EndometriosisYOGENDOCHIRNCT07765680
Perioperative Yoga Therapy and Endometriosis Surgery
A study testing Standard surgical management for endometriosis and Structured perioperative yogatherapy programme plus standard surgical management in people with Endometriosis and Chronic Pain, run by University Hospital, Lille at 4 sites in France.
Trial summary
YOGENDOCHIR is a multicentre, prospective, randomised, controlled, parallel-group study involving 188 adult women scheduled to undergo surgery for endometriosis. The study compares standard surgical management alone with the same management combined with a structured perioperative yoga therapy programme comprising 32… Read more about this study
- Who is it for?
- Ages 18 years and older, women only
- Conditions the study is for
- Endometriosis, Chronic Pain, Impairment of Quality of Life
- What is being tested?
- Standard surgical management for endometriosis and Structured perioperative yogatherapy programme plus standard surgical management
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 188 participants
- Where
- 4 sitesFrance
- Study dates
- 1 Oct 2026to 1 Oct 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- No healthy volunteers
- Adult, Older adult
- Adult woman (18 years or older) covered by a social health insurance scheme.
- Surgery for endometriosis is indicated.
- No assisted reproductive technology (ART) protocol planned within 6 months after surgery.
- No chronic pain attributable to another disease or condition.
- No yoga practice outside the study during participation.
Trial locations and contacts
4 sites in 1 country. Contact the study team or a site near you to ask about taking part.
France4 sites
CHU Amiens
Amiens
Arthur Foulon, PU PH
CH de Calais
Calais
FICHAUX Hélène, PH
CHU de Lille
Lille, 59000
CHU de Lille
Lille, 59037
RUBOD Chrystele, PU PH
RUBOD Chrystele
About this study
Official title: The Effectiveness of Yoga Therapy on Chronic Pain, Endometriosis Symptoms and Quality of Life Following Surgery for Endometriosis
YOGENDOCHIR is a multicentre, prospective, randomised, controlled, parallel-group study involving 188 adult women scheduled to undergo surgery for endometriosis.
The study compares standard surgical management alone with the same management combined with a structured perioperative yoga therapy programme comprising 32 guided sessions (16 before and 16 after surgery), supplemented by a secure digital platform supporting independent practice and adherence monitoring.
Read more
The primary objective is to assess the effect of yoga therapy on endometriosis-related pain, as measured by the pain subscale of the Endometriosis Health Profile-30 (EHP-30). Participants are assessed before surgery and at 3, 6, and 12 months after the procedure.
Secondary outcomes include quality of life, pain characteristics, fatigue, sleep, anxiety and depressive symptoms, sexual health, kinesiophobia, activities of daily living, medication use, healthcare utilisation, absenteeism, adherence, satisfaction, and the participants' ability to use the platform independently.
- Conditions
- Endometriosis, Chronic Pain, Impairment of Quality of Life
- Being tested
- Standard surgical management for endometriosis, Structured perioperative yogatherapy programme plus standard surgical management
- Keywords
- Endometriosis, chronic pain, yogatherapy, surgery
- Medical subject headings
- Endometriosis, Chronic Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Standard surgical management for endometriosisProcedure or surgery
Participants undergo the indicated surgery for endometriosis and receive standard perioperative and follow-up care, without study yoga therapy sessions. They complete the same scheduled clinical and patient-reported assessments as the intervention group.
Structured perioperative yogatherapy programme plus standard surgical managementProcedure or surgery
Participants undergo the indicated surgery for endometriosis and receive 32 live, guided yoga therapy sessions: 16 sessions during the 2 months before surgery and 16 sessions during the 3 months after surgery. Sessions are delivered by healthcare professionals trained in yoga therapy and combine adapted postures, breathing techniques, and meditative practices. A secure digital platform provides videos, audio materials, questionnaires, support for independent practice, and pseudonymised monitoring of session opening, initiation, interruption, completion, validation, frequency, and regularity.
| Study group | Role | What they receive |
|---|---|---|
| Perioperative yogatherapy plus standard surgery | Experimental | Participants undergo the indicated surgery for endometriosis and receive 32 live, guided yoga therapy sessions: 16 sessions during the 2 months before surgery and 16 sessions during the 3 months after surgery. Sessions are delivered by healthcare professionals trained in yoga therapy and combine adapted postures, breathing techniques, and meditative practices. A secure digital platform provides videos, audio materials, questionnaires, support for independent practice, and pseudonymised monitoring of session opening, initiation, interruption, completion, validation, frequency, and regularity. Receives: Procedure: Structured perioperative yogatherapy programme plus standard surgical management |
| Standard surgery alone (control group) | Active comparator | Standard surgical management for endometriosis Receives: Procedure: Standard surgical management for endometriosis |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in endometriosis-related pain measured by the EHP-30 pain subscale
Between-group difference in change from the preoperative baseline in the pain subscale of the Endometriosis Health Profile-30 (EHP-30), comparing perioperative yoga therapy plus standard surgery with standard surgery alone. The sample-size calculation is based on detecting an additional clinically relevant 11-point reduction in the EHP-30 pain subscore.
Measured: baseline3 Months6 monthes12 months after surgery
Secondary outcomes (4)
Endometriosis-specific and generic health-related quality of life
Changes in the non-pain EHP-30 domains (control and powerlessness, emotional well-being, social support, and self-esteem) and in EQ-5D-5L dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression). A subjective quality-of-life assessment is also recorded in the self-care book.
Measured: baseline3 months6 months12 months after surgery
Pain characteristics, fatigue, sleep, emotional symptoms, sexual health, kinesiophobia, and daily functioning
Pain intensity and sensory/affective characteristics are assessed using a 0-10 visual analogue scale and the short-form Saint-Antoine Pain Questionnaire. Anxiety and depressive symptoms are assessed with the Hospital Anxiety and Depression Scale. General health observations document sleep, fatigue, urinary and digestive symptoms, emotions, and bodily sensations. Sexual health, fear of movement, and limitations in activities of daily living are also evaluated.
Measured: baseline3 months6 months12 months after surgery. 14 days before each study visit
Medication use, healthcare utilisation, hospitalisations, and work absenteeism
Between-group comparison of medication use, healthcare contacts and consultations, hospital admissions, sick leave, and absence from work over the 12-month follow-up period.
Measured: baseline3 months6 months12 months after surgery. 14 days before each study visit
Adherence, acceptability, satisfaction, and autonomous use of the digital platform
Attendance at guided sessions, satisfaction with the programme, autonomy, and appropriation of the tools are evaluated. Pseudonymised platform metrics include opening, initiation, interruption, completion and validation of sessions, together with the frequency and regularity of independent practice.
Measured: During the 16 preoperative and 16 postoperative guided sessions3 to 9 months after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Aug 2026
- Study start1 Oct 2026 (estimated)
- Primary completion1 Feb 2028 (estimated)
- Study completion1 Oct 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for EndometriosisStudies of the same condition, open and under way.
- More trials run by University Hospital, LilleThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 188 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Lille
- Sponsor type
- University, hospital or other
- Collaborators
- Direction Générale de l'Offre de Soins
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07765680
- Sponsor's protocol ID
- 2024_0326
- Acronym
- YOGENDOCHIR
- Status last verified
- Aug 2026
- First submitted
- 3 Aug 2026
- Last updated
- 2 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effectiveness of Yoga Therapy on Chronic Pain, Endometriosis Symptoms and Quality of Life Following Surgery for Endometriosis
- ClinicalTrials.gov ID
- NCT07765680
- Acronym / sponsor ID
- YOGENDOCHIR / 2024_0326
- Conditions
- Endometriosis, Chronic Pain, Impairment of Quality of Life
- Keywords
- Endometriosis, chronic pain, yogatherapy, surgery
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 188 participants (estimated)
- Lead sponsor
- University Hospital, LilleUniversity, hospital or other
- Collaborators
- Direction Générale de l'Offre de Soins
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- 1 Feb 2028 (estimated)
- Study completion
- 1 Oct 2029 (estimated)
- First posted
- 14 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
YOGENDOCHIR is a multicentre, prospective, randomised, controlled, parallel-group study involving 188 adult women scheduled to undergo surgery for endometriosis.
The study compares standard surgical management alone with the same management combined with a structured perioperative yoga therapy programme comprising 32 guided sessions (16 before and 16 after surgery), supplemented by a secure digital platform supporting independent practice and adherence monitoring.
The primary objective is to assess the effect of yoga therapy on endometriosis-related pain, as measured by the pain subscale of the Endometriosis Health Profile-30 (EHP-30). Participants are assessed before surgery and at 3, 6, and 12 months after the procedure.
Secondary outcomes include quality of life, pain characteristics, fatigue, sleep, anxiety and depressive symptoms, sexual health, kinesiophobia, activities of daily living, medication use, healthcare utilisation, absenteeism, adherence, satisfaction, and the participants' ability to use the platform independently.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Perioperative yogatherapy plus standard surgery | Experimental | Procedure: Structured perioperative yogatherapy programme plus standard surgical managementParticipants undergo the indicated surgery for endometriosis and receive 32 live, guided yoga therapy sessions: 16 sessions during the 2 months before surgery and 16 sessions during the 3 months after surgery. Sessions are delivered by healthcare professionals trained in yoga therapy and combine adapted postures, breathing techniques, and meditative practices. A secure digital platform provides videos, audio materials, questionnaires, support for independent practice, and pseudonymised monitoring of session opening, initiation, interruption, completion, validation, frequency, and regularity. |
| Standard surgery alone (control group) | Active comparator | Procedure: Standard surgical management for endometriosisStandard surgical management for endometriosis |
Who may qualify
- Ages
- 18 years and older
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Standard surgical management for endometriosisParticipants undergo the indicated surgery for endometriosis and receive standard perioperative and follow-up care, without study yoga therapy sessions. They complete the same scheduled clinical and patient-reported assessments as the intervention group. | Procedure or surgery | Standard surgery alone (control group) |
| Structured perioperative yogatherapy programme plus standard surgical managementParticipants undergo the indicated surgery for endometriosis and receive 32 live, guided yoga therapy sessions: 16 sessions during the 2 months before surgery and 16 sessions during the 3 months after surgery. Sessions are delivered by healthcare professionals trained in yoga therapy and combine adapted postures, breathing techniques, and meditative practices. A secure digital platform provides videos, audio materials, questionnaires, support for independent practice, and pseudonymised monitoring of session opening, initiation, interruption, completion, validation, frequency, and regularity. | Procedure or surgery | Perioperative yogatherapy plus standard surgery |
Primary outcome
Change in endometriosis-related pain measured by the EHP-30 pain subscale
Time frame: baseline3 Months6 monthes12 months after surgery
Between-group difference in change from the preoperative baseline in the pain subscale of the Endometriosis Health Profile-30 (EHP-30), comparing perioperative yoga therapy plus standard surgery with standard surgery alone. The sample-size calculation is based on detecting an additional clinically relevant 11-point reduction in the EHP-30 pain subscore.
4 secondary outcomes
Endometriosis-specific and generic health-related quality of life
Time frame: baseline3 months6 months12 months after surgery
Pain characteristics, fatigue, sleep, emotional symptoms, sexual health, kinesiophobia, and daily functioning
Time frame: baseline3 months6 months12 months after surgery. 14 days before each study visit
Medication use, healthcare utilisation, hospitalisations, and work absenteeism
Time frame: baseline3 months6 months12 months after surgery. 14 days before each study visit
Adherence, acceptability, satisfaction, and autonomous use of the digital platform
Time frame: During the 16 preoperative and 16 postoperative guided sessions3 to 9 months after surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
4 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Standard surgical management for endometriosis and Structured perioperative yogatherapy programme plus standard surgical management in people with Endometriosis and Chronic Pain, run by University Hospital, Lille at 4 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 2 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 4 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact GUENEAU Nina (03 20 44 67 57, nina.gueneau@chu-lille.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in endometriosis-related pain measured by the EHP-30 pain subscale (time frame: baseline3 Months6 monthes12 months after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2026.