Skeletal Class III MalocclusionNCT07749638
Figuring Out the Genetic Mutations That Lead to Lower Jaw Advancement More Than the Upper Jaw
An observational study of Skeletal Class III Malocclusion, run by Cairo University at 1 site in Egypt.
Trial summary
Purpose of the Research: To reveal the genetic cause for the occurrence of Class III malocclusion, or what may be described as a reverse bite (underbite). Introduction and Detailed Procedures for the Patient (Work Plan): 1. The volunteer will rinse their mouth with chlorhexidine before taking the swab. 2. Read more about this study
- Who is it for?
- Ages 10 years and older
- Conditions the study is for
- Skeletal Class III Malocclusion
- How many people
- 93 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Oct 2023to 9 Jul 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 10 years and older
- All sexes
- Child, Adult, Older adult
Study population: * Patients of Egyptian nationality. * ANB (angle between point A, nasion and point B at nasion) angle (point A-nasion point B) of less than 0 degrees. * Negative Wits appraisal greater than -3.0 mm.
Who may be able to join
- Patients of Egyptian nationality.
- ANB from 0° to 4.8°.ANB from 0° to 4.8°.
- Wits appraisal no less than -3.0 mm.
- Patients of Egyptian nationality.
- ANB (angle between point A, nasion and point B at nasion) angle (point A-nasion point B) of less than 0 degrees.
- Negative Wits appraisal greater than -3.0 mm.
Who cannot join
- The presence of any growth disturbances, syndromes, congenital abnormalities, \& endocrine disorders.
- Patients subjected to previous orthodontic, orthopedic, or orthognathic treatment.
- Poor quality of radiographic records.
- Consent form not signed.
- Trauma.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Investigating Genetic Biomarkers in the Early Detection of Skeletal Class III Malocclusion: An Observational Study
Purpose of the Research:
To reveal the genetic cause for the occurrence of Class III malocclusion, or what may be described as a reverse bite (underbite).
Read more
Introduction and Detailed Procedures for the Patient (Work Plan):
- The volunteer will rinse their mouth with chlorhexidine before taking the swab.
- A saliva sample will be collected from the patient using a syringe, along with a frontal facial photograph and a lateral cephalometric X-ray.
- DNA / genetic material will be extracted from the sample.
- Screening will be conducted for genetic mutations that may be responsible for the occurrence of the underbite.
- The photographs and X-rays will be analyzed and compared with the swab results.
- This data will be analyzed to determine whether the detected mutations are the cause of the underbite.
- The sample will be retained for use in future research studies.
Side Effects, Expected Risk Levels, and Management"
- Pain: Mild discomfort during swab collection, which does not require any painkillers.
- Infection/Inflammation: Mild inflammation at the sample site or a secondary bacterial infection; in this case, antibiotics may be prescribed if necessary.
- Risk Level: Low risk, estimated to be less than 5%.
- Conditions
- Skeletal Class III Malocclusion
- Keywords
- skeletal class III malocclusion, Genetic mutation, SNPs
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Study Group | skeletal class III, Negative Wits appraisal greater than -3.0 mm, ANB < 0° | |
| Control Group | skeletal class I, Wits appraisal no less than -3.0 mm, ANB from 0° to 4.8°. |
What is being measured
The primary outcome is the main question the study is designed to answer.
presence of single nucleotide polymorphism
difference in snps between control and study group
Measured: cross-sectional - results are assessed at one point of time (Preintervention)
Secondary outcomes (2)
lateral cephalometric measurements
if the snps found have a correlation with different linear and angular measurements
Measured: cross-sectional - results are assessed at one point of time (Preintervention)
Frontal photos measurements
If the snps found have a correlation with different ratios on frontal photos:
Measured: cross-sectional - results are assessed at one point of time (Preintervention)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Aug 2026
- Study start1 Oct 2023
- Primary completion5 Feb 2026
- Study completion9 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Skeletal Class III MalocclusionStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 93 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Beshoy Magdy Kamel Moharib, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07749638
- Sponsor's protocol ID
- 22723
- Status last verified
- Aug 2026
- First submitted
- 31 Jul 2026
- Last updated
- 6 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigating Genetic Biomarkers in the Early Detection of Skeletal Class III Malocclusion: An Observational Study
- ClinicalTrials.gov ID
- NCT07749638
- Acronym / sponsor ID
- 22723
- Conditions
- Skeletal Class III Malocclusion
- Keywords
- skeletal class III malocclusion, Genetic mutation, SNPs
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 93 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Oct 2023 (actual)
- Primary completion
- 5 Feb 2026 (actual)
- Study completion
- 9 Jul 2026 (actual)
- First posted
- 6 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Purpose of the Research:
To reveal the genetic cause for the occurrence of Class III malocclusion, or what may be described as a reverse bite (underbite).
Introduction and Detailed Procedures for the Patient (Work Plan):
- The volunteer will rinse their mouth with chlorhexidine before taking the swab.
- A saliva sample will be collected from the patient using a syringe, along with a frontal facial photograph and a lateral cephalometric X-ray.
- DNA / genetic material will be extracted from the sample.
- Screening will be conducted for genetic mutations that may be responsible for the occurrence of the underbite.
- The photographs and X-rays will be analyzed and compared with the swab results.
- This data will be analyzed to determine whether the detected mutations are the cause of the underbite.
- The sample will be retained for use in future research studies.
Side Effects, Expected Risk Levels, and Management"
- Pain: Mild discomfort during swab collection, which does not require any painkillers.
- Infection/Inflammation: Mild inflammation at the sample site or a secondary bacterial infection; in this case, antibiotics may be prescribed if necessary.
- Risk Level: Low risk, estimated to be less than 5%.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Study Group | – | –skeletal class III, Negative Wits appraisal greater than -3.0 mm, ANB < 0° |
| Control Group | – | –skeletal class I, Wits appraisal no less than -3.0 mm, ANB from 0° to 4.8°. |
Who may qualify
- Ages
- 10 years and older
- Sex
- All
- Age groups
- Child, Adult, Older adult
- Study population
- * Patients of Egyptian nationality. * ANB (angle between point A, nasion and point B at nasion) angle (point A-nasion point B) of less than 0 degrees. * Negative Wits appraisal greater than -3.0 mm.
Key inclusion criteria (6 listed)
- Patients of Egyptian nationality.
- ANB from 0° to 4.8°.ANB from 0° to 4.8°.
- Wits appraisal no less than -3.0 mm.
- Patients of Egyptian nationality.
- ANB (angle between point A, nasion and point B at nasion) angle (point A-nasion point B) of less than 0 degrees.
Key exclusion criteria (5 listed)
- The presence of any growth disturbances, syndromes, congenital abnormalities, \& endocrine disorders.
- Patients subjected to previous orthodontic, orthopedic, or orthognathic treatment.
- Poor quality of radiographic records.
- Consent form not signed.
- Trauma.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
presence of single nucleotide polymorphism
Time frame: cross-sectional - results are assessed at one point of time (Preintervention)
difference in snps between control and study group
2 secondary outcomes
lateral cephalometric measurements
Time frame: cross-sectional - results are assessed at one point of time (Preintervention)
Frontal photos measurements
Time frame: cross-sectional - results are assessed at one point of time (Preintervention)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Skeletal Class III Malocclusion, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
presence of single nucleotide polymorphism (time frame: cross-sectional - results are assessed at one point of time (Preintervention)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Aug 2026.