HysterectomyMTAPA-TLHNCT07740252
Postoperative Analgesic Effectiveness of the Modified Thoracoabdominal Nerve Block Through a Perichondrial Approach in Total Laparoscopic Hysterectomy
An observational study of Hysterectomy and Postoperative Pain, run by Namik Kemal University at 1 site in Turkey (Türkiye).
Trial summary
This single-center retrospective cohort study evaluated the effect of the modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) on postoperative analgesia in patients undergoing elective total laparoscopic hysterectomy. Read more about this study
- Who is it for?
- Ages 18 to 65 years, women only
- Conditions the study is for
- Hysterectomy, Postoperative Pain
- What is being tested?
- Modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA)
- Type of treatment
- Surgery or procedure
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 25 Dec 2023to 25 Dec 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- Women only
- No healthy volunteers
- Adult, Older adult
Study population: Female patients aged 18-65 years with ASA physical status I-II who underwent elective total laparoscopic hysterectomy at Tekirdag Namik Kemal University Faculty of Medicine Hospital between December 25, 2023, and December 25, 2024.
Who may be able to join
- Female patients aged 18 to 65 years.
- American Society of Anesthesiologists (ASA) physical status I or II.
- Undergoing elective total laparoscopic hysterectomy under general anesthesia.
- Availability of complete perioperative and postoperative medical records.
Who cannot join
- Neurological disorders affecting pain perception.
- Coagulopathy or bleeding disorders.
- Known allergy to local anesthetics.
- Chronic opioid use before surgery.
- Body mass index (BMI) greater than 35 kg/m².
- Incomplete medical records.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Tekirdag Namik Kemal University Faculty of Medicine Hospital
Tekirdağ, Tekirdağ, 59030
About this study
Official title: Retrospective Evaluation of the Effect of the Modified Thoracoabdominal Nerve Block Through a Perichondrial Approach on Postoperative Analgesic Consumption in Patients Undergoing Total Laparoscopic Hysterectomy
This single-center retrospective cohort study evaluated the effect of the modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) on postoperative analgesia in patients undergoing elective total laparoscopic hysterectomy. Medical records of 60 patients who underwent surgery at Tekirdag Namik Kemal University Faculty of Medicine Hospital between December 25, 2023 and December 25, 2024 were retrospectively reviewed. Patients who received bilateral ultrasound-guided M-TAPA block were compared with patients who received standard general anesthesia and systemic analgesia without M-TAPA block. The primary outcome was cumulative tramadol consumption during the first 24 postoperative hours. Secondary outcomes included postoperative Visual Analog Scale (VAS) pain scores at predefined time points, rescue analgesic requirements, postoperative nausea and vomiting, Quality of Recovery-15 (QoR-15) scores, and block-related complications.
Read the detailed description
Postoperative pain following total laparoscopic hysterectomy remains an important clinical concern because inadequate analgesia may delay mobilization, prolong recovery, increase opioid consumption, and reduce patient satisfaction. Ultrasound-guided fascial plane blocks have become an important component of multimodal analgesia strategies. The modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) is a relatively new regional anesthesia technique that provides analgesia of the anterior thoracoabdominal wall by targeting the thoracoabdominal nerves beneath the costal cartilage.
This single-center retrospective cohort study reviewed the medical records of patients who underwent elective total laparoscopic hysterectomy at Tekirdag Namik Kemal University Faculty of Medicine Hospital between December 25, 2023 and December 25, 2024. After application of predefined inclusion and exclusion criteria, 60 patients were included in the analysis. Thirty patients received bilateral ultrasound-guided M-TAPA block with 20 mL of 0.25% bupivacaine on each side (total volume: 40 mL) in addition to standard general anesthesia, whereas 30 patients received standard general anesthesia and systemic analgesia without M-TAPA block.
The primary outcome was cumulative tramadol consumption during the first 24 postoperative hours. Secondary outcomes included postoperative Visual Analog Scale (VAS) pain scores at 0, 6, 12, and 24 hours after surgery, rescue analgesic requirements, postoperative nausea and vomiting, Quality of Recovery-15 (QoR-15) scores at 24 hours, and block-related complications documented in the medical records.
The study was approved by the Tekirdag Namik Kemal University Non-Interventional Clinical Research Ethics Committee (Approval No. 2025.11.01.11) before data collection and was conducted in accordance with institutional and ethical standards.
- Conditions
- Hysterectomy, Postoperative Pain
- Being tested
- Modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA)
- Keywords
- Modified thoracoabdominal nerves block through perichondrial approach, M-TAPA, Regional anesthesia, Postoperative analgesia
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA)Procedure or surgery
Bilateral ultrasound-guided modified thoracoabdominal nerves block through a perichondrial approach using 20 mL of 0.25% bupivacaine on each side (total volume: 40 mL), performed before surgical incision as part of multimodal analgesia.
| Study group | Role | What they receive |
|---|---|---|
| M-TAPA Group | Patients who underwent elective total laparoscopic hysterectomy under general anesthesia and received bilateral ultrasound-guided modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) in addition to standard perioperative analgesia. Receives: Procedure: Modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) | |
| Control Group | Patients who underwent elective total laparoscopic hysterectomy under general anesthesia and received standard perioperative analgesia without modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA). |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cumulative tramadol consumption during the first 24 postoperative hours
Total tramadol consumption delivered by patient-controlled analgesia (PCA) during the first 24 postoperative hours.
Measured: During the first 24 postoperative hours
Secondary outcomes (5)
Postoperative pain intensity
Postoperative pain intensity assessed using the Visual Analog Scale (VAS). The VAS ranges from 0 to 10, where 0 indicates no pain, 10 indicates the worst imaginable pain, and higher scores indicate greater pain intensity.
Measured: At 0, 6, 12, and 24 hours after surgery
Quality of recovery (QoR-15)
Postoperative recovery quality assessed using the validated Quality of Recovery-15 (QoR-15) questionnaire. The QoR-15 score ranges from 0 to 150, with higher scores indicating better postoperative recovery.
Measured: At 24 hours after surgery
Rescue analgesic requirements
Requirement for additional rescue analgesic medication when postoperative pain remained inadequately controlled despite patient-controlled analgesia.
Measured: During the first 24 hours after surgery
Postoperative nausea and vomiting
Incidence of postoperative nausea and vomiting documented in the medical records.
Measured: During the first 24 hours after surgery
Block-related complications
Complications related to bilateral ultrasound-guided modified thoracoabdominal nerves block through a perichondrial approach documented in the medical records.
Measured: During the first 24 postoperative hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Jul 2026
- Study start25 Dec 2023
- Primary completion25 Dec 2024
- Study completion25 Dec 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HysterectomyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Namik Kemal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Onur Baran, Namik Kemal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07740252
- Sponsor's protocol ID
- TNKU-MTAPA-TLH-001
- Acronym
- MTAPA-TLH
- Status last verified
- Jul 2026
- First submitted
- 23 Jul 2026
- Last updated
- 31 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 31 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Retrospective Evaluation of the Effect of the Modified Thoracoabdominal Nerve Block Through a Perichondrial Approach on Postoperative Analgesic Consumption in Patients Undergoing Total Laparoscopic Hysterectomy
- ClinicalTrials.gov ID
- NCT07740252
- Acronym / sponsor ID
- MTAPA-TLH / TNKU-MTAPA-TLH-001
- Conditions
- Hysterectomy, Postoperative Pain
- Keywords
- Modified thoracoabdominal nerves block through perichondrial approach, M-TAPA, Regional anesthesia, Postoperative analgesia
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Namik Kemal UniversityUniversity, hospital or other
- Study start
- 25 Dec 2023 (actual)
- Primary completion
- 25 Dec 2024 (actual)
- Study completion
- 25 Dec 2024 (actual)
- First posted
- 31 Jul 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This single-center retrospective cohort study evaluated the effect of the modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) on postoperative analgesia in patients undergoing elective total laparoscopic hysterectomy. Medical records of 60 patients who underwent surgery at Tekirdag Namik Kemal University Faculty of Medicine Hospital between December 25, 2023 and December 25, 2024 were retrospectively reviewed. Patients who received bilateral ultrasound-guided M-TAPA block were compared with patients who received standard general anesthesia and systemic analgesia without M-TAPA block. The primary outcome was cumulative tramadol consumption during the first 24 postoperative hours. Secondary outcomes included postoperative Visual Analog Scale (VAS) pain scores at predefined time points, rescue analgesic requirements, postoperative nausea and vomiting, Quality of Recovery-15 (QoR-15) scores, and block-related complications.
Detailed description
Postoperative pain following total laparoscopic hysterectomy remains an important clinical concern because inadequate analgesia may delay mobilization, prolong recovery, increase opioid consumption, and reduce patient satisfaction. Ultrasound-guided fascial plane blocks have become an important component of multimodal analgesia strategies. The modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) is a relatively new regional anesthesia technique that provides analgesia of the anterior thoracoabdominal wall by targeting the thoracoabdominal nerves beneath the costal cartilage.
This single-center retrospective cohort study reviewed the medical records of patients who underwent elective total laparoscopic hysterectomy at Tekirdag Namik Kemal University Faculty of Medicine Hospital between December 25, 2023 and December 25, 2024. After application of predefined inclusion and exclusion criteria, 60 patients were included in the analysis. Thirty patients received bilateral ultrasound-guided M-TAPA block with 20 mL of 0.25% bupivacaine on each side (total volume: 40 mL) in addition to standard general anesthesia, whereas 30 patients received standard general anesthesia and systemic analgesia without M-TAPA block.
The primary outcome was cumulative tramadol consumption during the first 24 postoperative hours. Secondary outcomes included postoperative Visual Analog Scale (VAS) pain scores at 0, 6, 12, and 24 hours after surgery, rescue analgesic requirements, postoperative nausea and vomiting, Quality of Recovery-15 (QoR-15) scores at 24 hours, and block-related complications documented in the medical records.
The study was approved by the Tekirdag Namik Kemal University Non-Interventional Clinical Research Ethics Committee (Approval No. 2025.11.01.11) before data collection and was conducted in accordance with institutional and ethical standards.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| M-TAPA Group | – | Procedure: Modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA)Patients who underwent elective total laparoscopic hysterectomy under general anesthesia and received bilateral ultrasound-guided modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA) in addition to standard perioperative analgesia. |
| Control Group | – | –Patients who underwent elective total laparoscopic hysterectomy under general anesthesia and received standard perioperative analgesia without modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA). |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Female patients aged 18-65 years with ASA physical status I-II who underwent elective total laparoscopic hysterectomy at Tekirdag Namik Kemal University Faculty of Medicine Hospital between December 25, 2023, and December 25, 2024.
Key inclusion criteria (4 listed)
- Female patients aged 18 to 65 years.
- American Society of Anesthesiologists (ASA) physical status I or II.
- Undergoing elective total laparoscopic hysterectomy under general anesthesia.
- Availability of complete perioperative and postoperative medical records.
Key exclusion criteria (6 listed)
- Neurological disorders affecting pain perception.
- Coagulopathy or bleeding disorders.
- Known allergy to local anesthetics.
- Chronic opioid use before surgery.
- Body mass index (BMI) greater than 35 kg/m².
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Modified thoracoabdominal nerves block through a perichondrial approach (M-TAPA)Bilateral ultrasound-guided modified thoracoabdominal nerves block through a perichondrial approach using 20 mL of 0.25% bupivacaine on each side (total volume: 40 mL), performed before surgical incision as part of multimodal analgesia. | Procedure or surgery | M-TAPA Group |
Primary outcome
Cumulative tramadol consumption during the first 24 postoperative hours
Time frame: During the first 24 postoperative hours
Total tramadol consumption delivered by patient-controlled analgesia (PCA) during the first 24 postoperative hours.
5 secondary outcomes
Postoperative pain intensity
Time frame: At 0, 6, 12, and 24 hours after surgery
Quality of recovery (QoR-15)
Time frame: At 24 hours after surgery
Rescue analgesic requirements
Time frame: During the first 24 hours after surgery
Postoperative nausea and vomiting
Time frame: During the first 24 hours after surgery
Block-related complications
Time frame: During the first 24 postoperative hours
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Jul 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Hysterectomy and Postoperative Pain, run by Namik Kemal University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cumulative tramadol consumption during the first 24 postoperative hours (time frame: During the first 24 postoperative hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Jul 2026.