Muscle StrengthNCT07763574
Omega-3 Fatty Acids and Muscle Strength
A study testing Effects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults, Effects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults and Effects of Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults in people with Muscle Strength and Cognitive Function Assessment, run by Gdansk University of Physical Education and Sport at 1 site in Poland.
Trial summary
The purpose of the study is to evaluate the effects of 12-week supplementation with algae-derived DHA combined with strength training on muscle strength, neuromuscular parameters, post-exercise inflammation and cognitive functions in healthy adults compared to fish-derived EPA and DHA combined with strength training… Read more about this study
- Who is it for?
- Ages 20 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Muscle Strength, Cognitive Function Assessment
- What is being tested?
- Effects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults, Effects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults and Effects of Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 120 participants
- Where
- 1 sitePoland
- Study dates
- 23 Aug 2026to Jan 2030
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- at least 1 year of strength training experience,
- without chronic or autoimmune diseases,
- between the ages of 20 and 40,
- not obese,
- not taking omega-3 fatty acids,
- not taking BCAAs, creatine, anabolic steroids,
Show all 9Show fewer
- for women: not pregnant or breastfeeding, and at least 1 year after childbirth (to allow for hormonal balance to stabilize).
- For the control group (non-exercisers):
- Requirements as above, except for exercise: we recruit individuals who exercise less than 1 hour per week
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effects of Strength Training Combined With Sustainable Source of Omega-3 Fatty Acids on Muscle Strength and Cognitive Functions in Adults
The purpose of the study is to evaluate the effects of 12-week supplementation with algae-derived DHA combined with strength training on muscle strength, neuromuscular parameters, post-exercise inflammation and cognitive functions in healthy adults compared to fish-derived EPA and DHA combined with strength training, strength training plus placebo and groups receiving only supplementation (algae-derived DHA, fish-derived EPA and DHA or placebo).
The research methods and measurement tools include:
Read more
- Body composition assessed prior to the training intervention and after 12 weeks of training: body mass index (BMI) and body composition - fat mass [kg], body fat percentage [%] and skeletal muscle mass [kg] - will be determined using bioimpedance methods (In Body 720, Biospace, Seoul, Korea) following an overnight fast.
- Assessment of physical activity levels using the long version of the International Physical Activity Questionnaire (IPAQ).
- Assessment of mood (UMACL Adjective Mood Scale) and depression (DASS-21, Beck Depression Scale).
- The SarQoL (Sarcopenia and Quality of Life) questionnaire, used to specifically assess quality of life in people with reduced muscle mass and function.
- Assessment of participants' diet: each participant will be required to record their diet in 3-day food diaries (to be checked on the first day of testing).
- Blood sampling: blood will be collected from each participant at two time points before and after the intervention (on an empty stomach, and 40 minutes after the training session). The following will be collected: 1 × 6 ml blood count tube and 3 tubes with a clotting activator, with a total volume of 20 ml. Blood will be collected before the start of the training intervention and after 12 weeks of training. The tubes will be centrifuged at 4 °C (4000 × g for 10 minutes). The serum, plasma and erythrocyte fractions will then be frozen at -80 °C until analysis.
- Peak force, relative peak force, start time to peak force and force at 100 and 200 milliseconds will be measured during isometric mid-thigh pull-ups using ForceDecks FD Lite dual uniaxial force plates with ForceDecks software (VALD Performance, Brisbane, Queensland, Australia). Upper limb grip strength will be measured using a SAEHAN electronic dynamometer.
- In addition, muscle electrical activity using a Noraxon Telemyo surface electromyograph will be assessed during isometric mid-thigh pull-ups.
- Cognitive function will be assessed using the following tests: the Stroop Test, the Corsi Block-Tapping Task and the Pattern Separation Task.
All analysis (beside IPAQ) will be performed before and after 12 weeks of intervention.
- During the study, all participants will take part in a strength training session (around 40 mins duration) led by an experienced trainer to stimulate the muscles to release myokines.
- Blood tests will include: BDNF, IGF-1, IL-6, hs-CRP, TNF-alpha, and IL-1B as well as concentrations of metabolites of the kynurenine pathway.
- Conditions
- Muscle Strength, Cognitive Function Assessment
- Being tested
- Effects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults, Effects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults, Effects of Strength Training Combined With Placebo on Muscle Strength and Cognitive Functions in adults, Effects of Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults, Effects of Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults
- Keywords
- algae-derived DHA, omega-3 fatty acids, muscle strength
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Effects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adultsDietary supplement
Healthy men and women with few years of training experience will participate in a 12-week strength training program combined with 3g/per day DHA from algae supplementation. The training will be 3 times a week, with 1-hour strength-training exercises for the upper and lower body.
At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.
Effects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adultsDietary supplement
Healthy men and women with few years of training experience will participate in a 12-week strength training program combined with EPA and DHA from fish supplementation (3g per day). The training will be 3 times a week, with 1-hour strength-training exercises for the upper and lower body.
At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.
Effects of Strength Training Combined With Placebo on Muscle Strength and Cognitive Functions in adultsDietary supplement
Healthy men and women with few years of training experience will participate in a 12-week strength training program combined with placebo supplementation. The training will be 3 times a week, with 1-hour strength-training exercises for the upper and lower body.
At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.
Effects of Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adultsDietary supplement
Healthy, untrained men and women will participate in a 12-week DHA from algae supplementation (3g per day). At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.
Effects of Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adultsDietary supplement
Healthy, untrained men and women will participate in a 12-week EPA and DHA from fish supplementation (3g per day).
At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.
Effects of Placebo on Muscle Strength and Cognitive Functions in adultsDietary supplement
Healthy, untrained men and women will participate in a 12-week placebo supplementation. At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.
| Study group | Role | What they receive |
|---|---|---|
| algae-derived DHA + strength training | Experimental | 3g of a algae-derived DHA + strength training 3 times a week through 12 weeks Receives: Dietary Supplement: Effects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults |
| fish-derived omega-3 + strength training | Experimental | 3g of a fish-derived omega-3 (EPA+DHA) + strength training 3 times a week through 12 weeks Receives: Dietary Supplement: Effects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults |
| placebo + strength training | Placebo comparator | 3g of a placebo + strength training 3 times a week through 12 weeks Receives: Dietary Supplement: Effects of Strength Training Combined With Placebo on Muscle Strength and Cognitive Functions in adults |
| algae-derived DHA without strength training | Active comparator | 3g of a algae-derived DHA through 12 weeks Receives: Dietary Supplement: Effects of Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults |
| fish-derived omega-3 without strength training | Active comparator | 3g of a fish-derived omega-3 (EPA+DHA) through 12 weeks Receives: Dietary Supplement: Effects of Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults |
| placebo without strength training | Placebo comparator | 3g of a placebo through 12 weeks Receives: Dietary Supplement: Effects of Placebo on Muscle Strength and Cognitive Functions in adults |
What is being measured
The primary outcome is the main question the study is designed to answer.
Relative peak force (N/kg bw) during Isometric Mid-Thigh Pull (IMTP) and Back Squat
Measured: 12 weeks intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Aug 2026
- Study start23 Aug 2026
- Primary completionJan 2029 (estimated)
- Study completionJan 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle StrengthStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- A randomised, double-blind, controlled trial comprising six experimental arms receiving fish-derived omega-3 (EPA+DHA), algae-derived DHA, or a placebo, who are concurrently subjected to a 12-week resistance training intervention or no training, depending on group allocation.
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Gdansk University of Physical Education and Sport
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07763574
- Sponsor's protocol ID
- AWFiS/2026_1_MT
- Status last verified
- Oct 2026
- First submitted
- 13 Jul 2026
- Last updated
- 29 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Strength Training Combined With Sustainable Source of Omega-3 Fatty Acids on Muscle Strength and Cognitive Functions in Adults
- ClinicalTrials.gov ID
- NCT07763574
- Acronym / sponsor ID
- AWFiS/2026_1_MT
- Conditions
- Muscle Strength, Cognitive Function Assessment
- Keywords
- algae-derived DHA, omega-3 fatty acids, muscle strength
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- Gdansk University of Physical Education and SportUniversity, hospital or other
- Study start
- 23 Aug 2026 (actual)
- Primary completion
- Jan 2029 (estimated)
- Study completion
- Jan 2030 (estimated)
- First posted
- 13 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of the study is to evaluate the effects of 12-week supplementation with algae-derived DHA combined with strength training on muscle strength, neuromuscular parameters, post-exercise inflammation and cognitive functions in healthy adults compared to fish-derived EPA and DHA combined with strength training, strength training plus placebo and groups receiving only supplementation (algae-derived DHA, fish-derived EPA and DHA or placebo).
The research methods and measurement tools include:
- Body composition assessed prior to the training intervention and after 12 weeks of training: body mass index (BMI) and body composition - fat mass [kg], body fat percentage [%] and skeletal muscle mass [kg] - will be determined using bioimpedance methods (In Body 720, Biospace, Seoul, Korea) following an overnight fast.
- Assessment of physical activity levels using the long version of the International Physical Activity Questionnaire (IPAQ).
- Assessment of mood (UMACL Adjective Mood Scale) and depression (DASS-21, Beck Depression Scale).
- The SarQoL (Sarcopenia and Quality of Life) questionnaire, used to specifically assess quality of life in people with reduced muscle mass and function.
- Assessment of participants' diet: each participant will be required to record their diet in 3-day food diaries (to be checked on the first day of testing).
- Blood sampling: blood will be collected from each participant at two time points before and after the intervention (on an empty stomach, and 40 minutes after the training session). The following will be collected: 1 × 6 ml blood count tube and 3 tubes with a clotting activator, with a total volume of 20 ml. Blood will be collected before the start of the training intervention and after 12 weeks of training. The tubes will be centrifuged at 4 °C (4000 × g for 10 minutes). The serum, plasma and erythrocyte fractions will then be frozen at -80 °C until analysis.
- Peak force, relative peak force, start time to peak force and force at 100 and 200 milliseconds will be measured during isometric mid-thigh pull-ups using ForceDecks FD Lite dual uniaxial force plates with ForceDecks software (VALD Performance, Brisbane, Queensland, Australia). Upper limb grip strength will be measured using a SAEHAN electronic dynamometer.
- In addition, muscle electrical activity using a Noraxon Telemyo surface electromyograph will be assessed during isometric mid-thigh pull-ups.
- Cognitive function will be assessed using the following tests: the Stroop Test, the Corsi Block-Tapping Task and the Pattern Separation Task.
All analysis (beside IPAQ) will be performed before and after 12 weeks of intervention.
- During the study, all participants will take part in a strength training session (around 40 mins duration) led by an experienced trainer to stimulate the muscles to release myokines.
- Blood tests will include: BDNF, IGF-1, IL-6, hs-CRP, TNF-alpha, and IL-1B as well as concentrations of metabolites of the kynurenine pathway.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 6
- Model description
- A randomised, double-blind, controlled trial comprising six experimental arms receiving fish-derived omega-3 (EPA+DHA), algae-derived DHA, or a placebo, who are concurrently subjected to a 12-week resistance training intervention or no training, depending on group allocation.
| Arm | Type | Receives |
|---|---|---|
| algae-derived DHA + strength training | Experimental | Dietary Supplement: Effects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults3g of a algae-derived DHA + strength training 3 times a week through 12 weeks |
| fish-derived omega-3 + strength training | Experimental | Dietary Supplement: Effects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults3g of a fish-derived omega-3 (EPA+DHA) + strength training 3 times a week through 12 weeks |
| placebo + strength training | Placebo comparator | Dietary Supplement: Effects of Strength Training Combined With Placebo on Muscle Strength and Cognitive Functions in adults3g of a placebo + strength training 3 times a week through 12 weeks |
| algae-derived DHA without strength training | Active comparator | Dietary Supplement: Effects of Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults3g of a algae-derived DHA through 12 weeks |
| fish-derived omega-3 without strength training | Active comparator | Dietary Supplement: Effects of Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults3g of a fish-derived omega-3 (EPA+DHA) through 12 weeks |
| placebo without strength training | Placebo comparator | Dietary Supplement: Effects of Placebo on Muscle Strength and Cognitive Functions in adults3g of a placebo through 12 weeks |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (9 listed)
- at least 1 year of strength training experience,
- without chronic or autoimmune diseases,
- between the ages of 20 and 40,
- not obese,
- not taking omega-3 fatty acids,
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Effects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adultsHealthy men and women with few years of training experience will participate in a 12-week strength training program combined with 3g/per day DHA from algae supplementation. The training will be 3 times a week, with 1-hour strength-training exercises for the upper and lower body. At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins. | Dietary supplement | algae-derived DHA + strength training |
| Effects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adultsHealthy men and women with few years of training experience will participate in a 12-week strength training program combined with EPA and DHA from fish supplementation (3g per day). The training will be 3 times a week, with 1-hour strength-training exercises for the upper and lower body. At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins. | Dietary supplement | fish-derived omega-3 + strength training |
| Effects of Strength Training Combined With Placebo on Muscle Strength and Cognitive Functions in adultsHealthy men and women with few years of training experience will participate in a 12-week strength training program combined with placebo supplementation. The training will be 3 times a week, with 1-hour strength-training exercises for the upper and lower body. At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins. | Dietary supplement | placebo + strength training |
| Effects of Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adultsHealthy, untrained men and women will participate in a 12-week DHA from algae supplementation (3g per day). At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins. | Dietary supplement | algae-derived DHA without strength training |
| Effects of Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adultsHealthy, untrained men and women will participate in a 12-week EPA and DHA from fish supplementation (3g per day). At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins. | Dietary supplement | fish-derived omega-3 without strength training |
| Effects of Placebo on Muscle Strength and Cognitive Functions in adultsHealthy, untrained men and women will participate in a 12-week placebo supplementation. At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins. | Dietary supplement | placebo without strength training |
Primary outcome
Relative peak force (N/kg bw) during Isometric Mid-Thigh Pull (IMTP) and Back Squat
Time frame: 12 weeks intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Effects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults, Effects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults and Effects of Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults in people with Muscle Strength and Cognitive Function Assessment, run by Gdansk University of Physical Education and Sport at 1 site in Poland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 29 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Poland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Relative peak force (N/kg bw) during Isometric Mid-Thigh Pull (IMTP) and Back Squat (time frame: 12 weeks intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Oct 2026.