Nasal CavityNCT07739927
Serrated Inferior Turbinate Variation and Sinonasal Findings on CBCT
An observational study of Nasal Cavity and CBCT Segmentation, run by Recep Tayyip Erdogan University Training and Research Hospital.
Trial summary
regulate nasal airflow, humidify and filter inspired air. Serrated inferior turbinate is a rare anatomical variation characterized by an irregular, serrated appearance of the inferior turbinate bone. Read more about this study
- Who is it for?
- Ages 18 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Nasal Cavity, CBCT Segmentation
- How many people
- 105 participants
- Where
- No sites listed yet
- Study dates
- 15 Jul 2026to 30 Aug 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The study population will consist of adult individuals aged 18-75 years who underwent cone-beam computed tomography (CBCT) imaging for routine diagnostic purposes at Recep Tayyip Erdoğan University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology between January 2025 and June 2026. Existing CBCT images from the institutional radiology archive will be retrospectively reviewed. The study population will include individuals whose CBCT images provide adequate visualization of the maxillary sinuses, nasal cavity, ostiomeatal complex, and inferior turbinates for evaluation of sinonasal anatomical structures. Patients with craniofacial anomalies, maxillofacial trauma, previous sinonasal surgery, pathological conditions affecting the evaluated anatomical structures, or CBCT images unsuitable for accurate assessment will be excluded. The study aims to evaluate the relationship between serrated inferior turbinate variation, maxillary sinus mucosal thickness, and other sin
Who may be able to join
- Individuals aged 18-75 years.
- Patients who underwent cone-beam computed tomography (CBCT) imaging for routine diagnostic purposes between January 2025 and June 2026.
- CBCT images including both maxillary sinuses, nasal cavity, ostiomeatal complex, and inferior turbinates.
- CBCT images with sufficient diagnostic quality and clearly visible anatomical boundaries for evaluation and measurements.
- CBCT images in which the anatomical landmarks required for nasal septal deviation angle measurement (crista galli, maxillary spine, and the most deviated point of the nasal septum) can be clearly identified.
Who cannot join
- Patients with maxillofacial trauma, fractures, or conditions affecting the midface anatomy.
- Patients with congenital craniofacial anomalies (e.g., cleft lip and palate) or syndromes affecting facial anatomy.
- Patients with a history of sinonasal, inferior turbinate, or maxillary sinus surgery.
- CBCT images with insufficient diagnostic quality, motion artifacts, or metal artifacts preventing accurate evaluation.
- Patients with pathological lesions affecting the maxillary sinus or nasal cavity anatomy, including cysts, tumors, or aggressive inflammatory lesions.
- CBCT findings suggestive of fungal sinusitis, including heterogeneous hyperdense contents, calcifications, bone expansion, or invasive changes.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Evaluation of the Relationship Between Serrated Inferior Turbinate Variation, Maxillary Sinus Mucosal Thickness, and Sinonasal Anatomical Structures Using Cone-Beam Computed Tomography
regulate nasal airflow, humidify and filter inspired air. Serrated inferior turbinate is a rare anatomical variation characterized by an irregular, serrated appearance of the inferior turbinate bone. Although this variation has been described in radiological studies, its possible relationship with maxillary sinus mucosal changes and other sinonasal anatomical features remains unclear.
This retrospective observational study aims to evaluate the relationship between serrated inferior turbinate variation and maxillary sinus mucosal thickness, mucosal abnormalities, and other sinonasal anatomical structures using cone-beam computed tomography (CBCT) images.
Read more
CBCT images obtained from patients who underwent imaging for routine diagnostic purposes will be retrospectively reviewed. The presence of serrated inferior turbinate variation, maxillary sinus findings, inferior turbinate measurements, and nasal septum characteristics will be evaluated.
The study aims to improve understanding of the radiological significance of serrated inferior turbinate variation and to provide information that may contribute to more accurate evaluation and reporting of sinonasal anatomical variations.
Read the detailed description
The nasal cavity contains several anatomical structures that contribute to normal respiratory function, including regulation of airflow, filtration, humidification, and temperature control of inspired air. The inferior turbinate is a key component of the lateral nasal wall and consists of a bony framework covered by vascular mucosa. Variations in the morphology and dimensions of the inferior turbinate may influence nasal airflow and the anatomical relationship between the nasal cavity and adjacent sinonasal structures.
Serrated inferior turbinate is a rare anatomical variation characterized by irregular serrated bony contours along the medial surface of the inferior turbinate. Previous studies have mainly focused on the prevalence and morphological description of inferior turbinate variations; however, the potential association between serrated inferior turbinate variation and maxillary sinus mucosal changes has not been sufficiently investigated.
Cone-beam computed tomography (CBCT) provides three-dimensional, high-resolution imaging of the maxillofacial region and allows detailed assessment of bony structures, paranasal sinuses, and sinonasal anatomical variations. In this study, CBCT images will be retrospectively analyzed to determine whether the presence of serrated inferior turbinate variation is associated with changes in the ipsilateral maxillary sinus mucosa and other sinonasal anatomical parameters.
The study population will consist of individuals who underwent CBCT imaging for routine diagnostic purposes. Images will be evaluated for the presence or absence of serrated inferior turbinate variation. Additional radiological assessments will include maxillary sinus mucosal thickness, presence of polypoid mucosal thickening or retention cysts, inferior turbinate dimensions, nasal septal deviation angle, and other sinonasal anatomical findings.
All evaluations will be performed on existing CBCT datasets without additional imaging procedures or interventions. Patient confidentiality will be maintained throughout the study, and all analyses will be performed using anonymized imaging data.
The findings of this study may contribute to a better understanding of the clinical and radiological significance of serrated inferior turbinate variation and may improve the assessment and reporting of sinonasal anatomical variations in CBCT examinations.
- Conditions
- Nasal Cavity, CBCT Segmentation
- Being tested
- No intervention (retrospective CBCT imaging analysis)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No intervention (retrospective CBCT imaging analysis)Other
This is a retrospective observational imaging study. No intervention, treatment, or procedure will be assigned to participants. Existing cone-beam computed tomography (CBCT) images obtained for routine diagnostic purposes will be evaluated.
What is being measured
The primary outcome is the main question the study is designed to answer.
Maxillary sinus mucosal thickness associated with serrated inferior turbinate variation
The maximum mucosal thickness of the ipsilateral maxillary sinus will be measured in millimeters (mm) on cone-beam computed tomography (CBCT) images and compared between sides with serrated inferior turbinate variation and sides without this variation.
Measured: At the time of CBCT image evaluation
Secondary outcomes (1)
Presence of polypoid mucosal thickening and mucous retention cysts in the maxillary sinus
The presence or absence of polypoid mucosal thickening and mucous retention cysts in the maxillary sinus will be evaluated on CBCT images.
Measured: At the time of CBCT image evaluation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Jul 2026
- Study start15 Jul 2026 (estimated)
- Primary completion15 Aug 2026 (estimated)
- Study completion30 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Nasal CavityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case crossover
- Time perspective
- Retrospective
- Enrolment
- 105 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, DİLARA NİL GÜNAÇAR, Recep Tayyip Erdogan University Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07739927
- Sponsor's protocol ID
- 2026/297
- Status last verified
- Jul 2026
- First submitted
- 28 Jul 2026
- Last updated
- 31 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 31 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Relationship Between Serrated Inferior Turbinate Variation, Maxillary Sinus Mucosal Thickness, and Sinonasal Anatomical Structures Using Cone-Beam Computed Tomography
- ClinicalTrials.gov ID
- NCT07739927
- Acronym / sponsor ID
- 2026/297
- Conditions
- Nasal Cavity, CBCT Segmentation
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 105 participants (estimated)
- Lead sponsor
- Recep Tayyip Erdogan University Training and Research HospitalUniversity, hospital or other
- Study start
- 15 Jul 2026 (estimated)
- Primary completion
- 15 Aug 2026 (estimated)
- Study completion
- 30 Aug 2026 (estimated)
- First posted
- 31 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
regulate nasal airflow, humidify and filter inspired air. Serrated inferior turbinate is a rare anatomical variation characterized by an irregular, serrated appearance of the inferior turbinate bone. Although this variation has been described in radiological studies, its possible relationship with maxillary sinus mucosal changes and other sinonasal anatomical features remains unclear.
This retrospective observational study aims to evaluate the relationship between serrated inferior turbinate variation and maxillary sinus mucosal thickness, mucosal abnormalities, and other sinonasal anatomical structures using cone-beam computed tomography (CBCT) images.
CBCT images obtained from patients who underwent imaging for routine diagnostic purposes will be retrospectively reviewed. The presence of serrated inferior turbinate variation, maxillary sinus findings, inferior turbinate measurements, and nasal septum characteristics will be evaluated.
The study aims to improve understanding of the radiological significance of serrated inferior turbinate variation and to provide information that may contribute to more accurate evaluation and reporting of sinonasal anatomical variations.
Detailed description
The nasal cavity contains several anatomical structures that contribute to normal respiratory function, including regulation of airflow, filtration, humidification, and temperature control of inspired air. The inferior turbinate is a key component of the lateral nasal wall and consists of a bony framework covered by vascular mucosa. Variations in the morphology and dimensions of the inferior turbinate may influence nasal airflow and the anatomical relationship between the nasal cavity and adjacent sinonasal structures.
Serrated inferior turbinate is a rare anatomical variation characterized by irregular serrated bony contours along the medial surface of the inferior turbinate. Previous studies have mainly focused on the prevalence and morphological description of inferior turbinate variations; however, the potential association between serrated inferior turbinate variation and maxillary sinus mucosal changes has not been sufficiently investigated.
Cone-beam computed tomography (CBCT) provides three-dimensional, high-resolution imaging of the maxillofacial region and allows detailed assessment of bony structures, paranasal sinuses, and sinonasal anatomical variations. In this study, CBCT images will be retrospectively analyzed to determine whether the presence of serrated inferior turbinate variation is associated with changes in the ipsilateral maxillary sinus mucosa and other sinonasal anatomical parameters.
The study population will consist of individuals who underwent CBCT imaging for routine diagnostic purposes. Images will be evaluated for the presence or absence of serrated inferior turbinate variation. Additional radiological assessments will include maxillary sinus mucosal thickness, presence of polypoid mucosal thickening or retention cysts, inferior turbinate dimensions, nasal septal deviation angle, and other sinonasal anatomical findings.
All evaluations will be performed on existing CBCT datasets without additional imaging procedures or interventions. Patient confidentiality will be maintained throughout the study, and all analyses will be performed using anonymized imaging data.
The findings of this study may contribute to a better understanding of the clinical and radiological significance of serrated inferior turbinate variation and may improve the assessment and reporting of sinonasal anatomical variations in CBCT examinations.
Study design
- Observational model
- Case crossover
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The study population will consist of adult individuals aged 18-75 years who underwent cone-beam computed tomography (CBCT) imaging for routine diagnostic purposes at Recep Tayyip Erdoğan University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology between January 2025 and June 2026. Existing CBCT images from the institutional radiology archive will be retrospectively reviewed. The study population will include individuals whose CBCT images provide adequate visualization of the maxillary sinuses, nasal cavity, ostiomeatal complex, and inferior turbinates for evaluation of sinonasal anatomical structures. Patients with craniofacial anomalies, maxillofacial trauma, previous sinonasal surgery, pathological conditions affecting the evaluated anatomical structures, or CBCT images unsuitable for accurate assessment will be excluded. The study aims to evaluate the relationship between serrated inferior turbinate variation, maxillary sinus mucosal thickness, and other sin
Key inclusion criteria (5 listed)
- Individuals aged 18-75 years.
- Patients who underwent cone-beam computed tomography (CBCT) imaging for routine diagnostic purposes between January 2025 and June 2026.
- CBCT images including both maxillary sinuses, nasal cavity, ostiomeatal complex, and inferior turbinates.
- CBCT images with sufficient diagnostic quality and clearly visible anatomical boundaries for evaluation and measurements.
- CBCT images in which the anatomical landmarks required for nasal septal deviation angle measurement (crista galli, maxillary spine, and the most deviated point of the nasal septum) can be clearly identified.
Key exclusion criteria (6 listed)
- Patients with maxillofacial trauma, fractures, or conditions affecting the midface anatomy.
- Patients with congenital craniofacial anomalies (e.g., cleft lip and palate) or syndromes affecting facial anatomy.
- Patients with a history of sinonasal, inferior turbinate, or maxillary sinus surgery.
- CBCT images with insufficient diagnostic quality, motion artifacts, or metal artifacts preventing accurate evaluation.
- Patients with pathological lesions affecting the maxillary sinus or nasal cavity anatomy, including cysts, tumors, or aggressive inflammatory lesions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No intervention (retrospective CBCT imaging analysis)This is a retrospective observational imaging study. No intervention, treatment, or procedure will be assigned to participants. Existing cone-beam computed tomography (CBCT) images obtained for routine diagnostic purposes will be evaluated. | Other | – |
Primary outcome
Maxillary sinus mucosal thickness associated with serrated inferior turbinate variation
Time frame: At the time of CBCT image evaluation
The maximum mucosal thickness of the ipsilateral maxillary sinus will be measured in millimeters (mm) on cone-beam computed tomography (CBCT) images and compared between sides with serrated inferior turbinate variation and sides without this variation.
1 secondary outcome
Presence of polypoid mucosal thickening and mucous retention cysts in the maxillary sinus
Time frame: At the time of CBCT image evaluation
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Nasal Cavity and CBCT Segmentation, run by Recep Tayyip Erdogan University Training and Research Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 31 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Dilara Nil GÜNAÇAR (+905412940104, dilaranil.tomrukcu@erdogan.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maxillary sinus mucosal thickness associated with serrated inferior turbinate variation (time frame: At the time of CBCT image evaluation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jul 2026.