CryptozoospermiaNCT07759713
Varicocelectomy for Cryptozoospermic Men.
A study testing Varicoceles ligation in people with Cryptozoospermia, run by Sohag University at 1 site in Egypt.
Trial summary
Patient Information leaflet on varicoceles surgery Read more about this study
- Who is it for?
- Ages 18 to 60 years, men only
- Conditions the study is for
- Cryptozoospermia
- What is being tested?
- Varicoceles ligation
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 69 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Feb 2024to 30 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- Men only
- No healthy volunteers
- Adult
Who may be able to join
- Male Infertility with cryptozoospermia and clinical varicoceles
Who cannot join
- Genetic abnormalities. Other causes of male infertility
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Varicocelectomy Versus Antioxidant Medication for Cryptozoospermic Men, A Prospective Randomized Trial
Patient Information leaflet on varicoceles surgery
- Conditions
- Cryptozoospermia
- Being tested
- Varicoceles ligation
- Keywords
- cryptozoospermia, Varicoceles, varicocelectomy
- Medical subject headings
- Oligospermia, Varicocele
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Varicoceles ligationProcedure or surgery
Microscopic surgery
| Study group | Role | What they receive |
|---|---|---|
| Medical Treatment | No intervention | Medical treatment |
| Surgical | Experimental | Varicoceles surgery Receives: Procedure: Varicoceles ligation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Semen
Improvement in the semen concentration (measured by million/ml). This will be checked by repeat semen analysis 6 and 12 months in both study groups.
Measured: 12 months
Secondary outcomes (1)
IVF/pregnancy outcomes
- The percentage of biological pregnancy (The number of biological pregnancy/total patients) In both groups.
- The percentage of live births (the Number of live birth/total number of patients) in both groups.
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Aug 2026
- Study start1 Feb 2024
- Primary completion30 Jul 2025
- Study completion30 Jul 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CryptozoospermiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 69 participants (actual)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohammed Saber-Khalaf, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07759713
- Sponsor's protocol ID
- 4,799/1/24
- Status last verified
- Aug 2026
- First submitted
- 21 Jul 2026
- Last updated
- 12 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 12 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Varicocelectomy Versus Antioxidant Medication for Cryptozoospermic Men, A Prospective Randomized Trial
- ClinicalTrials.gov ID
- NCT07759713
- Acronym / sponsor ID
- 4,799/1/24
- Conditions
- Cryptozoospermia
- Keywords
- cryptozoospermia, Varicoceles, varicocelectomy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 69 participants (actual)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 1 Feb 2024 (actual)
- Primary completion
- 30 Jul 2025 (actual)
- Study completion
- 30 Jul 2025 (actual)
- First posted
- 12 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Patient Information leaflet on varicoceles surgery
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Medical Treatment | No intervention | –Medical treatment |
| Surgical | Experimental | Procedure: Varicoceles ligationVaricoceles surgery |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Male Infertility with cryptozoospermia and clinical varicoceles
Key exclusion criteria (1 listed)
- Genetic abnormalities. Other causes of male infertility
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Varicoceles ligationMicroscopic surgery | Procedure or surgery | Surgical |
Primary outcome
Semen
Time frame: 12 months
Improvement in the semen concentration (measured by million/ml). This will be checked by repeat semen analysis 6 and 12 months in both study groups.
1 secondary outcome
IVF/pregnancy outcomes
Time frame: 12 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Aug 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Cryptozoospermia
RecruitingObservational study
Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in Men
Azoospermia, Nonobstructive, Cryptozoospermia
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Varicoceles ligation in people with Cryptozoospermia, run by Sohag University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Semen (time frame: 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Aug 2026.