Bipolar Affective Disorder; Remission inNCT07748910
Enhancing Resilience and Quality of Life in Bipolar Disorder Through Cognitive Behavioral Therapy
A study testing CBT-Based Psychological Resilience Enhancement Program for Individuals with BD in people with Bipolar Affective Disorder; Remission in, run by Cumhuriyet University at 1 site in Turkey (Türkiye).
Trial summary
Bipolar disorder (BD) is a chronic and recurrent mood disorder characterized by alternating episodes of mania, depression, or mixed states, interspersed with periods of remission. These episodes can severely impair interpersonal relationships, occupational functioning, and overall quality of life. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Bipolar Affective Disorder; Remission in
- What is being tested?
- CBT-Based Psychological Resilience Enhancement Program for Individuals with BD
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 14 May 2021to 3 Apr 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Aged between 18 and 60 years
- Minimum of primary school education
- Ability to communicate verbally
- Score ≤ 5 on the YMRS
- Score ≤ 17 on the BDI
- Residence within the city center
- Voluntary participation with signed informed consent
Who cannot join
- Diagnosis of intellectual disability
- Speech or hearing impairment
- Presence of comorbid psychiatric disorders
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Impact of Resilience Improvement Program on Resilience and Quality of Life of Patients Diagnosed With Bipolar Disorder
Bipolar disorder (BD) is a chronic and recurrent mood disorder characterized by alternating episodes of mania, depression, or mixed states, interspersed with periods of remission. These episodes can severely impair interpersonal relationships, occupational functioning, and overall quality of life. In 2019, approximately 40 million people worldwide were diagnosed with BD.
BD is a lifelong chronic condition despite pharmacotherapy and lifestyle changes. Traditional psychiatric care has primarily focused on symptom reduction and relapse prevention, often overlooking broader psychosocial aspects such as interpersonal functioning and life satisfaction. Recently, recovery has come to include living a meaningful life despite illness-related challenges.
Read more
Psychological resilience has gained prominence within this recovery framework. It refers to the capacity to adapt positively to adversity, shaped by both internal traits and external supports. Core elements include effective coping, adaptability, and recovery from stress, which support functional outcomes in mental illness.
Given the strong link between stress and relapse in BD, resilience is thought to play a critical role in illness trajectory. Research consistently shows that individuals with BD have lower resilience than healthy controls, and resilience is associated with fewer depressive symptoms and better quality of life.
Importantly, resilience is modifiable and can be enhanced through psychosocial interventions. Studies highlight the benefits of resilience-building programs in reducing depressive vulnerability and improving life satisfaction and emotion regulation. Among these, CBT effectively promotes cognitive and functional recovery in BD by targeting maladaptive thought patterns and building adaptive coping skills.
Despite growing evidence, few CBT-based interventions target resilience in individuals with BD. However, resilience is linked to key psychosocial competencies such as problem-solving, self-efficacy, assertiveness, and self-management. Based on this, the current study implemented a CBT-based Psychological Resilience Enhancement Program designed to strengthen adaptive coping and functional adjustment in individuals with BD.
Considering the substantial personal and societal burden of BD, enhancing psychological resilience is a critical therapeutic goal. This study aimed to evaluate the effects of a CBT-based intervention on psychological resilience and quality of life in individuals with BD.
- Conditions
- Bipolar Affective Disorder; Remission in
- Being tested
- CBT-Based Psychological Resilience Enhancement Program for Individuals with BD
- Keywords
- bipolar disorder, CBT, resilience, quality of life, psychiatric nurse
- Medical subject headings
- Bipolar Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
CBT-Based Psychological Resilience Enhancement Program for Individuals with BDBehavioural
Also called Intervention group
Session 1 (Psychoeducation): Enhancing knowledge and insight regarding Bipolar Disorder via Socratic questioning and case formulation.
Session 2 (Locus of Control): Shifting belief from external determinism to an internal locus of control using pie charts and didactic instruction.
Session 3 (Self-Management): Acquiring skills to manage early warning signs and high-risk behaviors.
Session 4 (Coping with Stress): Developing and implementing effective coping strategies.
Session 5 (Problem-Solving): Utilizing a structured approach to resolve daily life problems.
Session 6 (Thoughts and Emotions): Identifying emotional reactions to stimuli using the downward arrow technique, playing devil's advocate, and imagery.
Session 7 (Realistic Thoughts): Fostering cognitive flexibility through examining evidence and evaluating thought functionality.
Session 8 (Social Skills): Establishing external support systems to reinforce self-esteem and self-efficacy via role-playing.
| Study group | Role | What they receive |
|---|---|---|
| Standard Treatment | No intervention | The control group simply continued treatment. In Türkiye, standard treatment consists of medication use, prescriptions every three to six months, and outpatient check-ups for laboratory tests such as drug levels. In the study, however, patients in the control group were interviewed, their questions about their illness and treatment were answered, and their general condition was assessed. Treatment adherence levels were determined based on their remission status. It consists of a total of 12 individuals with bipolar disorders |
| Resilience Improvement Program | Experimental | The intervention is based on the assumption that individuals with high psychological resilience cope better with psychosocial stressors, return to normal life more quickly after stressful events, adapt more easily to new situations, and can continue their lives even under difficult circumstances. An individual diagnosed with bipolar disorder who increases their psychological resilience will both prevent the triggering of attacks and gain skills to manage the symptoms of the illness. The program was designed focusing on areas emphasized in resilience theory, which can be developed and modified through education and life experience, and which also fall within the scope of cognitive behavioral therapy. These are internal locus of control, self-management, cognitive evaluation, social skills, social support, positive mood, stress management, and problem-solving skills. The intervention was each targeting specific therapeutic goals using relevant CBT techniques in 8weekly Receives: Behavioral: CBT-Based Psychological Resilience Enhancement Program for Individuals with BD |
What is being measured
The primary outcome is the main question the study is designed to answer.
Connor-Davidson Resilience Scale (CD-RISC)
Connor-Davidson Resilience Scale (CD-RISC): Developed by Connor and Davidson in 2003 to measure individuals' psychological resilience, this scale primarily focuses on stress, coping, and adaptability. It is a 25-item, five-point Likert-type scale, with each item evaluated between 0 and 4, ranging from "not true at all" (0 points) to "true nearly all the time" (4 points). The maximum achievable score on the scale is 100. Higher scores denote greater psychological resilience, whereas lower scores indicate reduced resilience. During its development phase, the scale was administered to both normative and clinical populations.
Data collected face-to-face via clinical interview
Measured: Baseline, 9 week and 21. week
Brief Quality of Life in Bipolar Disorder Scale (Brief QoL.BD)
Brief Quality of Life in Bipolar Disorder Scale (Brief QoL.BD): Developed by Michalak and Murray (2010) to evaluate the quality of life in patients with bipolar disorder. It is a 12-item quality of life scale specifically designed for bipolar disorder. It comprises one item for each of the following core domains: physical health, sleep, mood, cognition, leisure, social relationships, spirituality, finances, household, self-esteem, independence, and identity. The scale is rated on a five-point Likert scale ranging from 1 ("strongly disagree") to 5 ("strongly agree"), yielding a total score between 12 and 60. Higher scores indicate a better quality of life.
Data collected face-to-face via clinical interview
Measured: Baseline, 9. week and 21. week
Beck Depression Inventory (BDI)
Beck Depression Inventory (BDI): This scale consists of 21 items designed to measure the affective, somatic, cognitive, and motivational symptoms of depression, with each item scored on a scale from 0 to 3. The total possible score ranges from 0 to 63. The assessment is based on the cumulative score obtained from all items, where higher scores indicate greater depression severity. In the present study, the BDI was utilized to verify the remission status required for the inclusion of patients diagnosed with bipolar disorder. Patients who scored 17 or lower on the inventory were included in the research.
Data collected face-to-face via clinical interview
Measured: Baseline, 9. week and 21. week
Young Mania Rating Scale (YMRS)
Young Mania Rating Scale (YMRS): Developed by Young et al. in 1978, this scale is utilized to assess the severity of manic states. It comprises 11 Likert-type items, each assessing symptom severity across five levels. The total score ranges from 0 to 60, with higher scores denoting increased mania severity. In the current study, the YMRS was employed to confirm the remission status necessary for the inclusion of patients with bipolar disorder. Patients obtaining a score of 5 or lower on the scale were eligible for inclusion.
Data collected face-to-face via clinical interview
Measured: Baseline, 9. week and 21. week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Aug 2026
- Study start14 May 2021
- Primary completion2 Apr 2023
- Study completion3 Apr 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (16)Papers the sponsor has linked to this study.
- Other trials for Bipolar Affective Disorder; Remission inStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- A randomized controlled trial with a pretest-posttest-follow-up design was conducted between May 2021 and April 2023. Twenty-two participants were randomly assigned to an intervention group (n = 10), which completed an eight-week CBT-based resilience program, or a control group (n = 12), which received standard care. Psychological resilience and quality of life were assessed at baseline, post-intervention (week 9), and follow-up (week 21) using the Connor-Davidson Resilience Scale (CD-RISC) and the Brief Quality of Life in Bipolar Disorder Scale (Brief QoL.BD). Data were analyzed using independent samples t-tests and repeated measures ANOVA. Effect sizes were calculated to assess clinical relevance.
- Masking
- None (open label)
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cumhuriyet University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ayse Aksoy, Dr, Cumhuriyet University
- Investigators
- AYŞE AKSOY, Dr., Principal investigator, Karaman Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07748910
- Sponsor's protocol ID
- 13.11.2019-2019-11/22
- Status last verified
- Aug 2023
- First submitted
- 23 Jul 2026
- Last updated
- 6 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Publications
Bozikas VP, Parlapani E, Ntouros E, Bargiota SI, Floros G, Nazlidou EI, Garyfallos G. Resilience Predicts Social Functioning in Clinically Stable Patients With Bipolar Disorder. J Nerv Ment Dis. 2018 Jul;206(7):567-574. doi: 10.1097/NMD.0000000000000843.
PubMed 29905660Vieta E, Berk M, Schulze TG, Carvalho AF, Suppes T, Calabrese JR, Gao K, Miskowiak KW, Grande I. Bipolar disorders. Nat Rev Dis Primers. 2018 Mar 8;4:18008. doi: 10.1038/nrdp.2018.8.
PubMed 29516993Tse S, Murray G, Chung KF, Davidson L, Ng KL, Yu CH. Exploring the recovery concept in bipolar disorder: a decision tree analysis of psychosocial correlates of recovery stages. Bipolar Disord. 2014 Jun;16(4):366-77. doi: 10.1111/bdi.12153. Epub 2013 Nov 22.
PubMed 24261315Sood A, Sharma V, Schroeder DR, Gorman B. Stress Management and Resiliency Training (SMART) program among Department of Radiology faculty: a pilot randomized clinical trial. Explore (NY). 2014 Nov-Dec;10(6):358-63. doi: 10.1016/j.explore.2014.08.002. Epub 2014 Aug 21.
PubMed 25443423Sood A, Prasad K, Schroeder D, Varkey P. Stress management and resilience training among Department of Medicine faculty: a pilot randomized clinical trial. J Gen Intern Med. 2011 Aug;26(8):858-61. doi: 10.1007/s11606-011-1640-x. Epub 2011 Jan 29.
PubMed 21279454Scott J, Paykel E, Morriss R, Bentall R, Kinderman P, Johnson T, Abbott R, Hayhurst H. Cognitive-behavioural therapy for severe and recurrent bipolar disorders: randomised controlled trial. Br J Psychiatry. 2006 Apr;188:313-20. doi: 10.1192/bjp.188.4.313.
PubMed 16582056Post RM, Leverich GS. The role of psychosocial stress in the onset and progression of bipolar disorder and its comorbidities: the need for earlier and alternative modes of therapeutic intervention. Dev Psychopathol. 2006 Fall;18(4):1181-211. doi: 10.1017/S0954579406060573.
PubMed 17064434Mizuno Y, Hofer A, Suzuki T, Frajo-Apor B, Wartelsteiner F, Kemmler G, Saruta J, Tsukinoki K, Mimura M, Fleischhacker WW, Uchida H. Clinical and biological correlates of resilience in patients with schizophrenia and bipolar disorder: A cross-sectional study. Schizophr Res. 2016 Aug;175(1-3):148-153. doi: 10.1016/j.schres.2016.04.047. Epub 2016 May 13.
PubMed 27185483Lee S, Lee J, Choi JY. The effect of a resilience improvement program for adolescents with complex congenital heart disease. Eur J Cardiovasc Nurs. 2017 Apr;16(4):290-298. doi: 10.1177/1474515116659836. Epub 2016 Jul 10.
PubMed 27400701Jones S, Mulligan LD, Higginson S, Dunn G, Morrison AP. The bipolar recovery questionnaire: psychometric properties of a quantitative measure of recovery experiences in bipolar disorder. J Affect Disord. 2013 May;147(1-3):34-43. doi: 10.1016/j.jad.2012.10.003. Epub 2012 Nov 22.
PubMed 23182591Hofer A, Mizuno Y, Wartelsteiner F, Wolfgang Fleischhacker W, Frajo-Apor B, Kemmler G, Mimura M, Pardeller S, Sondermann C, Suzuki T, Welte A, Uchida H. Quality of life in schizophrenia and bipolar disorder: The impact of symptomatic remission and resilience. Eur Psychiatry. 2017 Oct;46:42-47. doi: 10.1016/j.eurpsy.2017.08.005. Epub 2017 Sep 1.
PubMed 28992535Echezarraga A, Las Hayas C, Gonzalez-Pinto AM, Jones S. The Resilience Questionnaire for Bipolar Disorder: Development and validation. Arch Psychiatr Nurs. 2017 Aug;31(4):376-385. doi: 10.1016/j.apnu.2017.04.010. Epub 2017 Apr 24.
PubMed 28693874Cohen AN, Hammen C, Henry RM, Daley SE. Effects of stress and social support on recurrence in bipolar disorder. J Affect Disord. 2004 Oct 1;82(1):143-7. doi: 10.1016/j.jad.2003.10.008.
PubMed 15465589Choi JW, Cha B, Jang J, Park CS, Kim BJ, Lee CS, Lee SJ. Resilience and impulsivity in euthymic patients with bipolar disorder. J Affect Disord. 2015 Jan 1;170:172-7. doi: 10.1016/j.jad.2014.08.056. Epub 2014 Sep 6.
PubMed 25243746Bowie CR, Best MW, Depp C, Mausbach BT, Patterson TL, Pulver AE, Harvey PD. Cognitive and functional deficits in bipolar disorder and schizophrenia as a function of the presence and history of psychosis. Bipolar Disord. 2018 Nov;20(7):604-613. doi: 10.1111/bdi.12654. Epub 2018 May 18.
PubMed 29777563
Study at a glance
From the registry record, last updated by the sponsor on 6 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Resilience Improvement Program on Resilience and Quality of Life of Patients Diagnosed With Bipolar Disorder
- ClinicalTrials.gov ID
- NCT07748910
- Acronym / sponsor ID
- 13.11.2019-2019-11/22
- Conditions
- Bipolar Affective Disorder; Remission in
- Keywords
- bipolar disorder, CBT, resilience, quality of life, psychiatric nurse
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- Cumhuriyet UniversityUniversity, hospital or other
- Study start
- 14 May 2021 (actual)
- Primary completion
- 2 Apr 2023 (actual)
- Study completion
- 3 Apr 2023 (actual)
- First posted
- 6 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Bipolar disorder (BD) is a chronic and recurrent mood disorder characterized by alternating episodes of mania, depression, or mixed states, interspersed with periods of remission. These episodes can severely impair interpersonal relationships, occupational functioning, and overall quality of life. In 2019, approximately 40 million people worldwide were diagnosed with BD.
BD is a lifelong chronic condition despite pharmacotherapy and lifestyle changes. Traditional psychiatric care has primarily focused on symptom reduction and relapse prevention, often overlooking broader psychosocial aspects such as interpersonal functioning and life satisfaction. Recently, recovery has come to include living a meaningful life despite illness-related challenges.
Psychological resilience has gained prominence within this recovery framework. It refers to the capacity to adapt positively to adversity, shaped by both internal traits and external supports. Core elements include effective coping, adaptability, and recovery from stress, which support functional outcomes in mental illness.
Given the strong link between stress and relapse in BD, resilience is thought to play a critical role in illness trajectory. Research consistently shows that individuals with BD have lower resilience than healthy controls, and resilience is associated with fewer depressive symptoms and better quality of life.
Importantly, resilience is modifiable and can be enhanced through psychosocial interventions. Studies highlight the benefits of resilience-building programs in reducing depressive vulnerability and improving life satisfaction and emotion regulation. Among these, CBT effectively promotes cognitive and functional recovery in BD by targeting maladaptive thought patterns and building adaptive coping skills.
Despite growing evidence, few CBT-based interventions target resilience in individuals with BD. However, resilience is linked to key psychosocial competencies such as problem-solving, self-efficacy, assertiveness, and self-management. Based on this, the current study implemented a CBT-based Psychological Resilience Enhancement Program designed to strengthen adaptive coping and functional adjustment in individuals with BD.
Considering the substantial personal and societal burden of BD, enhancing psychological resilience is a critical therapeutic goal. This study aimed to evaluate the effects of a CBT-based intervention on psychological resilience and quality of life in individuals with BD.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- A randomized controlled trial with a pretest-posttest-follow-up design was conducted between May 2021 and April 2023. Twenty-two participants were randomly assigned to an intervention group (n = 10), which completed an eight-week CBT-based resilience program, or a control group (n = 12), which received standard care. Psychological resilience and quality of life were assessed at baseline, post-intervention (week 9), and follow-up (week 21) using the Connor-Davidson Resilience Scale (CD-RISC) and the Brief Quality of Life in Bipolar Disorder Scale (Brief QoL.BD). Data were analyzed using independent samples t-tests and repeated measures ANOVA. Effect sizes were calculated to assess clinical relevance.
| Arm | Type | Receives |
|---|---|---|
| Standard Treatment | No intervention | –The control group simply continued treatment. In Türkiye, standard treatment consists of medication use, prescriptions every three to six months, and outpatient check-ups for laboratory tests such as drug levels. In the study, however, patients in the control group were interviewed, their questions about their illness and treatment were answered, and their general condition was assessed. Treatment adherence levels were determined based on their remission status. It consists of a total of 12 individuals with bipolar disorders |
| Resilience Improvement Program | Experimental | Behavioral: CBT-Based Psychological Resilience Enhancement Program for Individuals with BDThe intervention is based on the assumption that individuals with high psychological resilience cope better with psychosocial stressors, return to normal life more quickly after stressful events, adapt more easily to new situations, and can continue their lives even under difficult circumstances. An individual diagnosed with bipolar disorder who increases their psychological resilience will both prevent the triggering of attacks and gain skills to manage the symptoms of the illness. The program was designed focusing on areas emphasized in resilience theory, which can be developed and modified through education and life experience, and which also fall within the scope of cognitive behavioral therapy. These are internal locus of control, self-management, cognitive evaluation, social skills, social support, positive mood, stress management, and problem-solving skills. The intervention was each targeting specific therapeutic goals using relevant CBT techniques in 8weekly |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Aged between 18 and 60 years
- Minimum of primary school education
- Ability to communicate verbally
- Score ≤ 5 on the YMRS
- Score ≤ 17 on the BDI
Key exclusion criteria (3 listed)
- Diagnosis of intellectual disability
- Speech or hearing impairment
- Presence of comorbid psychiatric disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| CBT-Based Psychological Resilience Enhancement Program for Individuals with BDAlso: Intervention groupSession 1 (Psychoeducation): Enhancing knowledge and insight regarding Bipolar Disorder via Socratic questioning and case formulation. Session 2 (Locus of Control): Shifting belief from external determinism to an internal locus of control using pie charts and didactic instruction. Session 3 (Self-Management): Acquiring skills to manage early warning signs and high-risk behaviors. Session 4 (Coping with Stress): Developing and implementing effective coping strategies. Session 5 (Problem-Solving): Utilizing a structured approach to resolve daily life problems. Session 6 (Thoughts and Emotions): Identifying emotional reactions to stimuli using the downward arrow technique, playing devil's advocate, and imagery. Session 7 (Realistic Thoughts): Fostering cognitive flexibility through examining evidence and evaluating thought functionality. Session 8 (Social Skills): Establishing external support systems to reinforce self-esteem and self-efficacy via role-playing. | Behavioural | Resilience Improvement Program |
Primary outcome
Connor-Davidson Resilience Scale (CD-RISC)
Time frame: Baseline, 9 week and 21. week
Connor-Davidson Resilience Scale (CD-RISC): Developed by Connor and Davidson in 2003 to measure individuals' psychological resilience, this scale primarily focuses on stress, coping, and adaptability. It is a 25-item, five-point Likert-type scale, with each item evaluated between 0 and 4, ranging from "not true at all" (0 points) to "true nearly all the time" (4 points). The maximum achievable score on the scale is 100. Higher scores denote greater psychological resilience, whereas lower scores indicate reduced resilience. During its development phase, the scale was administered to both normative and clinical populations. Data collected face-to-face via clinical interview
Brief Quality of Life in Bipolar Disorder Scale (Brief QoL.BD)
Time frame: Baseline, 9. week and 21. week
Brief Quality of Life in Bipolar Disorder Scale (Brief QoL.BD): Developed by Michalak and Murray (2010) to evaluate the quality of life in patients with bipolar disorder. It is a 12-item quality of life scale specifically designed for bipolar disorder. It comprises one item for each of the following core domains: physical health, sleep, mood, cognition, leisure, social relationships, spirituality, finances, household, self-esteem, independence, and identity. The scale is rated on a five-point Likert scale ranging from 1 ("strongly disagree") to 5 ("strongly agree"), yielding a total score between 12 and 60. Higher scores indicate a better quality of life. Data collected face-to-face via clinical interview
Beck Depression Inventory (BDI)
Time frame: Baseline, 9. week and 21. week
Beck Depression Inventory (BDI): This scale consists of 21 items designed to measure the affective, somatic, cognitive, and motivational symptoms of depression, with each item scored on a scale from 0 to 3. The total possible score ranges from 0 to 63. The assessment is based on the cumulative score obtained from all items, where higher scores indicate greater depression severity. In the present study, the BDI was utilized to verify the remission status required for the inclusion of patients diagnosed with bipolar disorder. Patients who scored 17 or lower on the inventory were included in the research. Data collected face-to-face via clinical interview
Young Mania Rating Scale (YMRS)
Time frame: Baseline, 9. week and 21. week
Young Mania Rating Scale (YMRS): Developed by Young et al. in 1978, this scale is utilized to assess the severity of manic states. It comprises 11 Likert-type items, each assessing symptom severity across five levels. The total score ranges from 0 to 60, with higher scores denoting increased mania severity. In the current study, the YMRS was employed to confirm the remission status necessary for the inclusion of patients with bipolar disorder. Patients obtaining a score of 5 or lower on the scale were eligible for inclusion. Data collected face-to-face via clinical interview
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Aug 2026.
- Background: PubMed 29905660Bozikas VP, Parlapani E, Ntouros E, Bargiota SI, Floros G, Nazlidou EI, Garyfallos G. Resilience Predicts Social Functioning in Clinically Stable Patients With Bipolar Disorder. J Nerv Ment Dis. 2018 Jul;206(7):567-574. doi: 10.1097/NMD.0000000000000843.
- Background: PubMed 29516993Vieta E, Berk M, Schulze TG, Carvalho AF, Suppes T, Calabrese JR, Gao K, Miskowiak KW, Grande I. Bipolar disorders. Nat Rev Dis Primers. 2018 Mar 8;4:18008. doi: 10.1038/nrdp.2018.8.
- Background: PubMed 24261315Tse S, Murray G, Chung KF, Davidson L, Ng KL, Yu CH. Exploring the recovery concept in bipolar disorder: a decision tree analysis of psychosocial correlates of recovery stages. Bipolar Disord. 2014 Jun;16(4):366-77. doi: 10.1111/bdi.12153. Epub 2013 Nov 22.
- Background: PubMed 25443423Sood A, Sharma V, Schroeder DR, Gorman B. Stress Management and Resiliency Training (SMART) program among Department of Radiology faculty: a pilot randomized clinical trial. Explore (NY). 2014 Nov-Dec;10(6):358-63. doi: 10.1016/j.explore.2014.08.002. Epub 2014 Aug 21.
- Background: PubMed 21279454Sood A, Prasad K, Schroeder D, Varkey P. Stress management and resilience training among Department of Medicine faculty: a pilot randomized clinical trial. J Gen Intern Med. 2011 Aug;26(8):858-61. doi: 10.1007/s11606-011-1640-x. Epub 2011 Jan 29.
- Background: PubMed 16582056Scott J, Paykel E, Morriss R, Bentall R, Kinderman P, Johnson T, Abbott R, Hayhurst H. Cognitive-behavioural therapy for severe and recurrent bipolar disorders: randomised controlled trial. Br J Psychiatry. 2006 Apr;188:313-20. doi: 10.1192/bjp.188.4.313.
- Background: PubMed 17064434Post RM, Leverich GS. The role of psychosocial stress in the onset and progression of bipolar disorder and its comorbidities: the need for earlier and alternative modes of therapeutic intervention. Dev Psychopathol. 2006 Fall;18(4):1181-211. doi: 10.1017/S0954579406060573.
- Background: PubMed 27185483Mizuno Y, Hofer A, Suzuki T, Frajo-Apor B, Wartelsteiner F, Kemmler G, Saruta J, Tsukinoki K, Mimura M, Fleischhacker WW, Uchida H. Clinical and biological correlates of resilience in patients with schizophrenia and bipolar disorder: A cross-sectional study. Schizophr Res. 2016 Aug;175(1-3):148-153. doi: 10.1016/j.schres.2016.04.047. Epub 2016 May 13.
- Background: PubMed 27400701Lee S, Lee J, Choi JY. The effect of a resilience improvement program for adolescents with complex congenital heart disease. Eur J Cardiovasc Nurs. 2017 Apr;16(4):290-298. doi: 10.1177/1474515116659836. Epub 2016 Jul 10.
- Background: PubMed 23182591Jones S, Mulligan LD, Higginson S, Dunn G, Morrison AP. The bipolar recovery questionnaire: psychometric properties of a quantitative measure of recovery experiences in bipolar disorder. J Affect Disord. 2013 May;147(1-3):34-43. doi: 10.1016/j.jad.2012.10.003. Epub 2012 Nov 22.
- Background: PubMed 28992535Hofer A, Mizuno Y, Wartelsteiner F, Wolfgang Fleischhacker W, Frajo-Apor B, Kemmler G, Mimura M, Pardeller S, Sondermann C, Suzuki T, Welte A, Uchida H. Quality of life in schizophrenia and bipolar disorder: The impact of symptomatic remission and resilience. Eur Psychiatry. 2017 Oct;46:42-47. doi: 10.1016/j.eurpsy.2017.08.005. Epub 2017 Sep 1.
- Background: PubMed 28693874Echezarraga A, Las Hayas C, Gonzalez-Pinto AM, Jones S. The Resilience Questionnaire for Bipolar Disorder: Development and validation. Arch Psychiatr Nurs. 2017 Aug;31(4):376-385. doi: 10.1016/j.apnu.2017.04.010. Epub 2017 Apr 24.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
AYŞE AKSOY, Dr. principal investigator
Karaman Training and Research Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing CBT-Based Psychological Resilience Enhancement Program for Individuals with BD in people with Bipolar Affective Disorder; Remission in, run by Cumhuriyet University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Connor-Davidson Resilience Scale (CD-RISC) (time frame: Baseline, 9 week and 21. week). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07748910, which also lists 16 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Aug 2026.