Acute PancreatitisNCT07753980
Presentations and Outcomes of Acute Pancreatitis
An observational study of Acute Pancreatitis, run by Assiut University.
Trial summary
Evaluate the outcomes of the patients and their possible predictors. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Pancreatitis
- What is being tested?
- US,MSCT abdomen,arterial blood gases
- How many people
- 100 participants
- Where
- No sites listed yet
- Study dates
- Sep 2026to Oct 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: All enrolled patients will undergo: * Detailed medical history taking including demographic data, comorbidities, smoking, alcohol intake, and possible etiological factors. * Complete clinical examination. * Laboratory investigations including CBC, liver function tests, kidney function tests, serum amylase, serum lipase, calcium profile, lipid profile, and CRP. * Radiological investigations including abdominal ultrasonography and CT abdomen when indicated. * Assessment of severity using Ranson score, APACHE II score and Revised Atlanta classification. * Follow-up during admission for complications, ICU admission, length of hospital stay, and mortality.
Who may be able to join
- 1. Adult patients aged 18 years or older. 2. Patients fulfilling at least two diagnostic criteria of acute pancreatitis. 3. Patients willing to participate in the study.
Who cannot join
- Patients with chronic pancreatitis.
- Patients diagnosed with pancreatic malignancy.
- Patients less than 18 years old.
- Patients with incomplete clinical data.
- Refusal to participate. -
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Clinical Presentations and Outcomes in Patients With Acute Pancreatitis at Al-Rajhi University Hospital-Prospective Study
Evaluate the outcomes of the patients and their possible predictors.
Read the detailed description
Acute pancreatitis (AP) is an acute inflammatory disease of the pancreas characterized by variable involvement of regional tissues and distant organ systems. The disease may range from mild interstitial edema to severe pancreatic necrosis associated with multiple organ failure and high mortality rates [1,2]. Acute pancreatitis is considered one of the leading gastrointestinal causes of hospital admission worldwide and its incidence has progressively increased over recent decades [3]. The pathogenesis of acute pancreatitis is mainly related to premature activation of pancreatic digestive enzymes within pancreatic acinar cells, resulting in autodigestion of pancreatic tissue and activation of inflammatory pathways [1]. This inflammatory response may progress to systemic inflammatory response syndrome (SIRS), acute respiratory distress syndrome (ARDS), renal failure, shock, and multiorgan dysfunction syndrome (MODS) in severe cases[ 2,4]. Although approximately 80% of patients experience mild self-limited disease with favorable outcomes, nearly 20% develop severe acute pancreatitis associated with pancreatic necrosis, infected collections, persistent organ failure, and systemic complications [3,8]. The overall mortality rate of acute pancreatitis ranges from 3% to 10%, while mortality in severe acute pancreatitis may reach 20-30%, particularly in patients with infected pancreatic necrosis and persistent organ failure4 and [8].Early identification of severe disease and accurate assessment of prognosis are therefore essential to improve patient outcomes and reduce morbidity and mortality [7,8]. In Upper Egypt, particularly at Al-Rajhi University Hospital, prospective data regarding the clinical presentation, etiological factors, disease severity, complications, and outcomes of patients admitted with acute pancreatitis remain limited. In addition, the association between demographic characteristics, comorbidities, severity scores, and short-term clinical outcomes has not been adequately evaluated in the local population.
Accordingly, this prospective study aims to describe the clinical characteristics of hospitalized patients with acute pancreatitis, identify factors associated with adverse outcomes, and evaluate the prognostic value of the Ranson and APACHE II scoring systems. The findings may contribute to improved early risk stratification, support clinical decision-making, optimize resource utilization, and ultimately enhance patient care at Al-Rajhi University Hospital.
- Conditions
- Acute Pancreatitis
- Being tested
- US,MSCT abdomen,arterial blood gases
- Keywords
- acute pancreatitis, Al-Rajhi University Hospital
- Medical subject headings
- Pancreatitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
US,MSCT abdomen,arterial blood gasesOther
arterial blood gases
What is being measured
The primary outcome is the main question the study is designed to answer.
Frequency and types of clinical patterns of acute pancreatitis and the fates of patients.
Measured: july 2026-july 2027
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Aug 2026
- Study startSep 2026 (estimated)
- Primary completionSep 2027 (estimated)
- Study completionOct 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute PancreatitisStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Roaa Khaled Mohamed Hasanin, Assiut University
- Investigators
- Rasha H shehata, assistant professor, Study director, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07753980
- Sponsor's protocol ID
- acute pancreatitis at Al-Rajhi
- Status last verified
- Aug 2026
- First submitted
- 4 Aug 2026
- Last updated
- 10 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 10 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Presentations and Outcomes in Patients With Acute Pancreatitis at Al-Rajhi University Hospital-Prospective Study
- ClinicalTrials.gov ID
- NCT07753980
- Acronym / sponsor ID
- acute pancreatitis at Al-Rajhi
- Conditions
- Acute Pancreatitis
- Keywords
- acute pancreatitis, Al-Rajhi University Hospital
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- Sep 2026 (estimated)
- Primary completion
- Sep 2027 (estimated)
- Study completion
- Oct 2027 (estimated)
- First posted
- 10 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Evaluate the outcomes of the patients and their possible predictors.
Detailed description
Acute pancreatitis (AP) is an acute inflammatory disease of the pancreas characterized by variable involvement of regional tissues and distant organ systems. The disease may range from mild interstitial edema to severe pancreatic necrosis associated with multiple organ failure and high mortality rates [1,2]. Acute pancreatitis is considered one of the leading gastrointestinal causes of hospital admission worldwide and its incidence has progressively increased over recent decades [3]. The pathogenesis of acute pancreatitis is mainly related to premature activation of pancreatic digestive enzymes within pancreatic acinar cells, resulting in autodigestion of pancreatic tissue and activation of inflammatory pathways [1]. This inflammatory response may progress to systemic inflammatory response syndrome (SIRS), acute respiratory distress syndrome (ARDS), renal failure, shock, and multiorgan dysfunction syndrome (MODS) in severe cases[ 2,4]. Although approximately 80% of patients experience mild self-limited disease with favorable outcomes, nearly 20% develop severe acute pancreatitis associated with pancreatic necrosis, infected collections, persistent organ failure, and systemic complications [3,8]. The overall mortality rate of acute pancreatitis ranges from 3% to 10%, while mortality in severe acute pancreatitis may reach 20-30%, particularly in patients with infected pancreatic necrosis and persistent organ failure4 and [8].Early identification of severe disease and accurate assessment of prognosis are therefore essential to improve patient outcomes and reduce morbidity and mortality [7,8]. In Upper Egypt, particularly at Al-Rajhi University Hospital, prospective data regarding the clinical presentation, etiological factors, disease severity, complications, and outcomes of patients admitted with acute pancreatitis remain limited. In addition, the association between demographic characteristics, comorbidities, severity scores, and short-term clinical outcomes has not been adequately evaluated in the local population.
Accordingly, this prospective study aims to describe the clinical characteristics of hospitalized patients with acute pancreatitis, identify factors associated with adverse outcomes, and evaluate the prognostic value of the Ranson and APACHE II scoring systems. The findings may contribute to improved early risk stratification, support clinical decision-making, optimize resource utilization, and ultimately enhance patient care at Al-Rajhi University Hospital.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- All enrolled patients will undergo: * Detailed medical history taking including demographic data, comorbidities, smoking, alcohol intake, and possible etiological factors. * Complete clinical examination. * Laboratory investigations including CBC, liver function tests, kidney function tests, serum amylase, serum lipase, calcium profile, lipid profile, and CRP. * Radiological investigations including abdominal ultrasonography and CT abdomen when indicated. * Assessment of severity using Ranson score, APACHE II score and Revised Atlanta classification. * Follow-up during admission for complications, ICU admission, length of hospital stay, and mortality.
Key inclusion criteria (1 listed)
- 1. Adult patients aged 18 years or older. 2. Patients fulfilling at least two diagnostic criteria of acute pancreatitis. 3. Patients willing to participate in the study.
Key exclusion criteria (5 listed)
- Patients with chronic pancreatitis.
- Patients diagnosed with pancreatic malignancy.
- Patients less than 18 years old.
- Patients with incomplete clinical data.
- Refusal to participate. -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| US,MSCT abdomen,arterial blood gasesarterial blood gases | Other | – |
Primary outcome
Frequency and types of clinical patterns of acute pancreatitis and the fates of patients.
Time frame: july 2026-july 2027
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Aug 2026.
- Hines OJ, Pandol SJ. Management of acute pancreatitis. BMJ. 2019;367:l6227.Link provided by the sponsor.
- Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-184.Link provided by the sponsor.
- Tenner S, Baillie J, DeWitt J, Vege SS. American College of Gastroenterology guidelineManagement of acute pancreatitis. Am J Gastroenterol. 2013;108(9):1400-1415.Link provided by the sponsor.
- . Szatmary P, Grammatikopoulos T, Cai W, et al. Acute pancreatitis: Diagnosis and treatment. Drugs. 2022;82(12):1251-1276.Link provided by the sponsor.
- Ranson JH, Rifkind KM, Roses DF, et al. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet. 1974;139(1):69-81.Link provided by the sponsor.
- Papachristou GI, Muddana V, Yadav D, et al. Comparison of BISAP, Ranson's, APACHE II, and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis. Am J Gastroenterol. 2010;105(2):435-441.Link provided by the sponsor.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Rasha H shehata, assistant professor study director
Assiut University
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Pancreatitis, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Roaa M Khaled Hasanin, Resident doctor (00201008753743, ro2a5aled12@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Frequency and types of clinical patterns of acute pancreatitis and the fates of patients. (time frame: july 2026-july 2027). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Aug 2026.