LeukemiaDYAD-PANCT07737418
Dyadic Physical Activity Intervention for Children Undergoing Cancer Treatment
A study testing Dyadic Physical Activity Intervention, Individual Intervention and Psychological Support in people with Leukemia and Physical Inactivity, run by The Hong Kong Polytechnic University.
Trial summary
The goal of this study is to learn if a parent-child dyadic physical activity (PA) intervention works to improve physical activity levels in children with leukaemia. It will also learn about the intervention's effects on children's self-confidence in doing physical activity and their quality of life. Read more about this study
- Who is it for?
- Ages 9 to 18 years
- Conditions the study is for
- Leukemia, Physical Inactivity
- What is being tested?
- Dyadic Physical Activity Intervention, Individual Intervention and Psychological Support
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 198 participants
- Where
- No sites listed yet
- Study dates
- 1 Jan 2027to 1 Jan 2030
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 9 to 18 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Children aged 9-18 years old
- Diagnosed with leukaemia
- Currently undergoing maintenance therapy
- Have a parent willing to participate in the study
- Both the child and participating parent speak Cantonese and read Chinese
Who cannot join
- Children under palliative care with evidence of cancer recurrence or second malignancies
- Children with medical contraindications for PA, such as thrombosis, as documented by physicians
- Children or parents with physical impairment or cognitive and learning problems (identified from medical records)
- Participants in the team's other interventional studies
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Dyadic-based Physical Activity Intervention for Children Who Are Undergoing Cancer Treatment: A Randomized Controlled Trial
The goal of this study is to learn if a parent-child dyadic physical activity (PA) intervention works to improve physical activity levels in children with leukaemia. It will also learn about the intervention's effects on children's self-confidence in doing physical activity and their quality of life. The main questions it aims to answer are:
Does the dyadic PA intervention increase the amount of physical activity children do, compared with an individual PA intervention or usual care? Does the dyadic PA intervention improve children's confidence in doing physical activity and their overall quality of life? What is the cost-effectiveness of the dyadic intervention relative to the individual intervention and psychological support control group?
Read more
Researchers will compare three groups: children and parents doing physical activity together (dyadic intervention), children doing physical activity individually (individual intervention), and children receiving psychological support sessions only (control group), to see if involving parents makes a difference.
Participants will:
Attend weekly sessions for 3 months (12 sessions total) Wear an activity tracker for 7 days and complete questionnaires at 5 different time points over 12 months Some participants will also be invited to take part in an interview about their experience
- Conditions
- Leukemia, Physical Inactivity
- Being tested
- Dyadic Physical Activity Intervention, Individual Intervention, Psychological Support
- Keywords
- Leukemia, Physical Activity, Self-Efficacy, Parent-Child Dyad, Quality of Life, Randomized Controlled Trial, Maintenance Therapy, Under treatment, Exercise, Dyadic intervention, Pediatric oncology
- Medical subject headings
- Leukemia, Sedentary Behavior, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Dyadic Physical Activity InterventionBehavioural
Parent-child dyads receive a structured physical activity intervention delivered by a trained Research Assistant over 12 weekly sessions across 3 months. Parents perform the physical activity together with their child in each session. Exercise intensity is individually tailored to each child.
Individual InterventionBehavioural
Children receive the same structured 12-session, weekly physical activity intervention as the dyadic group, delivered over 3 months by a trained Research Assistant, without parental participation. Exercise intensity is individually tailored to each child.
Psychological SupportBehavioural
Children receive 12 weekly sessions of simple psychological support over 3 months, delivered by a trained Research Assistant, without a physical activity component.
| Study group | Role | What they receive |
|---|---|---|
| Dyadic Intervention | Experimental | Parent-child dyads complete a 3-month, 12-session physical activity program together, with intensity tailored to each child. Receives: Behavioral: Dyadic Physical Activity Intervention |
| Individual Intervention | Active comparator | Children complete the same 3-month, 12 weekly sessions physical activity program as the dyadic group, but without parental participation. Receives: Behavioral: Individual Intervention |
| Control | Active comparator | Children receive 12 weekly sessions of simple psychological support over 3 months, without a physical activity component. Receives: Behavioral: Psychological Support |
What is being measured
The primary outcome is the main question the study is designed to answer.
Physical Activity Level
Children's physical activity levels will be objectively measured using ActiGraph GT3X accelerometers, worn for 7 consecutive days at each assessment timepoint. The primary outcome is the minutes engaged in moderate-to-vigorous physical activity (MVPA).
Measured: Baseline and 12 months（T4）
Secondary outcomes (3)
Self-Reported Physical Activity Level
Children's self-reported PA levels measured using the Chinese University of Hong Kong: Physical Activity Rating for Children and Youth, an 11-point scale (0-10) asking children to self-rate their PA levels in the past 7 days, from 0 (no exercise at all) to 10 (vigorous exercise on most days).
Measured: Baseline, 3 months (T1), 6 months (T2), 9 months (T3), and 12 months (T4)
Health-Related Quality of Life Score (EQ-5D-Y-5L)
Children's health-related quality of life will be measured using the EQ-5D-Y-5L. It includes a descriptive system covering five health dimensions, each scored from 1 to 5, with higher scores indicating worse outcomes, and the EQ visual analogue scale , scored from 0 to 100, with higher scores indicating better outcomes.
Measured: Baseline, 3 months (T1), 6 months (T2), 9 months (T3), and 12 months (T4)
Physical Activity Self-Efficacy Score
Children's physical activity self-efficacy will be assessed using the five-item Physical Activity Self-Efficacy Scale. Each item is rated on a three-point Likert scale. Total scores range from 5 to 15, with higher scores indicating greater physical activity self-efficacy.
Measured: Baseline, 3 months (T1), 6 months (T2), 9 months (T3), and 12 months (T4)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Jul 2026
- Study start1 Jan 2027 (estimated)
- Primary completion1 Jan 2030 (estimated)
- Study completion1 Jan 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for LeukemiaStudies of the same condition, open and under way.
- More trials run by The Hong Kong Polytechnic UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 198 participants (estimated)
Sponsor and investigators
- Lead sponsor
- The Hong Kong Polytechnic University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr Katherine Lam, The Hong Kong Polytechnic University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07737418
- Sponsor's protocol ID
- Dyadic PA Child Cancer
- Acronym
- DYAD-PA
- Status last verified
- Jul 2026
- First submitted
- 24 Jul 2026
- Last updated
- 31 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 31 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dyadic-based Physical Activity Intervention for Children Who Are Undergoing Cancer Treatment: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07737418
- Acronym / sponsor ID
- DYAD-PA / Dyadic PA Child Cancer
- Conditions
- Leukemia, Physical Inactivity
- Keywords
- Leukemia, Physical Activity, Self-Efficacy, Parent-Child Dyad, Quality of Life, Randomized Controlled Trial, Maintenance Therapy, Under treatment
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 198 participants (estimated)
- Lead sponsor
- The Hong Kong Polytechnic UniversityUniversity, hospital or other
- Study start
- 1 Jan 2027 (estimated)
- Primary completion
- 1 Jan 2030 (estimated)
- Study completion
- 1 Jan 2030 (estimated)
- First posted
- 30 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to learn if a parent-child dyadic physical activity (PA) intervention works to improve physical activity levels in children with leukaemia. It will also learn about the intervention's effects on children's self-confidence in doing physical activity and their quality of life. The main questions it aims to answer are:
Does the dyadic PA intervention increase the amount of physical activity children do, compared with an individual PA intervention or usual care? Does the dyadic PA intervention improve children's confidence in doing physical activity and their overall quality of life? What is the cost-effectiveness of the dyadic intervention relative to the individual intervention and psychological support control group?
Researchers will compare three groups: children and parents doing physical activity together (dyadic intervention), children doing physical activity individually (individual intervention), and children receiving psychological support sessions only (control group), to see if involving parents makes a difference.
Participants will:
Attend weekly sessions for 3 months (12 sessions total) Wear an activity tracker for 7 days and complete questionnaires at 5 different time points over 12 months Some participants will also be invited to take part in an interview about their experience
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Dyadic Intervention | Experimental | Behavioral: Dyadic Physical Activity InterventionParent-child dyads complete a 3-month, 12-session physical activity program together, with intensity tailored to each child. |
| Individual Intervention | Active comparator | Behavioral: Individual InterventionChildren complete the same 3-month, 12 weekly sessions physical activity program as the dyadic group, but without parental participation. |
| Control | Active comparator | Behavioral: Psychological SupportChildren receive 12 weekly sessions of simple psychological support over 3 months, without a physical activity component. |
Who may qualify
- Ages
- 9 to 18 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (5 listed)
- Children aged 9-18 years old
- Diagnosed with leukaemia
- Currently undergoing maintenance therapy
- Have a parent willing to participate in the study
- Both the child and participating parent speak Cantonese and read Chinese
Key exclusion criteria (4 listed)
- Children under palliative care with evidence of cancer recurrence or second malignancies
- Children with medical contraindications for PA, such as thrombosis, as documented by physicians
- Children or parents with physical impairment or cognitive and learning problems (identified from medical records)
- Participants in the team's other interventional studies
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Dyadic Physical Activity InterventionParent-child dyads receive a structured physical activity intervention delivered by a trained Research Assistant over 12 weekly sessions across 3 months. Parents perform the physical activity together with their child in each session. Exercise intensity is individually tailored to each child. | Behavioural | Dyadic Intervention |
| Individual InterventionChildren receive the same structured 12-session, weekly physical activity intervention as the dyadic group, delivered over 3 months by a trained Research Assistant, without parental participation. Exercise intensity is individually tailored to each child. | Behavioural | Individual Intervention |
| Psychological SupportChildren receive 12 weekly sessions of simple psychological support over 3 months, delivered by a trained Research Assistant, without a physical activity component. | Behavioural | Control |
Primary outcome
Physical Activity Level
Time frame: Baseline and 12 months（T4）
Children's physical activity levels will be objectively measured using ActiGraph GT3X accelerometers, worn for 7 consecutive days at each assessment timepoint. The primary outcome is the minutes engaged in moderate-to-vigorous physical activity (MVPA).
3 secondary outcomes
Self-Reported Physical Activity Level
Time frame: Baseline, 3 months (T1), 6 months (T2), 9 months (T3), and 12 months (T4)
Health-Related Quality of Life Score (EQ-5D-Y-5L)
Time frame: Baseline, 3 months (T1), 6 months (T2), 9 months (T3), and 12 months (T4)
Physical Activity Self-Efficacy Score
Time frame: Baseline, 3 months (T1), 6 months (T2), 9 months (T3), and 12 months (T4)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Dyadic Physical Activity Intervention, Individual Intervention and Psychological Support in people with Leukemia and Physical Inactivity, run by The Hong Kong Polytechnic University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 31 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ka Wai Katherine LAM (+852 27666420, kw-katherine.lam@polyu.edu.hk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Physical Activity Level (time frame: Baseline and 12 months（T4）). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jul 2026.