Skin AgingNCT07746076
A Clinical Trial to Evaluate the Effects of Naila's Collagen Marine Plus Food Supplement on Skin Hydration, Elasticity, Fine Lines and Wrinkles, and Hair and Nail Health
A study testing Naila's Collagen Marine Plus Food Supplement in people with Skin Aging and Skin Hydration, run by Gulf Bird.
Trial summary
This is a single-group, open-label, virtual (decentralized) clinical trial evaluating the effects of Naila's Collagen Marine Plus Food Supplement on skin hydration, elasticity, firmness, fine lines and wrinkles, and hair and nail health over 12 weeks. Read more about this study
- Who is it for?
- Ages 30 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Skin Aging, Skin Hydration, Skin Elasticity
- What is being tested?
- Naila's Collagen Marine Plus Food Supplement
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- No sites listed yet
- Study dates
- Aug 2026to Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy adults aged 40-60 years at the time of enrollment.
- Self-reported visible signs of skin aging, including at least one of the following: fine lines, wrinkles, reduced skin firmness or elasticity, or skin dryness.
- Self-reports hair shedding and a desire to improve hair health.
- Willing to take one sachet of the study product daily for 12 weeks as directed.
- Willing to avoid taking any other collagen-containing dietary supplements for the duration of the study.
- Willing to maintain current diet, skincare routine, sleep patterns, and physical activity levels for the duration of the trial.
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- Willing and able to submit standardized facial and hair photographs at Baseline and Week 12.
- Has access to a smartphone or digital camera capable of producing photographs.
- Resides in the United States.
- Willing to follow the study protocol and complete all required questionnaires.
Who cannot join
- Known allergy or sensitivity to fish, marine-derived products, or any of the study product ingredients (marine collagen, hyaluronic acid, ascorbic acid, biotin).
- Previous diagnosis of a hair loss condition such as alopecia areata, androgenetic alopecia, or telogen effluvium.
- Currently taking any collagen-containing dietary supplements, or planning to start taking any collagen supplements in the next 12 weeks.
- Any current uncontrolled chronic medical condition that would prevent the participant from safely completing the study protocol.
- History of a diagnosed dermatological condition that significantly affects facial skin appearance (e.g., severe eczema, psoriasis, rosacea, or active acne) and could confound assessment of skin aging outcomes.
- Use of prescription retinoids, injectable dermal fillers, botulinum toxin, chemical peels, laser skin treatments, or other professional aesthetic procedures on the face within 3 months prior to enrollment or planned during the study period.
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- Currently pregnant, breastfeeding, or planning to become pregnant during the study period.
- Currently participating in another research study or planning to participate in another study during this study's duration.
- Any condition that, in the judgment of the investigator, would make the participant unsuitable for inclusion in the study.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
This is a single-group, open-label, virtual (decentralized) clinical trial evaluating the effects of Naila's Collagen Marine Plus Food Supplement on skin hydration, elasticity, firmness, fine lines and wrinkles, and hair and nail health over 12 weeks. Forty healthy adults aged 40-60 years with self-reported mature skin showing early signs of aging will take one sachet of the supplement daily and complete questionnaires at Baseline, Week 4, Week 8, and Week 12.
Participants will also submit standardized facial and hair photographs at Baseline and Week 12 for evaluation by a board-certified dermatologist. The primary objectives are to assess changes in skin aging parameters and hair health. Secondary objectives include evaluation of nail health, hair shedding and density, participant-reported satisfaction, and product safety and tolerability.
- Conditions
- Skin Aging, Skin Hydration, Skin Elasticity, Fine Lines and Wrinkles, Hair Health, Nail Health
- Being tested
- Naila's Collagen Marine Plus Food Supplement
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Naila's Collagen Marine Plus Food SupplementDietary supplement
All 40 participants receive Naila's Collagen Marine Plus Food Supplement (one sachet daily, dissolved in approximately 200 mL of water, taken once daily in the morning) for 12 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Naila's Collagen Marine Plus Food Supplement | Experimental | Not described Receives: Dietary Supplement: Naila's Collagen Marine Plus Food Supplement |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Self-Reported Skin Hydration
Mean change from Baseline in self-reported skin hydration assessed via self-reported questionnaire
Measured: Baseline to Week 12
Change in Self-Reported Skin Elasticity
Mean change from Baseline in self-reported skin elasticity assessed via self-reported questionnaire
Measured: Baseline to Week 12
Change in Self-Reported Skin Firmness
Mean change from Baseline in self-reported skin firmness assessed via self-reported questionnaire
Measured: Baseline to Week 12
Change in Self-Reported Fine Lines and Wrinkles
Mean change from Baseline in self-reported appearance of fine lines and wrinkles assessed via self-reported questionnaire
Measured: Baseline to Week 12
Change in Dermatologist-Graded Fine Line and Wrinkle Severity
Mean change from Baseline in fine line and wrinkle severity assessed by dermatologist review of standardized facial photographs
Measured: Baseline to Week 12
Change in Dermatologist-Graded Skin Firmness
Mean change from Baseline in skin firmness assessed by dermatologist review of standardized facial photographs
Measured: Baseline to Week 12
Change in Dermatologist-Graded Overall Skin Quality
Mean change from Baseline in overall skin quality assessed by dermatologist review of standardized facial photographs
Measured: Baseline to Week 12
Change in Dermatologist-Graded Hair Parameters
Mean change from Baseline in hair health parameters assessed by dermatologist review of standardized hair photographs
Measured: Baseline to Week 12
Secondary outcomes (8)
Change in Self-Reported Nail Strength
Mean change from Baseline in self-reported nail strength assessed via self-reported questionnaire
Measured: Baseline to Week 12
Change in Self-Reported Nail Brittleness
Mean change from Baseline in self-reported nail brittleness assessed via self-reported questionnaire
Measured: Baseline to Week 12
Change in Self-Reported Nail Growth Rate
Mean change from Baseline in self-reported nail growth rate assessed via self-reported questionnaire
Measured: Baseline to Week 12
Change in Self-Reported Overall Nail Appearance
Mean change from Baseline in self-reported overall nail appearance assessed via self-reported questionnaire
Measured: Baseline to Week 12
Change in Self-Reported Hair Shedding
Mean change from Baseline in self-reported hair shedding assessed via self-reported questionnaire
Measured: Baseline to Week 12
Change in Self-Reported Hair Thickness and Density
Mean change from Baseline in self-reported hair thickness and density assessed via self-reported questionnaire
Measured: Baseline to Week 12
Participant-Reported Product Satisfaction and Perceived Global Improvement
Participant-reported satisfaction and perceived global improvement assessed via self-reported questionnaire at Week 12
Measured: Week 12
Incidence of Adverse Events
Number and severity of adverse events reported by participants throughout the 12-week study period, assessed via study questionnaires and reviewed by the study team
Measured: Baseline through Week 12
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Aug 2026
- Study startAug 2026 (estimated)
- Primary completionNov 2026 (estimated)
- Study completionNov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Skin AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Gulf Bird
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07746076
- Sponsor's protocol ID
- GULFB-52447
- Status last verified
- Aug 2026
- First submitted
- 18 Jul 2026
- Last updated
- 4 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Clinical Trial to Evaluate the Effects of Naila's Collagen Marine Plus Food Supplement on Skin Hydration, Elasticity, Fine Lines and Wrinkles, and Hair and Nail Health
- ClinicalTrials.gov ID
- NCT07746076
- Acronym / sponsor ID
- GULFB-52447
- Conditions
- Skin Aging, Skin Hydration, Skin Elasticity, Fine Lines and Wrinkles, Hair Health, Nail Health
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Gulf BirdIndustry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Study start
- Aug 2026 (estimated)
- Primary completion
- Nov 2026 (estimated)
- Study completion
- Nov 2026 (estimated)
- First posted
- 4 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a single-group, open-label, virtual (decentralized) clinical trial evaluating the effects of Naila's Collagen Marine Plus Food Supplement on skin hydration, elasticity, firmness, fine lines and wrinkles, and hair and nail health over 12 weeks. Forty healthy adults aged 40-60 years with self-reported mature skin showing early signs of aging will take one sachet of the supplement daily and complete questionnaires at Baseline, Week 4, Week 8, and Week 12.
Participants will also submit standardized facial and hair photographs at Baseline and Week 12 for evaluation by a board-certified dermatologist. The primary objectives are to assess changes in skin aging parameters and hair health. Secondary objectives include evaluation of nail health, hair shedding and density, participant-reported satisfaction, and product safety and tolerability.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Naila's Collagen Marine Plus Food Supplement | Experimental | Dietary Supplement: Naila's Collagen Marine Plus Food Supplement |
Who may qualify
- Ages
- 30 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (10 listed)
- Healthy adults aged 40-60 years at the time of enrollment.
- Self-reported visible signs of skin aging, including at least one of the following: fine lines, wrinkles, reduced skin firmness or elasticity, or skin dryness.
- Self-reports hair shedding and a desire to improve hair health.
- Willing to take one sachet of the study product daily for 12 weeks as directed.
- Willing to avoid taking any other collagen-containing dietary supplements for the duration of the study.
Key exclusion criteria (9 listed)
- Known allergy or sensitivity to fish, marine-derived products, or any of the study product ingredients (marine collagen, hyaluronic acid, ascorbic acid, biotin).
- Previous diagnosis of a hair loss condition such as alopecia areata, androgenetic alopecia, or telogen effluvium.
- Currently taking any collagen-containing dietary supplements, or planning to start taking any collagen supplements in the next 12 weeks.
- Any current uncontrolled chronic medical condition that would prevent the participant from safely completing the study protocol.
- History of a diagnosed dermatological condition that significantly affects facial skin appearance (e.g., severe eczema, psoriasis, rosacea, or active acne) and could confound assessment of skin aging outcomes.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Naila's Collagen Marine Plus Food SupplementAll 40 participants receive Naila's Collagen Marine Plus Food Supplement (one sachet daily, dissolved in approximately 200 mL of water, taken once daily in the morning) for 12 weeks. | Dietary supplement | Naila's Collagen Marine Plus Food Supplement |
Primary outcome
Change in Self-Reported Skin Hydration
Time frame: Baseline to Week 12
Mean change from Baseline in self-reported skin hydration assessed via self-reported questionnaire
Change in Self-Reported Skin Elasticity
Time frame: Baseline to Week 12
Mean change from Baseline in self-reported skin elasticity assessed via self-reported questionnaire
Change in Self-Reported Skin Firmness
Time frame: Baseline to Week 12
Mean change from Baseline in self-reported skin firmness assessed via self-reported questionnaire
Change in Self-Reported Fine Lines and Wrinkles
Time frame: Baseline to Week 12
Mean change from Baseline in self-reported appearance of fine lines and wrinkles assessed via self-reported questionnaire
Change in Dermatologist-Graded Fine Line and Wrinkle Severity
Time frame: Baseline to Week 12
Mean change from Baseline in fine line and wrinkle severity assessed by dermatologist review of standardized facial photographs
Change in Dermatologist-Graded Skin Firmness
Time frame: Baseline to Week 12
Mean change from Baseline in skin firmness assessed by dermatologist review of standardized facial photographs
Change in Dermatologist-Graded Overall Skin Quality
Time frame: Baseline to Week 12
Mean change from Baseline in overall skin quality assessed by dermatologist review of standardized facial photographs
Change in Dermatologist-Graded Hair Parameters
Time frame: Baseline to Week 12
Mean change from Baseline in hair health parameters assessed by dermatologist review of standardized hair photographs
8 secondary outcomes
Change in Self-Reported Nail Strength
Time frame: Baseline to Week 12
Change in Self-Reported Nail Brittleness
Time frame: Baseline to Week 12
Change in Self-Reported Nail Growth Rate
Time frame: Baseline to Week 12
Change in Self-Reported Overall Nail Appearance
Time frame: Baseline to Week 12
Change in Self-Reported Hair Shedding
Time frame: Baseline to Week 12
Change in Self-Reported Hair Thickness and Density
Time frame: Baseline to Week 12
Participant-Reported Product Satisfaction and Perceived Global Improvement
Time frame: Week 12
Incidence of Adverse Events
Time frame: Baseline through Week 12
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Naila's Collagen Marine Plus Food Supplement in people with Skin Aging and Skin Hydration, run by Gulf Bird.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 4 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Patrick Renner (4242450284, hello@citruslabs.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Self-Reported Skin Hydration (time frame: Baseline to Week 12). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Aug 2026.