MastectomyNCT07763080
Reverse Fly Exercise On Supraspinatus Tendinitis In Patients Receiving Aromatase Inhibitors Therapy After Mastectomy
A study testing Reverse fly excercise in people with Mastectomy and Aromatase Inhibitors Therapy, run by Cairo University at 1 site in Egypt.
Trial summary
Reverse Fly Exercise On Supraspinatus Tendinitis In Patients Receiving Aromatase Inhibitors Therapy After Mastectomy Read more about this study
- Who is it for?
- Ages 50 to 70 years, women only
- Conditions the study is for
- Mastectomy, Aromatase Inhibitors Therapy
- What is being tested?
- Reverse fly excercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteEgypt
- Study dates
- 18 Aug 2026to 11 Jul 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 70 years
- Women only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age range between 50:70 years.
- Female patients participate in the study.
- All patients with unilateral mastectomy.
- Patients who receiving aromatase inhibitors treatment.
- All patients will enroll in this study with have their informed consent.
Who cannot join
- Patients have Metastases
- Patients with Lymphedema
- Patients with Rheumatoid arthritis
- Patients have Neurological deficits (stroke, Parkinsonism)
- Patients with Psychological disorders
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Reverse Fly Exercise On Supraspinatus Tendinitis In Patients Receiving Aromatase Inhibitors Therapy After Mastectomy
Read the detailed description
40 female patients who have mastectomy and receiving aromatase inhibitor therapy will participate in this study. Their ages will be ranged from 50 to 70 years. The participants will be selected from (national cancer institution
Design of the study:
In this study the patients will be randomly assigned into two equal groups Group A (Study group): This group will include 20 patients who will receive after 3:6 weeks from starting aromatase inhibitor the reverse fly exercise , in additions Traditional treatment for tendonitis post mastectomy and their medical treatment. (physiotherapeutic treatments 3 times a week for 8 weeks , including , (pendulum ex , soft tissue release , stretching ex., strengthening ex. and ROM ex.) and their medical treatment.
Group B (Control group):
This group includes 20 patients who will receive the traditional physical therapy program (pendulum ex , soft tissue release, stretching ex., strengthening ex. and ROM ex.) and their medical treatment ,3 times a week for 8 weeks.
- Conditions
- Mastectomy, Aromatase Inhibitors Therapy
- Being tested
- Reverse fly excercise, Control group
- Keywords
- Mastectomy, Aromatase inhibitors therapy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Reverse fly excerciseOther
The procedure Stand with feet shoulder width apart while holding a dumbbell in each hand Flex the hips and knees slightly leaning the trunk forward while maintaining a neutral spine Allow the arms to hang perpendicular to the floor with elbows slightly flexed Horizontally abduct the shoulders by lifting the arms laterally until they are level with the shoulders Retract the scapulae at the top of the movement without elevating the shoulders Lower the arms slowly and with control back to the starting position Repeat for the desired number of repetitions
Control groupOther
This group includes 20 patients who will receive the traditional physical therapy program (pendulum ex , soft tissue release, stretching ex., strengthening ex. and ROM ex.) and their medical treatment ,3 times a week for 8 weeks. 1.2 Criteria for the patient selection:
| Study group | Role | What they receive |
|---|---|---|
| Patients will receieve Reverse fly excercise | Experimental | This group will include 20 patients who will receive after 3:6 weeks from starting aromatase inhibitor the reverse fly exercise , in additions Traditional treatment for tendonitis post mastectomy and their medical treatment. (physiotherapeutic treatments 3 times a week for 8 weeks , including , (pendulum ex , soft tissue release , stretching ex., strengthening ex. and ROM ex.) and their medical treatment. Receives: Other: Reverse fly excercise |
| Control group | Other | This group includes 20 patients who will receive the traditional physical therapy program (pendulum ex , soft tissue release, stretching ex., strengthening ex. and ROM ex.) and their medical treatment ,3 times a week for 8 weeks. 1.2 Criteria for the patient selection: Receives: Other: Control group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Supraspinatus Tendon Thickness
Using Dynamic ultrasonography for measuring
Measured: Before 1st physical therapy session And after 8 weeks of regular 3 session per week of physical therapy
Functional ability
By Quik DASH Questionnaire
Measured: Before 1st physical therapy session And after 8 weeks of regular 3 sessions/week of physical therapy
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Aug 2026
- Study start18 Aug 2026
- Primary completion11 May 2027 (estimated)
- Study completion11 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for MastectomyStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- RCT study
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Collaborators
- National Cancer Institute (NCI)
- Responsible party
- Principal investigator, Nourhan Ahmed Mahmoud Souliman, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07763080
- Sponsor's protocol ID
- P.T.REC/012/006575
- Other IDs
- RD2607-208-234-212
- Status last verified
- Oct 2026
- First submitted
- 5 Aug 2026
- Last updated
- 6 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Jatan N, Talo S, Azar AJ, Adrian TE, Kellett CF. Mechanisms and biomarkers for musculoskeletal signs and symptoms in patients treated with aromatase inhibitors: A comprehensive systematic review. Cancer Treat Rev. 2026 Feb;143:103075. doi: 10.1016/j.ctrv.2025.103075. Epub 2026 Jan 1.
PubMed 41506128Kaidar-Person O, Poortmans P, Offersen BV, Siesling S, Sklair-Levy M, Meattini I, de Ruysscher D, Kuhn T, Boersma LJ. Spatial location of local recurrences after mastectomy: a systematic review. Breast Cancer Res Treat. 2020 Sep;183(2):263-273. doi: 10.1007/s10549-020-05774-4. Epub 2020 Jul 13.
PubMed 32661665Lukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanislawek A. Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review. Cancers (Basel). 2021 Aug 25;13(17):4287. doi: 10.3390/cancers13174287.
PubMed 34503097
Study at a glance
From the registry record, last updated by the sponsor on 6 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Reverse Fly Exercise On Supraspinatus Tendinitis In Patients Receiving Aromatase Inhibitors Therapy After Mastectomy
- ClinicalTrials.gov ID
- NCT07763080
- Acronym / sponsor ID
- P.T.REC/012/006575
- Conditions
- Mastectomy, Aromatase Inhibitors Therapy
- Keywords
- Mastectomy, Aromatase inhibitors therapy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Collaborators
- National Cancer Institute (NCI)
- Study start
- 18 Aug 2026 (actual)
- Primary completion
- 11 May 2027 (estimated)
- Study completion
- 11 Jul 2027 (estimated)
- First posted
- 13 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Reverse Fly Exercise On Supraspinatus Tendinitis In Patients Receiving Aromatase Inhibitors Therapy After Mastectomy
Detailed description
40 female patients who have mastectomy and receiving aromatase inhibitor therapy will participate in this study. Their ages will be ranged from 50 to 70 years. The participants will be selected from (national cancer institution
Design of the study:
In this study the patients will be randomly assigned into two equal groups Group A (Study group): This group will include 20 patients who will receive after 3:6 weeks from starting aromatase inhibitor the reverse fly exercise , in additions Traditional treatment for tendonitis post mastectomy and their medical treatment. (physiotherapeutic treatments 3 times a week for 8 weeks , including , (pendulum ex , soft tissue release , stretching ex., strengthening ex. and ROM ex.) and their medical treatment.
Group B (Control group):
This group includes 20 patients who will receive the traditional physical therapy program (pendulum ex , soft tissue release, stretching ex., strengthening ex. and ROM ex.) and their medical treatment ,3 times a week for 8 weeks.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
- Model description
- RCT study
| Arm | Type | Receives |
|---|---|---|
| Patients will receieve Reverse fly excercise | Experimental | Other: Reverse fly excerciseThis group will include 20 patients who will receive after 3:6 weeks from starting aromatase inhibitor the reverse fly exercise , in additions Traditional treatment for tendonitis post mastectomy and their medical treatment. (physiotherapeutic treatments 3 times a week for 8 weeks , including , (pendulum ex , soft tissue release , stretching ex., strengthening ex. and ROM ex.) and their medical treatment. |
| Control group | Other | Other: Control groupThis group includes 20 patients who will receive the traditional physical therapy program (pendulum ex , soft tissue release, stretching ex., strengthening ex. and ROM ex.) and their medical treatment ,3 times a week for 8 weeks. 1.2 Criteria for the patient selection: |
Who may qualify
- Ages
- 50 to 70 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age range between 50:70 years.
- Female patients participate in the study.
- All patients with unilateral mastectomy.
- Patients who receiving aromatase inhibitors treatment.
- All patients will enroll in this study with have their informed consent.
Key exclusion criteria (5 listed)
- Patients have Metastases
- Patients with Lymphedema
- Patients with Rheumatoid arthritis
- Patients have Neurological deficits (stroke, Parkinsonism)
- Patients with Psychological disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Reverse fly excerciseThe procedure Stand with feet shoulder width apart while holding a dumbbell in each hand Flex the hips and knees slightly leaning the trunk forward while maintaining a neutral spine Allow the arms to hang perpendicular to the floor with elbows slightly flexed Horizontally abduct the shoulders by lifting the arms laterally until they are level with the shoulders Retract the scapulae at the top of the movement without elevating the shoulders Lower the arms slowly and with control back to the starting position Repeat for the desired number of repetitions | Other | Patients will receieve Reverse fly excercise |
| Control groupThis group includes 20 patients who will receive the traditional physical therapy program (pendulum ex , soft tissue release, stretching ex., strengthening ex. and ROM ex.) and their medical treatment ,3 times a week for 8 weeks. 1.2 Criteria for the patient selection: | Other | Control group |
Primary outcome
Supraspinatus Tendon Thickness
Time frame: Before 1st physical therapy session And after 8 weeks of regular 3 session per week of physical therapy
Using Dynamic ultrasonography for measuring
Functional ability
Time frame: Before 1st physical therapy session And after 8 weeks of regular 3 sessions/week of physical therapy
By Quik DASH Questionnaire
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2026.
- Background: PubMed 41506128Jatan N, Talo S, Azar AJ, Adrian TE, Kellett CF. Mechanisms and biomarkers for musculoskeletal signs and symptoms in patients treated with aromatase inhibitors: A comprehensive systematic review. Cancer Treat Rev. 2026 Feb;143:103075. doi: 10.1016/j.ctrv.2025.103075. Epub 2026 Jan 1.
- Background: PubMed 32661665Kaidar-Person O, Poortmans P, Offersen BV, Siesling S, Sklair-Levy M, Meattini I, de Ruysscher D, Kuhn T, Boersma LJ. Spatial location of local recurrences after mastectomy: a systematic review. Breast Cancer Res Treat. 2020 Sep;183(2):263-273. doi: 10.1007/s10549-020-05774-4. Epub 2020 Jul 13.
- Background: PubMed 34503097Lukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanislawek A. Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review. Cancers (Basel). 2021 Aug 25;13(17):4287. doi: 10.3390/cancers13174287.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Reverse fly excercise in people with Mastectomy and Aromatase Inhibitors Therapy, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Nourhan Ahmed Mahmoud Souliman, Master degree (+201112852496, nourhan.souliman@pt.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Supraspinatus Tendon Thickness (time frame: Before 1st physical therapy session And after 8 weeks of regular 3 session per week of physical therapy). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07763080, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.