Cerebral PalsyNCT07748052
Strength Training Combined With Blood Flow Restriction and Cerebral Palsy
A study testing strength training combined with blood flow restriction and designed physical therapy program and a specially designed physical therapy program in people with Cerebral Palsy, run by Cairo University.
Trial summary
load resistance exercises are performed while partially restricting venous blood flow to the exercising limb using a pneumatic cuff. In children with hemiplegic cerebral palsy, this intervention has been proposed to enhance muscle strength and hypertrophy while minimizing mechanical stress on joints and soft tissues. Read more about this study
- Who is it for?
- Ages 4 to 10 years
- Conditions the study is for
- Cerebral Palsy
- What is being tested?
- strength training combined with blood flow restriction and designed physical therapy program and a specially designed physical therapy program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- No sites listed yet
- Study dates
- 6 Aug 2026to 11 Jul 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 4 to 10 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- A diagnosis of spastic hemiplegic CP
- Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)
- The age of the selected children will range from 4 to 6 years old.
- Children are levels II and III according to GMFCS
Who cannot join
- 1- Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effect of Strength Training Combined With Blood Flow Restriction on Deltoid Muscle Thickness and Upper Limb Functions in Children With Hemiplegic Cerebral Palsy
load resistance exercises are performed while partially restricting venous blood flow to the exercising limb using a pneumatic cuff. In children with hemiplegic cerebral palsy, this intervention has been proposed to enhance muscle strength and hypertrophy while minimizing mechanical stress on joints and soft tissues. Previous studies suggest that BFR training may improve muscle thickness, muscle strength, functional mobility, gait performance, and overall physical function compared with conventional low-intensity strength training alone. However, careful monitoring of cuff pressure, exercise intensity, and safety considerations is essential when applying this technique in pediatric populations.
- Conditions
- Cerebral Palsy
- Being tested
- strength training combined with blood flow restriction and designed physical therapy program, a specially designed physical therapy program
- Keywords
- cerebral palsy, progressive resistive exercise, low load resistive training, blood flow restriction
- Medical subject headings
- Cerebral Palsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
strength training combined with blood flow restriction and designed physical therapy programOther
A specially designed physical therapy program in addition to progressive resistive exercises for 60 min (30 min designed P.T program and other 30 min for progressive resistive exercise with blood flow restriction ), 3 sessions/ week for 6 successive weeks. strengthening exercise for shoulder flexors, abductors and external rotators, elbow flexors and extensors will be applied with low load while blood flow restriction is applied proximal to the limb
a specially designed physical therapy programOther
conventional physical therapy program including reinforcement of the normal motor development, reflex inhibiting patterns, postural reaction, stretching, strengthening exercises, and gait training was applied to children in the control group
| Study group | Role | What they receive |
|---|---|---|
| strength training combined with blood flow restriction and designed physical therapy program | Experimental | Not described Receives: Other: strength training combined with blood flow restriction and designed physical therapy program |
| designed physical therapy program | Experimental | Not described Receives: Other: a specially designed physical therapy program |
What is being measured
The primary outcome is the main question the study is designed to answer.
ultrasonography for measuring muscle thickness
Measured: 6 weeks
quality of upper-extremity skills test for measuring upper limb function
Measured: 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Aug 2026
- Study start6 Aug 2026 (estimated)
- Primary completion1 Feb 2027 (estimated)
- Study completion11 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cerebral PalsyStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 26 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alaa Fahmy Hassan Al Nemr, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07748052
- Sponsor's protocol ID
- No.P.T.REC/012/005093
- Status last verified
- Aug 2026
- First submitted
- 30 Jul 2026
- Last updated
- 5 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Strength Training Combined With Blood Flow Restriction on Deltoid Muscle Thickness and Upper Limb Functions in Children With Hemiplegic Cerebral Palsy
- ClinicalTrials.gov ID
- NCT07748052
- Acronym / sponsor ID
- No.P.T.REC/012/005093
- Conditions
- Cerebral Palsy
- Keywords
- cerebral palsy, progressive resistive exercise, low load resistive training, blood flow restriction
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 26 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 6 Aug 2026 (estimated)
- Primary completion
- 1 Feb 2027 (estimated)
- Study completion
- 11 Jul 2027 (estimated)
- First posted
- 5 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
load resistance exercises are performed while partially restricting venous blood flow to the exercising limb using a pneumatic cuff. In children with hemiplegic cerebral palsy, this intervention has been proposed to enhance muscle strength and hypertrophy while minimizing mechanical stress on joints and soft tissues. Previous studies suggest that BFR training may improve muscle thickness, muscle strength, functional mobility, gait performance, and overall physical function compared with conventional low-intensity strength training alone. However, careful monitoring of cuff pressure, exercise intensity, and safety considerations is essential when applying this technique in pediatric populations.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| strength training combined with blood flow restriction and designed physical therapy program | Experimental | Other: strength training combined with blood flow restriction and designed physical therapy program |
| designed physical therapy program | Experimental | Other: a specially designed physical therapy program |
Who may qualify
- Ages
- 4 to 10 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (4 listed)
- A diagnosis of spastic hemiplegic CP
- Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)
- The age of the selected children will range from 4 to 6 years old.
- Children are levels II and III according to GMFCS
Key exclusion criteria (1 listed)
- 1- Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| strength training combined with blood flow restriction and designed physical therapy programA specially designed physical therapy program in addition to progressive resistive exercises for 60 min (30 min designed P.T program and other 30 min for progressive resistive exercise with blood flow restriction ), 3 sessions/ week for 6 successive weeks. strengthening exercise for shoulder flexors, abductors and external rotators, elbow flexors and extensors will be applied with low load while blood flow restriction is applied proximal to the limb | Other | strength training combined with blood flow restriction and designed physical therapy program |
| a specially designed physical therapy programconventional physical therapy program including reinforcement of the normal motor development, reflex inhibiting patterns, postural reaction, stretching, strengthening exercises, and gait training was applied to children in the control group | Other | designed physical therapy program |
Primary outcome
ultrasonography for measuring muscle thickness
Time frame: 6 weeks
quality of upper-extremity skills test for measuring upper limb function
Time frame: 6 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing strength training combined with blood flow restriction and designed physical therapy program and a specially designed physical therapy program in people with Cerebral Palsy, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Alaa Alnemr (+201003727467, alaaalnemr28@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
ultrasonography for measuring muscle thickness (time frame: 6 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Aug 2026.