HealthyNCT07739238
THE EFFECTS OF DIFFERENT BREATHING EXERCISES ON RESPIRATORY PARAMETERS AND HEART RATE VARIABILITY
A study testing breathing exercises in people with Healthy, run by Bandırma Onyedi Eylül University at 1 site in Turkey (Türkiye).
Trial summary
Breathing is a vital process that occurs automatically, but it can also be voluntarily controlled to achieve specific goals, especially preventive and therapeutic ones. Slow breathing has been reported to have many physical and mental health benefits. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- breathing exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Feb 2024to Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Individuals willing to participate in the study
- Individuals aged between 18 and 30 years
- Individuals without a history of regular sports or physical activity habits
Who cannot join
- Immobilized individuals
- Athletes
- Individuals with respiratory, cardiovascular, or renal system diseases
- Individuals using medication for respiratory, cardiovascular, or renal system problems
- Individuals who have undergone any surgery in the last 6 months
- Individuals with neurological, systemic, or musculoskeletal disorders
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Bandirma Onyedi Eylül University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation
Balıkesir, In the USA Or Canada, Please Select..., 10250
ESRA KESKİN, DR, +902667170117 ext. 4550, ekeskin@bandirma.edu.tr
About this study
Breathing is a vital process that occurs automatically, but it can also be voluntarily controlled to achieve specific goals, especially preventive and therapeutic ones. Slow breathing has been reported to have many physical and mental health benefits. The activation of the sympathetic system during inhalation and the increase in heart rate, as well as the activation of the parasympathetic system during exhalation and the resulting decrease in heart rate variability, can be affected by breathing exercises. The physiological effects associated with breathing exercises vary depending on the type of exercise performed. Therefore, investigating and comparing the clinical effects and contributions of different breathing exercises will shed light on which breathing exercises should be preferred in different situations.
This study aims to examine the effects of diaphragmatic breathing, square breathing technique, alternative nostril breathing exercises, and diaphragmatic breathing exercises on respiratory function parameters and heart rate variability, and to compare these different breathing exercises. Healthy individuals aged 18-30 years from the Department of Physiotherapy and Rehabilitation at Bandırma Onyedi Eylül University will be invited to participate in the study. For the study, a sample size of 40 was determined in the "G*Power" analysis system with a moderate effect size according to Cohen, a statistical significance threshold of 5% (alpha level = 0.05), and 80% power (Cohen, J.; 2013), allowing for evaluation of the four groups before the training program, immediately after the first session (acute effect), and after the training program (6 weeks). To account for potential dropouts, the target is to reach 44 participants, which is 10% more than the calculated sample size. Power calculations will be performed during the study process, and revisions regarding sample size will be made if necessary. Participants will be randomized using a sealed envelope randomization method. Respiratory function tests (FVC-FEV1- FEV1/FVC- FEF- PEF) will be performed using a COSMED Pony FX portable spirometer to evaluate participants' respiratory functions. Heart rate variability will be assessed by taking a 5-minute measurement using a Polar H10 device. Four different breathing exercise groups will be created, and participants will undergo diaphragmatic breathing exercises, square breathing technique exercises, alternative nostril breathing exercises, and dynamic neuromuscular stabilization-based breathing exercises for 6 weeks, with sessions lasting 20 minutes, four times a week. The initial session will be conducted face-to-face, while subsequent sessions will be conducted online (via zoom/video calls/Google Meet, etc.). Assessments will be conducted three times: at baseline, immediately after the first session (acute effect), and after the 6-week training program, and will be performed face-to-face.
- Conditions
- Healthy
- Being tested
- breathing exercises
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
breathing exercisesOther
diaphragmatic breathing exercises, square breathing technique exercises, alternative nostril breathing exercises, and dynamic neuromuscular stabilization-based breathing exercises
| Study group | Role | What they receive |
|---|---|---|
| diaphragmatic breathing exercises | Experimental | diaphragmatic breathing exercises Receives: Other: breathing exercises |
| square breathing technique exercises | Experimental | Not described Receives: Other: breathing exercises |
| alternative nostril breathing exercises | Experimental | Not described Receives: Other: breathing exercises |
| dynamic neuromuscular stabilization-based breathing exercises | Experimental | Not described Receives: Other: breathing exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
Heart Rate Variability
Heart Rate Variability
Measured: day 1/ acute (after the first session-in an hour)/six week
respiratory parameters
FEV
Measured: day 1/ acute (after the first session-in an hour)/six week
respiratory parameters
FEV1
Measured: day 1/ acute (after the first session-in an hour)/six week
respiratory parameters
FVC
Measured: day 1/ acute (after the first session-in an hour)/six week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Jul 2026
- Study start1 Feb 2024
- Primary completionAug 2026 (estimated)
- Study completionSep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 44 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Bandırma Onyedi Eylül University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Esra KESKİN, Bandırma Onyedi Eylül University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07739238
- Sponsor's protocol ID
- 2023-270
- Status last verified
- Oct 2025
- First submitted
- 31 Mar 2024
- Last updated
- 31 Jul 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 31 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- THE EFFECTS OF DIFFERENT BREATHING EXERCISES ON RESPIRATORY PARAMETERS AND HEART RATE VARIABILITY
- ClinicalTrials.gov ID
- NCT07739238
- Acronym / sponsor ID
- 2023-270
- Conditions
- Healthy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 44 participants (estimated)
- Lead sponsor
- Bandırma Onyedi Eylül UniversityUniversity, hospital or other
- Study start
- 1 Feb 2024 (actual)
- Primary completion
- Aug 2026 (estimated)
- Study completion
- Sep 2026 (estimated)
- First posted
- 31 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Breathing is a vital process that occurs automatically, but it can also be voluntarily controlled to achieve specific goals, especially preventive and therapeutic ones. Slow breathing has been reported to have many physical and mental health benefits. The activation of the sympathetic system during inhalation and the increase in heart rate, as well as the activation of the parasympathetic system during exhalation and the resulting decrease in heart rate variability, can be affected by breathing exercises. The physiological effects associated with breathing exercises vary depending on the type of exercise performed. Therefore, investigating and comparing the clinical effects and contributions of different breathing exercises will shed light on which breathing exercises should be preferred in different situations.
This study aims to examine the effects of diaphragmatic breathing, square breathing technique, alternative nostril breathing exercises, and diaphragmatic breathing exercises on respiratory function parameters and heart rate variability, and to compare these different breathing exercises. Healthy individuals aged 18-30 years from the Department of Physiotherapy and Rehabilitation at Bandırma Onyedi Eylül University will be invited to participate in the study. For the study, a sample size of 40 was determined in the "G*Power" analysis system with a moderate effect size according to Cohen, a statistical significance threshold of 5% (alpha level = 0.05), and 80% power (Cohen, J.; 2013), allowing for evaluation of the four groups before the training program, immediately after the first session (acute effect), and after the training program (6 weeks). To account for potential dropouts, the target is to reach 44 participants, which is 10% more than the calculated sample size. Power calculations will be performed during the study process, and revisions regarding sample size will be made if necessary. Participants will be randomized using a sealed envelope randomization method. Respiratory function tests (FVC-FEV1- FEV1/FVC- FEF- PEF) will be performed using a COSMED Pony FX portable spirometer to evaluate participants' respiratory functions. Heart rate variability will be assessed by taking a 5-minute measurement using a Polar H10 device. Four different breathing exercise groups will be created, and participants will undergo diaphragmatic breathing exercises, square breathing technique exercises, alternative nostril breathing exercises, and dynamic neuromuscular stabilization-based breathing exercises for 6 weeks, with sessions lasting 20 minutes, four times a week. The initial session will be conducted face-to-face, while subsequent sessions will be conducted online (via zoom/video calls/Google Meet, etc.). Assessments will be conducted three times: at baseline, immediately after the first session (acute effect), and after the 6-week training program, and will be performed face-to-face.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| diaphragmatic breathing exercises | Experimental | Other: breathing exercisesdiaphragmatic breathing exercises |
| square breathing technique exercises | Experimental | Other: breathing exercises |
| alternative nostril breathing exercises | Experimental | Other: breathing exercises |
| dynamic neuromuscular stabilization-based breathing exercises | Experimental | Other: breathing exercises |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
Key exclusion criteria (6 listed)
- Immobilized individuals
- Athletes
- Individuals with respiratory, cardiovascular, or renal system diseases
- Individuals using medication for respiratory, cardiovascular, or renal system problems
- Individuals who have undergone any surgery in the last 6 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| breathing exercisesdiaphragmatic breathing exercises, square breathing technique exercises, alternative nostril breathing exercises, and dynamic neuromuscular stabilization-based breathing exercises | Other | alternative nostril breathing exercises, diaphragmatic breathing exercises, dynamic neuromuscular stabilization-based breathing exercises, square breathing technique exercises |
Primary outcome
Heart Rate Variability
Time frame: day 1/ acute (after the first session-in an hour)/six week
Heart Rate Variability
respiratory parameters
Time frame: day 1/ acute (after the first session-in an hour)/six week
FEV
respiratory parameters
Time frame: day 1/ acute (after the first session-in an hour)/six week
FEV1
respiratory parameters
Time frame: day 1/ acute (after the first session-in an hour)/six week
FVC
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jul 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Bandirma Onyedi Eylül University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation
Balıkesir, Turkey (Türkiye)
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing breathing exercises in people with Healthy, run by Bandırma Onyedi Eylül University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 31 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Heart Rate Variability (time frame: day 1/ acute (after the first session-in an hour)/six week). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jul 2026.