PeriodontitisNCT07755644
Minimally Invasive Non-Surgical Periodontal Treatment
A study testing Minimally Invasive Non-Surgical Therapy (MINST) and Conventional Scaling and Root Planing in people with Periodontitis and Periodontitis (Stage 3), run by Ataturk University at 1 site in Turkey (Türkiye).
Trial summary
This single-center, split-mouth, randomized controlled clinical trial aims to evaluate the clinical effectiveness of Minimally Invasive Non-Surgical Therapy (MINST) as an adjunct to conventional non-surgical periodontal therapy in patients with Stage III/IV periodontitis. Read more about this study
- Who is it for?
- Ages 18 to 35 years
- Conditions the study is for
- Periodontitis, Periodontitis (Stage 3)
- What is being tested?
- Minimally Invasive Non-Surgical Therapy (MINST) and Conventional Scaling and Root Planing
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 23 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Aug 2026to Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Adults aged 18 to 35 years.
- Diagnosed with Stage III or Stage IV periodontitis.
- Systemically healthy.
- Presence of at least two bilateral molar teeth with probing pocket depth (PPD) ≥5 mm and bleeding on probing (BOP).
- At least 20 remaining teeth.
- Radiographic evidence of periodontal bone loss.
Show all 10Show fewer
- Non-smokers and non-users of tobacco or alcohol.
- Not pregnant or breastfeeding.
- Not receiving medications known to affect periodontal healing.
- Willing and able to provide written informed consent and comply with study procedures.
Who cannot join
- Individuals who do not meet the inclusion criteria.
- Pregnancy or breastfeeding.
- Presence of systemic diseases or medical conditions affecting periodontal status or healing.
- Current use of medications that may influence periodontal healing.
- Current smokers or users of tobacco or alcohol.
- Individuals unwilling or unable to provide informed consent.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
Ataturk University Faculty of Dentistry, Department of Periodontology
Erzurum, Erzurum, 25040
Alparslan Dilsiz, Professor, DDS, PhD, 05334760078, aydilsiz@yahoo.com
About this study
Official title: The Clinical Effects of Minimally Invasive NonSurgical Therapy (MINST) as an Alternative of Conventional NonSurgical Periodontal Therapy for Stage III Grade C Periodontitis in Molar Teeth- A 6-month Pilot Randomized Controlled Clinical Trial
This single-center, split-mouth, randomized controlled clinical trial aims to evaluate the clinical effectiveness of Minimally Invasive Non-Surgical Therapy (MINST) as an adjunct to conventional non-surgical periodontal therapy in patients with Stage III/IV periodontitis. Twenty-three systemically healthy adults presenting with bilateral molar teeth exhibiting periodontal pockets ≥5 mm with bleeding on probing will be enrolled. In each participant, molar teeth will be randomly allocated to receive either conventional subgingival scaling and root planing (SRP) using ultrasonic instruments alone (control) or conventional SRP followed by MINST using Mini-Five Gracey curettes under magnification loupes (test). Clinical periodontal parameters, including Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL), will be evaluated at baseline, 3 months, and 6 months after treatment. The study will investigate whether MINST provides superior clinical outcomes compared with conventional non-surgical periodontal therapy.
Read the detailed description
Periodontitis is a chronic inflammatory disease characterized by the destruction of the tooth-supporting tissues. Conventional non-surgical periodontal therapy based on scaling and root planing (SRP) is considered the first-line treatment for periodontal pockets. However, complete removal of subgingival biofilm and calculus may be difficult in deep pockets, furcation areas, and root concavities because of limited access.
Minimally Invasive Non-Surgical Therapy (MINST) has been introduced to improve access to deep periodontal defects while minimizing soft tissue trauma. The technique combines magnification loupes with Mini-Five Gracey curettes to allow more precise instrumentation and preservation of soft tissues during periodontal debridement.
This prospective, single-center, split-mouth randomized controlled clinical trial will include 23 patients diagnosed with Stage III/IV periodontitis. Bilateral molar teeth with probing pocket depth ≥5 mm and bleeding on probing will be randomly assigned to either the test or control intervention within each participant.
The control sites will receive conventional subgingival scaling and root planing using ultrasonic instruments. The test sites will receive conventional ultrasonic instrumentation followed by MINST performed with Mini-Five Gracey curettes under magnification loupes.
All participants will receive oral hygiene instructions and full-mouth supragingival periodontal therapy before subgingival treatment. Scaling and root planing will be completed over two treatment sessions separated by one week. Professional supportive periodontal therapy will be provided during follow-up according to the study protocol.
Clinical evaluations will be performed at baseline, 3 months, and 6 months. The primary clinical variables include Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL). Microbiological evaluation using the benzoyl-DL-arginine naphthylamide (BANA) assay will also be performed at the same follow-up intervals.
The objective of the study is to determine whether MINST provides improved clinical periodontal outcomes compared with conventional non-surgical periodontal therapy in molar teeth affected by Stage III/IV periodontitis.
- Conditions
- Periodontitis, Periodontitis (Stage 3)
- Being tested
- Minimally Invasive Non-Surgical Therapy (MINST), Conventional Scaling and Root Planing
- Keywords
- Periodontitis, Stage III Periodontitis, Stage IV Periodontitis, Minimally Invasive Non-Surgical Therapy, MINST, Scaling and Root Planing, Root Debridement
- Medical subject headings
- Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Minimally Invasive Non-Surgical Therapy (MINST)Procedure or surgery
Minimally Invasive Non-Surgical Therapy (MINST) consists of subgingival scaling and root planing performed using Mini-Five Gracey curettes under ×4.0 magnification loupes following conventional ultrasonic instrumentation. The procedure is designed to minimize soft tissue trauma while improving access to deep periodontal pockets and root surface debridement. Treatment is completed in two sessions separated by one week.
Conventional Scaling and Root PlaningProcedure or surgery
Also called SRP
Conventional non-surgical periodontal therapy consisting of subgingival scaling and root planing performed using ultrasonic instruments. Treatment is completed over two sessions separated by one week according to the study protocol.
| Study group | Role | What they receive |
|---|---|---|
| MINST Group | Experimental | Participants assigned to the experimental arm will receive conventional non-surgical periodontal therapy with ultrasonic scaling and root planing followed by Minimally Invasive Non-Surgical Therapy (MINST) using Mini-Five Gracey curettes under magnification loupes. Treatment will be performed over two sessions separated by one week. Receives: Procedure: Minimally Invasive Non-Surgical Therapy (MINST) |
| Conventional SRP Group | Active comparator | Participants assigned to the control arm will receive conventional non-surgical periodontal therapy consisting of subgingival scaling and root planing using ultrasonic instruments. Treatment will be performed over two sessions separated by one week. Receives: Procedure: Conventional Scaling and Root Planing |
What is being measured
The primary outcome is the main question the study is designed to answer.
Probing Pocket Depth (PPD)
Change in probing pocket depth (PPD) measured in millimeters using a UNC-15 periodontal probe.
Measured: Baseline, 3 months, and 6 months
Secondary outcomes (4)
Clinical Attachment Level (CAL)
Change in clinical attachment level (CAL) measured in millimeters using a UNC-15 periodontal probe.
Measured: Baseline, 3 months, and 6 months
Bleeding on Probing (BOP)
Change in bleeding on probing (BOP).
Measured: Baseline, 3 months, and 6 months
Plaque Index (PI)
Change in Plaque Index (PI).
Measured: Baseline, 3 months, and 6 months
BANA Test
Changes in subgingival microbial profile assessed using the benzoyl-DL-arginine naphthylamide (BANA) assay.
Measured: Baseline, 3 months, and 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Aug 2026
- Study start1 Aug 2026 (estimated)
- Primary completionJan 2027 (estimated)
- Study completionJan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for PeriodontitisStudies of the same condition, open and under way.
- More trials run by Ataturk UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This is a randomized split-mouth clinical trial in which bilateral molar teeth within the same participant are randomly assigned to either the test or control intervention, allowing each participant to serve as their own control.
- Masking
- None (open label)
- Enrolment
- 23 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ataturk University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alparslan Dilsiz, Ataturk University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07755644
- Sponsor's protocol ID
- ATAUNI-MINST-2026
- Status last verified
- Aug 2026
- First submitted
- 5 Aug 2026
- Last updated
- 10 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Chung WC, Huang CF, Feng SW. Clinical Benefits of Minimally Invasive Non-Surgical Periodontal Therapy as an Alternative of Conventional Non-Surgical Periodontal Therapy-A Pilot Study. Int J Environ Res Public Health. 2022 Jun 17;19(12):7456. doi: 10.3390/ijerph19127456.
PubMed 35742702Kucic AC, Gaspersic R. Minimally invasive non-surgical therapy (MINST) in stage III periodontitis patients: 6-month results of a split-mouth, randomised controlled clinical trial. Clin Oral Investig. 2023 May;27(5):2075-2087. doi: 10.1007/s00784-023-04994-4. Epub 2023 Apr 4.
PubMed 37014505
Study at a glance
From the registry record, last updated by the sponsor on 10 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Clinical Effects of Minimally Invasive NonSurgical Therapy (MINST) as an Alternative of Conventional NonSurgical Periodontal Therapy for Stage III Grade C Periodontitis in Molar Teeth- A 6-month Pilot Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07755644
- Acronym / sponsor ID
- ATAUNI-MINST-2026
- Conditions
- Periodontitis, Periodontitis (Stage 3)
- Keywords
- Periodontitis, Stage III Periodontitis, Stage IV Periodontitis, Minimally Invasive Non-Surgical Therapy, MINST, Scaling and Root Planing, Root Debridement
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 23 participants (estimated)
- Lead sponsor
- Ataturk UniversityUniversity, hospital or other
- Study start
- 1 Aug 2026 (estimated)
- Primary completion
- Jan 2027 (estimated)
- Study completion
- Jan 2027 (estimated)
- First posted
- 10 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This single-center, split-mouth, randomized controlled clinical trial aims to evaluate the clinical effectiveness of Minimally Invasive Non-Surgical Therapy (MINST) as an adjunct to conventional non-surgical periodontal therapy in patients with Stage III/IV periodontitis. Twenty-three systemically healthy adults presenting with bilateral molar teeth exhibiting periodontal pockets ≥5 mm with bleeding on probing will be enrolled. In each participant, molar teeth will be randomly allocated to receive either conventional subgingival scaling and root planing (SRP) using ultrasonic instruments alone (control) or conventional SRP followed by MINST using Mini-Five Gracey curettes under magnification loupes (test). Clinical periodontal parameters, including Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL), will be evaluated at baseline, 3 months, and 6 months after treatment. The study will investigate whether MINST provides superior clinical outcomes compared with conventional non-surgical periodontal therapy.
Detailed description
Periodontitis is a chronic inflammatory disease characterized by the destruction of the tooth-supporting tissues. Conventional non-surgical periodontal therapy based on scaling and root planing (SRP) is considered the first-line treatment for periodontal pockets. However, complete removal of subgingival biofilm and calculus may be difficult in deep pockets, furcation areas, and root concavities because of limited access.
Minimally Invasive Non-Surgical Therapy (MINST) has been introduced to improve access to deep periodontal defects while minimizing soft tissue trauma. The technique combines magnification loupes with Mini-Five Gracey curettes to allow more precise instrumentation and preservation of soft tissues during periodontal debridement.
This prospective, single-center, split-mouth randomized controlled clinical trial will include 23 patients diagnosed with Stage III/IV periodontitis. Bilateral molar teeth with probing pocket depth ≥5 mm and bleeding on probing will be randomly assigned to either the test or control intervention within each participant.
The control sites will receive conventional subgingival scaling and root planing using ultrasonic instruments. The test sites will receive conventional ultrasonic instrumentation followed by MINST performed with Mini-Five Gracey curettes under magnification loupes.
All participants will receive oral hygiene instructions and full-mouth supragingival periodontal therapy before subgingival treatment. Scaling and root planing will be completed over two treatment sessions separated by one week. Professional supportive periodontal therapy will be provided during follow-up according to the study protocol.
Clinical evaluations will be performed at baseline, 3 months, and 6 months. The primary clinical variables include Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL). Microbiological evaluation using the benzoyl-DL-arginine naphthylamide (BANA) assay will also be performed at the same follow-up intervals.
The objective of the study is to determine whether MINST provides improved clinical periodontal outcomes compared with conventional non-surgical periodontal therapy in molar teeth affected by Stage III/IV periodontitis.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- This is a randomized split-mouth clinical trial in which bilateral molar teeth within the same participant are randomly assigned to either the test or control intervention, allowing each participant to serve as their own control.
| Arm | Type | Receives |
|---|---|---|
| MINST Group | Experimental | Procedure: Minimally Invasive Non-Surgical Therapy (MINST)Participants assigned to the experimental arm will receive conventional non-surgical periodontal therapy with ultrasonic scaling and root planing followed by Minimally Invasive Non-Surgical Therapy (MINST) using Mini-Five Gracey curettes under magnification loupes. Treatment will be performed over two sessions separated by one week. |
| Conventional SRP Group | Active comparator | Procedure: Conventional Scaling and Root PlaningParticipants assigned to the control arm will receive conventional non-surgical periodontal therapy consisting of subgingival scaling and root planing using ultrasonic instruments. Treatment will be performed over two sessions separated by one week. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (10 listed)
- Adults aged 18 to 35 years.
- Diagnosed with Stage III or Stage IV periodontitis.
- Systemically healthy.
- Presence of at least two bilateral molar teeth with probing pocket depth (PPD) ≥5 mm and bleeding on probing (BOP).
- At least 20 remaining teeth.
Key exclusion criteria (6 listed)
- Individuals who do not meet the inclusion criteria.
- Pregnancy or breastfeeding.
- Presence of systemic diseases or medical conditions affecting periodontal status or healing.
- Current use of medications that may influence periodontal healing.
- Current smokers or users of tobacco or alcohol.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Minimally Invasive Non-Surgical Therapy (MINST)Minimally Invasive Non-Surgical Therapy (MINST) consists of subgingival scaling and root planing performed using Mini-Five Gracey curettes under ×4.0 magnification loupes following conventional ultrasonic instrumentation. The procedure is designed to minimize soft tissue trauma while improving access to deep periodontal pockets and root surface debridement. Treatment is completed in two sessions separated by one week. | Procedure or surgery | MINST Group |
| Conventional Scaling and Root PlaningAlso: SRPConventional non-surgical periodontal therapy consisting of subgingival scaling and root planing performed using ultrasonic instruments. Treatment is completed over two sessions separated by one week according to the study protocol. | Procedure or surgery | Conventional SRP Group |
Primary outcome
Probing Pocket Depth (PPD)
Time frame: Baseline, 3 months, and 6 months
Change in probing pocket depth (PPD) measured in millimeters using a UNC-15 periodontal probe.
4 secondary outcomes
Clinical Attachment Level (CAL)
Time frame: Baseline, 3 months, and 6 months
Bleeding on Probing (BOP)
Time frame: Baseline, 3 months, and 6 months
Plaque Index (PI)
Time frame: Baseline, 3 months, and 6 months
BANA Test
Time frame: Baseline, 3 months, and 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Aug 2026.
- Background: PubMed 35742702Chung WC, Huang CF, Feng SW. Clinical Benefits of Minimally Invasive Non-Surgical Periodontal Therapy as an Alternative of Conventional Non-Surgical Periodontal Therapy-A Pilot Study. Int J Environ Res Public Health. 2022 Jun 17;19(12):7456. doi: 10.3390/ijerph19127456.
- Background: PubMed 37014505Kucic AC, Gaspersic R. Minimally invasive non-surgical therapy (MINST) in stage III periodontitis patients: 6-month results of a split-mouth, randomised controlled clinical trial. Clin Oral Investig. 2023 May;27(5):2075-2087. doi: 10.1007/s00784-023-04994-4. Epub 2023 Apr 4.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Minimally Invasive Non-Surgical Therapy (MINST) and Conventional Scaling and Root Planing in people with Periodontitis and Periodontitis (Stage 3), run by Ataturk University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Alparslan Dilsiz, Professor, DDS, PhD (05334760078, aydilsiz@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Probing Pocket Depth (PPD) (time frame: Baseline, 3 months, and 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07755644, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Aug 2026.