Seroma FormationNCT07733921
Effect of Irrigation of Triamcinolone Versus Hypertonic Saline in Decreasing Seroma Post Abdominoplasty
A study testing Irrigation of Triamcinolone and Hypertonic Saline 10% in people with Seroma Formation, run by Cairo University at 1 site in Egypt.
Trial summary
A total of 90 abdominoplasty patients were randomly assigned into three groups: Group A: Triamcinolone group, Group B: Hypertonic saline group, Group C: Control group Randomization: It was performed using the closed envelope technique. Read more about this study
- Who is it for?
- Ages 18 to 65 years, women only
- Conditions the study is for
- Seroma Formation
- What is being tested?
- Irrigation of Triamcinolone and Hypertonic Saline 10%
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 90 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Nov 2023to 1 Aug 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Females
- Age: 18-65
- BMI ≤ 39
- Pendulous abdomen grades 3 and 4 according to the Matarasso classification of 1991.
Who cannot join
- Age: < 18 years and > 65 years
- BMI: >39.1
- Known allergies to steroidal compounds
- Uncontrolled medical comorbidities
- open abdominal surgeries other than caesarian sections.
- Ventral hernias
- Ehlers-Danlos and other hyper elasticity syndromes
Trial locations and contacts
1 site in 1 country.
About this study
A total of 90 abdominoplasty patients were randomly assigned into three groups:
Group A: Triamcinolone group, Group B: Hypertonic saline group, Group C: Control group
Randomization:
It was performed using the closed envelope technique.
Technique:
After performing a Lipo-abdominoplasty Group A (triamcinolone) irrigates 10 cm saline mixed with two 40 mg vials through the umbilicus into dead space; Group B (hypertonic saline) irrigates 20 cm of 10% solution similarly; Group C (control) receives no irrigation
Read the detailed description
A total of 90 patients were recruited in this study from November 2023 until July 2025. These patients presented to the outpatient clinic of the Plastic and Reconstructive Surgery Department, Kasr Al ainy Hospital with pendulous abdomen or manifestations of myofascial abdominal laxity and weakness or more commonly, a combination of both. In additions, almost all patients were complaining of localized stubborn fat deposits usually in the flank and epigastric areas that also needed to be addressed.
Randomization:
It was performed using . Opaque, sealed and sequentially numbered envelopes containing group assignments were prepared by an independent participant not enrolled in the study. Each envelope was opened only after a participant enrollment, ensuring allocation concealment and preventing selection bias.
Pre-operative: Before admission, patients were consented on the study methodology and the randomization process. The initial consultation of our patients revolved around the expected procedural details, the preoperative preparatory steps and the post-operative recovery time and details. Afterwards, proper history and examination were conducted along with routine preoperative labs and abdominal ultrasound to detect hernial defects.
Preoperative markings: In the standing position, after proper exposure of the trunk area, Markings of the liposuction area over the back were done. Followed by anterior markings which begins with identifying the anterior midline and marking both linae semilunaris while the patient contracts the rectus abdominis muscles. Next, the lateral ends of the expected abdominal scars are marked at the abdominal fold with the patient flexing the trunk 30 degrees. The midpoint of the proposed incision site is then marked in the midline at 6-8 cm under medium stretch, confirmed at 8-10 cm under maximum stretch. Measurements of 7 cm lateral to the midline at this site and 9 cm from the midline above the umbilicus are taken, ensuring these points coincide during closure for 2 cm abdominal flap medialization. This midpoint connects laterally to the 7 cm marking and then to the proposed incision ends. Using a pinch test, the proposed upper incision is marked in the midline above the umbilicus and connected to the lateral ends of the proposed lower incision. Finally, areas for liposuction in the anterior flanks and epigastrium are marked.
Operative details: The patient is placed prone, sterilized, draped, and positioned in jack-knife for initial preparation, receiving one dose of a 3rd generation cephalosporin. Super wet solution (1 mg adrenaline, 1 mg tranexamic acid, and 10 cc of 2% lidocaine per 500 ml normal saline) is infiltrated via sacral and bra-line access incisions, followed by a 15-minute wait, then liposuction in marked areas using a straight Mercedes-shaped blunt-tipped 4 mm cannula until a desirable pinch is achieved. The patient is turned supine with trunk extension at the hips, re-sterilized, draped, and anterior access incisions made for infiltrating the same super wet solution into flanks and epigastrium, awaiting 15 minutes before liposuction to desirable pinch endpoint. The proposed incision site opens slantingly to preserve fat over anterior superior iliac spines, followed by uniform supra-fascial dissection to the umbilicus; the umbilicus is incised superficially, dissected to the anterior rectus sheath, circled to free its stalk, and a narrow epigastric tunnel elevated supra-fascial along medial rectus borders per Saldanha's technique without wider undermining. Plication of divarication occurs in two layers above and below the umbilicus with PDS 1-0 loop and proline 1-0 if indicated. The patient flexes to 45 degrees for flap excision, with two suction drains placed laterally; the neo-umbilicus is incised appropriately, umbilicus brought up, and closure performed in layers using 0 Vicryl for Scarpa's fascia, 2-0 Vicryl sub-dermally, and 3-0 Monocryl sub-cuticular. Drains are closed, then per group: Group A (triamcinolone) ; Group B (hypertonic saline) ; Group C (control). Doses were used according to best available evidence. The umbilicus secures with 4-0 Vicryl interrupted dermal and 4-0 Monocryl subcuticular skin sutures. A compression garment with underlying foam support are applied immediately
Post-operative sequalae: The patient is transported to the ward in a semi-sitting position and maintained this way until discharge. Drains remain closed for 1 hour postoperatively, then fluid amount and color (categorized as dark red, serosanguineous, or serous) are measured and documented every 12 hours until removal, with patients instructed pre-discharge on consistent drainage collection and measurement, documenting every 12 hours themselves. Early ambulation with regular fluid intake prevents VTE, and chemoprophylaxis starts if indicated per the 2005 Caprini score. The first dressing occurs the next day to detect early liposuction complications, followed by discharge on antibiotics and analgesics. Lymphatic massage begins as early as postoperative day 3.
In cases of seroma: Clinical seromas, diagnosed by palpable bulge or swelling, are addressed and aspirated using a wide bore cannula and 20 cc syringe. The amount of aspirated fluid is documented per session. And the sessions are repeated every 3 to 4 days according to the patient's condition till the seroma is resolved.
- Conditions
- Seroma Formation
- Being tested
- Irrigation of Triamcinolone, Hypertonic Saline 10%, Control
- Keywords
- Triamcinolone, hypertonic saline, Lipo-abdominoplasty, seroma, drain output
- Medical subject headings
- Seroma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Irrigation of TriamcinoloneDrug
Irrigation of Triamcinolone 80 mg post abdominoplasty to decrease the incidence of seroma and allow early drain removal
Hypertonic Saline 10%Drug
Irrigation of Hypertonic saline 10%
ControlDrug
Control Group with no irrigation
| Study group | Role | What they receive |
|---|---|---|
| Group A Triamcinolone group | Active comparator | Irrigation of Triamcinolone post lipo-abdominoplasty 10cc normal saline 0.9% with 80mg of Triamcinolone Receives: Drug: Irrigation of Triamcinolone |
| Group B Hypertonic saline | Active comparator | Irrigation of Hypertonic Saline post lipo-abdominoplasty 20cc of 10% Hypertonic Saline Receives: Drug: Hypertonic Saline 10% |
| Group C Control Group | Placebo comparator | Lipo-Abdominoplasty Receives: Drug: Control |
What is being measured
The primary outcome is the main question the study is designed to answer.
number of abdominoplasty patients having seroma after intraoperative Triamcinolone irrigation
number of patients having seroma after irrigation of 10 cc of saline 0.9% mixed with 80 mg triamcinolone
Measured: 8 weeks
number of abdominoplasty patients having seroma after intraoperative hypertonic saline irrigation
number of patients having seroma after irrigation of 20cc of 10% hypertonic saline
Measured: 8 weeks
Secondary outcomes (6)
days needed to remove the drain post abdominoplasty after intraoperative triamcinolone irrigation
drains are removed when the amount in 24 hours is less than 50 cc
Measured: up to 15 days
Days needed to remove the drain post abdominoplasty after intraoperative Hypertonic saline irrigation
drains are removed when the amount in 24 hours is less than 50 cc
Measured: Up to 15 days
total amount of seroma, measured in cc, in patients who develop seroma after intraoperative Triamcinolone irrigation following abdominoplasty
amount is aspirated by a syringe and documented each session of aspiration
Measured: 8 weeks
total amount of seroma, measured in cc, in patients who develop seroma after intraoperative hypertonic saline irrigation following abdominoplasty
amount is aspirated by a syringe and documented each session of aspiration
Measured: 8 weeks
total drain output, measured in cc, post abdominoplasty after intraoperative triamcinolone irrigation
drains are monitored and emptied every 12 hours and the amount is documented
Measured: up to 15 days
total drain output, measured in cc, post abdominoplasty after intraoperative hypertonic saline irrigation
drains are monitored and emptied every 12 hours and the amount is documented
Measured: up to 15 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jul 2026
- Study start1 Nov 2023
- Primary completion1 Jul 2025
- Study completion1 Aug 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (13)Papers the sponsor has linked to this study.
- Other trials for Seroma FormationStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 90 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hamed M. Kadry, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07733921
- Sponsor's protocol ID
- MD-468-2023
- Status last verified
- Jul 2026
- First submitted
- 19 Jul 2026
- Last updated
- 29 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: We dont have plans on sharing it at the time being yet if it is needed for authentication of data we will are gladly willing to share it
Publications
Wang Y, Xie S. Intraoperative Hypertonic Saline Irrigation Preventing Seroma Formation in the Treatment of Axillary Bromhidrosis. Aesthetic Plast Surg. 2024 Sep;48(17):3216-3221. doi: 10.1007/s00266-024-03987-2. Epub 2024 May 8.
PubMed 38720102Dudai M, Gilboa Ittah K. Intraoperative hypertonic saline irrigation preventing seroma formation and reducing drain secretion in extended endoscopic hernia and linea alba reconstruction glue. Hernia. 2019 Dec;23(6):1291-1296. doi: 10.1007/s10029-019-01956-2. Epub 2019 May 4.
PubMed 31055707Anker AM, Lenhard J, Klein SM, Felthaus O, Prantl L, Ruewe M. Standard doses of Triamcinolone do not affect fibroblast cell migration of abdominoplasty patients in-vitro1. Clin Hemorheol Microcirc. 2023;85(3):307-314. doi: 10.3233/CH-229106.
PubMed 36502314Hart AM, Duggal C, Pinell-White X, Losken A. A Prospective Randomized Trial of the Efficacy of Fibrin Glue, Triamcinolone Acetonide, and Quilting Sutures in Seroma Prevention after Latissimus Dorsi Breast Reconstruction. Plast Reconstr Surg. 2017 Apr;139(4):854e-863e. doi: 10.1097/PRS.0000000000003213.
PubMed 28350654Qvamme G, Axelsson CK, Lanng C, Mortensen M, Wegeberg B, Okholm M, Arpi MR, Szecsi PB. Randomized clinical trial of prevention of seroma formation after mastectomy by local methylprednisolone injection. Br J Surg. 2015 Sep;102(10):1195-203. doi: 10.1002/bjs.9874. Epub 2015 Jul 14.
PubMed 26179672Bromley M, Marrou W, Charles-de-Sa L. Evaluation of the Number of Progressive Tension Sutures Needed to Prevent Seroma in Abdominoplasty with Drains: A Single-Blind, Prospective, Comparative, Randomized Clinical Trial. Aesthetic Plast Surg. 2018 Dec;42(6):1600-1608. doi: 10.1007/s00266-018-1227-6. Epub 2018 Sep 26.
PubMed 30259166Anker AM, Felthaus O, Prantl L, Geis S, Brebant V, Kehrer A, Strauss C, Ruewe M, Vykoukal J, Klein SM. Local Triamcinolone Treatment Affects Inflammatory Response in Seroma Exudate of Abdominoplasty Patients: A Randomized Controlled Trial. Plast Reconstr Surg. 2021 Feb 1;147(2):345-354. doi: 10.1097/PRS.0000000000007523.
PubMed 33565825Zhang L, Mendoza-Sassi RA, Wainwright CE, Aregbesola A, Klassen TP. Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev. 2023 Apr 4;4(4):CD006458. doi: 10.1002/14651858.CD006458.pub5.
PubMed 37014057Bhosale R, Dawar R, Manas RK. Role of Triamcinolone Acetonide in the Maturation of Scars. Plast Reconstr Surg Glob Open. 2024 Jul 15;12(7):e5966. doi: 10.1097/GOX.0000000000005966. eCollection 2024 Jul.
PubMed 39015354Seretis K, Goulis D, Demiri EC, Lykoudis EG. Prevention of Seroma Formation Following Abdominoplasty: A Systematic Review and Meta-Analysis. Aesthet Surg J. 2017 Mar 1;37(3):316-323. doi: 10.1093/asj/sjw192.
PubMed 28158391Liao CD, Zhao K, Nikkhahmanesh N, Bui DT. Decreasing Seroma Incidence Following Abdominoplasty: A Systematic Review and Meta-Analysis of High-Quality Evidence. Aesthet Surg J Open Forum. 2024 Mar 16;6:ojae016. doi: 10.1093/asjof/ojae016. eCollection 2024.
PubMed 38585023Salari N, Fatahi B, Bartina Y, Kazeminia M, Heydari M, Mohammadi M, Hemmati M, Shohaimi S. The Global Prevalence of Seroma After Abdominoplasty: A Systematic Review and Meta-Analysis. Aesthetic Plast Surg. 2021 Dec;45(6):2821-2836. doi: 10.1007/s00266-021-02365-6. Epub 2021 Jun 2.
PubMed 34080041Saldanha OR, Pinto EB, Matos WN Jr, Lucon RL, Magalhaes F, Bello EM. Lipoabdominoplasty without undermining. Aesthet Surg J. 2001 Nov;21(6):518-26. doi: 10.1067/maj.2001.121243.
PubMed 19331937
Study at a glance
From the registry record, last updated by the sponsor on 29 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Irrigation of Triamcinolone Versus Hypertonic Saline in Decreasing Seroma Post Abdominoplasty
- ClinicalTrials.gov ID
- NCT07733921
- Acronym / sponsor ID
- MD-468-2023
- Conditions
- Seroma Formation
- Keywords
- Triamcinolone, hypertonic saline, Lipo-abdominoplasty, seroma, drain output
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 90 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Nov 2023 (actual)
- Primary completion
- 1 Jul 2025 (actual)
- Study completion
- 1 Aug 2025 (actual)
- First posted
- 29 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A total of 90 abdominoplasty patients were randomly assigned into three groups:
Group A: Triamcinolone group, Group B: Hypertonic saline group, Group C: Control group
Randomization:
It was performed using the closed envelope technique.
Technique:
After performing a Lipo-abdominoplasty Group A (triamcinolone) irrigates 10 cm saline mixed with two 40 mg vials through the umbilicus into dead space; Group B (hypertonic saline) irrigates 20 cm of 10% solution similarly; Group C (control) receives no irrigation
Detailed description
A total of 90 patients were recruited in this study from November 2023 until July 2025. These patients presented to the outpatient clinic of the Plastic and Reconstructive Surgery Department, Kasr Al ainy Hospital with pendulous abdomen or manifestations of myofascial abdominal laxity and weakness or more commonly, a combination of both. In additions, almost all patients were complaining of localized stubborn fat deposits usually in the flank and epigastric areas that also needed to be addressed.
Randomization:
It was performed using . Opaque, sealed and sequentially numbered envelopes containing group assignments were prepared by an independent participant not enrolled in the study. Each envelope was opened only after a participant enrollment, ensuring allocation concealment and preventing selection bias.
Pre-operative: Before admission, patients were consented on the study methodology and the randomization process. The initial consultation of our patients revolved around the expected procedural details, the preoperative preparatory steps and the post-operative recovery time and details. Afterwards, proper history and examination were conducted along with routine preoperative labs and abdominal ultrasound to detect hernial defects.
Preoperative markings: In the standing position, after proper exposure of the trunk area, Markings of the liposuction area over the back were done. Followed by anterior markings which begins with identifying the anterior midline and marking both linae semilunaris while the patient contracts the rectus abdominis muscles. Next, the lateral ends of the expected abdominal scars are marked at the abdominal fold with the patient flexing the trunk 30 degrees. The midpoint of the proposed incision site is then marked in the midline at 6-8 cm under medium stretch, confirmed at 8-10 cm under maximum stretch. Measurements of 7 cm lateral to the midline at this site and 9 cm from the midline above the umbilicus are taken, ensuring these points coincide during closure for 2 cm abdominal flap medialization. This midpoint connects laterally to the 7 cm marking and then to the proposed incision ends. Using a pinch test, the proposed upper incision is marked in the midline above the umbilicus and connected to the lateral ends of the proposed lower incision. Finally, areas for liposuction in the anterior flanks and epigastrium are marked.
Operative details: The patient is placed prone, sterilized, draped, and positioned in jack-knife for initial preparation, receiving one dose of a 3rd generation cephalosporin. Super wet solution (1 mg adrenaline, 1 mg tranexamic acid, and 10 cc of 2% lidocaine per 500 ml normal saline) is infiltrated via sacral and bra-line access incisions, followed by a 15-minute wait, then liposuction in marked areas using a straight Mercedes-shaped blunt-tipped 4 mm cannula until a desirable pinch is achieved. The patient is turned supine with trunk extension at the hips, re-sterilized, draped, and anterior access incisions made for infiltrating the same super wet solution into flanks and epigastrium, awaiting 15 minutes before liposuction to desirable pinch endpoint. The proposed incision site opens slantingly to preserve fat over anterior superior iliac spines, followed by uniform supra-fascial dissection to the umbilicus; the umbilicus is incised superficially, dissected to the anterior rectus sheath, circled to free its stalk, and a narrow epigastric tunnel elevated supra-fascial along medial rectus borders per Saldanha's technique without wider undermining. Plication of divarication occurs in two layers above and below the umbilicus with PDS 1-0 loop and proline 1-0 if indicated. The patient flexes to 45 degrees for flap excision, with two suction drains placed laterally; the neo-umbilicus is incised appropriately, umbilicus brought up, and closure performed in layers using 0 Vicryl for Scarpa's fascia, 2-0 Vicryl sub-dermally, and 3-0 Monocryl sub-cuticular. Drains are closed, then per group: Group A (triamcinolone) ; Group B (hypertonic saline) ; Group C (control). Doses were used according to best available evidence. The umbilicus secures with 4-0 Vicryl interrupted dermal and 4-0 Monocryl subcuticular skin sutures. A compression garment with underlying foam support are applied immediately
Post-operative sequalae: The patient is transported to the ward in a semi-sitting position and maintained this way until discharge. Drains remain closed for 1 hour postoperatively, then fluid amount and color (categorized as dark red, serosanguineous, or serous) are measured and documented every 12 hours until removal, with patients instructed pre-discharge on consistent drainage collection and measurement, documenting every 12 hours themselves. Early ambulation with regular fluid intake prevents VTE, and chemoprophylaxis starts if indicated per the 2005 Caprini score. The first dressing occurs the next day to detect early liposuction complications, followed by discharge on antibiotics and analgesics. Lymphatic massage begins as early as postoperative day 3.
In cases of seroma: Clinical seromas, diagnosed by palpable bulge or swelling, are addressed and aspirated using a wide bore cannula and 20 cc syringe. The amount of aspirated fluid is documented per session. And the sessions are repeated every 3 to 4 days according to the patient's condition till the seroma is resolved.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Group A Triamcinolone group | Active comparator | Drug: Irrigation of TriamcinoloneIrrigation of Triamcinolone post lipo-abdominoplasty 10cc normal saline 0.9% with 80mg of Triamcinolone |
| Group B Hypertonic saline | Active comparator | Drug: Hypertonic Saline 10%Irrigation of Hypertonic Saline post lipo-abdominoplasty 20cc of 10% Hypertonic Saline |
| Group C Control Group | Placebo comparator | Drug: ControlLipo-Abdominoplasty |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Females
- Age: 18-65
- BMI ≤ 39
- Pendulous abdomen grades 3 and 4 according to the Matarasso classification of 1991.
Key exclusion criteria (7 listed)
- Age: < 18 years and > 65 years
- BMI: >39.1
- Known allergies to steroidal compounds
- Uncontrolled medical comorbidities
- open abdominal surgeries other than caesarian sections.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Irrigation of TriamcinoloneIrrigation of Triamcinolone 80 mg post abdominoplasty to decrease the incidence of seroma and allow early drain removal | Drug | Group A Triamcinolone group |
| Hypertonic Saline 10%Irrigation of Hypertonic saline 10% | Drug | Group B Hypertonic saline |
| ControlControl Group with no irrigation | Drug | Group C Control Group |
Primary outcome
number of abdominoplasty patients having seroma after intraoperative Triamcinolone irrigation
Time frame: 8 weeks
number of patients having seroma after irrigation of 10 cc of saline 0.9% mixed with 80 mg triamcinolone
number of abdominoplasty patients having seroma after intraoperative hypertonic saline irrigation
Time frame: 8 weeks
number of patients having seroma after irrigation of 20cc of 10% hypertonic saline
6 secondary outcomes
days needed to remove the drain post abdominoplasty after intraoperative triamcinolone irrigation
Time frame: up to 15 days
Days needed to remove the drain post abdominoplasty after intraoperative Hypertonic saline irrigation
Time frame: Up to 15 days
total amount of seroma, measured in cc, in patients who develop seroma after intraoperative Triamcinolone irrigation following abdominoplasty
Time frame: 8 weeks
total amount of seroma, measured in cc, in patients who develop seroma after intraoperative hypertonic saline irrigation following abdominoplasty
Time frame: 8 weeks
total drain output, measured in cc, post abdominoplasty after intraoperative triamcinolone irrigation
Time frame: up to 15 days
total drain output, measured in cc, post abdominoplasty after intraoperative hypertonic saline irrigation
Time frame: up to 15 days
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Jul 2026.
- Background: PubMed 38720102Wang Y, Xie S. Intraoperative Hypertonic Saline Irrigation Preventing Seroma Formation in the Treatment of Axillary Bromhidrosis. Aesthetic Plast Surg. 2024 Sep;48(17):3216-3221. doi: 10.1007/s00266-024-03987-2. Epub 2024 May 8.
- Background: PubMed 31055707Dudai M, Gilboa Ittah K. Intraoperative hypertonic saline irrigation preventing seroma formation and reducing drain secretion in extended endoscopic hernia and linea alba reconstruction glue. Hernia. 2019 Dec;23(6):1291-1296. doi: 10.1007/s10029-019-01956-2. Epub 2019 May 4.
- Background: PubMed 36502314Anker AM, Lenhard J, Klein SM, Felthaus O, Prantl L, Ruewe M. Standard doses of Triamcinolone do not affect fibroblast cell migration of abdominoplasty patients in-vitro1. Clin Hemorheol Microcirc. 2023;85(3):307-314. doi: 10.3233/CH-229106.
- Background: PubMed 28350654Hart AM, Duggal C, Pinell-White X, Losken A. A Prospective Randomized Trial of the Efficacy of Fibrin Glue, Triamcinolone Acetonide, and Quilting Sutures in Seroma Prevention after Latissimus Dorsi Breast Reconstruction. Plast Reconstr Surg. 2017 Apr;139(4):854e-863e. doi: 10.1097/PRS.0000000000003213.
- Background: PubMed 26179672Qvamme G, Axelsson CK, Lanng C, Mortensen M, Wegeberg B, Okholm M, Arpi MR, Szecsi PB. Randomized clinical trial of prevention of seroma formation after mastectomy by local methylprednisolone injection. Br J Surg. 2015 Sep;102(10):1195-203. doi: 10.1002/bjs.9874. Epub 2015 Jul 14.
- Background: PubMed 30259166Bromley M, Marrou W, Charles-de-Sa L. Evaluation of the Number of Progressive Tension Sutures Needed to Prevent Seroma in Abdominoplasty with Drains: A Single-Blind, Prospective, Comparative, Randomized Clinical Trial. Aesthetic Plast Surg. 2018 Dec;42(6):1600-1608. doi: 10.1007/s00266-018-1227-6. Epub 2018 Sep 26.
- Background: PubMed 33565825Anker AM, Felthaus O, Prantl L, Geis S, Brebant V, Kehrer A, Strauss C, Ruewe M, Vykoukal J, Klein SM. Local Triamcinolone Treatment Affects Inflammatory Response in Seroma Exudate of Abdominoplasty Patients: A Randomized Controlled Trial. Plast Reconstr Surg. 2021 Feb 1;147(2):345-354. doi: 10.1097/PRS.0000000000007523.
- Background: PubMed 37014057Zhang L, Mendoza-Sassi RA, Wainwright CE, Aregbesola A, Klassen TP. Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev. 2023 Apr 4;4(4):CD006458. doi: 10.1002/14651858.CD006458.pub5.
- Background: PubMed 39015354Bhosale R, Dawar R, Manas RK. Role of Triamcinolone Acetonide in the Maturation of Scars. Plast Reconstr Surg Glob Open. 2024 Jul 15;12(7):e5966. doi: 10.1097/GOX.0000000000005966. eCollection 2024 Jul.
- Background: PubMed 28158391Seretis K, Goulis D, Demiri EC, Lykoudis EG. Prevention of Seroma Formation Following Abdominoplasty: A Systematic Review and Meta-Analysis. Aesthet Surg J. 2017 Mar 1;37(3):316-323. doi: 10.1093/asj/sjw192.
- Background: PubMed 38585023Liao CD, Zhao K, Nikkhahmanesh N, Bui DT. Decreasing Seroma Incidence Following Abdominoplasty: A Systematic Review and Meta-Analysis of High-Quality Evidence. Aesthet Surg J Open Forum. 2024 Mar 16;6:ojae016. doi: 10.1093/asjof/ojae016. eCollection 2024.
- Background: PubMed 34080041Salari N, Fatahi B, Bartina Y, Kazeminia M, Heydari M, Mohammadi M, Hemmati M, Shohaimi S. The Global Prevalence of Seroma After Abdominoplasty: A Systematic Review and Meta-Analysis. Aesthetic Plast Surg. 2021 Dec;45(6):2821-2836. doi: 10.1007/s00266-021-02365-6. Epub 2021 Jun 2.
- Individual participant dataSharing planned: No. We dont have plans on sharing it at the time being yet if it is needed for authentication of data we will are gladly willing to share it
Related trials for Seroma Formation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Irrigation of Triamcinolone and Hypertonic Saline 10% in people with Seroma Formation, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
number of abdominoplasty patients having seroma after intraoperative Triamcinolone irrigation (time frame: 8 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07733921, which also lists 13 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Jul 2026.