Third Molars ExtractionNCT07761338
The Use of Advanced Platelet-rich Fibrin in Mandibular Third Molar Surgery
An observational study of Third Molars Extraction, run by University of Copenhagen at 1 site in Denmark.
Trial summary
The purpose of the study is to quantify the levels of platelets and inflammatory markers in A-PRF from a standard venous whole blood sample, and to evaluate the effect of A-PRF on postoperative discomfort and complications following surgical removal of M3. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Third Molars Extraction
- What is being tested?
- Third molar
- Type of treatment
- Surgery or procedure
- How many people
- 60 participants
- Where
- 1 siteDenmark
- Study dates
- 1 Oct 2024to 31 Jan 2025
- How long will I take part?
- 1 Week
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Healthy patients with indication for surgical removal of mandibular third molar
Who may be able to join
- indication for surgical removal of mandibular third molar
Who cannot join
- breastfeading, pregnancy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Use of Advanced Platelet-rich Fibrin in Mandibular Third Molar Surgery. Levels of Platelets, Leucocytes, Inflammatory Biomarkers and the Effect on Postoperative Discomfort and Complications.
The purpose of the study is to quantify the levels of platelets and inflammatory markers in A-PRF from a standard venous whole blood sample, and to evaluate the effect of A-PRF on postoperative discomfort and complications following surgical removal of M3.
The study will be prospective and include 60 patients referred to Specialtandlægerne Vestergade for surgical removal of one M3. It is expected that the study will contribute with important information on the impact of A-PRF on postoperative sequelae and complications following surgical removal of mandibular third molars.
Read the detailed description
Three venous whole blood samples will be collected by a dental assistant, which has undergone special training, supervised by a medical doctor affiliated with Specialtandlægerne Vestergade.
Surgical removal of M3 will be performed by one certified maxillofacial surgeon under local anaesthesia using a standard technique.
An incision from the anterior border of the ascending ramus of the mandible to the distal part of the lower first molar will be performed. The muco-periosteal flap will be reflected and the bone around the M3 will be removed with a round burr under constant irrigation with 0.9% saline solution. If necessary, the M3 will be sectioned with a fissure bur before the tooth is elevated out. The extraction socket and surrounding bone will be irrigated with 0.9 % saline solution, and the surgical site will be sutured with vicryl suture.
All patients will receive standard postoperative instructions. Sutures will be removed 7 days postoperatively. All patients will be seen in the clinic before surgery (T0) and one week following surgical removal of M3 .
- Conditions
- Third Molars Extraction
- Being tested
- Third molar
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Third molarProcedure or surgery
Evaluate the level of thrombocytes and growth factors in A-PRF and whole blood sample
What is being measured
The primary outcome is the main question the study is designed to answer.
Levels of thrombocytes and growth factors in advanced platelet-rich fibrin
Quantification of thrombocytes and specific growth factors (FGF, TGH-B1, VEGF, PDGF-B) released from advanced platelet-rich fibrin measured in concentration levels
Measured: From enrollment to one week following surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Aug 2026
- Study start1 Oct 2024
- Primary completion31 Dec 2024
- Study completion31 Jan 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Third Molars ExtractionStudies of the same condition, open and under way.
- More trials run by University of CopenhagenThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 60 participants (actual)
- Target duration
- 1 Week
Sponsor and investigators
- Lead sponsor
- University of Copenhagen
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07761338
- Sponsor's protocol ID
- H-22029533
- Status last verified
- Sep 2024
- First submitted
- 18 Sep 2024
- Last updated
- 12 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Use of Advanced Platelet-rich Fibrin in Mandibular Third Molar Surgery. Levels of Platelets, Leucocytes, Inflammatory Biomarkers and the Effect on Postoperative Discomfort and Complications.
- ClinicalTrials.gov ID
- NCT07761338
- Acronym / sponsor ID
- H-22029533
- Conditions
- Third Molars Extraction
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- University of CopenhagenUniversity, hospital or other
- Study start
- 1 Oct 2024 (actual)
- Primary completion
- 31 Dec 2024 (actual)
- Study completion
- 31 Jan 2025 (actual)
- First posted
- 12 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of the study is to quantify the levels of platelets and inflammatory markers in A-PRF from a standard venous whole blood sample, and to evaluate the effect of A-PRF on postoperative discomfort and complications following surgical removal of M3.
The study will be prospective and include 60 patients referred to Specialtandlægerne Vestergade for surgical removal of one M3. It is expected that the study will contribute with important information on the impact of A-PRF on postoperative sequelae and complications following surgical removal of mandibular third molars.
Detailed description
Three venous whole blood samples will be collected by a dental assistant, which has undergone special training, supervised by a medical doctor affiliated with Specialtandlægerne Vestergade.
Surgical removal of M3 will be performed by one certified maxillofacial surgeon under local anaesthesia using a standard technique.
An incision from the anterior border of the ascending ramus of the mandible to the distal part of the lower first molar will be performed. The muco-periosteal flap will be reflected and the bone around the M3 will be removed with a round burr under constant irrigation with 0.9% saline solution. If necessary, the M3 will be sectioned with a fissure bur before the tooth is elevated out. The extraction socket and surrounding bone will be irrigated with 0.9 % saline solution, and the surgical site will be sutured with vicryl suture.
All patients will receive standard postoperative instructions. Sutures will be removed 7 days postoperatively. All patients will be seen in the clinic before surgery (T0) and one week following surgical removal of M3 .
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 1 Week
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Healthy patients with indication for surgical removal of mandibular third molar
Key inclusion criteria (1 listed)
- indication for surgical removal of mandibular third molar
Key exclusion criteria (1 listed)
- breastfeading, pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Third molarEvaluate the level of thrombocytes and growth factors in A-PRF and whole blood sample | Procedure or surgery | – |
Primary outcome
Levels of thrombocytes and growth factors in advanced platelet-rich fibrin
Time frame: From enrollment to one week following surgery
Quantification of thrombocytes and specific growth factors (FGF, TGH-B1, VEGF, PDGF-B) released from advanced platelet-rich fibrin measured in concentration levels
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Third Molars Extraction, run by University of Copenhagen at 1 site in Denmark.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Denmark. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Levels of thrombocytes and growth factors in advanced platelet-rich fibrin (time frame: From enrollment to one week following surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Aug 2026.