Heart Failure With Preserved Ejection Fraction (HFpEF)Phase 3Elevate-HFNCT07761117

A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

A Phase 3 study testing Elecoglipron in people with Heart Failure With Preserved Ejection Fraction (HFpEF) and Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF), run by AstraZeneca at 679 sites in 32 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts

Official record

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Trial summary

This is a Phase III, randomized, double-blind, parallel-group, placebo-controlled, multicenter study to investigate CV outcomes with elecoglipron compared with placebo, in adults with heart failure with preserved ejection fraction (HFpEF)/heart failure with mildly reduced ejection fraction (HFmrEF), irrespective of… Read more about this study

Who is it for?: Ages 18 years and older
Conditions the study is for: Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
What is being tested?: Elecoglipron
Type of treatment: Pill or oral medicine
Could I receive a placebo?: Yes, some participants may receive a placebo
How many people: 6,950 participants
Where: 679 sitesin 32 countries
Study dates: 24 Aug 2026to 3 Sep 2029
Phase: Phase 3
Are there results?: Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 years and older
All sexes
No healthy volunteers
Adult, Older adult

Who may be able to join

Left ventricular ejection fraction (LVEF) of > 40% within 12 months prior to screening.
Structural heart disease evidence.
HF diagnosed with New York Heart Association (NYHA) Class II-IV at the time of screening.

Who cannot join

BMI <25 kg/m² at screening.
Diabetes exclusions:
History of type 1 diabetes.
HbA1c ≥10% at screening.
Currently receiving or anticipated to receive therapeutic intervention for diabetic retinopathy and/or macular edema.
more than 1 episode of severe hypoglycemic event within 180 days prior to screening, or hypoglycemia unawareness/poor recognition.

Show all 16Show fewer

Renal exclusions:
On a prespecified renal replacement therapy, or eGFR below a prespecified threshold at screening
Cardiovascular exclusions:
Major cardiac surgery, coronary revascularization, valvular repair/replacement, AF/AFL ablation, CRT implantation, or ICD without CRT within 90 days prior to screening, or planned after randomization.
Heart failure due to infiltrative cardiomyopathy, active myocarditis, constrictive pericarditis, cardiac tamponade, genetic hypertrophic cardiomyopathy (including obstructive), or arrhythmogenic right ventricular cardiomyopathy/dysplasia.
GI exclusions:
Clinically significant upper GI condition affecting gastric emptying, drug absorption, or safety/tolerability interpretation; chronic use of drugs directly affecting GI motility; severe disease or prior surgery.
History of acute or chronic pancreatitis.
Endocrine exclusions:
History/ family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2, or basal calcitonin ≥35 ng/L at screening.

Trial locations and contacts

679 sites in 32 countries. Contact the study team or a site near you to ask about taking part.

AstraZeneca Clinical Study Information Center contact

1-877-240-9479

information.center@astrazeneca.com

Country

City, postcode or hospital

Sites recruiting now only

679 sites in 32 countries

United States120 sites, 109 recruiting

Research Site
Anchorage, Alaska, 99508
Not yet recruiting
Research Site
Annapolis, Maryland, 21401
Not yet recruiting
Research Site
Arlington, Virginia, 22205
Not yet recruiting
Research Site
Atlanta, Georgia, 30303
Not yet recruiting
Research Site
Baltimore, Maryland, 21229
Not yet recruiting
Research Site
Bethlehem, Pennsylvania, 18015
Withdrawn
Research Site
Beverly Hills, California, 90211
Not yet recruiting
Research Site
Bossier City, Louisiana, 71111
Not yet recruiting
Research Site
Boston, Massachusetts, 02114
Not yet recruiting
Research Site
Boston, Massachusetts, 02118
Not yet recruiting
Research Site
Bradenton, Florida, 34209
Withdrawn
Research Site
Bridgeton, Missouri, 63044
Not yet recruiting
Research Site
Bridgewater, New Jersey, 08807
Not yet recruiting
Research Site
Brooklyn, New York, 11220
Recruiting
Research Site
Buffalo, New York, 14215
Not yet recruiting
Research Site
Burlington, Vermont, 05401
Withdrawn
Research Site
Champaign, Illinois, 61822
Withdrawn
Research Site
Chapel Hill, North Carolina, 27514
Not yet recruiting
Research Site
Chicago, Illinois, 60640
Not yet recruiting
Research Site
Colorado Springs, Colorado, 80909
Not yet recruiting
Research Site
Columbus, Georgia, 31904
Not yet recruiting
Research Site
Columbus, Ohio, 43215
Not yet recruiting
Research Site
Columbus, Ohio, 43228
Withdrawn
Research Site
Covington, Louisiana, 70433
Not yet recruiting
Research Site
Dallas, Texas, 75216
Not yet recruiting
Research Site
Dayton, Ohio, 45435
Not yet recruiting
Research Site
DeSoto, Texas, 75115
Not yet recruiting
Research Site
Durham, North Carolina, 27710
Not yet recruiting
Research Site
East Providence, Rhode Island, 02914
Not yet recruiting
Research Site
El Paso, Texas, 79905
Not yet recruiting
Research Site
Fairhope, Alabama, 36532
Recruiting
Research Site
Fargo, North Dakota, 58104
Not yet recruiting
Research Site
Flint, Michigan, 48503
Recruiting
Research Site
Gilbert, Arizona, 85295
Not yet recruiting
Research Site
Grand Forks, North Dakota, 58201
Not yet recruiting
Research Site
Greensboro, North Carolina, 27401
Not yet recruiting
Research Site
Gurnee, Illinois, 60031
Not yet recruiting
Research Site
Hallandale, Florida, 33009
Not yet recruiting
Research Site
Houston, Texas, 77025
Not yet recruiting
Research Site
Houston, Texas, 77082
Not yet recruiting
Research Site
Humble, Texas, 77338
Recruiting
Research Site
Huntington Beach, California, 92647
Not yet recruiting
Research Site
Huntington Park, California, 90255
Not yet recruiting
Research Site
Indianapolis, Indiana, 46254
Not yet recruiting
Research Site
Jacksonville, Florida, 32209
Not yet recruiting
Research Site
Kansas City, Missouri, 64111
Withdrawn
Research Site
Kansas City, Missouri, 64112
Not yet recruiting
Research Site
Kingwood, West Virginia, 26537
Not yet recruiting
Research Site
Lafayette, Louisiana, 70503
Not yet recruiting
Research Site
Lakeland, Florida, 33813
Not yet recruiting
Research Site
Lanham, Maryland, 20706
Not yet recruiting
Research Site
Leavenworth, Kansas, 66048
Not yet recruiting
Research Site
Lincoln, Nebraska, 68510
Not yet recruiting
Research Site
Loma Linda, California, 92354
Not yet recruiting
Research Site
Lomita, California, 90717
Recruiting
Research Site
Mather, California, 95655
Not yet recruiting
Research Site
Maumee, Ohio, 43537
Not yet recruiting
Research Site
Media, Pennsylvania, 19063
Not yet recruiting
Research Site
Melrose Park, Illinois, 60160
Not yet recruiting
Research Site
Miami, Florida, 33125
Not yet recruiting
Research Site
Miami, Florida, 33144
Not yet recruiting
Research Site
Miami, Florida, 33176
Not yet recruiting
Research Site
Miami Lakes, Florida, 33014
Withdrawn
Research Site
Miami Lakes, Florida, 33016
Recruiting
Research Site
Millville, New Jersey, 08332
Not yet recruiting
Research Site
Moline, Illinois, 61265
Not yet recruiting
Research Site
Morgantown, West Virginia, 26505
Not yet recruiting
Research Site
New Bedford, Massachusetts, 02740
Not yet recruiting
Research Site
New Haven, Connecticut, 06519
Not yet recruiting
Research Site
New Orleans, Louisiana, 70121
Not yet recruiting
Research Site
New York, New York, 10001
Not yet recruiting
Research Site
New York, New York, 10019
Not yet recruiting
Research Site
Niles, Illinois, 60714
Not yet recruiting
Research Site
Northridge, California, 91324
Not yet recruiting
Research Site
Ocala, Florida, 34470
Not yet recruiting
Research Site
Ocoee, Florida, 34761
Withdrawn
Research Site
Oklahoma City, Oklahoma, 73134
Not yet recruiting
Research Site
Owensboro, Kentucky, 42301
Not yet recruiting
Research Site
Oxon Hill, Maryland, 20745
Not yet recruiting
Research Site
Palmetto Bay, Florida, 33157
Not yet recruiting
Research Site
Palo Alto, California, 94304
Not yet recruiting
Research Site
Philadelphia, Pennsylvania, 19104
Not yet recruiting
Research Site
Philadelphia, Pennsylvania, 19107
Not yet recruiting
Research Site
Plano, Texas, 75093
Withdrawn
Research Site
Rapid City, South Dakota, 57701
Not yet recruiting
Research Site
Redding, California, 96001
Not yet recruiting
Research Site
Redmond, Washington, 98052
Recruiting
Research Site
Riverview, Florida, 33578
Not yet recruiting
Research Site
Rockford, Illinois, 61107
Not yet recruiting
Research Site
Rosedale, New York, 11422
Not yet recruiting
Research Site
San Antonio, Texas, 78231
Not yet recruiting
Research Site
San Antonio, Texas, 78257
Not yet recruiting
Research Site
San Diego, California, 92117
Not yet recruiting
Research Site
Schaumburg, Illinois, 60173
Not yet recruiting
Research Site
Sewell, New Jersey, 08080
Not yet recruiting
Research Site
Shreveport, Louisiana, 71105
Not yet recruiting
Research Site
Smithfield, Pennsylvania, 15478
Not yet recruiting
Research Site
Southfield, Michigan, 48075
Not yet recruiting
Research Site
Southfield, Michigan, 48076
Not yet recruiting
Research Site
Spartanburg, South Carolina, 29303
Not yet recruiting
Research Site
Statesville, North Carolina, 28677
Not yet recruiting
Research Site
Sun City, Arizona, 85351
Not yet recruiting
Research Site
Tampa, Florida, 33617
Not yet recruiting
Research Site
Tarzana, California, 91356
Withdrawn
Research Site
The Bronx, New York, 10451
Not yet recruiting
Research Site
The Bronx, New York, 10455
Recruiting
Research Site
Tomball, Texas, 77375
Recruiting
Research Site
Trenton, New Jersey, 08690
Not yet recruiting
Research Site
Troy, Michigan, 48098
Not yet recruiting
Research Site
Tucker, Georgia, 30084
Not yet recruiting
Research Site
Tyler, Texas, 75701
Not yet recruiting
Research Site
Victoria, Texas, 77901
Not yet recruiting
Research Site
Vineland, New Jersey, 08360
Not yet recruiting
Research Site
Waterloo, Iowa, 50701
Not yet recruiting
Research Site
Wichita, Kansas, 67214
Not yet recruiting
Research Site
Wilmington, North Carolina, 28401
Not yet recruiting
Research Site
Winfield, Illinois, 60190
Not yet recruiting
Research Site
Worcester, Massachusetts, 01655
Withdrawn
Research Site
Yardley, Pennsylvania, 19067
Not yet recruiting
Research Site
Zachary, Louisiana, 70791
Not yet recruiting

Other trials in United States

China88 sites, 84 recruiting

Research Site
Baoding, 072750
Not yet recruiting
Research Site
Baotou
Not yet recruiting
Research Site
Beijing, 100000
Not yet recruiting
Research Site
Beijing, 100022
Not yet recruiting
Research Site
Beijing, 100034
Not yet recruiting
Research Site
Beijing, 100037
Not yet recruiting
Research Site
Beijing, 100044
Not yet recruiting
Research Site
Beijing, 100050
Not yet recruiting
Research Site
Beijing, 100053
Not yet recruiting
Research Site
Beijing, 100142
Not yet recruiting
Research Site
Beijing, 102218
Not yet recruiting
Research Site
Beijing
Not yet recruiting
Research Site
Bozhou, 236000
Not yet recruiting
Research Site
Changchun, 130021
Not yet recruiting
Research Site
Changchun, 130033
Not yet recruiting
Research Site
Changchun, 130041
Not yet recruiting
Research Site
Changde, 415000
Withdrawn
Research Site
Changsha, 410300
Withdrawn
Research Site
Chengdu, 610031
Not yet recruiting
Research Site
Chengdu, 610041
Not yet recruiting
Research Site
Chengdu, 610078
Not yet recruiting
Research Site
Chifeng, 024000
Not yet recruiting
Research Site
Daqing, 163000
Not yet recruiting
Research Site
Foshan, 528308
Not yet recruiting
Research Site
Guangzhou, 510000
Not yet recruiting
Research Site
Guangzhou, 510289
Not yet recruiting
Research Site
Haikou, 570311
Not yet recruiting
Research Site
Hefei, 230601
Not yet recruiting
Research Site
Heze, 274099
Not yet recruiting
Research Site
Huaian, 223300
Not yet recruiting
Research Site
Huizhou, 516002
Not yet recruiting
Research Site
Jiangmen, 529000
Not yet recruiting
Research Site
Jinan, 250012
Not yet recruiting
Research Site
Jinan, 250031
Not yet recruiting
Research Site
Jining, 272006
Not yet recruiting
Research Site
Lanzhou, 730000
Not yet recruiting
Research Site
Linhai, 317000
Not yet recruiting
Research Site
Lishui, 323000
Not yet recruiting
Research Site
Luoyang, 471001
Not yet recruiting
Research Site
Nanchang, 330009
Not yet recruiting
Research Site
Nanjing, 2100008
Not yet recruiting
Research Site
Nanjing, 210009
Not yet recruiting
Research Site
Nanjing, 210011
Not yet recruiting
Research Site
Nanyang, 473000
Not yet recruiting
Research Site
Ningbo, 315000
Not yet recruiting
Research Site
Panjin, 124009
Not yet recruiting
Research Site
Pingxiang, 337055
Not yet recruiting
Research Site
Qingzhou, 262550
Not yet recruiting
Research Site
Sanya, 572000
Not yet recruiting
Research Site
Shanghai, 200090
Not yet recruiting
Research Site
Shanghai, 200135
Not yet recruiting
Research Site
Shanghai, 201107
Not yet recruiting
Research Site
Shanghai, 201199
Not yet recruiting
Research Site
Shantou, 515041
Not yet recruiting
Research Site
Shaoguan, 512027
Not yet recruiting
Research Site
Shaoxing, 312000
Not yet recruiting
Research Site
Shenyang, 110016
Not yet recruiting
Research Site
Shenzhen, 518053
Not yet recruiting
Research Site
Siping, 136000
Not yet recruiting
Research Site
Suining, 629000
Not yet recruiting
Research Site
Suzhou, 215004
Not yet recruiting
Research Site
Suzhou, 215006
Not yet recruiting
Research Site
Taian, 271099
Not yet recruiting
Research Site
Tianjin, 300000
Not yet recruiting
Research Site
Tianjin, 300050
Withdrawn
Research Site
Ürümqi, 830001
Not yet recruiting
Research Site
Wanzhou, 404000
Not yet recruiting
Research Site
Weifang, 261000
Not yet recruiting
Research Site
Wenzhou, 325000
Not yet recruiting
Research Site
Wuhan, 430000
Not yet recruiting
Research Site
Wuhan, 430033
Not yet recruiting
Research Site
Wuxi, 214023
Not yet recruiting
Research Site
Xi'an, 710061
Not yet recruiting
Research Site
Xi'an, 710068
Not yet recruiting
Research Site
Xiangtan, 411100
Not yet recruiting
Research Site
Xuzhou, 221000
Not yet recruiting
Research Site
Xuzhou, 221009
Not yet recruiting
Research Site
Yancheng, 224005
Not yet recruiting
Research Site
Yangzhou, 225001
Not yet recruiting
Research Site
Yueyang, 414000
Not yet recruiting
Research Site
Yuncheng, 044099
Not yet recruiting
Research Site
Zhangjiakou, 075061
Not yet recruiting
Research Site
Zhengzhou, 450002
Withdrawn
Research Site
Zhengzhou, 450007
Not yet recruiting
Research Site
Zhengzhou, 450052
Not yet recruiting
Research Site
Zibo, 255036
Not yet recruiting
Research Site
Zigong, 643021
Not yet recruiting
Research Site
Zunyi, 563100
Not yet recruiting

Other trials in China

Japan61 sites, 59 recruiting

Research Site
Aomori, 030-8553
Not yet recruiting
Research Site
Chikushino-shi, 818-8516
Not yet recruiting
Research Site
Chūōku, 103-0027
Not yet recruiting
Research Site
Fukui-shi, 910-8526
Not yet recruiting
Research Site
Fukushima, 960-1295
Not yet recruiting
Research Site
Higashiibaraki-gun, 311-3193
Not yet recruiting
Research Site
Higashiohmi-shi, 527-8505
Not yet recruiting
Research Site
Iwakuni-shi, 740-8510
Not yet recruiting
Research Site
Kagoshima, 890-8760
Not yet recruiting
Research Site
Kamakura-shi, 247-8533
Not yet recruiting
Research Site
Kanazawa, 920-8650
Not yet recruiting
Research Site
Kashihara-shi, 634-8522
Not yet recruiting
Research Site
Kasugai-shi, 486-8510
Recruiting
Research Site
Kawagoe-shi, 350-8550
Not yet recruiting
Research Site
Kishiwada-shi, 596-0042
Not yet recruiting
Research Site
Kitakyusyu-shi, 806-8501
Not yet recruiting
Research Site
Kobe, 650-0017
Not yet recruiting
Research Site
Kobe, 650-0047
Not yet recruiting
Research Site
Kobe, 654-0081
Not yet recruiting
Research Site
Kobe, 654-0155
Not yet recruiting
Research Site
Kure-shi, 737-0193
Not yet recruiting
Research Site
Kyoto, 604-8845
Not yet recruiting
Research Site
Kyoto, 605-0981
Not yet recruiting
Research Site
Maebashi, 371-8511
Not yet recruiting
Research Site
Matsusaka-shi, 515-8557
Not yet recruiting
Research Site
Minatoku, 108-0073
Not yet recruiting
Research Site
Mito, 311-4198
Recruiting
Research Site
Morioka, 020-0066
Not yet recruiting
Research Site
Nagasaki, 851-0301
Not yet recruiting
Research Site
Nagoya, 454-8502
Not yet recruiting
Research Site
Nagoya, 466-8560
Not yet recruiting
Research Site
Nagoya, 467-8602
Not yet recruiting
Research Site
Ōmihachiman, 523-0082
Not yet recruiting
Research Site
Osaka, 558-8558
Withdrawn
Research Site
Sagamihara-shi, 252-0315
Not yet recruiting
Research Site
Sapporo, 003-0026
Recruiting
Research Site
Sayama-shi,, 350-1305
Not yet recruiting
Research Site
Sendai, 981-3133
Not yet recruiting
Research Site
Shibuya-ku, 150-0013
Not yet recruiting
Research Site
Shizuoka, 420-8527
Withdrawn
Research Site
Shizuoka, 420-8630
Not yet recruiting
Research Site
Suginami City, 168-0065
Not yet recruiting
Research Site
Suita, 565-0862
Not yet recruiting
Research Site
Suzuka-shi, 513-8630
Not yet recruiting
Research Site
Tachikawa-shi, 190-8531
Not yet recruiting
Research Site
Takaoka-shi, 933-8555
Not yet recruiting
Research Site
Takatsuki-shi, 569-8686
Not yet recruiting
Research Site
Tokushima, 770-8503
Not yet recruiting
Research Site
Toshima-ku, 171-0014
Not yet recruiting
Research Site
Toyama, 930-8550
Not yet recruiting
Research Site
Ueda-shi, 386-8610
Not yet recruiting
Research Site
Urasoe-Shi, 901-2102
Not yet recruiting
Research Site
Urayasu-shi, 279-0021
Not yet recruiting
Research Site
Uruma, 904-2293
Not yet recruiting
Research Site
Utsunomiya, 320-8580
Not yet recruiting
Research Site
Wakayama, 640-8158
Not yet recruiting
Research Site
Yakushi, 581-0011
Not yet recruiting
Research Site
Yokohama, 224-8503
Not yet recruiting
Research Site
Yokohama, 231-8682
Not yet recruiting
Research Site
Yokohama, 236-0004
Not yet recruiting
Research Site
Yokohama, 236-0037
Not yet recruiting

Other trials in Japan

Germany45 sites, 42 recruiting

Research Site
Bad Oldesloe, 23843
Not yet recruiting
Research Site
Bamberg, 96049
Not yet recruiting
Research Site
Berlin, 13187
Withdrawn
Research Site
Berlin, 13405
Not yet recruiting
Research Site
Berlin, 13509
Not yet recruiting
Research Site
Bielefeld, 33604
Not yet recruiting
Research Site
Bochum, 44789
Not yet recruiting
Research Site
Bremen, 28277
Not yet recruiting
Research Site
Chemnitz, 09116
Not yet recruiting
Research Site
Cologne, 50733
Not yet recruiting
Research Site
Dresden, 1307
Not yet recruiting
Research Site
Elsterwerda, 04910
Not yet recruiting
Research Site
Erlangen, 91504
Not yet recruiting
Research Site
Essen, 45147
Not yet recruiting
Research Site
Freiburg im Breisgau, 79106
Not yet recruiting
Research Site
Gera, 07548
Not yet recruiting
Research Site
Giessen, 35394
Not yet recruiting
Research Site
Hamburg, 20099
Not yet recruiting
Research Site
Hamburg, 21075
Not yet recruiting
Research Site
Hamburg, 22459
Recruiting
Research Site
Hamburg, 22559
Not yet recruiting
Research Site
Heidelberg, 69120
Not yet recruiting
Research Site
Homburg, 66424
Not yet recruiting
Research Site
Jena, 07747
Not yet recruiting
Research Site
Kaiserslautern, 67655
Not yet recruiting
Research Site
Karlsbad, 76307
Not yet recruiting
Research Site
Kiel, 24105
Not yet recruiting
Research Site
Ludwigshafen, 67063
Not yet recruiting
Research Site
Ludwigshafen am Rhein, 67071
Not yet recruiting
Research Site
Lüneburg, 21339
Recruiting
Research Site
Magdeburg, 39120
Not yet recruiting
Research Site
Mainz, 55122
Recruiting
Research Site
Mainz, 55131
Not yet recruiting
Research Site
Markkleeberg, 04416
Suspended
Research Site
Mühldorf A. Inn, 84453
Not yet recruiting
Research Site
Neuruppin, 16816
Not yet recruiting
Research Site
Nuremberg, 90402
Not yet recruiting
Research Site
Obertshausen, 63179
Not yet recruiting
Research Site
Paderborn, 33098
Not yet recruiting
Research Site
Papenburg, 26871
Suspended
Research Site
Stuttgart, 70199
Not yet recruiting
Research Site
Trier, 54292
Not yet recruiting
Research Site
Tübingen, 72076
Not yet recruiting
Research Site
Ulm, 89077
Not yet recruiting
Research Site
Weyhe, 28844
Not yet recruiting

Other trials in Germany

Canada21 sites, 18 recruiting

Research Site
Barrie, Ontario, L4M 6M2
Not yet recruiting
Research Site
Etobicoke, Ontario, M8Z 4E4
Not yet recruiting
Research Site
Greater Sudbury, Ontario, P3E 5J1
Not yet recruiting
Research Site
Hamilton, Ontario, L8L 5G4
Not yet recruiting
Research Site
Kingston, Ontario, K7M 7E4
Recruiting
Research Site
London, Ontario, N6A 5A5
Not yet recruiting
Research Site
London, Ontario, N6A 5W9
Withdrawn
Research Site
Markham, Ontario, L3P 7P3
Not yet recruiting
Research Site
Markham, Ontario, L3S 0A2
Not yet recruiting
Research Site
Montreal, Quebec, H4A 3J1
Not yet recruiting
Research Site
Newmarket, Ontario, L3Y 2P6
Recruiting
Research Site
North York, Ontario, M6B 3H7
Recruiting
Research Site
North York, Ontario, M9N 1W4
Withdrawn
Research Site
Oakville, Ontario, L6K 3W7
Recruiting
Research Site
Ottawa, Ontario, K1Y 4W7
Not yet recruiting
Research Site
Stoney Creek, Ontario, L8J 3W2
Recruiting
Research Site
Thunder Bay, Ontario, P7B 5N3
Withdrawn
Research Site
Thunder Bay, Ontario, P7B 5N3
Not yet recruiting
Research Site
Toronto, Ontario, M4N 3M5
Not yet recruiting
Research Site
Toronto, Ontario, M6G 1M2
Not yet recruiting
Research Site
Trois-Rivières, Quebec, G8Z 3R9
Not yet recruiting

Other trials in Canada

Czechia20 sites, 16 recruiting

Research Site
Benešov, 256 01
Not yet recruiting
Research Site
Boskovice, 680 01
Not yet recruiting
Research Site
Brno, 60200
Not yet recruiting
Research Site
Broumov, 55001
Not yet recruiting
Research Site
Česká Lípa, 470 77
Withdrawn
Research Site
Český Krumlov, 381 01
Not yet recruiting
Research Site
Chlumec nad Cidlinou, 503 51
Withdrawn
Research Site
Hradec Králové, 500 02
Not yet recruiting
Research Site
Hustopeče, 693 01
Not yet recruiting
Research Site
Jaroměř, 551 01
Not yet recruiting
Research Site
Kadaň, 432 01
Withdrawn
Research Site
Klatovy, 339 01
Not yet recruiting
Research Site
Liberec, 460 01
Not yet recruiting
Research Site
Louny, 440 01
Not yet recruiting
Research Site
Prague, 130 00
Not yet recruiting
Research Site
Prague, 150 00
Withdrawn
Research Site
Prague, 150 00
Not yet recruiting
Research Site
Prague, 198 00
Not yet recruiting
Research Site
Teplice, 415 01
Not yet recruiting
Research Site
Vsetín, 755 01
Not yet recruiting

Other trials in Czechia

India20 sites, 20 recruiting

Research Site
Belagavi, 590010
Not yet recruiting
Research Site
Calicut, 673008
Not yet recruiting
Research Site
Coimbatore, 641018
Not yet recruiting
Research Site
Dehradun, 248001
Not yet recruiting
Research Site
Delhi, 110029
Not yet recruiting
Research Site
Delhi, 110062
Not yet recruiting
Research Site
Hyderabad, 500035
Not yet recruiting
Research Site
Jaipur, 302017
Not yet recruiting
Research Site
Kanpur, 208001
Not yet recruiting
Research Site
Kochi, 682018
Not yet recruiting
Research Site
Kochi, 682040
Not yet recruiting
Research Site
Kolkata, 700014
Not yet recruiting
Research Site
Kolkata, 700020
Not yet recruiting
Research Site
Ludhiana, 141001
Not yet recruiting
Research Site
Meerut, 250005
Not yet recruiting
Research Site
Mumbai, 400012
Not yet recruiting
Research Site
Nagpur, 441108
Not yet recruiting
Research Site
New Delhi, 110017
Not yet recruiting
Research Site
Rudrapur, 263153
Not yet recruiting
Research Site
Vadodara, 390002
Not yet recruiting

Other trials in India

Poland20 sites, 19 recruiting

Research Site
Bialystok, 15-375
Not yet recruiting
Research Site
Bialystok, 15-481
Not yet recruiting
Research Site
Częstochowa, 42-217
Not yet recruiting
Research Site
Gdynia, 81-157
Not yet recruiting
Research Site
Gdynia, 81-338
Not yet recruiting
Research Site
Katowice, 40-600
Not yet recruiting
Research Site
Katowice, 40-635
Not yet recruiting
Research Site
Krakow, 30-082
Suspended
Research Site
Krakow, 30-901
Not yet recruiting
Research Site
Krakow, 31-271
Not yet recruiting
Research Site
Poznan, 61-848
Not yet recruiting
Research Site
Przemyśl, 37-700
Not yet recruiting
Research Site
Radzionków, 41-922
Not yet recruiting
Research Site
Skórzewo, 60-185
Not yet recruiting
Research Site
Szczecin, 71-526
Recruiting
Research Site
Torun, 87-100
Not yet recruiting
Research Site
Warsaw, 02-758
Recruiting
Research Site
Warsaw, 04-628
Not yet recruiting
Research Site
Włocławek, 87-800
Not yet recruiting
Research Site
Wroclaw, 50-981
Not yet recruiting

Other trials in Poland

Argentina17 sites, 17 recruiting

Research Site
Buenos Aires, C1425AGC
Not yet recruiting
Research Site
CABA, C1061
Not yet recruiting
Research Site
Ciudad de Buenos Aires, 1060
Not yet recruiting
Research Site
Ciudad de Buenos Aires, C1428
Not yet recruiting
Research Site
Córdoba, 5000
Not yet recruiting
Research Site
Córdoba, X5003DCE
Not yet recruiting
Research Site
Córdoba, X5006CBI
Not yet recruiting
Research Site
Corrientes, 3400
Not yet recruiting
Research Site
Esperanza, S3080BQU
Not yet recruiting
Research Site
Granadero Baigorria, S2152BOF
Not yet recruiting
Research Site
Lanus, B1824KAJ
Not yet recruiting
Research Site
Mar del Plata, B7600GNY
Not yet recruiting
Research Site
Mendoza, 5500
Not yet recruiting
Research Site
Rosario, S2000CVD
Not yet recruiting
Research Site
Rosario, S2000PBJ
Not yet recruiting
Research Site
San Nicolás, B2900ACL
Not yet recruiting
Research Site
Santa Fe, S3000FWO
Not yet recruiting

Other trials in Argentina

South Korea17 sites, 17 recruiting

Research Site
Busan, 49201
Not yet recruiting
Research Site
Busan, 49267
Not yet recruiting
Research Site
Daegu, 42601
Not yet recruiting
Research Site
Daejeon, 35015
Not yet recruiting
Research Site
Gwangju, 61469
Not yet recruiting
Research Site
Gyeonggi-do, 13620
Not yet recruiting
Research Site
Incheon, 21431
Not yet recruiting
Research Site
Incheon, 22332
Not yet recruiting
Research Site
Seongbuk-Gu, 02841
Not yet recruiting
Research Site
Seoul, 04763
Not yet recruiting
Research Site
Seoul, 05278
Not yet recruiting
Research Site
Seoul, 06591
Not yet recruiting
Research Site
Seoul, 3722
Not yet recruiting
Research Site
Seoul, 5505
Not yet recruiting
Research Site
Suwon, 16499
Not yet recruiting
Research Site
Uijeongbu-si, 11765
Not yet recruiting
Research Site
Yangsan, 50612
Not yet recruiting

Other trials in South Korea

United Kingdom16 sites, 16 recruiting

Research Site
Ashton-under-Lyne, OL6 6EW
Not yet recruiting
Research Site
Basildon, SS16 5NL
Not yet recruiting
Research Site
Belfast, BT16 1RH
Not yet recruiting
Research Site
Birmingham, B75 7RR
Not yet recruiting
Research Site
Brighton, BN2 5BE
Not yet recruiting
Research Site
Bristol, BS34 5TF
Not yet recruiting
Research Site
Cardiff, CF14 4XW
Not yet recruiting
Research Site
Clydebank, G81 4DY
Not yet recruiting
Research Site
Dundee, DD1 9SY
Not yet recruiting
Research Site
Glasgow, G51 4TF
Not yet recruiting
Research Site
Kings Lynn, PE30 4ET
Recruiting
Research Site
Leeds, LS1 3EX
Not yet recruiting
Research Site
London, EC1M 6BQ
Recruiting
Research Site
Sandbach, CW11 1EQ
Not yet recruiting
Research Site
Southampton, SO303JB
Not yet recruiting
Research Site
Woodbridge, IP136TH
Not yet recruiting

Other trials in United Kingdom

Bulgaria15 sites, 15 recruiting

Research Site
Blagoevgrad, 2700
Not yet recruiting
Research Site
Dupnitsa, 2600
Not yet recruiting
Research Site
Haskovo, 6300
Not yet recruiting
Research Site
Haskovo, 6304
Not yet recruiting
Research Site
Plovdiv, 4000
Not yet recruiting
Research Site
Plovdiv, 4023
Not yet recruiting
Research Site
Sliven, 8800
Not yet recruiting
Research Site
Sofia, 1000
Not yet recruiting
Research Site
Sofia, 1309
Not yet recruiting
Research Site
Sofia, 1404
Not yet recruiting
Research Site
Sofia, 1527
Not yet recruiting
Research Site
Sofia, 1618
Not yet recruiting
Research Site
Sofia, 1680
Not yet recruiting
Research Site
Sofia, 1756
Not yet recruiting
Research Site
Varna, 9000
Not yet recruiting

Other trials in Bulgaria

Austria14 sites, 14 recruiting

Research Site
Bad Ischl, 4820
Not yet recruiting
Research Site
Feldkirch, 6800
Not yet recruiting
Research Site
Graz, 8020
Not yet recruiting
Research Site
Graz, 8036
Not yet recruiting
Research Site
Innsbruck, 6020
Not yet recruiting
Research Site
Klagenfurt, 9020
Not yet recruiting
Research Site
Linz, 4021
Not yet recruiting
Research Site
Saint Stefan/Stainz, 8511
Not yet recruiting
Research Site
Sankt Pölten, 3100
Not yet recruiting
Research Site
Vienna, 1090
Not yet recruiting
Research Site
Vienna, 1100
Not yet recruiting
Research Site
Vienna, 1160
Not yet recruiting
Research Site
Vienna, 1210
Not yet recruiting
Research Site
Wels, 4600
Not yet recruiting

Other trials in Austria

Brazil14 sites, 13 recruiting

Research Site
Aracaju, 49055-530
Not yet recruiting
Research Site
Belém, 66073-005
Not yet recruiting
Research Site
Bragança Paulista, 12916-542
Not yet recruiting
Research Site
Brasília, 70390-700
Not yet recruiting
Research Site
Campinas, 13060-080
Not yet recruiting
Research Site
Curitiba, 80230-130
Not yet recruiting
Research Site
Joinville, 89204-251
Not yet recruiting
Research Site
Natal, 59020-500
Not yet recruiting
Research Site
Porto Alegre, 90410-000
Not yet recruiting
Research Site
Porto Alegre, 91350-280
Not yet recruiting
Research Site
Ribeirão Preto, 14051-140
Not yet recruiting
Research Site
Rio Branco, 69915-030
Not yet recruiting
Research Site
Rio de Janeiro, 22270-060
Not yet recruiting
Research Site
São Paulo, 04012-180
Withdrawn

Other trials in Brazil

Spain14 sites, 14 recruiting

Research Site
Barcelona, 08003
Not yet recruiting
Research Site
Barcelona, 08035
Not yet recruiting
Research Site
Barcelona, 08036
Not yet recruiting
Research Site
Jaén, 23007
Not yet recruiting
Research Site
Madrid, 28034
Not yet recruiting
Research Site
Madrid, 28041
Not yet recruiting
Research Site
Murcia, 30120
Not yet recruiting
Research Site
Salamanca, 37007
Not yet recruiting
Research Site
Sanlúcar de Barrameda (Cádiz), 11540
Not yet recruiting
Research Site
Seville, 41013
Not yet recruiting
Research Site
Valencia, 46010
Not yet recruiting
Research Site
Valencia, 46014
Not yet recruiting
Research Site
Valencia, 46026
Not yet recruiting
Research Site
Villamartín, 11650
Not yet recruiting

Other trials in Spain

Taiwan14 sites, 13 recruiting

Research Site
Kaohsiung City, 80756
Not yet recruiting
Research Site
New Taipei City, 220
Not yet recruiting
Research Site
New Taipei City, 231
Not yet recruiting
Research Site
Taichung, 40201
Not yet recruiting
Research Site
Taichung, 40705
Not yet recruiting
Research Site
Taichung, 433004
Not yet recruiting
Research Site
Taipei, 10002
Not yet recruiting
Research Site
Taipei, 10449
Not yet recruiting
Research Site
Taipei, 110
Withdrawn
Research Site
Taipei, 11101
Not yet recruiting
Research Site
Taipei, 11217
Not yet recruiting
Research Site
Taipei, 11490
Not yet recruiting
Research Site
Taoyuan, 333
Not yet recruiting
Research Site
Yilan, 260
Not yet recruiting

Other trials in Taiwan

France13 sites, 13 recruiting

Research Site
Bron, 69500
Not yet recruiting
Research Site
Corbeil-Essonnes, 91100
Not yet recruiting
Research Site
La Tronche, 38043
Not yet recruiting
Research Site
Le Coudray, 28630
Not yet recruiting
Research Site
Lens, 62300
Not yet recruiting
Research Site
Metz-Tessy, 74370
Not yet recruiting
Research Site
Pau, 6400
Not yet recruiting
Research Site
Rennes, 35033
Not yet recruiting
Research Site
Rodez, 12000
Not yet recruiting
Research Site
Rouen, 76031
Not yet recruiting
Research Site
Saint-Brieuc, 22027
Not yet recruiting
Research Site
Toulon, 83100
Not yet recruiting
Research Site
Vandœuvre-lès-Nancy, 54500
Not yet recruiting

Other trials in France

Hungary12 sites, 12 recruiting

Research Site
Balatonfüred, 8230
Not yet recruiting
Research Site
Budapest, 1122
Not yet recruiting
Research Site
Budapest, 1132
Not yet recruiting
Research Site
Budapest, 1134
Not yet recruiting
Research Site
Dunaújváros, 2400
Not yet recruiting
Research Site
Kaposvár, 7400
Not yet recruiting
Research Site
Miskolc, 3530
Not yet recruiting
Research Site
Nyíregyháza, 4400
Not yet recruiting
Research Site
Orosháza, 5900
Not yet recruiting
Research Site
Szeged, 6725
Not yet recruiting
Research Site
Szombathely, 9700
Not yet recruiting
Research Site
Zalaegerszeg, 8900
Not yet recruiting

Other trials in Hungary

Slovakia12 sites, 11 recruiting

Research Site
Bratislava, 82107
Not yet recruiting
Research Site
Bratislava, 83101
Withdrawn
Research Site
Bratislava, 83101
Not yet recruiting
Research Site
Brezno, 977 01
Not yet recruiting
Research Site
Košice, 04001
Not yet recruiting
Research Site
Košice, 04022
Not yet recruiting
Research Site
Lučenec, 984 01
Not yet recruiting
Research Site
Lučenec, 98401
Not yet recruiting
Research Site
Nitra, 949 11
Not yet recruiting
Research Site
Prešov, 08001
Not yet recruiting
Research Site
Šahy, 93601
Not yet recruiting
Research Site
Svidník, 08901
Not yet recruiting

Other trials in Slovakia

Turkey (Türkiye)12 sites, 11 recruiting

Research Site
Adana, 01330
Not yet recruiting
Research Site
Ankara, 06530
Not yet recruiting
Research Site
Antalya, 07100
Not yet recruiting
Research Site
Center, 23200
Not yet recruiting
Research Site
Center, 78200
Not yet recruiting
Research Site
Istanbul, 34300
Not yet recruiting
Research Site
Izmir, 35330
Not yet recruiting
Research Site
Kahramanmaraş, 46100
Withdrawn
Research Site
Kütahya, 43100
Not yet recruiting
Research Site
Odunpazari, 26040
Not yet recruiting
Research Site
Odunpazari, 26080
Not yet recruiting
Research Site
Yenimahalle, 06170
Not yet recruiting

Other trials in Turkey (Türkiye)

Ukraine12 sites, 12 recruiting

Research Site
Kyiv, 01601
Not yet recruiting
Research Site
Kyiv, 02002
Not yet recruiting
Research Site
Kyiv, 03037
Not yet recruiting
Research Site
Kyiv, 03049
Not yet recruiting
Research Site
Kyiv, 03057
Not yet recruiting
Research Site
Kyiv, 03151
Not yet recruiting
Research Site
Kyiv, 04050
Not yet recruiting
Research Site
Kyiv, 04114
Not yet recruiting
Research Site
Kyiv, 04210
Not yet recruiting
Research Site
Lviv, 79016
Not yet recruiting
Research Site
Uzhhorod, 88002
Not yet recruiting
Research Site
Uzhhorod, 88014
Not yet recruiting

Other trials in Ukraine

Malaysia11 sites, 11 recruiting

Research Site
Alor Star, 05460
Not yet recruiting
Research Site
Cheras, 56000
Not yet recruiting
Research Site
Kajang, 43000
Not yet recruiting
Research Site
Kuala Lumpur, 50400
Not yet recruiting
Research Site
Kuala Lumpur, 50586
Not yet recruiting
Research Site
Kuala Lumpur, 59100
Not yet recruiting
Research Site
Kuala Terengganu, 20400
Not yet recruiting
Research Site
Kuantan, 25100
Not yet recruiting
Research Site
Kuching, 93586
Not yet recruiting
Research Site
Miri, 98000
Not yet recruiting
Research Site
Sungai Buloh, 47000
Not yet recruiting

Other trials in Malaysia

Mexico11 sites, 10 recruiting

Research Site
Guadalajara, 44676
Not yet recruiting
Research Site
México, 06090
Not yet recruiting
Research Site
México, 14080
Not yet recruiting
Research Site
Monterrey, 64030
Not yet recruiting
Research Site
Monterrey, 64060
Not yet recruiting
Research Site
Monterrey, 64460
Not yet recruiting
Research Site
Querétaro, 76000
Not yet recruiting
Research Site
San Luis Potosí City, 78200
Not yet recruiting
Research Site
Tijuana, 22150
Withdrawn
Research Site
Xalapa, 91193
Not yet recruiting
Research Site
Zapopan, 45070
Not yet recruiting

Other trials in Mexico

Netherlands11 sites, 11 recruiting

Research Site
Alkmaar, 1815 JD
Not yet recruiting
Research Site
Almere Stad, 1315 RA
Not yet recruiting
Research Site
Amstelveen, 1186 AM
Not yet recruiting
Research Site
Doetinchem, 7009 BL
Not yet recruiting
Research Site
Leeuwarden, 8934 AD
Not yet recruiting
Research Site
Rotterdam, 3015
Not yet recruiting
Research Site
Sneek, 8601 ZR
Not yet recruiting
Research Site
The Hague, 2545 AA
Not yet recruiting
Research Site
Tilburg, 5042 AD
Not yet recruiting
Research Site
Zutphens, 7207 AE
Not yet recruiting
Research Site
Zwolle, 8025 AB
Not yet recruiting

Other trials in Netherlands

Sweden11 sites, 10 recruiting

Research Site
Gothenburg, 416 85
Not yet recruiting
Research Site
Jönköping, 553 05
Not yet recruiting
Research Site
Karlstad, 651 85
Not yet recruiting
Research Site
Lund, 222 21
Not yet recruiting
Research Site
Mölndal, SE431 80
Not yet recruiting
Research Site
Örebro, 701 85
Not yet recruiting
Research Site
Stockholm, 112 19
Not yet recruiting
Research Site
Stockholm, 113 61
Not yet recruiting
Research Site
Stockholm, 118 83
Withdrawn
Research Site
Stockholm, 171 64
Not yet recruiting
Research Site
Uppsala, 751 85
Not yet recruiting

Other trials in Sweden

Greece10 sites, 10 recruiting

Research Site
Athens, 11521
Not yet recruiting
Research Site
Athens, 11526
Not yet recruiting
Research Site
Athens, 11527
Not yet recruiting
Research Site
Athens, 11528
Not yet recruiting
Research Site
Athens, 15123
Not yet recruiting
Research Site
Dragana, 68100
Not yet recruiting
Research Site
Heraklio, 71110
Not yet recruiting
Research Site
Heraklion, 71409
Not yet recruiting
Research Site
Thessaloniki, 54636
Not yet recruiting
Research Site
Voula, 16673
Not yet recruiting

Other trials in Greece

Italy10 sites, 10 recruiting

Research Site
Ancona, 60100
Not yet recruiting
Research Site
Bergamo, 24127
Not yet recruiting
Research Site
Brescia, 25123
Not yet recruiting
Research Site
Milan, 20132
Not yet recruiting
Research Site
Pavia, 27100
Not yet recruiting
Research Site
Perugia, 06132
Not yet recruiting
Research Site
Riccione, 47838
Not yet recruiting
Research Site
Salerno, 84131
Not yet recruiting
Research Site
Sesto San Giovanni, 20099
Not yet recruiting
Research Site
Vizzolo Predabissi, 20070
Not yet recruiting

Other trials in Italy

Romania10 sites, 10 recruiting

Research Site
Baia Mare, 430124
Not yet recruiting
Research Site
Brasov, 500102
Not yet recruiting
Research Site
Bucharest, 031441
Not yet recruiting
Research Site
Bucharest, 050098
Not yet recruiting
Research Site
Bucharest, 050659
Not yet recruiting
Research Site
Craiova, 200505
Not yet recruiting
Research Site
Satu Mare, 440055
Not yet recruiting
Research Site
Timișoara, 300002
Not yet recruiting
Research Site
Timișoara, 300024
Not yet recruiting
Research Site
Timișoara, 300362
Not yet recruiting

Other trials in Romania

Thailand10 sites, 10 recruiting

Research Site
Bangkok, 10300
Not yet recruiting
Research Site
Bangkok, 10330
Not yet recruiting
Research Site
Bangkok, 10700
Not yet recruiting
Research Site
Changwat Sara Buri, 18000
Not yet recruiting
Research Site
Chiang Mai, 50200
Not yet recruiting
Research Site
Hat Yai, 90110
Not yet recruiting
Research Site
Khlong Luang, 12120
Not yet recruiting
Research Site
Khon Kaen, 40002
Not yet recruiting
Research Site
Phitsanulok, 65000
Not yet recruiting
Research Site
Ratchaburi, 70000
Not yet recruiting

Other trials in Thailand

Vietnam8 sites, 7 recruiting

Research Site
Can Tho, 900000
Not yet recruiting
Research Site
Hà Nội, 100000
Not yet recruiting
Research Site
Hanoi, 100000
Not yet recruiting
Research Site
Ho Chi Minh City, 700000
Not yet recruiting
Research Site
Ho Chi Minh City, 700000
Withdrawn
Research Site
Ho Chi Minh City, 70000
Not yet recruiting
Research Site
Hochiminh, 700000
Not yet recruiting
Research Site
Hochiminh City, 700000
Not yet recruiting

Other trials in Vietnam

Australia7 sites, 7 recruiting

Research Site
Blacktown, 2148
Not yet recruiting
Research Site
Campbelltown, 2560
Not yet recruiting
Research Site
Frankston, 3199
Not yet recruiting
Research Site
Hoppers Crossing, 3029
Not yet recruiting
Research Site
North Tamworth, 2340
Not yet recruiting
Research Site
Rockhampton, 4700
Not yet recruiting
Research Site
Wollongong, 2500
Not yet recruiting

Other trials in Australia

United Arab Emirates3 sites, 3 recruiting

Research Site
Abo Dhabi, 20011
Not yet recruiting
Research Site
Abu Dhabi, 11001
Not yet recruiting
Research Site
Abu Dhabi, 48481
Not yet recruiting

Other trials in United Arab Emirates

About this study

Official title: A Phase III, Randomized, Double-blind, Parallel-group, Placebo-controlled, Multicenter Study to Evaluate the Effect of Elecoglipron in Reducing Cardiovascular Outcomes in Participants With HFpEF and HFmrEF (Elevate-HF)

Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
Being tested: Elecoglipron, Placebo
Keywords: Heart failure, Elecoglipron
Medical subject headings: Heart Failure

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

ElecoglipronDrug
Elecoglipron tablet
PlaceboDrug
Placebo tablet

Study groups in NCT07761117
Study group	Role	What they receive
Elecoglipron	Experimental	Elecoglipron tablet once daily Receives: Drug: Elecoglipron
Placebo	Active comparator	Placebo matching Elecoglipron tablet once daily Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

To evaluate the effect of elecoglipron compared with placebo in reducing the risk of CV death or HHF/urgent HF visit
Time to first event of the composite of:
- CV death
- HHF
- Urgent HF visit
Measured: Up to 42 months

Secondary outcomes (3)

To evaluate the effect of elecoglipron compared with placebo in reducing the rate of HF events (HHF or urgent HF visit)
Total occurrences (first and recurrent) of HF events
- HHF
- Urgent HF visit
Measured: Up to 42 months
To evaluate the effect of elecoglipron compared to placebo on improving patient-reported outcomes using a questionnaire.
Change from baseline to Week 52
Measured: Baseline and 52 weeks
To evaluate the effect of elecoglipron compared with placebo in reducing the risk of the 4-point composite of all-cause death, HHF, MI, or stroke
Time to first event of the composite of:
- All-cause death
- HHF
- MI
- Stroke
Measured: Up to 42 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

24 Aug 20263 Sep 2029

First posted12 Aug 2026
Study start24 Aug 2026
Primary completion3 Sep 2029 (estimated)
Study completion3 Sep 2029 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Heart Failure With Preserved Ejection Fraction (HFpEF)Studies of the same condition, open and under way.
More trials run by AstraZenecaThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase 3
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Quadruple blind
Who is masked: Participant, Care provider, Investigator, Outcomes assessor
Enrolment: 6,950 participants (estimated)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07761117
Sponsor's protocol ID: D7266C00001
Other IDs: 2026-526304-79-00
Acronym: Elevate-HF
Status last verified: Aug 2026
First submitted: 3 Aug 2026
Last updated: 28 Sep 2026
Results posted: No
Data monitoring committee: Yes
FDA-regulated drug: Yes
FDA-regulated device: No
Individual data sharing: Yes: Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal Vivli.org. All requests will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

Interested in taking part?

AstraZeneca Clinical Study Information Center

1-877-240-9479

information.center@astrazeneca.com

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See sites and contacts

RecruitingPhase 2
The Clinical Trial of Tamibarotene for Patients With HFpEF (RELIEF Trial)
HFpEF - Heart Failure With Preserved Ejection Fraction
Recruiting
Renal Denervation in Patients With Atrial Fibrillation and Hypertension
Atrial Fibrillation (Paroxysmal), Hypertension
Active, not recruitingPhase 1
A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Heart, Heart Failure With Preserved Ejection Fraction (HFPEF)
Recruiting
Cardiopulmonary Exercise Testing-based High-intensity Interval Training For Improving Heart Failure With Preserved Ejection Fraction
HFpEF - Heart Failure With Preserved Ejection Fraction
Not yet recruiting
Exercise, Mediterranean Diet and Inflammation in Heart Failure
Heart Failure, Heart Failure Preserved Ejection Fraction

All Heart Failure With Preserved Ejection Fraction (HFpEF) trials

Study at a glance

From the registry record, last updated by the sponsor on 28 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: A Phase III, Randomized, Double-blind, Parallel-group, Placebo-controlled, Multicenter Study to Evaluate the Effect of Elecoglipron in Reducing Cardiovascular Outcomes in Participants With HFpEF and HFmrEF (Elevate-HF)
ClinicalTrials.gov ID: NCT07761117
Acronym / sponsor ID: Elevate-HF / D7266C00001
Conditions: Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
Keywords: Heart failure, Elecoglipron
Phase: Phase 3
Study type: Interventional
Recruitment status: Recruiting
Enrolment: 6,950 participants (estimated)
Lead sponsor: AstraZenecaIndustry (pharma, biotech, devices)
Study start: 24 Aug 2026 (actual)
Primary completion: 3 Sep 2029 (estimated)
Study completion: 3 Sep 2029 (estimated)
First posted: 12 Aug 2026 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Study design

Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Quadruple blind (participant, care provider, investigator, outcomes assessor)
Number of arms: 2

Arm	Type	Receives
Elecoglipron	Experimental	Drug: ElecoglipronElecoglipron tablet once daily
Placebo	Active comparator	Drug: PlaceboPlacebo matching Elecoglipron tablet once daily

Who may qualify

Ages: 18 years and older
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult, Older adult

Key inclusion criteria (3 listed)

Left ventricular ejection fraction (LVEF) of > 40% within 12 months prior to screening.
Structural heart disease evidence.
HF diagnosed with New York Heart Association (NYHA) Class II-IV at the time of screening.

Key exclusion criteria (16 listed)

BMI <25 kg/m² at screening.
Diabetes exclusions:
History of type 1 diabetes.
HbA1c ≥10% at screening.
Currently receiving or anticipated to receive therapeutic intervention for diabetic retinopathy and/or macular edema.

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
ElecoglipronElecoglipron tablet	Drug	Elecoglipron
PlaceboPlacebo tablet	Drug	Placebo

Primary outcome

To evaluate the effect of elecoglipron compared with placebo in reducing the risk of CV death or HHF/urgent HF visit
Time frame: Up to 42 months
Time to first event of the composite of: * CV death * HHF * Urgent HF visit

3 secondary outcomes

To evaluate the effect of elecoglipron compared with placebo in reducing the rate of HF events (HHF or urgent HF visit)
Time frame: Up to 42 months
To evaluate the effect of elecoglipron compared to placebo on improving patient-reported outcomes using a questionnaire.
Time frame: Baseline and 52 weeks
To evaluate the effect of elecoglipron compared with placebo in reducing the risk of the 4-point composite of all-cause death, HHF, MI, or stroke
Time frame: Up to 42 months

Results and safety

This study is still under way. Results are not available in the source record yet.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 28 Sep 2026.
Individual participant dataSharing planned: Yes. Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal Vivli.org. All requests will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

Related trials for Heart Failure With Preserved Ejection Fraction (HFpEF)

RecruitingPhase 2
The Clinical Trial of Tamibarotene for Patients With HFpEF (RELIEF Trial)
HFpEF - Heart Failure With Preserved Ejection Fraction
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Renal Denervation in Patients With Atrial Fibrillation and Hypertension
Atrial Fibrillation (Paroxysmal), Hypertension
Active, not recruitingPhase 1
A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Heart, Heart Failure With Preserved Ejection Fraction (HFPEF)
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Cardiopulmonary Exercise Testing-based High-intensity Interval Training For Improving Heart Failure With Preserved Ejection Fraction
HFpEF - Heart Failure With Preserved Ejection Fraction
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Exercise, Mediterranean Diet and Inflammation in Heart Failure
Heart Failure, Heart Failure Preserved Ejection Fraction

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.

AstraZeneca Clinical Study Information Center contact

1-877-240-9479

information.center@astrazeneca.com

679 sites in 32 countries: see every site and its status.

Questions about this trial

What is this clinical trial studying?

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 16 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 28 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 679 sites in United States, China, Japan, Germany, Canada and 27 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact AstraZeneca Clinical Study Information Center (1-877-240-9479, information.center@astrazeneca.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

To evaluate the effect of elecoglipron compared with placebo in reducing the risk of CV death or HHF/urgent HF visit (time frame: Up to 42 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07761117.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Sep 2026; AzTrials last refreshed its copy on 3 Nov 2026.