HandNCT07762937
Neurodynamic Tensioning Plus Grip Strengthening for Hand Grip Strength
A study testing Grip Strengthening Program and Neurodynamic Tensioning in people with Hand and Grip, run by Tokat Gaziosmanpasa University.
Trial summary
This randomized controlled trial will investigate whether adding neurodynamic tensioning to a grip strengthening program provides additional improvements in hand grip strength in healthy adults. Sixty participants aged 18 to 40 years will be randomly assigned to two groups. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- What is being tested?
- Grip Strengthening Program and Neurodynamic Tensioning
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- No sites listed yet
- Study dates
- 15 Sep 2026to 15 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Aged between 18 and 40 years.
- Willing to participate voluntarily in the study.
- No history of upper-extremity pain, injury, or surgery within the previous three months.
- No diagnosed neurological, rheumatological, or systemic disease affecting the peripheral nervous system.
- Sufficient cognitive ability to understand and follow the study protocol.
Who cannot join
- History of carpal tunnel syndrome, cervical radiculopathy, peripheral neuropathy, or upper-extremity entrapment neuropathy.
- History of upper-extremity fracture or surgery within the previous six months.
- Regular participation in grip strengthening exercises or intensive upper-extremity resistance training.
- Use of medication that may affect neuromuscular performance.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effect of Neurodynamic Tensioning Added to a Grip Strengthening Program on Hand Grip Strength: A Randomized Controlled Trial
This randomized controlled trial will investigate whether adding neurodynamic tensioning to a grip strengthening program provides additional improvements in hand grip strength in healthy adults. Sixty participants aged 18 to 40 years will be randomly assigned to two groups. Both groups will perform a standardized grip strengthening program for six weeks, three days per week. The experimental group will additionally receive neurodynamic tensioning exercises targeting the median and ulnar nerves. Hand grip strength will be assessed at baseline, week 3, and week 6. The study aims to determine whether neurodynamic tensioning provides additional benefit beyond grip strengthening alone.
Read the detailed description
This study is designed as a prospective, two-arm, parallel-group randomized controlled trial investigating the additional effects of neurodynamic tensioning on hand grip strength in healthy adults. A total of 60 participants aged 18 to 40 years will be enrolled and randomly allocated in a 1:1 ratio to either a control group or an experimental group using computer-based block randomization.
Participants in both groups will perform a standardized grip strengthening program using an adjustable hand gripper for six weeks, three sessions per week. Each session will include three sets of 8-12 repetitions, with progressive resistance according to participant performance and perceived exertion.
In addition to the same grip strengthening program, participants in the experimental group will receive neurodynamic tensioning targeting the median and ulnar nerves. Neurodynamic techniques will be performed within pain-free limits using controlled tensioning movements. For each nerve, three sets of 10 repetitions will be performed before the grip strengthening exercises.
The primary outcome will be hand grip strength, measured using a Jamar hand dynamometer or an equivalent valid and reliable hand dynamometer. Grip strength will be assessed in standardized and different upper-extremity positions. Secondary outcomes will include pinch strength, manual dexterity, perceived exertion, intervention adherence, and adverse events.
Assessments will be performed at baseline (T0), week 3 (T1), and week 6 (T2). The outcome assessor will be blinded to group allocation. The main analysis will evaluate group, time, and group-by-time interaction effects to determine whether adding neurodynamic tensioning to grip strengthening results in greater improvement in hand grip strength than grip strengthening alone.
- Being tested
- Grip Strengthening Program, Neurodynamic Tensioning
- Keywords
- Neurodynamic Tensioning, Grip Strengthening, Resistance Training, Healthy Adults
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Grip Strengthening ProgramOther
Participants will perform a standardized grip strengthening program using an adjustable hand gripper with the dominant hand for six weeks, three sessions per week. Each session will consist of 3 sets of 8-12 repetitions, with approximately 2 seconds of gripping and 2 seconds of relaxation per repetition. Rest periods of 60-90 seconds will be provided between sets. Resistance will be progressively adjusted according to performance and perceived exertion.
Neurodynamic TensioningOther
Neurodynamic tensioning targeting the median and ulnar nerves will be applied before the grip strengthening program. For each nerve, 3 sets of 10 repetitions will be performed, with each repetition consisting of approximately 4-5 seconds of controlled rhythmic tensioning. A 30-second rest period will be provided between sets. The technique will be performed within pain-free limits, producing only a mild stretching sensation.
| Study group | Role | What they receive |
|---|---|---|
| Grip Strengthening Group | Active comparator | Participants will perform a standardized grip strengthening program using an adjustable hand gripper for six weeks, three sessions per week. Each session will consist of 3 sets of 8-12 repetitions. Resistance will be progressively adjusted according to performance and perceived exertion. No neurodynamic tensioning, neural gliding, or sham intervention will be applied to this group. Receives: Other: Grip Strengthening Program |
| Neurodynamic Tensioning Plus Grip Strengthening Group | Experimental | Participants will receive neurodynamic tensioning targeting the median and ulnar nerves in addition to the same standardized grip strengthening program. For each nerve, neurodynamic tensioning will be performed as 3 sets of 10 repetitions using controlled rhythmic tensioning within pain-free limits. The intervention will be performed for six weeks together with the grip strengthening program. Receives: Other: Grip Strengthening Program; Other: Neurodynamic Tensioning |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Hand Grip Strength
Hand grip strength of the dominant hand will be measured in kilograms (kg) using a Jamar hand dynamometer or an equivalent valid and reliable hand dynamometer. Measurements will be performed in three upper-extremity positions: standard seated position with the elbow at 90 degrees of flexion, elbow extension with the shoulder in a neutral position, and shoulder at 90 degrees of flexion with the elbow extended. Three trials will be performed in each position, and the mean of the three measurements will be used for analysis.
Measured: Baseline, Week 3, and Week 6
Secondary outcomes (3)
Change in Pinch Strength
Pinch strength will be assessed using a pinch gauge, if available, including lateral and/or palmar pinch measurements. Measurements will be performed on the dominant hand, and changes over time will be compared between groups.
Measured: Baseline, Week 3, and Week 6
Change in Manual Dexterity
Manual dexterity will be assessed using the Nine-Hole Peg Test or an equivalent valid and reliable manual dexterity test. Performance will be recorded at each assessment time point, and changes over time will be compared between groups.
Measured: Baseline, Week 3, and Week 6
Perceived Exertion During the Intervention
Perceived exertion during the grip strengthening exercises will be recorded using a rating of perceived exertion (RPE). RPE will be used to monitor exercise intensity and guide progression of resistance throughout the intervention.
Measured: Baseline, Week 3, and Week 6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Aug 2026
- Study start15 Sep 2026 (estimated)
- Primary completion15 Jan 2027 (estimated)
- Study completion15 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for HandStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned in a 1:1 ratio to two parallel groups: grip strengthening alone or neurodynamic tensioning combined with grip strengthening. Both groups will be followed for six weeks.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Tokat Gaziosmanpasa University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Uğur Sözlü, Tokat Gaziosmanpasa University
- Investigators
- Uğur Sözlü, PhD, Principal investigator, Tokat Gaziosmanpaşa Üniversitesi
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07762937
- Sponsor's protocol ID
- 36-04.08.2026
- Status last verified
- Aug 2026
- First submitted
- 10 Aug 2026
- Last updated
- 13 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Gamelas T, Fernandes A, Magalhaes I, Ferreira M, Machado S, Silva AG. Neural gliding versus neural tensioning: Effects on heat and cold thresholds, pain thresholds and hand grip strength in asymptomatic individuals. J Bodyw Mov Ther. 2019 Oct;23(4):799-804. doi: 10.1016/j.jbmt.2019.04.011. Epub 2019 Apr 24.
PubMed 31733764Dierick F, Brismee JM, White O, Bouche AF, Perichon C, Filoni N, Barvaux V, Buisseret F. Fine adaptive precision grip control without maximum pinch strength changes after upper limb neurodynamic mobilization. Sci Rep. 2021 Jul 7;11(1):14009. doi: 10.1038/s41598-021-93036-8.
PubMed 34234161
Study at a glance
From the registry record, last updated by the sponsor on 13 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Neurodynamic Tensioning Added to a Grip Strengthening Program on Hand Grip Strength: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07762937
- Acronym / sponsor ID
- 36-04.08.2026
- Keywords
- Neurodynamic Tensioning, Grip Strengthening, Resistance Training, Healthy Adults
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Tokat Gaziosmanpasa UniversityUniversity, hospital or other
- Study start
- 15 Sep 2026 (estimated)
- Primary completion
- 15 Jan 2027 (estimated)
- Study completion
- 15 Jan 2027 (estimated)
- First posted
- 13 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial will investigate whether adding neurodynamic tensioning to a grip strengthening program provides additional improvements in hand grip strength in healthy adults. Sixty participants aged 18 to 40 years will be randomly assigned to two groups. Both groups will perform a standardized grip strengthening program for six weeks, three days per week. The experimental group will additionally receive neurodynamic tensioning exercises targeting the median and ulnar nerves. Hand grip strength will be assessed at baseline, week 3, and week 6. The study aims to determine whether neurodynamic tensioning provides additional benefit beyond grip strengthening alone.
Detailed description
This study is designed as a prospective, two-arm, parallel-group randomized controlled trial investigating the additional effects of neurodynamic tensioning on hand grip strength in healthy adults. A total of 60 participants aged 18 to 40 years will be enrolled and randomly allocated in a 1:1 ratio to either a control group or an experimental group using computer-based block randomization.
Participants in both groups will perform a standardized grip strengthening program using an adjustable hand gripper for six weeks, three sessions per week. Each session will include three sets of 8-12 repetitions, with progressive resistance according to participant performance and perceived exertion.
In addition to the same grip strengthening program, participants in the experimental group will receive neurodynamic tensioning targeting the median and ulnar nerves. Neurodynamic techniques will be performed within pain-free limits using controlled tensioning movements. For each nerve, three sets of 10 repetitions will be performed before the grip strengthening exercises.
The primary outcome will be hand grip strength, measured using a Jamar hand dynamometer or an equivalent valid and reliable hand dynamometer. Grip strength will be assessed in standardized and different upper-extremity positions. Secondary outcomes will include pinch strength, manual dexterity, perceived exertion, intervention adherence, and adverse events.
Assessments will be performed at baseline (T0), week 3 (T1), and week 6 (T2). The outcome assessor will be blinded to group allocation. The main analysis will evaluate group, time, and group-by-time interaction effects to determine whether adding neurodynamic tensioning to grip strengthening results in greater improvement in hand grip strength than grip strengthening alone.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned in a 1:1 ratio to two parallel groups: grip strengthening alone or neurodynamic tensioning combined with grip strengthening. Both groups will be followed for six weeks.
| Arm | Type | Receives |
|---|---|---|
| Grip Strengthening Group | Active comparator | Other: Grip Strengthening ProgramParticipants will perform a standardized grip strengthening program using an adjustable hand gripper for six weeks, three sessions per week. Each session will consist of 3 sets of 8-12 repetitions. Resistance will be progressively adjusted according to performance and perceived exertion. No neurodynamic tensioning, neural gliding, or sham intervention will be applied to this group. |
| Neurodynamic Tensioning Plus Grip Strengthening Group | Experimental | Other: Grip Strengthening Program, Other: Neurodynamic TensioningParticipants will receive neurodynamic tensioning targeting the median and ulnar nerves in addition to the same standardized grip strengthening program. For each nerve, neurodynamic tensioning will be performed as 3 sets of 10 repetitions using controlled rhythmic tensioning within pain-free limits. The intervention will be performed for six weeks together with the grip strengthening program. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Aged between 18 and 40 years.
- Willing to participate voluntarily in the study.
- No history of upper-extremity pain, injury, or surgery within the previous three months.
- No diagnosed neurological, rheumatological, or systemic disease affecting the peripheral nervous system.
- Sufficient cognitive ability to understand and follow the study protocol.
Key exclusion criteria (4 listed)
- History of carpal tunnel syndrome, cervical radiculopathy, peripheral neuropathy, or upper-extremity entrapment neuropathy.
- History of upper-extremity fracture or surgery within the previous six months.
- Regular participation in grip strengthening exercises or intensive upper-extremity resistance training.
- Use of medication that may affect neuromuscular performance.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Grip Strengthening ProgramParticipants will perform a standardized grip strengthening program using an adjustable hand gripper with the dominant hand for six weeks, three sessions per week. Each session will consist of 3 sets of 8-12 repetitions, with approximately 2 seconds of gripping and 2 seconds of relaxation per repetition. Rest periods of 60-90 seconds will be provided between sets. Resistance will be progressively adjusted according to performance and perceived exertion. | Other | Grip Strengthening Group, Neurodynamic Tensioning Plus Grip Strengthening Group |
| Neurodynamic TensioningNeurodynamic tensioning targeting the median and ulnar nerves will be applied before the grip strengthening program. For each nerve, 3 sets of 10 repetitions will be performed, with each repetition consisting of approximately 4-5 seconds of controlled rhythmic tensioning. A 30-second rest period will be provided between sets. The technique will be performed within pain-free limits, producing only a mild stretching sensation. | Other | Neurodynamic Tensioning Plus Grip Strengthening Group |
Primary outcome
Change in Hand Grip Strength
Time frame: Baseline, Week 3, and Week 6
Hand grip strength of the dominant hand will be measured in kilograms (kg) using a Jamar hand dynamometer or an equivalent valid and reliable hand dynamometer. Measurements will be performed in three upper-extremity positions: standard seated position with the elbow at 90 degrees of flexion, elbow extension with the shoulder in a neutral position, and shoulder at 90 degrees of flexion with the elbow extended. Three trials will be performed in each position, and the mean of the three measurements will be used for analysis.
3 secondary outcomes
Change in Pinch Strength
Time frame: Baseline, Week 3, and Week 6
Change in Manual Dexterity
Time frame: Baseline, Week 3, and Week 6
Perceived Exertion During the Intervention
Time frame: Baseline, Week 3, and Week 6
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Aug 2026.
- Background: PubMed 31733764Gamelas T, Fernandes A, Magalhaes I, Ferreira M, Machado S, Silva AG. Neural gliding versus neural tensioning: Effects on heat and cold thresholds, pain thresholds and hand grip strength in asymptomatic individuals. J Bodyw Mov Ther. 2019 Oct;23(4):799-804. doi: 10.1016/j.jbmt.2019.04.011. Epub 2019 Apr 24.
- Background: PubMed 34234161Dierick F, Brismee JM, White O, Bouche AF, Perichon C, Filoni N, Barvaux V, Buisseret F. Fine adaptive precision grip control without maximum pinch strength changes after upper limb neurodynamic mobilization. Sci Rep. 2021 Jul 7;11(1):14009. doi: 10.1038/s41598-021-93036-8.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Uğur Sözlü, PhD principal investigator
Tokat Gaziosmanpaşa Üniversitesi
Questions about this trial
What is this clinical trial studying?
A study testing Grip Strengthening Program and Neurodynamic Tensioning in people with Hand and Grip, run by Tokat Gaziosmanpasa University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 13 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Uğur Sözlü, PhD (05368921936, ugur.sozlu@gop.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Hand Grip Strength (time frame: Baseline, Week 3, and Week 6). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07762937, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Aug 2026; AzTrials last refreshed its copy on 6 Nov 2026.