CancerNCT07739563
EXERT-BC Cardio: Cardio or Conditioning Training With Breast Cancer
A study testing Resistance Training with Cardio and Resistance Training with Conditioning in people with Cancer and Breast Cancer, run by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) at 1 site in United States.
Trial summary
In this study, the investigators hypothesize that observed intense resistance training with conditioning elicits similar changes in body composition, muscle mass, and blood pressure as that with cardiovascular training (or cardio) for women treated with breast cancer. Read more about this study
- Who is it for?
- Ages 20 to 89 years, women only
- Conditions the study is for
- Cancer, Breast Cancer
- What is being tested?
- Resistance Training with Cardio and Resistance Training with Conditioning
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteUnited States
- Study dates
- 27 Jul 2026to Jul 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 89 years
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 20-89 years
- Women prescribed exercise as a SOC
- Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast
- Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.
- Women with > 3 months of resistance training experience under expert guidance by a CSCS
- Must be able to read and understand English and consent for themselves.
Who cannot join
- Any current treatment with cytotoxic chemotherapy for breast cancer
- Inability to safely engage in group sessions of resistance training as deemed by study PI
- Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by PI to be unsafe to engage in resistance training
- Beta blocker or GLP-1 inhibitor medications
- Pregnant women
- Males
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
AHN Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
Clinical Trials Contact, 412-330-6151, ctgov@ahn.org
About this study
Official title: EXERT-BC Cardio: Randomized Study of EXErcise Regimens After Treatment for Breast Cancer Utilizing Cardio or Conditioning Training
In this study, the investigators hypothesize that observed intense resistance training with conditioning elicits similar changes in body composition, muscle mass, and blood pressure as that with cardiovascular training (or cardio) for women treated with breast cancer.
- Conditions
- Cancer, Breast Cancer
- Being tested
- Resistance Training with Cardio, Resistance Training with Conditioning
- Keywords
- Exercise
- Medical subject headings
- Neoplasms, Breast Neoplasms, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance Training with CardioBehavioural
Participants in this arm will engage in a supervised exercise regimen three times per week, for approximately 2 months (8 weeks). The regimen combines two days of hypertrophy-focused resistance training with a third day dedicated to steady-state cardiovascular exercise. The cardio day will utilize ergometer-based exercises (rowing ergometer, Assault Air Bike) and unweighted sled pushes, with each activity lasting 10 minutes continuously. The overall program aims to improve cardiorespiratory fitness and body composition in breast cancer survivors, under the guidance of Certified Strength and Conditioning Specialists (CSCS).
Resistance Training with ConditioningBehavioural
Participants in this arm will engage in a supervised exercise regimen three times per week, for approximately 2 months (8 weeks). The regimen combines two days of hypertrophy-focused resistance training with a third day dedicated to high-intensity conditioning. The conditioning day involves a circuit format of 6 total exercises, completed for 8 repetitions each across 8 sets, with limited rest periods (10 seconds or less) between exercises and sets. Exercise selection is total-body focused, alternating between upper and lower body movements. The program aims to improve muscular conditioning and body composition in breast cancer survivors, under the guidance of Certified Strength and Conditioning Specialists (CSCS).
| Study group | Role | What they receive |
|---|---|---|
| Cardio Training | Experimental | Not described Receives: Behavioral: Resistance Training with Cardio |
| Conditioning Training | Experimental | Not described Receives: Behavioral: Resistance Training with Conditioning |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Muscle Mass
Measured as total muscle mass (kg), determined via InBody 970 bioimpedance analysis and ultrasound (BodyMetrix) for muscle tissue thickness.
Measured: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Change in Fat Mass
Measured as total fat mass (kg), determined via InBody 970 bioimpedance analysis and ultrasound (BodyMetrix) for adipose tissue thickness.
Measured: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Secondary outcomes (6)
Change in Blood Pressure
Pre-workout blood pressure (systolic and diastolic) measurements.
Measured: Baseline (Prior to Program), at Month 1, and At Exercise Program Completion (approximately 2 months).
Change in Resting Metabolic Rate
Resting metabolic rate (RMR) at the completion of the exercise regimen.
Measured: At Exercise Program Completion (approximately 2 months).
Change in Body Composition Metrics (Other than Muscle/Fat Mass)
Includes body mass, % fat, and % fat-free mass, measured via InBody 970 bioimpedance analysis.
Measured: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Change in Phase Angle
Phase angle, determined via InBody 970 bioimpedance analysis.
Measured: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Exercise Adherence
Defined as the number of sessions attended out of total sessions, as recorded by attendance logs.
Measured: Throughout the Exercise Program (approximately 2 months).
Change in Grip Strength
Grip strength assessed via Jamar Hand Dynamometer bilaterally (three consecutive measures per hand).
Measured: Baseline (Prior to Program), During Exercise Program (before and after each workout), and At Exercise Program Completion (approximately 2 months).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Jul 2026
- Study start27 Jul 2026
- Primary completionApr 2027 (estimated)
- Study completionJul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CancerStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Colin Champ, MD, Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
- Investigators
- Colin Champ, MD, CSCS, Principal investigator, AHN Radiation Oncology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07739563
- Sponsor's protocol ID
- 2026-195
- Status last verified
- Aug 2026
- First submitted
- 28 Jul 2026
- Last updated
- 17 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- EXERT-BC Cardio: Randomized Study of EXErcise Regimens After Treatment for Breast Cancer Utilizing Cardio or Conditioning Training
- ClinicalTrials.gov ID
- NCT07739563
- Acronym / sponsor ID
- 2026-195
- Conditions
- Cancer, Breast Cancer
- Keywords
- Exercise
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)University, hospital or other
- Study start
- 27 Jul 2026 (actual)
- Primary completion
- Apr 2027 (estimated)
- Study completion
- Jul 2027 (estimated)
- First posted
- 31 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this study, the investigators hypothesize that observed intense resistance training with conditioning elicits similar changes in body composition, muscle mass, and blood pressure as that with cardiovascular training (or cardio) for women treated with breast cancer.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Cardio Training | Experimental | Behavioral: Resistance Training with Cardio |
| Conditioning Training | Experimental | Behavioral: Resistance Training with Conditioning |
Who may qualify
- Ages
- 20 to 89 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Age 20-89 years
- Women prescribed exercise as a SOC
- Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast
- Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.
- Women with > 3 months of resistance training experience under expert guidance by a CSCS
Key exclusion criteria (6 listed)
- Any current treatment with cytotoxic chemotherapy for breast cancer
- Inability to safely engage in group sessions of resistance training as deemed by study PI
- Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by PI to be unsafe to engage in resistance training
- Beta blocker or GLP-1 inhibitor medications
- Pregnant women
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance Training with CardioParticipants in this arm will engage in a supervised exercise regimen three times per week, for approximately 2 months (8 weeks). The regimen combines two days of hypertrophy-focused resistance training with a third day dedicated to steady-state cardiovascular exercise. The cardio day will utilize ergometer-based exercises (rowing ergometer, Assault Air Bike) and unweighted sled pushes, with each activity lasting 10 minutes continuously. The overall program aims to improve cardiorespiratory fitness and body composition in breast cancer survivors, under the guidance of Certified Strength and Conditioning Specialists (CSCS). | Behavioural | Cardio Training |
| Resistance Training with ConditioningParticipants in this arm will engage in a supervised exercise regimen three times per week, for approximately 2 months (8 weeks). The regimen combines two days of hypertrophy-focused resistance training with a third day dedicated to high-intensity conditioning. The conditioning day involves a circuit format of 6 total exercises, completed for 8 repetitions each across 8 sets, with limited rest periods (10 seconds or less) between exercises and sets. Exercise selection is total-body focused, alternating between upper and lower body movements. The program aims to improve muscular conditioning and body composition in breast cancer survivors, under the guidance of Certified Strength and Conditioning Specialists (CSCS). | Behavioural | Conditioning Training |
Primary outcome
Change in Muscle Mass
Time frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Measured as total muscle mass (kg), determined via InBody 970 bioimpedance analysis and ultrasound (BodyMetrix) for muscle tissue thickness.
Change in Fat Mass
Time frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Measured as total fat mass (kg), determined via InBody 970 bioimpedance analysis and ultrasound (BodyMetrix) for adipose tissue thickness.
6 secondary outcomes
Change in Blood Pressure
Time frame: Baseline (Prior to Program), at Month 1, and At Exercise Program Completion (approximately 2 months).
Change in Resting Metabolic Rate
Time frame: At Exercise Program Completion (approximately 2 months).
Change in Body Composition Metrics (Other than Muscle/Fat Mass)
Time frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Change in Phase Angle
Time frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).
Exercise Adherence
Time frame: Throughout the Exercise Program (approximately 2 months).
Change in Grip Strength
Time frame: Baseline (Prior to Program), During Exercise Program (before and after each workout), and At Exercise Program Completion (approximately 2 months).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Colin Champ, MD, CSCS principal investigator
AHN Radiation Oncology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance Training with Cardio and Resistance Training with Conditioning in people with Cancer and Breast Cancer, run by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Clinical Trials Contact (412-330-6151, ctgov@ahn.org), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Muscle Mass (time frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2026.