Cardiac Arrest (CA)NCT07754656
Adapted Cardiopulmonary Resuscitation Study
A study testing aCPR algorithm and ERC ALS 2025 in people with Cardiac Arrest (CA), run by Johannes Kepler University of Linz at 1 site in Austria.
Trial summary
The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest. Two different algorithms (control-and interventiongroup) of advanced cardiac life support will be used to treat patients. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest (CA)
- What is being tested?
- aCPR algorithm and ERC ALS 2025
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 216 participants
- Where
- 1 siteAustria
- Study dates
- 28 Jan 2026to 28 Mar 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age> 18 years
- time of resuscitation <21 minutes when enrollement starts
Who cannot join
- obvious pregnancy
- contraindications for the use of Lucas 3
- time of resuscitation >21 minutes and etCO2 <15 mmHg upon arrival of the emergency physician on scene
- Exclusion from the emergency physician from study due to futility.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Austria1 site, 1 recruiting
- Recruiting
Kepler University Hospital
Linz, Upper Austria, 4020
Jens Meier, Univ. Prof. Dr. med, +43 5 7680 83 - 2158, jens.meier@kepleruniklinikum.at
Johannes Szasz, Dr.med, +43 5 7680 83 - 78947, johannes.szasz@jku.at
About this study
Official title: Adapted CPR (aCPR) a Bundle of Measures for Out of Hospital Cardiac Arrest (OHCA) Patients
The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest. Two different algorithms (control-and interventiongroup) of advanced cardiac life support will be used to treat patients. In patients over 18 years suffering from cardiac arrest. The main question aims to answer if the frequency of ROSC differs between the groups receiving either the new Advanced Life Support (ALS) algorithm, or standard treatment.
Researchers will compare the new algorithm to the standard care algorithm to see if there is a difference .
Read more
Participants will be randomized to treatment on scene. The controlgroup will receive ALS standard treatment as performed in local protocols.
The intervention group will receive a modified treatment including:
- thorax compression via mechanical device (LUCAS 3)
- head up Cardiopulmonary Resuscitation (cpr)
- use of an impendance threshold device (ITD) module
- arterial line placement
- continuous epinephrin infusion via infusion pump
- double sequence defibrillation
- Conditions
- Cardiac Arrest (CA)
- Being tested
- aCPR algorithm, ERC ALS 2025
- Keywords
- cardiac arrest, head up cpr, continuous adrenalin infusion, mechanical thorax compression, ITD, arterial line, diastolic blood pressure, ROSC, OHCA
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
aCPR algorithmProcedure or surgery
- thorax compression via mechanical device (LUCAS 3)
- head up cpr
- use of an ITD module
- arterial line placement
- continuous epinephrin infusion via infusion pump
- double sequence defibrillation
ERC ALS 2025Procedure or surgery
Placement of an IV line, placement of a supraglottic airway device or endotracheal intubation. Optional use of an intraosseus acces
| Study group | Role | What they receive |
|---|---|---|
| ALS ERC 2025 | Active comparator | Not described Receives: Procedure: ERC ALS 2025 |
| adapted CPR algorithm | Experimental | * thorax compression via mechanical device (LUCAS 3)
* head up cpr
* use of an ITD module
* arterial line placement
* continuous epinephrin infusion via infusion pump
* double sequence defibrillation Receives: Procedure: aCPR algorithm |
What is being measured
The primary outcome is the main question the study is designed to answer.
ROSC
frequency of ROSC in the study cohort
Measured: one minute
Secondary outcomes (3)
Time to ROSC
comparison between the groups if ROSC can be achieved faster in one group
Measured: Periprocedural: from enrollement to ROSC or Termination of Resuscitation (TOR)
CO2
Measurement of CO2 differences between study arms
Measured: Periprocedural: from enrollement to ROSC orTOR
descriptive data
analyzing vital parameters measured
Measured: Periprocedural: during study intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Aug 2026
- Study start28 Jan 2026
- Primary completion28 Jan 2029 (estimated)
- Study completion28 Mar 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 216 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Johannes Kepler University of Linz
- Sponsor type
- University, hospital or other
- Collaborators
- Red Cross Upper Austria, Kepler University Hospital
- Responsible party
- Sponsor
- Investigators
- Jens Meier, Univ. Prof., Principal investigator, Kepler University Hospital / Johannes Kepler University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07754656
- Sponsor's protocol ID
- JKULinz
- Status last verified
- Aug 2026
- First submitted
- 8 May 2026
- Last updated
- 10 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Deidentified participant data utilized in this study can be made available upon reasonable request to the corresponding author. Access to the data will be subject to approval by institutional and ethical considerations.
Study at a glance
From the registry record, last updated by the sponsor on 10 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Adapted CPR (aCPR) a Bundle of Measures for Out of Hospital Cardiac Arrest (OHCA) Patients
- ClinicalTrials.gov ID
- NCT07754656
- Acronym / sponsor ID
- JKULinz
- Conditions
- Cardiac Arrest (CA)
- Keywords
- cardiac arrest, head up cpr, continuous adrenalin infusion, mechanical thorax compression, ITD, arterial line, diastolic blood pressure, ROSC
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 216 participants (estimated)
- Lead sponsor
- Johannes Kepler University of LinzUniversity, hospital or other
- Collaborators
- Red Cross Upper Austria, Kepler University Hospital
- Study start
- 28 Jan 2026 (actual)
- Primary completion
- 28 Jan 2029 (estimated)
- Study completion
- 28 Mar 2029 (estimated)
- First posted
- 10 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest. Two different algorithms (control-and interventiongroup) of advanced cardiac life support will be used to treat patients. In patients over 18 years suffering from cardiac arrest. The main question aims to answer if the frequency of ROSC differs between the groups receiving either the new Advanced Life Support (ALS) algorithm, or standard treatment.
Researchers will compare the new algorithm to the standard care algorithm to see if there is a difference .
Participants will be randomized to treatment on scene. The controlgroup will receive ALS standard treatment as performed in local protocols.
The intervention group will receive a modified treatment including:
- thorax compression via mechanical device (LUCAS 3)
- head up Cardiopulmonary Resuscitation (cpr)
- use of an impendance threshold device (ITD) module
- arterial line placement
- continuous epinephrin infusion via infusion pump
- double sequence defibrillation
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ALS ERC 2025 | Active comparator | Procedure: ERC ALS 2025 |
| adapted CPR algorithm | Experimental | Procedure: aCPR algorithm* thorax compression via mechanical device (LUCAS 3) * head up cpr * use of an ITD module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Age> 18 years
- time of resuscitation <21 minutes when enrollement starts
Key exclusion criteria (4 listed)
- obvious pregnancy
- contraindications for the use of Lucas 3
- time of resuscitation >21 minutes and etCO2 <15 mmHg upon arrival of the emergency physician on scene
- Exclusion from the emergency physician from study due to futility.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| aCPR algorithm* thorax compression via mechanical device (LUCAS 3) * head up cpr * use of an ITD module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation | Procedure or surgery | adapted CPR algorithm |
| ERC ALS 2025Placement of an IV line, placement of a supraglottic airway device or endotracheal intubation. Optional use of an intraosseus acces | Procedure or surgery | ALS ERC 2025 |
Primary outcome
ROSC
Time frame: one minute
frequency of ROSC in the study cohort
3 secondary outcomes
Time to ROSC
Time frame: Periprocedural: from enrollement to ROSC or Termination of Resuscitation (TOR)
CO2
Time frame: Periprocedural: from enrollement to ROSC orTOR
descriptive data
Time frame: Periprocedural: during study intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Aug 2026.
- Individual participant dataSharing planned: No. Deidentified participant data utilized in this study can be made available upon reasonable request to the corresponding author. Access to the data will be subject to approval by institutional and ethical considerations.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Jens Meier, Univ. Prof. principal investigator
Kepler University Hospital / Johannes Kepler University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing aCPR algorithm and ERC ALS 2025 in people with Cardiac Arrest (CA), run by Johannes Kepler University of Linz at 1 site in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 10 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
ROSC (time frame: one minute). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Aug 2026.