LearningNCT07735507
Effects of a Familiarization Protocol on Time to Exhaustion Performance
A study testing time to exhaustion in people with Learning, run by University of Maia.
Trial summary
Familiarization is widely recommended before exercise performance testing to improve measurement consistency and reduce learning effects. However, practical constraints often limit researchers to a single-or no-familiarization session, raising the possibility that improvements observed following an intervention may… Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Learning
- What is being tested?
- time to exhaustion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- No sites listed yet
- Study dates
- 1 Sep 2026to 30 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- healthy and physically active
Who cannot join
- current or recently injured participants
About this study
Official title: Effects of a Familiarization Protocol on Time to Exhaustion Performance Treadmill Running Protocol
Familiarization is widely recommended before exercise performance testing to improve measurement consistency and reduce learning effects. However, practical constraints often limit researchers to a single-or no-familiarization session, raising the possibility that improvements observed following an intervention may partially reflect increased familiarity with the testing procedure rather than genuine physiological adaptations. This issue may be particularly relevant for time-to-exhaustion (TTE) protocols, which have been reported to exhibit greater between-session variability than self-paced endurance tests.
This exploratory analysis examined the magnitude of the familiarization effect during treadmill TTE testing by comparing a familiarization trial with a subsequent experimental trial. Linear mixed-effects models will be used to evaluate changes in TTE performance while accounting for pre-exercise fatigue and recovery, and between-session agreement was assessed using intraclass correlation coefficients and Bland-Altman analysis.
- Conditions
- Learning
- Being tested
- time to exhaustion
- Keywords
- familiarization
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
time to exhaustionOther
Time to exhaustion performed at 95% VO2max
| Study group | Role | What they receive |
|---|---|---|
| familiarization | Active comparator | familiarization group Receives: Other: time to exhaustion |
| experimental | Experimental | Experimental group (2nd session) Receives: Other: time to exhaustion |
What is being measured
The primary outcome is the main question the study is designed to answer.
time to exhaustion
time spent running at a speed of 95% VO2max
Measured: immediate (0 hours)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Jul 2026
- Study start1 Sep 2026 (estimated)
- Primary completion1 Oct 2026 (estimated)
- Study completion30 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for LearningStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Maia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Filipe Silvano Pinto Maia, University of Maia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07735507
- Sponsor's protocol ID
- LE_TTE
- Status last verified
- Jul 2026
- First submitted
- 24 Jul 2026
- Last updated
- 30 Jul 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 30 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of a Familiarization Protocol on Time to Exhaustion Performance Treadmill Running Protocol
- ClinicalTrials.gov ID
- NCT07735507
- Acronym / sponsor ID
- LE_TTE
- Conditions
- Learning
- Keywords
- familiarization
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- University of MaiaUniversity, hospital or other
- Study start
- 1 Sep 2026 (estimated)
- Primary completion
- 1 Oct 2026 (estimated)
- Study completion
- 30 Jan 2027 (estimated)
- First posted
- 30 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Familiarization is widely recommended before exercise performance testing to improve measurement consistency and reduce learning effects. However, practical constraints often limit researchers to a single-or no-familiarization session, raising the possibility that improvements observed following an intervention may partially reflect increased familiarity with the testing procedure rather than genuine physiological adaptations. This issue may be particularly relevant for time-to-exhaustion (TTE) protocols, which have been reported to exhibit greater between-session variability than self-paced endurance tests.
This exploratory analysis examined the magnitude of the familiarization effect during treadmill TTE testing by comparing a familiarization trial with a subsequent experimental trial. Linear mixed-effects models will be used to evaluate changes in TTE performance while accounting for pre-exercise fatigue and recovery, and between-session agreement was assessed using intraclass correlation coefficients and Bland-Altman analysis.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| familiarization | Active comparator | Other: time to exhaustionfamiliarization group |
| experimental | Experimental | Other: time to exhaustionExperimental group (2nd session) |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- healthy and physically active
Key exclusion criteria (1 listed)
- current or recently injured participants
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| time to exhaustionTime to exhaustion performed at 95% VO2max | Other | experimental, familiarization |
Primary outcome
time to exhaustion
Time frame: immediate (0 hours)
time spent running at a speed of 95% VO2max
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jul 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Learning
Not yet recruitingObservational study
Validation of the Healthcare Relationship Assessment Scale (ERA) in Health Sciences Students.
Health Adult Subjects, Communication
RecruitingEarly Phase 1
Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making
Normal Physiology
Active, not recruitingPhase 1/2
A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment
Multiple Myeloma
RecruitingPhase 3
Study to Learn About a Respiratory Syncytial Virus Vaccine in Children at High Risk of RSV Disease
Respiratory Syncytial Virus (RSV)
RecruitingPhase 3
A Study to Learn About Safety and Effects of Once-monthly Treatment With Berobenatide in Adults With Obesity Disease in Japan (VESPER-JM)
Obesity
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing time to exhaustion in people with Learning, run by University of Maia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 30 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
time to exhaustion (time frame: immediate (0 hours)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jul 2026.