Caesarian SectionNCT07761585
Effect of Preoperative Dexamethasone in Preventing Spinal Hypotension In Patients Undergoing Elective Caesarian Section
A study testing Dexamethasone in people with Caesarian Section, run by Liaquat National Hospital & Medical College at 1 site in Pakistan.
Trial summary
The goal of this clinical trial is to learn whether giving a single dose of intravenous dexamethasone before spinal anesthesia can help prevent low blood pressure (spinal hypotension) in pregnant women undergoing elective cesarean section. Read more about this study
- Who is it for?
- Ages 18 years and older, women onlyHealthy volunteers can take part
- Conditions the study is for
- Caesarian Section
- What is being tested?
- Dexamethasone
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 80 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Feb 2026to 21 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Pregnant females Consenting No contraindications
Who cannot join
- Non consenting
Trial locations and contacts
1 site in 1 country.
About this study
The goal of this clinical trial is to learn whether giving a single dose of intravenous dexamethasone before spinal anesthesia can help prevent low blood pressure (spinal hypotension) in pregnant women undergoing elective cesarean section. Low blood pressure after spinal anesthesia is common and may cause nausea, vomiting, dizziness, and reduced blood flow to the baby. If dexamethasone works, it may help maintain stable blood pressure during surgery, reduce the need for medicines used to treat low blood pressure, and improve the safety and comfort of both the mother and baby.
The main questions it aims to answer are:
Read more
- Does preoperative intravenous dexamethasone reduce the occurrence of spinal hypotension after spinal anesthesia?
- Does dexamethasone reduce the amount of vasopressor medicine needed to treat low blood pressure during surgery?
Researchers will compare 8 mg intravenous dexamethasone with normal saline (placebo) to determine whether dexamethasone is more effective in preventing spinal hypotension during elective cesarean section.
Participants will:
- Receive either intravenous dexamethasone or a placebo before spinal anesthesia.
- Undergo elective cesarean section under spinal anesthesia.
- Have their blood pressure monitored during surgery.
- Receive standard treatment if their blood pressure becomes too low.
- Have their blood pressure measurements and the need for blood pressure-raising medicines recorded to compare the effects of the two treatments.
- Conditions
- Caesarian Section
- Being tested
- Dexamethasone
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
DexamethasoneDrug
Dexamethasone
| Study group | Role | What they receive |
|---|---|---|
| Dexamethasone | Active comparator | Not described Receives: Drug: Dexamethasone |
| Placebo | Placebo comparator | Not described Receives: Drug: Dexamethasone |
What is being measured
The primary outcome is the main question the study is designed to answer.
Spinal hypotension
The incidence of spinal hypotension, defined as a decrease in systolic blood pressure (SBP) greater than 20% of the baseline value or an absolute SBP <90 mmHg after spinal anesthesia, will be compared between the dexamethasone and placebo groups. Blood pressure will be measured every 5 minutes until delivery of the baby.
Measured: From spinal anesthesia until delivery of the baby (approximately 20 minutes) at 5 minutes interval for a period of 6 months.
Secondary outcomes (1)
Vasopressor Requirement
Total dose and frequency of vasopressor administration required to treat spinal hypotension following spinal anesthesia will be compared between the dexamethasone and placebo groups.
Measured: From spinal anesthesia until delivery of the baby (approximately 20 minutes ) at 5 minutes interval for a period of 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Aug 2026
- Study start1 Feb 2026
- Primary completion21 Jul 2026
- Study completion21 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Caesarian SectionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Investigator
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Liaquat National Hospital & Medical College
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Maryam Khan, Liaquat National Hospital & Medical College
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07761585
- Sponsor's protocol ID
- LiaquatNHMC1
- Status last verified
- Aug 2026
- First submitted
- 25 Jul 2026
- Last updated
- 12 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 12 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Preoperative Dexamethasone in Preventing Spinal Hypotension In Patients Undergoing Elective Caesarian Section
- ClinicalTrials.gov ID
- NCT07761585
- Acronym / sponsor ID
- LiaquatNHMC1
- Conditions
- Caesarian Section
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Liaquat National Hospital & Medical CollegeUniversity, hospital or other
- Study start
- 1 Feb 2026 (actual)
- Primary completion
- 21 Jul 2026 (actual)
- Study completion
- 21 Jul 2026 (actual)
- First posted
- 12 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn whether giving a single dose of intravenous dexamethasone before spinal anesthesia can help prevent low blood pressure (spinal hypotension) in pregnant women undergoing elective cesarean section. Low blood pressure after spinal anesthesia is common and may cause nausea, vomiting, dizziness, and reduced blood flow to the baby. If dexamethasone works, it may help maintain stable blood pressure during surgery, reduce the need for medicines used to treat low blood pressure, and improve the safety and comfort of both the mother and baby.
The main questions it aims to answer are:
- Does preoperative intravenous dexamethasone reduce the occurrence of spinal hypotension after spinal anesthesia?
- Does dexamethasone reduce the amount of vasopressor medicine needed to treat low blood pressure during surgery?
Researchers will compare 8 mg intravenous dexamethasone with normal saline (placebo) to determine whether dexamethasone is more effective in preventing spinal hypotension during elective cesarean section.
Participants will:
- Receive either intravenous dexamethasone or a placebo before spinal anesthesia.
- Undergo elective cesarean section under spinal anesthesia.
- Have their blood pressure monitored during surgery.
- Receive standard treatment if their blood pressure becomes too low.
- Have their blood pressure measurements and the need for blood pressure-raising medicines recorded to compare the effects of the two treatments.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Dexamethasone | Active comparator | Drug: Dexamethasone |
| Placebo | Placebo comparator | Drug: Dexamethasone |
Who may qualify
- Ages
- 18 years and older
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Pregnant females Consenting No contraindications
Key exclusion criteria (1 listed)
- Non consenting
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| DexamethasoneDexamethasone | Drug | Dexamethasone, Placebo |
Primary outcome
Spinal hypotension
Time frame: From spinal anesthesia until delivery of the baby (approximately 20 minutes) at 5 minutes interval for a period of 6 months.
The incidence of spinal hypotension, defined as a decrease in systolic blood pressure (SBP) greater than 20% of the baseline value or an absolute SBP <90 mmHg after spinal anesthesia, will be compared between the dexamethasone and placebo groups. Blood pressure will be measured every 5 minutes until delivery of the baby.
1 secondary outcome
Vasopressor Requirement
Time frame: From spinal anesthesia until delivery of the baby (approximately 20 minutes ) at 5 minutes interval for a period of 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Aug 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Caesarian Section
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Ultrasound Assessment Of Gastric Volume In Pregnant Women Undergoing Elective Cesarean Section
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Dexamethasone in people with Caesarian Section, run by Liaquat National Hospital & Medical College at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Spinal hypotension (time frame: From spinal anesthesia until delivery of the baby (approximately 20 minutes) at 5 minutes interval for a period of 6 months.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Aug 2026.