Post-Cardiac Arrest SyndromeNCT07762144
Clinical Cohort Construction Program of Peking University Third Hospital
An observational study of Post-Cardiac Arrest Syndrome, run by Peking University Third Hospital at 1 site in China.
Trial summary
Cardiac arrest is one of the leading life-threatening emergencies, with approximately 540,000 cases occurring annually in China. Among patients who experience cardiac arrest, active cardiopulmonary resuscitation can achieve return of spontaneous circulation in 40% of cases; however, only 1-2% ultimately survive with… Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Post-Cardiac Arrest Syndrome
- How many people
- 500 participants
- Where
- 1 siteChina
- Study dates
- 1 Jan 2014to 31 Dec 2030
- How long will I take part?
- 1 Year
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: This study will enroll all eligible patients presenting to the emergency departments of the six centers who satisfy the following inclusion and exclusion criteria
Who may be able to join
- Patients who have achieved return of spontaneous circulation (ROSC) after cardiac arrest;
- With accessible intravenous or intraosseous vascular access;
- Clinical manifestations meeting any one of the following criteria: presenting with post-resuscitation brain injury, post-resuscitation cardiac dysfunction, manifestations of systemic ischemia-reperfusion injury, or other ongoing deteriorating pathological changes.
Who cannot join
- Patients who have not achieved return of spontaneous circulation (ROSC) after cardiac arrest;
- Patients who have declined cardiopulmonary resuscitation (CPR) (or whose legally authorized representative has refused CPR).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site
Emergency Dept of Peking University Third Hospital
Beijing, Beijing Municipality, 100191
About this study
Cardiac arrest is one of the leading life-threatening emergencies, with approximately 540,000 cases occurring annually in China. Among patients who experience cardiac arrest, active cardiopulmonary resuscitation can achieve return of spontaneous circulation in 40% of cases; however, only 1-2% ultimately survive with favorable neurological outcomes. The primary contributor to mortality and morbidity is post-cardiac arrest syndrome (PCAS). PCAS represents a distinct pathophysiological process resulting from systemic ischemia/reperfusion injury, involving multiple systems and organs, and thus requires comprehensive, systematic evaluation. At present, numerous challenges remain in the field of PCAS, including the optimal targeted temperature, additional interventions that may improve neurological prognosis, post-resuscitation myocardial dysfunction and its protective strategies, characteristics and management of dysfunction in other organs, and accurate neurological prognostication after resuscitation. Therefore, in-depth research on PCAS is urgently needed to improve outcomes in cardiac arrest survivors.
This study is initiated by the Department of Emergency Medicine, Peking University Third Hospital, and involves a total of six tertiary hospitals across China, constituting a multicenter investigation. The study aims to explore the effects of different targeted temperature management strategies on mortality and neurological outcomes, and to actively investigate other interventions that may ameliorate post-resuscitation brain injury, cardiac injury, and microcirculatory dysfunction, thereby reducing mortality and improving neurological prognosis in cardiac arrest patients. Furthermore, we aim to develop a neurological prediction model for cardiac arrest patients to enable accurate prognostication of neurological outcomes, which will assist emergency physicians in providing precise prognostic information to families and facilitate shared decision-making regarding subsequent treatment plans.
Read the detailed description
For patients with cardiac arrest, brain injury is the leading cause of mortality and disability, followed by cardiac dysfunction and microcirculatory disorders. Therefore, post-resuscitation cerebral protection, myocardial protection, and the prevention and treatment of microcirculatory failure are key to the management of post-cardiac arrest syndrome (PCAS). This cohort study aims to observe exposure factors related to the cardiopulmonary resuscitation (CPR) process and the subsequent treatment of post-resuscitation syndrome, in order to explore the factors contributing to the low quality of CPR in China and to provide evidence for improving prehospital emergency care. Simultaneously, it aims to investigate exposure factors during in-hospital treatment and to identify effective interventions for improving brain function, cardiac function, and microcirculatory dysfunction.
③ Prognostic factor exploration and prognostic model establishment (may be broken down into multiple sub-questions).
For patients with cardiac arrest, neurological assessment, i.e., the evaluation of the severity of brain injury, represents both a major challenge and a key priority in the field of CPR, and it remains a current research hotspot. Accurate neurological assessment can prevent premature withdrawal of life-sustaining therapy in patients with potential for cerebral recovery-early withdrawal being a primary cause of death in cardiac arrest patients in the ICU. Conversely, it also enables early identification of patients without hope of neurological recovery, thereby providing families with more accurate prognostic information, facilitating shared decision-making regarding subsequent treatment, and reasonably optimizing the utilization of medical resources. The objective of this cohort is to establish a predictive model for mortality and poor neurological outcomes in patients with cardiac arrest, based on multimodal data incorporating clinical assessments, imaging, neuroelectrophysiology, and biomarkers.
- Conditions
- Post-Cardiac Arrest Syndrome
- Keywords
- Cardiac Arrest
- Medical subject headings
- Post-Cardiac Arrest Syndrome, Heart Arrest
What is being measured
The primary outcome is the main question the study is designed to answer.
Whether death has occurred
Death: any death, regardless of cause (i.e., all-cause mortality)
Measured: 1 year
Secondary outcomes (1)
Assessment of neurological prognosis
CPC (Cerebral Performance Category) Score:
CPC grades 1-2 indicate favorable neurological outcome, while grades 3-5 indicate unfavorable outcome.
CPC 1: Good cerebral function; patient is conscious, alert, and able to work and live a normal life.
CPC 2: Moderate cerebral disability; patient is conscious and able to work part-time in a sheltered environment or perform independent activities of daily living.
CPC 3: Severe cerebral disability; patient is conscious but requires daily assistance from others and retains limited cognitive function.
CPC 4: Coma or vegetative state; patient is unaware, unresponsive to the environment, and has no cognitive function.
CPC 5: Death; patient is declared brain-dead or dead according to traditional criteria.
Measured: 1year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Aug 2026
- Study start1 Jan 2014
- Primary completion31 Dec 2030 (estimated)
- Study completion31 Dec 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Post-Cardiac Arrest SyndromeStudies of the same condition, open and under way.
- More trials run by Peking University Third HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Other
- Enrolment
- 500 participants (estimated)
- Target duration
- 1 Year
Sponsor and investigators
- Lead sponsor
- Peking University Third Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Qingbian Ma, MD, Peking University Third Hospital
- Investigators
- Qing bian Ma, Doctor of Medicine, Study chair, Peking University Third Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07762144
- Sponsor's protocol ID
- M2022179
- Status last verified
- Aug 2026
- First submitted
- 24 Jun 2026
- Last updated
- 13 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Belbasis L, Bellou V. Introduction to Epidemiological Studies. Methods Mol Biol. 2018;1793:1-6. doi: 10.1007/978-1-4939-7868-7_1.
PubMed 29876887Jentzer JC, Chonde MD, Dezfulian C. Myocardial Dysfunction and Shock after Cardiac Arrest. Biomed Res Int. 2015;2015:314796. doi: 10.1155/2015/314796. Epub 2015 Sep 2.
PubMed 26421284Lundin A, Djarv T, Engdahl J, Hollenberg J, Nordberg P, Ravn-Fischer A, Ringh M, Rysz S, Svensson L, Herlitz J, Lundgren P. Drug therapy in cardiac arrest: a review of the literature. Eur Heart J Cardiovasc Pharmacother. 2016 Jan;2(1):54-75. doi: 10.1093/ehjcvp/pvv047. Epub 2015 Nov 26.
PubMed 27533062Shao F, Li CS, Liang LR, Qin J, Ding N, Fu Y, Yang K, Zhang GQ, Zhao L, Zhao B, Zhu ZZ, Yang LP, Yu DM, Song ZJ, Yang QL. Incidence and outcome of adult in-hospital cardiac arrest in Beijing, China. Resuscitation. 2016 May;102:51-6. doi: 10.1016/j.resuscitation.2016.02.002. Epub 2016 Feb 23.
PubMed 26924514Trzeciak S, Jones AE, Kilgannon JH, Milcarek B, Hunter K, Shapiro NI, Hollenberg SM, Dellinger P, Parrillo JE. Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med. 2009 Nov;37(11):2895-903; quiz 2904. doi: 10.1097/ccm.0b013e3181b01d8c.
PubMed 19866506
Study at a glance
From the registry record, last updated by the sponsor on 13 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Cohort Construction Program of Peking University Third Hospital
- ClinicalTrials.gov ID
- NCT07762144
- Acronym / sponsor ID
- M2022179
- Conditions
- Post-Cardiac Arrest Syndrome
- Keywords
- Cardiac Arrest
- Study type
- Observational
- Recruitment status
- Enrolling by invitation
- Enrolment
- 500 participants (estimated)
- Lead sponsor
- Peking University Third HospitalUniversity, hospital or other
- Study start
- 1 Jan 2014 (actual)
- Primary completion
- 31 Dec 2030 (estimated)
- Study completion
- 31 Dec 2030 (estimated)
- First posted
- 13 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Cardiac arrest is one of the leading life-threatening emergencies, with approximately 540,000 cases occurring annually in China. Among patients who experience cardiac arrest, active cardiopulmonary resuscitation can achieve return of spontaneous circulation in 40% of cases; however, only 1-2% ultimately survive with favorable neurological outcomes. The primary contributor to mortality and morbidity is post-cardiac arrest syndrome (PCAS). PCAS represents a distinct pathophysiological process resulting from systemic ischemia/reperfusion injury, involving multiple systems and organs, and thus requires comprehensive, systematic evaluation. At present, numerous challenges remain in the field of PCAS, including the optimal targeted temperature, additional interventions that may improve neurological prognosis, post-resuscitation myocardial dysfunction and its protective strategies, characteristics and management of dysfunction in other organs, and accurate neurological prognostication after resuscitation. Therefore, in-depth research on PCAS is urgently needed to improve outcomes in cardiac arrest survivors.
This study is initiated by the Department of Emergency Medicine, Peking University Third Hospital, and involves a total of six tertiary hospitals across China, constituting a multicenter investigation. The study aims to explore the effects of different targeted temperature management strategies on mortality and neurological outcomes, and to actively investigate other interventions that may ameliorate post-resuscitation brain injury, cardiac injury, and microcirculatory dysfunction, thereby reducing mortality and improving neurological prognosis in cardiac arrest patients. Furthermore, we aim to develop a neurological prediction model for cardiac arrest patients to enable accurate prognostication of neurological outcomes, which will assist emergency physicians in providing precise prognostic information to families and facilitate shared decision-making regarding subsequent treatment plans.
Detailed description
For patients with cardiac arrest, brain injury is the leading cause of mortality and disability, followed by cardiac dysfunction and microcirculatory disorders. Therefore, post-resuscitation cerebral protection, myocardial protection, and the prevention and treatment of microcirculatory failure are key to the management of post-cardiac arrest syndrome (PCAS). This cohort study aims to observe exposure factors related to the cardiopulmonary resuscitation (CPR) process and the subsequent treatment of post-resuscitation syndrome, in order to explore the factors contributing to the low quality of CPR in China and to provide evidence for improving prehospital emergency care. Simultaneously, it aims to investigate exposure factors during in-hospital treatment and to identify effective interventions for improving brain function, cardiac function, and microcirculatory dysfunction.
③ Prognostic factor exploration and prognostic model establishment (may be broken down into multiple sub-questions).
For patients with cardiac arrest, neurological assessment, i.e., the evaluation of the severity of brain injury, represents both a major challenge and a key priority in the field of CPR, and it remains a current research hotspot. Accurate neurological assessment can prevent premature withdrawal of life-sustaining therapy in patients with potential for cerebral recovery-early withdrawal being a primary cause of death in cardiac arrest patients in the ICU. Conversely, it also enables early identification of patients without hope of neurological recovery, thereby providing families with more accurate prognostic information, facilitating shared decision-making regarding subsequent treatment, and reasonably optimizing the utilization of medical resources. The objective of this cohort is to establish a predictive model for mortality and poor neurological outcomes in patients with cardiac arrest, based on multimodal data incorporating clinical assessments, imaging, neuroelectrophysiology, and biomarkers.
Study design
- Observational model
- Cohort
- Time perspective
- Other
- Target follow-up
- 1 Year
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- This study will enroll all eligible patients presenting to the emergency departments of the six centers who satisfy the following inclusion and exclusion criteria
Key inclusion criteria (3 listed)
- Patients who have achieved return of spontaneous circulation (ROSC) after cardiac arrest;
- With accessible intravenous or intraosseous vascular access;
- Clinical manifestations meeting any one of the following criteria: presenting with post-resuscitation brain injury, post-resuscitation cardiac dysfunction, manifestations of systemic ischemia-reperfusion injury, or other ongoing deteriorating pathological changes.
Key exclusion criteria (2 listed)
- Patients who have not achieved return of spontaneous circulation (ROSC) after cardiac arrest;
- Patients who have declined cardiopulmonary resuscitation (CPR) (or whose legally authorized representative has refused CPR).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Whether death has occurred
Time frame: 1 year
Death: any death, regardless of cause (i.e., all-cause mortality)
1 secondary outcome
Assessment of neurological prognosis
Time frame: 1year
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Aug 2026.
- Background: PubMed 29876887Belbasis L, Bellou V. Introduction to Epidemiological Studies. Methods Mol Biol. 2018;1793:1-6. doi: 10.1007/978-1-4939-7868-7_1.
- Background: PubMed 26421284Jentzer JC, Chonde MD, Dezfulian C. Myocardial Dysfunction and Shock after Cardiac Arrest. Biomed Res Int. 2015;2015:314796. doi: 10.1155/2015/314796. Epub 2015 Sep 2.
- Background: PubMed 27533062Lundin A, Djarv T, Engdahl J, Hollenberg J, Nordberg P, Ravn-Fischer A, Ringh M, Rysz S, Svensson L, Herlitz J, Lundgren P. Drug therapy in cardiac arrest: a review of the literature. Eur Heart J Cardiovasc Pharmacother. 2016 Jan;2(1):54-75. doi: 10.1093/ehjcvp/pvv047. Epub 2015 Nov 26.
- Background: PubMed 26924514Shao F, Li CS, Liang LR, Qin J, Ding N, Fu Y, Yang K, Zhang GQ, Zhao L, Zhao B, Zhu ZZ, Yang LP, Yu DM, Song ZJ, Yang QL. Incidence and outcome of adult in-hospital cardiac arrest in Beijing, China. Resuscitation. 2016 May;102:51-6. doi: 10.1016/j.resuscitation.2016.02.002. Epub 2016 Feb 23.
- Background: PubMed 19866506Trzeciak S, Jones AE, Kilgannon JH, Milcarek B, Hunter K, Shapiro NI, Hollenberg SM, Dellinger P, Parrillo JE. Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med. 2009 Nov;37(11):2895-903; quiz 2904. doi: 10.1097/ccm.0b013e3181b01d8c.
- Individual participant dataSharing planned: Undecided
Related trials for Post-Cardiac Arrest Syndrome
Active, not recruitingPhase 3
The Danish Out-of-Hospital Cardiac Arrest Study
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
Recruiting
Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
RecruitingObservational study
Analysis of Life-threatening ARrhythMias After Acute Coronary Syndrome
Acute Coronary Syndromes (ACS), Ventricular Tachycardia (VT)
Recruiting
Cerebral Oximetry in Management of Post Cardiac Arrest
Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury
Active, not recruitingObservational study
Multiomics Profiling of CSF in Cardiac Arrest Survivors
Cardiac Arrest (CA), Hypoxic-Ischemic Brain Injury
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Qing bian Ma, Doctor of Medicine study chair
Peking University Third Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Post-Cardiac Arrest Syndrome, run by Peking University Third Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 13 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Whether death has occurred (time frame: 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07762144, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Aug 2026.