cardiac Rehabilitation | Active comparator | Standard stage I inpatient cardiac rehabilitation provided after myocardial infarction and individualized according to each participant's clinical condition and exercise capacity. The program includes standard kinesitherapy and exercise-based rehabilitation procedures. Receives: Behavioral: Standard Inpatient Cardiac Rehabilitation |
| Standard Cardiac Rehabilitation Plus Eccentric Cycling | Experimental | Supervised eccentric cycling exercise performed on a motor-driven semi-recumbent cycle ergometer in addition to standard inpatient cardiac rehabilitation. Sessions will last 10 to 30 minutes, with progressive adaptation during the first five sessions. Exercise workload will be individualized according to baseline exercise capacity. Perceived exertion and muscle soreness will be monitored during each session. Receives: Behavioral: Standard Inpatient Cardiac Rehabilitation; Behavioral: Eccentric Cycling Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change From Baseline in Serum Musclin Concentration
Serum musclin concentration will be measured in fasting venous blood samples using an enzyme-linked immunosorbent assay (ELISA). The outcome will be calculated as the concentration measured after the intervention minus the baseline concentration and reported in ng/mL.
Measured: Baseline and after completion of the 2-week inpatient cardiac rehabilitation program
Change From Baseline in Serum Myostatin Concentration
Serum myostatin concentration will be measured in fasting venous blood samples using an enzyme-linked immunosorbent assay (ELISA). The outcome will be calculated as the concentration measured after the intervention minus the baseline concentration.
Measured: Baseline and after completion of the 2-week inpatient cardiac rehabilitation program
Change From Baseline in Serum Interleukin-6 Concentration
Serum interleukin-6 concentration will be measured in fasting venous blood samples using an enzyme-linked immunosorbent assay (ELISA). The outcome will be calculated as the concentration measured after the intervention minus the baseline concentration.
Measured: Baseline and after completion of the 2-week inpatient cardiac rehabilitation program
Secondary outcomes (4)
Change From Baseline in Six-Minute Walk Distance
Functional exercise capacity will be assessed using the Six-Minute Walk Test. Participants will be instructed to walk as far as possible during 6 minutes along a designated walking course under the supervision of qualified medical personnel. The total distance covered will be recorded in meters. The outcome will be calculated as the post-intervention distance minus the baseline distance, with a positive value indicating an improvement in functional exercise capacity.
Measured: Baseline, before initiation of the inpatient cardiac rehabilitation program, and after completion of the 2-week intervention
30-Second Chair-Stand Test
Functional lower-limb strength will be assessed using the 30-Second Chair-Stand Test. Participants will be instructed to repeatedly rise to a full standing position and return to a seated position during a 30-second period. The number of correctly completed repetitions will be recorded. The outcome will be calculated as the post-intervention number of repetitions minus the baseline number, with a positive value indicating an improvement in functional lower-limb performance.
Measured: Baseline, before initiation of the inpatient cardiac rehabilitation program, and after completion of the 2-week intervention
Change From Baseline in Kinesiophobia Assessed Using the Tampa Scale for Kinesiophobia Heart
Fear of physical activity and movement related to the participant's cardiac condition will be assessed using the validated Polish version of the 17-item Tampa Scale for Kinesiophobia Heart. Participants will complete the questionnaire according to the standardized scoring procedure. The total score will be reported in points. The outcome will be calculated as the post-intervention total score minus the baseline total score. A negative change will indicate a reduction in kinesiophobia, whereas a positive change will indicate an increase in kinesiophobia.
Measured: Baseline, before initiation of the inpatient cardiac rehabilitation program, and after completion of the 2-week intervention
Change From Baseline in Peak Force During the Isometric Mid-Thigh Pull Test
Maximal isometric lower-limb strength will be assessed using the Isometric Mid-Thigh Pull test performed on a force platform. Participants will perform a maximal isometric pull against a fixed bar while standing with partial flexion of the knee and hip joints. Peak force will be determined from the recorded ground reaction force signal and reported in newtons. The outcome will be calculated as the post-intervention peak force minus the baseline peak force, with a positive value indicating an increase in maximal isometric strength.
Measured: Baseline, before initiation of the inpatient cardiac rehabilitation program, and after completion of the 2-week intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jul 2026
- Study start22 Jul 2026 (estimated)
- Primary completion21 Jul 2027 (estimated)
- Study completion21 Jul 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Myocardial Infarction (MI)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Prospective, controlled, two-arm parallel-group study comparing standard inpatient cardiac rehabilitation with the same rehabilitation program supplemented by eccentric cycling exercise in patients after myocardial infarction.
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Medical University of Gdansk
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07729410
- Sponsor's protocol ID
- GUMED-ECC-MI-001
- Other IDs
- KB/359/2026
- Acronym
- ECCENTRIC-MI
- Status last verified
- Jul 2026
- First submitted
- 22 Jul 2026
- Last updated
- 27 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is currently no plan to make de-identified individual participant data available to other researchers. Study findings will be reported in aggregate form in scientific publications and presentations.
Study at a glance
From the registry record, last updated by the sponsor on 27 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Two-Week Eccentric Exercise-Based Cardiac Rehabilitation on Myokines, Exerkines, and Physical Function in Patients After Myocardial Infarction
- ClinicalTrials.gov ID
- NCT07729410
- Acronym / sponsor ID
- ECCENTRIC-MI / GUMED-ECC-MI-001
- Conditions
- Myocardial Infarction (MI), Cardiac Rehabilitation
- Keywords
- Eccentric Exercise, Eccentric Cycling, Cardiac Rehabilitation, Post-Myocardial Infarction, Myokines, Exerkines, Functional Capacity, Kinesiophobia
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Medical University of GdanskUniversity, hospital or other
- Study start
- 22 Jul 2026 (estimated)
- Primary completion
- 21 Jul 2027 (estimated)
- Study completion
- 21 Jul 2028 (estimated)
- First posted
- 27 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical trial will evaluate a two-week eccentric exercise program conducted as part of comprehensive cardiac rehabilitation in patients after a heart attack (myocardial infarction). Eccentric exercise involves muscle contractions while the muscles are lengthening and may allow the muscles to work at a relatively high load with a lower cardiovascular and metabolic demand than traditional exercise.
The main aim of the study is to determine whether eccentric exercise affects blood levels of proteins released or regulated in response to physical activity, including musclin, interleukin-6, and myostatin. The study will also evaluate whether the program improves physical performance and functional capacity.
Participants will complete eccentric cycling exercise on a semi-recumbent cycle ergometer during a two-week cardiac rehabilitation program. Blood samples and physical-function measurements will be collected before and after the intervention.
Detailed description
Exercise-based cardiac rehabilitation is an important component of secondary prevention after myocardial infarction. However, some patients experience reduced exercise tolerance or fear of physical activity, which may limit participation in rehabilitation and contribute to physical deconditioning, loss of muscle mass, and reduced functional capacity.
Eccentric exercise is characterized by muscle contractions performed while the muscle is lengthening. Compared with traditional concentric exercise, eccentric exercise can provide a relatively high mechanical load to skeletal muscles while requiring lower oxygen consumption and imposing a lower metabolic demand. For this reason, eccentric training may be a useful rehabilitation strategy for patients who have limited exercise tolerance after myocardial infarction.
The intervention will consist of a two-week eccentric cycling program performed on a semi-recumbent cycle ergometer as part of comprehensive cardiac rehabilitation. The training is intended to provide controlled loading of the lower-limb muscles while limiting excessive cardiovascular strain.
The primary scientific objective is to evaluate changes in the molecular response to eccentric exercise, with particular emphasis on circulating myokines and exerkines. Blood concentrations of musclin, interleukin-6, and myostatin will be assessed before and after the rehabilitation period. The study will also evaluate changes in physical performance, muscle function, and functional exercise capacity using the assessments specified in the study protocol.
The findings may help determine whether eccentric exercise produces beneficial molecular and functional adaptations in patients undergoing cardiac rehabilitation after myocardial infarction.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Prospective, controlled, two-arm parallel-group study comparing standard inpatient cardiac rehabilitation with the same rehabilitation program supplemented by eccentric cycling exercise in patients after myocardial infarction.
| Arm | Type | Receives |
|---|---|---|
| Standard Cardiac Rehabilitation | Active comparator | Behavioral: Standard Inpatient Cardiac RehabilitationStandard stage I inpatient cardiac rehabilitation provided after myocardial infarction and individualized according to each participant's clinical condition and exercise capacity. The program includes standard kinesitherapy and exercise-based rehabilitation procedures. |
| Standard Cardiac Rehabilitation Plus Eccentric Cycling | Experimental | Behavioral: Standard Inpatient Cardiac Rehabilitation, Behavioral: Eccentric Cycling ExerciseSupervised eccentric cycling exercise performed on a motor-driven semi-recumbent cycle ergometer in addition to standard inpatient cardiac rehabilitation. Sessions will last 10 to 30 minutes, with progressive adaptation during the first five sessions. Exercise workload will be individualized according to baseline exercise capacity. Perceived exertion and muscle soreness will be monitored during each session. |
Who may qualify
- Ages
- 50 to 75 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Documented history of myocardial infarction confirmed by medical records.
- Qualification for stage I comprehensive inpatient cardiac rehabilitation.
- Clinically stable condition allowing participation in exercise-based cardiac rehabilitation.
- New York Heart Association functional class I or II.
- Moderate or good exercise tolerance, defined as an exercise capacity of at least 5 metabolic equivalents, assessed during an exercise test.
Key exclusion criteria (18 listed)
- Any contraindication to exercise-based cardiac rehabilitation or exercise testing.
- Acute myocardial infarction within the first 4 days before planned initiation of exercise rehabilitation.
- Unstable angina.
- Significant left main coronary artery stenosis considered a contraindication to exercise by the treating cardiologist.
- Symptomatic cardiac arrhythmias.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Standard Inpatient Cardiac RehabilitationStandard stage I inpatient cardiac rehabilitation provided after myocardial infarction and individualized according to each participant's clinical condition and exercise capacity. The program includes standard kinesitherapy and exercise-based rehabilitation procedures. | Behavioural | Standard Cardiac Rehabilitation, Standard Cardiac Rehabilitation Plus Eccentric Cycling |
| Eccentric Cycling ExerciseSupervised eccentric cycling exercise performed on a motor-driven semi-recumbent cycle ergometer in addition to standard inpatient cardiac rehabilitation. Sessions will last 10 to 30 minutes, with progressive adaptation during the first five sessions. Exercise workload will be individualized according to baseline exercise capacity. Perceived exertion and muscle soreness will be monitored during each session. | Behavioural | Standard Cardiac Rehabilitation Plus Eccentric Cycling |
Primary outcome
Change From Baseline in Serum Musclin Concentration
Time frame: Baseline and after completion of the 2-week inpatient cardiac rehabilitation program
Serum musclin concentration will be measured in fasting venous blood samples using an enzyme-linked immunosorbent assay (ELISA). The outcome will be calculated as the concentration measured after the intervention minus the baseline concentration and reported in ng/mL.
Change From Baseline in Serum Myostatin Concentration
Time frame: Baseline and after completion of the 2-week inpatient cardiac rehabilitation program
Serum myostatin concentration will be measured in fasting venous blood samples using an enzyme-linked immunosorbent assay (ELISA). The outcome will be calculated as the concentration measured after the intervention minus the baseline concentration.
Change From Baseline in Serum Interleukin-6 Concentration
Time frame: Baseline and after completion of the 2-week inpatient cardiac rehabilitation program
Serum interleukin-6 concentration will be measured in fasting venous blood samples using an enzyme-linked immunosorbent assay (ELISA). The outcome will be calculated as the concentration measured after the intervention minus the baseline concentration.
4 secondary outcomes
Change From Baseline in Six-Minute Walk Distance
Time frame: Baseline, before initiation of the inpatient cardiac rehabilitation program, and after completion of the 2-week intervention
30-Second Chair-Stand Test
Time frame: Baseline, before initiation of the inpatient cardiac rehabilitation program, and after completion of the 2-week intervention
Change From Baseline in Kinesiophobia Assessed Using the Tampa Scale for Kinesiophobia Heart
Time frame: Baseline, before initiation of the inpatient cardiac rehabilitation program, and after completion of the 2-week intervention
Change From Baseline in Peak Force During the Isometric Mid-Thigh Pull Test
Time frame: Baseline, before initiation of the inpatient cardiac rehabilitation program, and after completion of the 2-week intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jul 2026.
- Individual participant dataSharing planned: No. There is currently no plan to make de-identified individual participant data available to other researchers. Study findings will be reported in aggregate form in scientific publications and presentations.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Standard Inpatient Cardiac Rehabilitation and Eccentric Cycling Exercise in people with Myocardial Infarction (MI) and Cardiac Rehabilitation, run by Medical University of Gdansk at 1 site in Poland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 18 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 27 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Poland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Joanna Jaworska, PhD (+48503864566, joanna.jaworska@awf.gda.pl), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change From Baseline in Serum Musclin Concentration (time frame: Baseline and after completion of the 2-week inpatient cardiac rehabilitation program). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jul 2026.