Post-induction HypotensionNCT07742904
SV and IVC Collapsibility Index to Predict Postinduction Hypotension
An observational study of Post-induction Hypotension and Intestinal Obstruction, run by Ain Shams University.
Trial summary
Postinduction hypotension (PIH) is a frequent complication during general anesthesia. This study aims to compare the predictive effectiveness and diagnostic accuracy of stroke volume (SV) measured via left ventricular outflow tract velocity time integral (LVOT-VTI) versus the inferior vena cava collapsibility index… Read more about this study
- Who is it for?
- Ages 40 to 70 years
- Conditions the study is for
- Post-induction Hypotension, Intestinal Obstruction
- How many people
- 75 participants
- Where
- No sites listed yet
- Study dates
- 1 Oct 2026to 1 Feb 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients diagnosed with intestinal obstruction scheduled for exploratory abdominal surgery under general anesthesia at Ain-Shams University Hospitals.
Who may be able to join
- Adult patients with intestinal bowel obstruction undergoing exploratory abdominal surgery under general anesthesia.
- Age 40 to 70 years old.
- Body Mass Index (BMI) = 18 to 25 kg/m2.
- American Society of Anesthesiologists (ASA) physical status grade I or II.
Who cannot join
- American Society of Anesthesiologists (ASA) physical status grade >= III.
- Patients in whom the IVC cannot be visualized or patients with poor echogenicity.
- Patients with hemodynamic instability.
- Patients with vascular, respiratory, or cardiac diseases (e.g., cardiomyopathy, heart valve disease, arrhythmia, or bad exercise tolerance).
- Pregnant patients.
- Difficult airway or multiple intubatio
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
Islam A Taher, M.D. contact
About this study
Official title: Stroke Volume Versus Inferior Vena Cava Collapsibility Index to Predict Postinduction Hypotension in Intestinal Obstruction
Postinduction hypotension (PIH) is a frequent complication during general anesthesia. This study aims to compare the predictive effectiveness and diagnostic accuracy of stroke volume (SV) measured via left ventricular outflow tract velocity time integral (LVOT-VTI) versus the inferior vena cava collapsibility index (IVC-CI) using transthoracic echocardiography. The assessment will be conducted in adult patients with intestinal obstruction undergoing exploratory abdominal surgery under general anesthesia.
Read the detailed description
Postinduction hypotension (PIH) is associated with adverse postoperative outcomes. In this diagnostic accuracy observational study, adult patients aged 40-70 years with intestinal obstruction undergoing exploratory abdominal surgery under general anesthesia will be enrolled at Ain Shams University Hospitals. Prior to induction of general anesthesia, transthoracic echocardiography (TTE) will be performed to measure the stroke volume (SV) via LVOT-VTI and the inferior vena cava collapsibility index (IVC-CI). Patients will receive standard rapid sequence induction, and hemodynamic parameters will be monitored post-induction to evaluate the predictive value, sensitivity, and specificity of SV versus IVC-CI for postinduction hypotension. Secondary outcomes including incidence of PIH, length of hospital stay, PACU recovery time, and postoperative nausea and vomiting will also be recorded.
- Conditions
- Post-induction Hypotension, Intestinal Obstruction
- Keywords
- Stroke Volume, Inferior Vena Cava Collapsibility Index, LVOT-VTI, Echocardiography, General Anesthesia
- Medical subject headings
- Intestinal Obstruction
What is being measured
The primary outcome is the main question the study is designed to answer.
Diagnostic accuracy of Stroke Volume (SV) to predict post-induction hypotension.
Area under the receiver operating characteristic curve (AUC) of stroke volume measured via left ventricular outflow tract velocity-time integral (LVOT-VTI) as a predictor of post-induction hypotension.
Measured: Baseline (pre-induction) and immediately post-induction.
Diagnostic accuracy of Inferior Vena Cava Collapsibility Index (IVC-CI) to predict post-induction hypotension.
Area under the receiver operating characteristic curve (AUC) of inferior vena cava collapsibility index measured via transthoracic echocardiography (TTE) as a predictor of post-induction hypotension.
Measured: Baseline (pre-induction) and immediately post-induction.
Secondary outcomes (3)
Incidence of Post-Induction Hypotension
Assessment of the proportion of patients who develop post-induction hypotension, defined as SBP decrease > 30%, MAP decrease > 20% from baseline, or absolute SBP < 90 mmHg and MAP < 60 mmHg.
Measured: Within 3 minutes following induction of general anesthesia.
Length of Hospital Stay Length of Hospital Stay
Total duration of hospitalization from the day of surgery until discharge.
Measured: From date of surgery until hospital discharge (up to 9 months).
Time to Recovery from Post-Anesthesia Care Unit (PACU) Time to Recovery from Post-Anesthesia Care Unit (PACU)
Time elapsed from patient admission to the PACU until meeting discharge criteria.
Time elapsed from patient admission to the PACU until meeting discharge criteria.
Measured: Intraoperative / immediate postoperative period until PACU discharge (up to 24 hours).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Aug 2026
- Study start1 Oct 2026 (estimated)
- Primary completion1 Feb 2027 (estimated)
- Study completion1 Feb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post-induction HypotensionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 75 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Mohamed H Shokeir, M.D., Ph.D., Study chair, Ain Shams University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07742904
- Sponsor's protocol ID
- FMASU MD49/2025
- Status last verified
- Jul 2026
- First submitted
- 29 Jul 2026
- Last updated
- 10 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared to protect patient privacy and confidentiality.
Study at a glance
From the registry record, last updated by the sponsor on 10 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Stroke Volume Versus Inferior Vena Cava Collapsibility Index to Predict Postinduction Hypotension in Intestinal Obstruction
- ClinicalTrials.gov ID
- NCT07742904
- Acronym / sponsor ID
- FMASU MD49/2025
- Conditions
- Post-induction Hypotension, Intestinal Obstruction
- Keywords
- Stroke Volume, Inferior Vena Cava Collapsibility Index, LVOT-VTI, Echocardiography, General Anesthesia
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 75 participants (estimated)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- 1 Feb 2027 (estimated)
- Study completion
- 1 Feb 2027 (estimated)
- First posted
- 3 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Postinduction hypotension (PIH) is a frequent complication during general anesthesia. This study aims to compare the predictive effectiveness and diagnostic accuracy of stroke volume (SV) measured via left ventricular outflow tract velocity time integral (LVOT-VTI) versus the inferior vena cava collapsibility index (IVC-CI) using transthoracic echocardiography. The assessment will be conducted in adult patients with intestinal obstruction undergoing exploratory abdominal surgery under general anesthesia.
Detailed description
Postinduction hypotension (PIH) is associated with adverse postoperative outcomes. In this diagnostic accuracy observational study, adult patients aged 40-70 years with intestinal obstruction undergoing exploratory abdominal surgery under general anesthesia will be enrolled at Ain Shams University Hospitals. Prior to induction of general anesthesia, transthoracic echocardiography (TTE) will be performed to measure the stroke volume (SV) via LVOT-VTI and the inferior vena cava collapsibility index (IVC-CI). Patients will receive standard rapid sequence induction, and hemodynamic parameters will be monitored post-induction to evaluate the predictive value, sensitivity, and specificity of SV versus IVC-CI for postinduction hypotension. Secondary outcomes including incidence of PIH, length of hospital stay, PACU recovery time, and postoperative nausea and vomiting will also be recorded.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 40 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients diagnosed with intestinal obstruction scheduled for exploratory abdominal surgery under general anesthesia at Ain-Shams University Hospitals.
Key inclusion criteria (4 listed)
- Adult patients with intestinal bowel obstruction undergoing exploratory abdominal surgery under general anesthesia.
- Age 40 to 70 years old.
- Body Mass Index (BMI) = 18 to 25 kg/m2.
- American Society of Anesthesiologists (ASA) physical status grade I or II.
Key exclusion criteria (6 listed)
- American Society of Anesthesiologists (ASA) physical status grade >= III.
- Patients in whom the IVC cannot be visualized or patients with poor echogenicity.
- Patients with hemodynamic instability.
- Patients with vascular, respiratory, or cardiac diseases (e.g., cardiomyopathy, heart valve disease, arrhythmia, or bad exercise tolerance).
- Pregnant patients.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Diagnostic accuracy of Stroke Volume (SV) to predict post-induction hypotension.
Time frame: Baseline (pre-induction) and immediately post-induction.
Area under the receiver operating characteristic curve (AUC) of stroke volume measured via left ventricular outflow tract velocity-time integral (LVOT-VTI) as a predictor of post-induction hypotension.
Diagnostic accuracy of Inferior Vena Cava Collapsibility Index (IVC-CI) to predict post-induction hypotension.
Time frame: Baseline (pre-induction) and immediately post-induction.
Area under the receiver operating characteristic curve (AUC) of inferior vena cava collapsibility index measured via transthoracic echocardiography (TTE) as a predictor of post-induction hypotension.
3 secondary outcomes
Incidence of Post-Induction Hypotension
Time frame: Within 3 minutes following induction of general anesthesia.
Length of Hospital Stay Length of Hospital Stay
Time frame: From date of surgery until hospital discharge (up to 9 months).
Time to Recovery from Post-Anesthesia Care Unit (PACU) Time to Recovery from Post-Anesthesia Care Unit (PACU)
Time frame: Intraoperative / immediate postoperative period until PACU discharge (up to 24 hours).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared to protect patient privacy and confidentiality.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Islam A Taher, M.D. contact
Mohamed H Shokeir, M.D., Ph.D. study chair
Ain Shams University
Questions about this trial
What is this clinical trial studying?
An observational study of Post-induction Hypotension and Intestinal Obstruction, run by Ain Shams University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Noura A Kamal, M.Sc. (+201119774236, NouraAbdel-Monem@med.asu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Diagnostic accuracy of Stroke Volume (SV) to predict post-induction hypotension. (time frame: Baseline (pre-induction) and immediately post-induction.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2026.