Occupational AccidentsWEATHER-WORKNCT07750782
Environmental and Geographic Patterns of Occupational Injuries
An observational study of Occupational Accidents and Weather, run by Sergio Gabriel Susmallian at 1 site in Israel.
Trial summary
This study will determine whether extreme ambient temperatures increase the incidence and severity of occupational injuries in Israel, and we request Helsinki Committee approval to conduct the analysis using de-identified National Insurance and historical meteorological data, with a waiver of informed consent. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Occupational Accidents, Weather
- What is being tested?
- Ambient Weather Exposure
- How many people
- 350,000 participants
- Where
- 1 siteIsrael
- Study dates
- 1 Jan 2020to 31 Dec 2026
- How long will I take part?
- 2 Years
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population will include adults aged 18 years or older with occupational injuries recognized by the National Insurance Institute between January 1, 2020, and December 31, 2024. Eligible records will be selected from the national occupational-injury administrative database and assigned to one of seven predefined geographic-climatic regions according to the workplace or accident location. Environmental exposure will be determined by linking each injury date, time, and location to the nearest representative meteorological monitoring station. The study will include workplace, occupational-traffic, and commuting injuries meeting the prespecified eligibility criteria.
Who may be able to join
- Individuals aged 18 years or older with an occupational injury recognized by the National Insurance Institute.
- Occupational injury occurring between January 1, 2020, and December 31, 2024.
- Injury occurring at the workplace, during occupational travel, or while commuting to or from work.
- Valid injury date and geographic information sufficient to assign the accident to one of the seven predefined geographic-climatic regions and the nearest representative meteorological station.
- Meteorological measurements available for the injury period and eligible matched control periods.
- For time-specific analyses, a valid recorded accident time permitting linkage to the closest preceding three-hour meteorological observation.
Who cannot join
- Occupational diseases, repetitive-exposure conditions, or gradual-onset disorders without a clearly defined accident date.
- Rejected, withdrawn, or unconfirmed occupational-injury claims.
- Missing or invalid accident date or geographic information preventing linkage with meteorological data.
- Accidents occurring outside the predefined geographic-climatic regions or beyond the prespecified maximum distance from an eligible meteorological station.
- Duplicate or administratively repeated records referring to the same occupational-injury event.
- Injury events for which no eligible matched control periods or corresponding meteorological measurements are available.
- Individuals younger than 18 years.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Environmental and Geographic Patterns of Occupational Injuries: A Population-Based Retrospective Study
This study will determine whether extreme ambient temperatures increase the incidence and severity of occupational injuries in Israel, and we request Helsinki Committee approval to conduct the analysis using de-identified National Insurance and historical meteorological data, with a waiver of informed consent. The project will link the date, time, and geographic location of recognized occupational accidents with corresponding historical temperature and humidity measurements. The study is retrospective, observational, and involves no direct contact with participants, no intervention, and no alteration of medical care or benefit eligibility.
Read the detailed description
Occupational injuries represent an important source of preventable morbidity, permanent disability, loss of employment, and economic burden. Rising temperatures and increasingly frequent heatwaves may impair concentration, coordination, judgment, reaction time, hydration, and physical endurance, particularly among workers in construction, agriculture, transportation, manufacturing, and other outdoor or physically demanding occupations. However, the national relationship between ambient heat and work-related injury in Israel has not been adequately quantified. Without reliable population-level evidence, employers, occupational-health authorities, and policymakers cannot identify temperature thresholds at which preventive measures should be intensified or determine which workers and industries are at greatest risk.
- Conditions
- Occupational Accidents, Weather
- Being tested
- Ambient Weather Exposure
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ambient Weather ExposureOther
Ambient temperature, relative humidity, and wind speed at the occupational-injury location and time will be retrospectively obtained from the nearest representative meteorological monitoring station. Environmental exposures will be analyzed in relation to occupational-injury occurrence and severity.
| Study group | Role | What they receive |
|---|---|---|
| Northern valleys and inland north | Occupational injuries occurring in the northern valleys and inland northern region will be assigned to this geographic-climatic division according to the location of the workplace or accident. Meteorological exposure will be determined using data from the nearest representative monitoring station, including Dafna, Tavor Kadoorie, or Nazareth. This region is characterized by inland climatic conditions with substantial seasonal variation in temperature and humidity. Accident occurrence and severity will be evaluated in relation to temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. Receives: Other: Ambient Weather Exposure | |
| Northern Mediterranean coast | Occupational injuries occurring along the northern Mediterranean coastal region will be assigned to this geographic-climatic division according to the location of the workplace or accident. Meteorological exposure will be determined using data from the Haifa Technion monitoring station or the nearest available representative station. This region is characterized by a Mediterranean coastal climate, with relatively high humidity, moderate winter temperatures, warm summers, and frequent sea-breeze effects. Accident occurrence and severity will be evaluated in relation to ambient temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. Receives: Other: Ambient Weather Exposure | |
| Central Mediterranean coast | Occupational injuries occurring within the central Mediterranean coastal region will be assigned to this geographic-climatic division according to the workplace or accident location. Meteorological exposure will be determined using data from the Tel Aviv Coast monitoring station or the nearest available representative station. This region is characterized by a warm Mediterranean climate, relatively high humidity, mild winters, hot summers, and frequent sea-breeze effects. The occurrence and severity of occupational injuries will be evaluated in relation to ambient temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. Receives: Other: Ambient Weather Exposure | |
| Southern Mediterranean coast | Occupational injuries occurring within the southern Mediterranean coastal region will be assigned to this geographic-climatic division according to the workplace or accident location. Meteorological exposure will be determined using data from the Ashqelon Port monitoring station or the nearest available representative station. This region is characterized by a warm coastal Mediterranean climate, relatively high humidity, mild winters, hot summers, and frequent sea-breeze effects. The occurrence and severity of occupational injuries will be evaluated in relation to ambient temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. Receives: Other: Ambient Weather Exposure | |
| Central highlands | Occupational injuries occurring within the central highlands region will be assigned to this geographic-climatic division according to the workplace or accident location. Meteorological exposure will be determined using data from the Jerusalem Centre monitoring station or the nearest available representative station. This region is characterized by higher elevation, lower average humidity than the coastal areas, greater day-night temperature variation, cooler winters, and warm, dry summers. The occurrence and severity of occupational injuries will be evaluated in relation to ambient temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. Receives: Other: Ambient Weather Exposure | |
| Negev desert | Occupational injuries occurring within the Negev desert region will be assigned to this geographic-climatic division according to the workplace or accident location. Meteorological exposure will be determined using data from the Avdat monitoring station or the nearest available representative station. This region is characterized by an arid desert climate, very low relative humidity, intense solar exposure, high daytime temperatures, substantial day-night temperature variation, and limited rainfall. The occurrence and severity of occupational injuries will be evaluated in relation to ambient temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. Receives: Other: Ambient Weather Exposure | |
| Dead Sea and extreme arid region | Occupational injuries occurring within the Dead Sea and extreme arid region will be assigned to this geographic-climatic division according to the workplace or accident location. Meteorological exposure will be determined using data from the Massada monitoring station or the nearest available representative station. This region is characterized by very low elevation, an extremely hot and arid climate, low annual rainfall, intense solar radiation, prolonged periods of extreme heat, and substantial seasonal temperature variation. The occurrence and severity of occupational injuries will be evaluated in relation to ambient temperature, relative humidity, extreme heat, extreme cold, and other predefined environmental indicators. Wind speed will be analyzed when reliable measurements are available. Receives: Other: Ambient Weather Exposure |
What is being measured
The primary outcome is the main question the study is designed to answer.
Occurrence of Recognized Occupational Injury During Case Versus Matched Control Periods
The number of accepted occupational-injury events occurring during predefined case periods will be evaluated in relation to ambient temperature, relative humidity, and wind speed obtained from the nearest representative meteorological station. Each injury period will be compared with control periods matched by geographic-climatic region, calendar year and month, day of the week, and three-hour time interval. The association between environmental exposure and occupational-injury occurrence will be estimated using time-stratified case-crossover analysis with conditional logistic regression.
Measured: At the index injury date and matched control dates, January 1, 2020-December 31, 2024.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Aug 2026
- Study start1 Jan 2020
- Primary completion31 Dec 2024
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Occupational AccidentsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case crossover
- Time perspective
- Cross-sectional
- Enrolment
- 350,000 participants (actual)
- Target duration
- 2 Years
Sponsor and investigators
- Lead sponsor
- Sergio Gabriel Susmallian
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Sergio Gabriel Susmallian, Assuta Medical Center
- Investigators
- Eytan Ellenberg, M.D., Study director, The National Insurance Institute
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07750782
- Sponsor's protocol ID
- BTL 001-2026
- Other IDs
- work accidents and weather
- Acronym
- WEATHER-WORK
- Status last verified
- Aug 2026
- First submitted
- 2 Aug 2026
- Last updated
- 7 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be publicly shared because the study uses confidential administrative records owned and controlled by the National Insurance Institute. Access is restricted to authorized researchers within a secure research environment and is governed by institutional confidentiality agreements, data-protection requirements, and applicable privacy legislation. The combination of accident dates, geographic information, occupational characteristics, and disability outcomes may create a residual risk of participant re-identification even after removal of direct identifiers. Only aggregated, disclosure-controlled results approved by the data custodian may be reported or published.
Publications
Calkins MM, Bonauto D, Hajat A, Lieblich M, Seixas N, Sheppard L, Spector JT. A case-crossover study of heat exposure and injury risk among outdoor construction workers in Washington State. Scand J Work Environ Health. 2019 Nov 1;45(6):588-599. doi: 10.5271/sjweh.3814. Epub 2019 Mar 14.
PubMed 30869152Sheng R, Li C, Wang Q, Yang L, Bao J, Wang K, Ma R, Gao C, Lin S, Zhang Y, Bi P, Fu C, Huang C. Does hot weather affect work-related injury? A case-crossover study in Guangzhou, China. Int J Hyg Environ Health. 2018 Apr;221(3):423-428. doi: 10.1016/j.ijheh.2018.01.005. Epub 2018 Jan 11.
PubMed 29361390Marinaccio A, Scortichini M, Gariazzo C, Leva A, Bonafede M, De' Donato FK, Stafoggia M, Viegi G, Michelozzi P; BEEP Collaborative Group. Nationwide epidemiological study for estimating the effect of extreme outdoor temperature on occupational injuries in Italy. Environ Int. 2019 Dec;133(Pt A):105176. doi: 10.1016/j.envint.2019.105176. Epub 2019 Oct 22.
PubMed 31654985
Study at a glance
From the registry record, last updated by the sponsor on 7 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Environmental and Geographic Patterns of Occupational Injuries: A Population-Based Retrospective Study
- ClinicalTrials.gov ID
- NCT07750782
- Acronym / sponsor ID
- WEATHER-WORK / BTL 001-2026
- Conditions
- Occupational Accidents, Weather
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 350,000 participants (actual)
- Lead sponsor
- Sergio Gabriel SusmallianUniversity, hospital or other
- Study start
- 1 Jan 2020 (actual)
- Primary completion
- 31 Dec 2024 (actual)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 6 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will determine whether extreme ambient temperatures increase the incidence and severity of occupational injuries in Israel, and we request Helsinki Committee approval to conduct the analysis using de-identified National Insurance and historical meteorological data, with a waiver of informed consent. The project will link the date, time, and geographic location of recognized occupational accidents with corresponding historical temperature and humidity measurements. The study is retrospective, observational, and involves no direct contact with participants, no intervention, and no alteration of medical care or benefit eligibility.
Detailed description
Occupational injuries represent an important source of preventable morbidity, permanent disability, loss of employment, and economic burden. Rising temperatures and increasingly frequent heatwaves may impair concentration, coordination, judgment, reaction time, hydration, and physical endurance, particularly among workers in construction, agriculture, transportation, manufacturing, and other outdoor or physically demanding occupations. However, the national relationship between ambient heat and work-related injury in Israel has not been adequately quantified. Without reliable population-level evidence, employers, occupational-health authorities, and policymakers cannot identify temperature thresholds at which preventive measures should be intensified or determine which workers and industries are at greatest risk.
Study design
- Observational model
- Case crossover
- Time perspective
- Cross-sectional
- Target follow-up
- 2 Years
- Number of arms
- 7
| Arm | Type | Receives |
|---|---|---|
| Northern valleys and inland north | – | Other: Ambient Weather ExposureOccupational injuries occurring in the northern valleys and inland northern region will be assigned to this geographic-climatic division according to the location of the workplace or accident. Meteorological exposure will be determined using data from the nearest representative monitoring station, including Dafna, Tavor Kadoorie, or Nazareth. This region is characterized by inland climatic conditions with substantial seasonal variation in temperature and humidity. Accident occurrence and severity will be evaluated in relation to temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. |
| Northern Mediterranean coast | – | Other: Ambient Weather ExposureOccupational injuries occurring along the northern Mediterranean coastal region will be assigned to this geographic-climatic division according to the location of the workplace or accident. Meteorological exposure will be determined using data from the Haifa Technion monitoring station or the nearest available representative station. This region is characterized by a Mediterranean coastal climate, with relatively high humidity, moderate winter temperatures, warm summers, and frequent sea-breeze effects. Accident occurrence and severity will be evaluated in relation to ambient temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. |
| Central Mediterranean coast | – | Other: Ambient Weather ExposureOccupational injuries occurring within the central Mediterranean coastal region will be assigned to this geographic-climatic division according to the workplace or accident location. Meteorological exposure will be determined using data from the Tel Aviv Coast monitoring station or the nearest available representative station. This region is characterized by a warm Mediterranean climate, relatively high humidity, mild winters, hot summers, and frequent sea-breeze effects. The occurrence and severity of occupational injuries will be evaluated in relation to ambient temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. |
| Southern Mediterranean coast | – | Other: Ambient Weather ExposureOccupational injuries occurring within the southern Mediterranean coastal region will be assigned to this geographic-climatic division according to the workplace or accident location. Meteorological exposure will be determined using data from the Ashqelon Port monitoring station or the nearest available representative station. This region is characterized by a warm coastal Mediterranean climate, relatively high humidity, mild winters, hot summers, and frequent sea-breeze effects. The occurrence and severity of occupational injuries will be evaluated in relation to ambient temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. |
| Central highlands | – | Other: Ambient Weather ExposureOccupational injuries occurring within the central highlands region will be assigned to this geographic-climatic division according to the workplace or accident location. Meteorological exposure will be determined using data from the Jerusalem Centre monitoring station or the nearest available representative station. This region is characterized by higher elevation, lower average humidity than the coastal areas, greater day-night temperature variation, cooler winters, and warm, dry summers. The occurrence and severity of occupational injuries will be evaluated in relation to ambient temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. |
| Negev desert | – | Other: Ambient Weather ExposureOccupational injuries occurring within the Negev desert region will be assigned to this geographic-climatic division according to the workplace or accident location. Meteorological exposure will be determined using data from the Avdat monitoring station or the nearest available representative station. This region is characterized by an arid desert climate, very low relative humidity, intense solar exposure, high daytime temperatures, substantial day-night temperature variation, and limited rainfall. The occurrence and severity of occupational injuries will be evaluated in relation to ambient temperature, relative humidity, wind speed, extreme heat, extreme cold, and other predefined environmental indicators. |
| Dead Sea and extreme arid region | – | Other: Ambient Weather ExposureOccupational injuries occurring within the Dead Sea and extreme arid region will be assigned to this geographic-climatic division according to the workplace or accident location. Meteorological exposure will be determined using data from the Massada monitoring station or the nearest available representative station. This region is characterized by very low elevation, an extremely hot and arid climate, low annual rainfall, intense solar radiation, prolonged periods of extreme heat, and substantial seasonal temperature variation. The occurrence and severity of occupational injuries will be evaluated in relation to ambient temperature, relative humidity, extreme heat, extreme cold, and other predefined environmental indicators. Wind speed will be analyzed when reliable measurements are available. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population will include adults aged 18 years or older with occupational injuries recognized by the National Insurance Institute between January 1, 2020, and December 31, 2024. Eligible records will be selected from the national occupational-injury administrative database and assigned to one of seven predefined geographic-climatic regions according to the workplace or accident location. Environmental exposure will be determined by linking each injury date, time, and location to the nearest representative meteorological monitoring station. The study will include workplace, occupational-traffic, and commuting injuries meeting the prespecified eligibility criteria.
Key inclusion criteria (6 listed)
- Individuals aged 18 years or older with an occupational injury recognized by the National Insurance Institute.
- Occupational injury occurring between January 1, 2020, and December 31, 2024.
- Injury occurring at the workplace, during occupational travel, or while commuting to or from work.
- Valid injury date and geographic information sufficient to assign the accident to one of the seven predefined geographic-climatic regions and the nearest representative meteorological station.
- Meteorological measurements available for the injury period and eligible matched control periods.
Key exclusion criteria (7 listed)
- Occupational diseases, repetitive-exposure conditions, or gradual-onset disorders without a clearly defined accident date.
- Rejected, withdrawn, or unconfirmed occupational-injury claims.
- Missing or invalid accident date or geographic information preventing linkage with meteorological data.
- Accidents occurring outside the predefined geographic-climatic regions or beyond the prespecified maximum distance from an eligible meteorological station.
- Duplicate or administratively repeated records referring to the same occupational-injury event.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ambient Weather ExposureAmbient temperature, relative humidity, and wind speed at the occupational-injury location and time will be retrospectively obtained from the nearest representative meteorological monitoring station. Environmental exposures will be analyzed in relation to occupational-injury occurrence and severity. | Other | Central Mediterranean coast, Central highlands, Dead Sea and extreme arid region, Negev desert, Northern Mediterranean coast, Northern valleys and inland north, Southern Mediterranean coast |
Primary outcome
Occurrence of Recognized Occupational Injury During Case Versus Matched Control Periods
Time frame: At the index injury date and matched control dates, January 1, 2020-December 31, 2024.
The number of accepted occupational-injury events occurring during predefined case periods will be evaluated in relation to ambient temperature, relative humidity, and wind speed obtained from the nearest representative meteorological station. Each injury period will be compared with control periods matched by geographic-climatic region, calendar year and month, day of the week, and three-hour time interval. The association between environmental exposure and occupational-injury occurrence will be estimated using time-stratified case-crossover analysis with conditional logistic regression.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Aug 2026.
- Background: PubMed 30869152Calkins MM, Bonauto D, Hajat A, Lieblich M, Seixas N, Sheppard L, Spector JT. A case-crossover study of heat exposure and injury risk among outdoor construction workers in Washington State. Scand J Work Environ Health. 2019 Nov 1;45(6):588-599. doi: 10.5271/sjweh.3814. Epub 2019 Mar 14.
- Background: PubMed 29361390Sheng R, Li C, Wang Q, Yang L, Bao J, Wang K, Ma R, Gao C, Lin S, Zhang Y, Bi P, Fu C, Huang C. Does hot weather affect work-related injury? A case-crossover study in Guangzhou, China. Int J Hyg Environ Health. 2018 Apr;221(3):423-428. doi: 10.1016/j.ijheh.2018.01.005. Epub 2018 Jan 11.
- Background: PubMed 31654985Marinaccio A, Scortichini M, Gariazzo C, Leva A, Bonafede M, De' Donato FK, Stafoggia M, Viegi G, Michelozzi P; BEEP Collaborative Group. Nationwide epidemiological study for estimating the effect of extreme outdoor temperature on occupational injuries in Italy. Environ Int. 2019 Dec;133(Pt A):105176. doi: 10.1016/j.envint.2019.105176. Epub 2019 Oct 22.
- Individual participant dataSharing planned: No. Individual participant data will not be publicly shared because the study uses confidential administrative records owned and controlled by the National Insurance Institute. Access is restricted to authorized researchers within a secure research environment and is governed by institutional confidentiality agreements, data-protection requirements, and applicable privacy legislation. The combination of accident dates, geographic information, occupational characteristics, and disability outcomes may create a residual risk of participant re-identification even after removal of direct identifiers. Only aggregated, disclosure-controlled results approved by the data custodian may be reported or published.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Eytan Ellenberg, M.D. study director
The National Insurance Institute
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Occupational Accidents and Weather, run by Sergio Gabriel Susmallian at 1 site in Israel.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 7 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Israel. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Occurrence of Recognized Occupational Injury During Case Versus Matched Control Periods (time frame: At the index injury date and matched control dates, January 1, 2020-December 31, 2024.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07750782, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Aug 2026; AzTrials last refreshed its copy on 26 Oct 2026.