Chronic Total Occlusion (CTO)NCT07743437
Relationship Between Frontal QRS-T Angle and Collateral Circulation in Coronary Artery Chronic Total Occlusion
An observational study of Chronic Total Occlusion (CTO) and Frontal QRS-T Angle, run by Assiut University at 1 site in Egypt.
Trial summary
Aim of the work: To examine the relationship between collateral circulation and the frontal QRS-T angle in patients with chronic total occlusion (CTO) Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Chronic Total Occlusion (CTO), Frontal QRS-T Angle
- What is being tested?
- 12-lead Electrocardiogram (ECG) and Coronary Angiography
- How many people
- 100 participants
- Where
- 1 siteEgypt
- Study dates
- Aug 2026to Sep 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of adult patients presenting to the cardiology department who have experienced stable angina for a minimum of three months and are subsequently diagnosed with a chronic total occlusion (CTO) in at least one coronary artery during routine diagnostic coronary angiography.
Who may be able to join
- Patients undergoing diagnostic coronary angiography due to stable angina persisting for a minimum duration of three months.
- Patients diagnosed with total occlusion in at least one coronary artery, assessed to have chronic total occlusion (CTO) based on clinical and angiographic findings.
Who cannot join
- Patients presenting with malignancies, atrial fibrillation, connective tissue disorders, hepatic failure, or renal failure.
- A documented history of cardiac pacemaker implantation, prior bypass surgeries, or surgical valve replacements.
- Congenital heart anomalies.
- Patients receiving pharmacological interventions that affect ventricular repolarization (other than beta-adrenergic antagonists).
- Individuals exhibiting abnormal electrolyte levels at the time of admission.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Hosam Hasan contact
About this study
Official title: Frontal QRS-T Angle as an Electrocardiographic Marker for Collateral Circulation in Coronary Artery Chronic Total Occlusion
- Aim of the work: To examine the relationship between collateral circulation and the frontal QRS-T angle in patients with chronic total occlusion (CTO)
Read the detailed description
- Study Objectives
- Primary Objective:
- To examine the relationship between coronary collateral circulation and the electrocardiographic frontal QRS-T angle in patients diagnosed with chronic total occlusion (CTO).
- Secondary Objectives:
- To identify other independent clinical and laboratory predictors (such as serum albumin levels and neutrophil counts) associated with an increased frontal QRS-T angle in patients with CTO.
- To compare echocardiographic parameters (such as left ventricular ejection fraction and left ventricular dimensions) between patients with a normal QRS-T angle and those with an increased QRS-T angle.
- Conditions
- Chronic Total Occlusion (CTO), Frontal QRS-T Angle
- Being tested
- 12-lead Electrocardiogram (ECG) and Coronary Angiography
- Keywords
- frontal QRS-T angle, Chronic total occlusion
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
12-lead Electrocardiogram (ECG) and Coronary AngiographyDiagnostic test
A 12-lead ECG is performed to calculate the frontal QRS-T angle, and coronary angiography is performed to evaluate the coronary collateral circulation using the Rentrop Classification.
| Study group | Role | What they receive |
|---|---|---|
| Increased QRS-T Angle | Subjects exhibiting an increased frontal QRS-T angle (≥110° for men, >90° for women). Receives: Diagnostic Test: 12-lead Electrocardiogram (ECG) and Coronary Angiography | |
| Normal QRS-T Angle | Subjects presenting with a normative frontal QRS-T angle (<110° for men, <90° for women). Receives: Diagnostic Test: 12-lead Electrocardiogram (ECG) and Coronary Angiography |
What is being measured
The primary outcome is the main question the study is designed to answer.
correlation between frontal QRS-T angle and collateral circulation in CTO patients
- To examine the relationship between coronary collateral circulation and the electrocardiographic frontal QRS-T angle in patients diagnosed with chronic total occlusion (CTO).
Measured: baseline ( at the time of the diagnosis )
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Aug 2026
- Study startAug 2026 (estimated)
- Primary completionAug 2028 (estimated)
- Study completionSep 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Chronic Total Occlusion (CTO)Studies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tarek Yaser Fathi, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07743437
- Sponsor's protocol ID
- QRS-T Angle in CTO Patients
- Status last verified
- Aug 2026
- First submitted
- 29 Jul 2026
- Last updated
- 4 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Ozturk M, Emlek N, Ozyildiz AG, Ergul E, Durak H, Ozyildiz A, Cetin M. The Relationship Between Collateral Circulation and Electrocardiographic Frontal QRS-T Angle in Patients with Coronary Artery Chronic Total Occlusion. J Clin Med. 2025 Dec 24;15(1):148. doi: 10.3390/jcm15010148.
PubMed 41517395Sawant AC, Bhardwaj A, Srivatsa S, Sridhara S, Prakash MPH, Kanwar N, Rodriguez J, Tse G, Liu T, Kumar A, Beck H, Srivatsa SS. Prognostic value of frontal QRS-T angle in predicting survival after primary percutaneous coronary revascularization/coronary artery bypass grafting for ST-elevation myocardial infarction. Indian Heart J. 2019 Nov-Dec;71(6):481-487. doi: 10.1016/j.ihj.2019.09.008. Epub 2019 Sep 9.
PubMed 32248922Attar A, Sayadi M, Hosseinpour A, Brilakis ES, Mehdizade F, Namvar Z, Khosravi A, Boshtam M, Noohi F, Assareh A, Kazemi T, Farshidi H, Khaledifar A, Abbaszadeh M, Sarrafzadegan N. Prevalence and Clinical Parameters Associated With Chronic Total Occlusions in Patients With Chronic Coronary Syndromes: Insights From a Nationwide Registry. Health Sci Rep. 2025 Mar 18;8(3):e70583. doi: 10.1002/hsr2.70583. eCollection 2025 Mar.
PubMed 40109697
Study at a glance
From the registry record, last updated by the sponsor on 4 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Frontal QRS-T Angle as an Electrocardiographic Marker for Collateral Circulation in Coronary Artery Chronic Total Occlusion
- ClinicalTrials.gov ID
- NCT07743437
- Acronym / sponsor ID
- QRS-T Angle in CTO Patients
- Conditions
- Chronic Total Occlusion (CTO), Frontal QRS-T Angle
- Keywords
- frontal QRS-T angle, Chronic total occlusion
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- Aug 2026 (estimated)
- Primary completion
- Aug 2028 (estimated)
- Study completion
- Sep 2028 (estimated)
- First posted
- 3 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- Aim of the work: To examine the relationship between collateral circulation and the frontal QRS-T angle in patients with chronic total occlusion (CTO)
Detailed description
- Study Objectives
- Primary Objective:
- To examine the relationship between coronary collateral circulation and the electrocardiographic frontal QRS-T angle in patients diagnosed with chronic total occlusion (CTO).
- Secondary Objectives:
- To identify other independent clinical and laboratory predictors (such as serum albumin levels and neutrophil counts) associated with an increased frontal QRS-T angle in patients with CTO.
- To compare echocardiographic parameters (such as left ventricular ejection fraction and left ventricular dimensions) between patients with a normal QRS-T angle and those with an increased QRS-T angle.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Increased QRS-T Angle | – | Diagnostic Test: 12-lead Electrocardiogram (ECG) and Coronary AngiographySubjects exhibiting an increased frontal QRS-T angle (≥110° for men, >90° for women). |
| Normal QRS-T Angle | – | Diagnostic Test: 12-lead Electrocardiogram (ECG) and Coronary AngiographySubjects presenting with a normative frontal QRS-T angle (<110° for men, <90° for women). |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of adult patients presenting to the cardiology department who have experienced stable angina for a minimum of three months and are subsequently diagnosed with a chronic total occlusion (CTO) in at least one coronary artery during routine diagnostic coronary angiography.
Key inclusion criteria (2 listed)
- Patients undergoing diagnostic coronary angiography due to stable angina persisting for a minimum duration of three months.
- Patients diagnosed with total occlusion in at least one coronary artery, assessed to have chronic total occlusion (CTO) based on clinical and angiographic findings.
Key exclusion criteria (5 listed)
- Patients presenting with malignancies, atrial fibrillation, connective tissue disorders, hepatic failure, or renal failure.
- A documented history of cardiac pacemaker implantation, prior bypass surgeries, or surgical valve replacements.
- Congenital heart anomalies.
- Patients receiving pharmacological interventions that affect ventricular repolarization (other than beta-adrenergic antagonists).
- Individuals exhibiting abnormal electrolyte levels at the time of admission.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 12-lead Electrocardiogram (ECG) and Coronary AngiographyA 12-lead ECG is performed to calculate the frontal QRS-T angle, and coronary angiography is performed to evaluate the coronary collateral circulation using the Rentrop Classification. | Diagnostic test | Increased QRS-T Angle, Normal QRS-T Angle |
Primary outcome
correlation between frontal QRS-T angle and collateral circulation in CTO patients
Time frame: baseline ( at the time of the diagnosis )
• To examine the relationship between coronary collateral circulation and the electrocardiographic frontal QRS-T angle in patients diagnosed with chronic total occlusion (CTO).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Aug 2026.
- Results publication: PubMed 41517395Ozturk M, Emlek N, Ozyildiz AG, Ergul E, Durak H, Ozyildiz A, Cetin M. The Relationship Between Collateral Circulation and Electrocardiographic Frontal QRS-T Angle in Patients with Coronary Artery Chronic Total Occlusion. J Clin Med. 2025 Dec 24;15(1):148. doi: 10.3390/jcm15010148.
- Results publication: PubMed 32248922Sawant AC, Bhardwaj A, Srivatsa S, Sridhara S, Prakash MPH, Kanwar N, Rodriguez J, Tse G, Liu T, Kumar A, Beck H, Srivatsa SS. Prognostic value of frontal QRS-T angle in predicting survival after primary percutaneous coronary revascularization/coronary artery bypass grafting for ST-elevation myocardial infarction. Indian Heart J. 2019 Nov-Dec;71(6):481-487. doi: 10.1016/j.ihj.2019.09.008. Epub 2019 Sep 9.
- Results publication: PubMed 40109697Attar A, Sayadi M, Hosseinpour A, Brilakis ES, Mehdizade F, Namvar Z, Khosravi A, Boshtam M, Noohi F, Assareh A, Kazemi T, Farshidi H, Khaledifar A, Abbaszadeh M, Sarrafzadegan N. Prevalence and Clinical Parameters Associated With Chronic Total Occlusions in Patients With Chronic Coronary Syndromes: Insights From a Nationwide Registry. Health Sci Rep. 2025 Mar 18;8(3):e70583. doi: 10.1002/hsr2.70583. eCollection 2025 Mar.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Hosam Hasan contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Chronic Total Occlusion (CTO) and Frontal QRS-T Angle, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 4 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Tarek Yaser (+201005094712, tarek.18313588@med.aun.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
correlation between frontal QRS-T angle and collateral circulation in CTO patients (time frame: baseline ( at the time of the diagnosis )). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07743437, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Aug 2026; AzTrials last refreshed its copy on 26 Oct 2026.