War InjuryTRAUM-IMPACTNCT07766447
Long-term Medical Impact of War Injuries on Military Personnel
A study testing biological and radiological examinations in people with War Injury and Physical Injury, run by Direction Centrale du Service de Santé des Armées.
Trial summary
Beyond short-term multidisciplinary care, the French Armed Forces Health Service provides medical and surgical care, followed by medical and social care and long-term support for the wounded, especially when they have suffered multiple injuries during operations and are severely disabled. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- War Injury, Physical Injury
- What is being tested?
- biological and radiological examinations
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- No sites listed yet
- Study dates
- 1 Oct 2026to Dec 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥ 18 years
- French military patient
- Patient wounded in action
- Patient repatriated and treated at the Percy National Military Hospital for a physical war injury sustained between 2020 and 2025
- Life expectancy > 1 year
- Patient conscious and oriented at the time of inclusion
- Patient with health insurance
Who cannot join
- Isolated psychological injury
- Physical injury not related to war
- Patient unable to give free consent, under guardianship or curatorship
- Refusal to participate
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Beyond short-term multidisciplinary care, the French Armed Forces Health Service provides medical and surgical care, followed by medical and social care and long-term support for the wounded, especially when they have suffered multiple injuries during operations and are severely disabled. This involves primary phases of rehabilitation to limit the after-effects, preserve the functional prognosis and increase the autonomy of the injured person; secondary medical and social phases of rehabilitation and reintegration to restore the injured person's place in society.
The reconstruction stages are therefore essential. However, little data is available on the evolution of these patients' general health.
Read more
A similar follow-up cohort was set up by the British Army to monitor physical injuries during the conflict in Afghanistan. The results suggest the possibility of long-term cardiovascular and neoplastic complications in this population.
Furthermore, there is no data available on the evolution of the health status of war wounded in France. A retrospective study is currently underway, TRAUM-IMPACT RETRO, with the aim of assessing the consequences of 10 years of operational engagements from 2013 to 2023. This study should enable the medical French army service to clarify the topography of injuries and the medical and social outcomes of casualties treated at the Percy National Military Institute of Surgery (HNIA Percy) during this period. Initially, a pilot study followed by a cohort study will enable the investigators to standardise the medical follow-up of war casualties and determine their medical and social outcomes.
The population studied in this clinical trial corresponds to all military personnel repatriated and treated at the Percy National Military Hospital for a war injury defined as follows: "Any physical injury of a certain degree of severity directly related to the presence of the enemy, i.e. in combat or indirectly through effective participation in war operations, preparatory to or consequential to combat. " The investigators hypothesise that severely disabled wounded soldiers are at risk of specific complications leading to excess morbidity and disability, complications associated with ageing, and a risk of social and professional isolation. As a result, the participants require lifelong monitoring to prevent, detect and manage these complications, thereby ensuring that the nation gives its wounded children the recognition the participants deserve.
- Conditions
- War Injury, Physical Injury
- Being tested
- biological and radiological examinations
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
biological and radiological examinationsOther
The TRAUM-IMPACT study designed to assess the feasibility of establishing a long-term cohort study to monitor war casualties and will be carried out in parallel with the usual care provided.
| Study group | Role | What they receive |
|---|---|---|
| War wounded repatriated and treated at the Percy National Institute of Military Medicine | Experimental | Not described Receives: Other: biological and radiological examinations |
What is being measured
The primary outcome is the main question the study is designed to answer.
The primary outcome is the feasibility of a standardized multidisciplinary follow-up strategy, assessed by patient recruitment rate, retention rate during follow-up, completion
Health event reported during visits over the course of the study and type of injury at inclusion (multiple trauma, limb trauma, head trauma).
Measured: 2 years
Secondary outcomes (9)
Longitudinal evolution of quality of life according to type of injury
Short-Forme (SF) 36 quality of life score
Measured: 2 years
Longitudinal changes in gait performance
Gait performance will be evaluated using both clinical and instrumented assessments, including walking speed, walking perimeter, Timed Up and Go (TUG) test, wearable sensor-based gait analysis (spatiotemporal gait parameters), static postural assessment, and balance evaluation. These measures will be used to quantify changes in mobility, stability, and functional recovery throughout follow-up.
Measured: 2 yaers
Define predictive factors for the occurrence of a new diagnosis or new treatment (psychiatric illness, chronic illness, cardiovascular disease, neoplasia, or any relevant medical event).
Search for the occurrence of a new diagnosis or new treatment (psychiatric illness, chronic illness, cardiovascular disease, neoplasia, or any relevant medical event) and predictive factors.
Measured: 2 yaers
Level of generic pain
Generic pain questionnaire (QDSA)
Measured: 2 years
Level of anxiety and depression
HAD anxiety/depression scale
Measured: 2 years
Sleep quality
Sleep disorder screening (Epworth score)
Measured: 2 years
Level of physical inactivity
Specific questionnaire on returning to sport/sedentary lifestyle
Measured: 2 years
Addictive behaviours
Addictive behaviour screening questionnaire (alcohol, tobacco, drugs)
Measured: 2 years
Incidence of Post-Traumatic Stress Disorder
PCLS-5 questionnaire
Measured: 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Aug 2026
- Study start1 Oct 2026 (estimated)
- Primary completionDec 2028 (estimated)
- Study completionDec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for War InjuryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Cohort
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Direction Centrale du Service de Santé des Armées
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07766447
- Sponsor's protocol ID
- 2024PBMD01
- Other IDs
- 2025-A02095-44
- Acronym
- TRAUM-IMPACT
- Status last verified
- Mar 2026
- First submitted
- 4 Jun 2026
- Last updated
- 14 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The conditions for the transfer of all or part of the research database will be decided by the Central Directorate of the Armed Forces Health Service (research sponsor) and will be set out in a written contract.
Publications
Bennett AN, Dyball DM, Boos CJ, Fear NT, Schofield S, Bull AMJ, Cullinan P; ADVANCE Study. Study protocol for a prospective, longitudinal cohort study investigating the medical and psychosocial outcomes of UK combat casualties from the Afghanistan war: the ADVANCE Study. BMJ Open. 2020 Oct 30;10(10):e037850. doi: 10.1136/bmjopen-2020-037850.
PubMed 33127630Hoffmann C. Blessés de guerre français en Afghanistan: de la blessure à la réinsertion [Thèse d'exercice]. [France]: Université Pierre et Marie Curie (Paris). UFR de médecine Pierre et Marie Curie; 2014.
Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Back M, Benetos A, Biffi A, Boavida JM, Capodanno D, Cosyns B, Crawford C, Davos CH, Desormais I, Di Angelantonio E, Franco OH, Halvorsen S, Hobbs FDR, Hollander M, Jankowska EA, Michal M, Sacco S, Sattar N, Tokgozoglu L, Tonstad S, Tsioufis KP, van Dis I, van Gelder IC, Wanner C, Williams B; ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021 Sep 7;42(34):3227-3337. doi: 10.1093/eurheartj/ehab484. No abstract available.
PubMed 34458905Taylor AJ, Bindeman J, Feuerstein I, Cao F, Brazaitis M, O'Malley PG. Coronary calcium independently predicts incident premature coronary heart disease over measured cardiovascular risk factors: mean three-year outcomes in the Prospective Army Coronary Calcium (PACC) project. J Am Coll Cardiol. 2005 Sep 6;46(5):807-14. doi: 10.1016/j.jacc.2005.05.049.
PubMed 16139129
Study at a glance
From the registry record, last updated by the sponsor on 14 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Long-term Medical Impact of War Injuries on Military Personnel
- ClinicalTrials.gov ID
- NCT07766447
- Acronym / sponsor ID
- TRAUM-IMPACT / 2024PBMD01
- Conditions
- War Injury, Physical Injury
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Direction Centrale du Service de Santé des ArméesUniversity, hospital or other
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- Dec 2028 (estimated)
- Study completion
- Dec 2028 (estimated)
- First posted
- 14 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Beyond short-term multidisciplinary care, the French Armed Forces Health Service provides medical and surgical care, followed by medical and social care and long-term support for the wounded, especially when they have suffered multiple injuries during operations and are severely disabled. This involves primary phases of rehabilitation to limit the after-effects, preserve the functional prognosis and increase the autonomy of the injured person; secondary medical and social phases of rehabilitation and reintegration to restore the injured person's place in society.
The reconstruction stages are therefore essential. However, little data is available on the evolution of these patients' general health.
A similar follow-up cohort was set up by the British Army to monitor physical injuries during the conflict in Afghanistan. The results suggest the possibility of long-term cardiovascular and neoplastic complications in this population.
Furthermore, there is no data available on the evolution of the health status of war wounded in France. A retrospective study is currently underway, TRAUM-IMPACT RETRO, with the aim of assessing the consequences of 10 years of operational engagements from 2013 to 2023. This study should enable the medical French army service to clarify the topography of injuries and the medical and social outcomes of casualties treated at the Percy National Military Institute of Surgery (HNIA Percy) during this period. Initially, a pilot study followed by a cohort study will enable the investigators to standardise the medical follow-up of war casualties and determine their medical and social outcomes.
The population studied in this clinical trial corresponds to all military personnel repatriated and treated at the Percy National Military Hospital for a war injury defined as follows: "Any physical injury of a certain degree of severity directly related to the presence of the enemy, i.e. in combat or indirectly through effective participation in war operations, preparatory to or consequential to combat. " The investigators hypothesise that severely disabled wounded soldiers are at risk of specific complications leading to excess morbidity and disability, complications associated with ageing, and a risk of social and professional isolation. As a result, the participants require lifelong monitoring to prevent, detect and manage these complications, thereby ensuring that the nation gives its wounded children the recognition the participants deserve.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Cohort
| Arm | Type | Receives |
|---|---|---|
| War wounded repatriated and treated at the Percy National Institute of Military Medicine | Experimental | Other: biological and radiological examinations |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Age ≥ 18 years
- French military patient
- Patient wounded in action
- Patient repatriated and treated at the Percy National Military Hospital for a physical war injury sustained between 2020 and 2025
- Life expectancy > 1 year
Key exclusion criteria (4 listed)
- Isolated psychological injury
- Physical injury not related to war
- Patient unable to give free consent, under guardianship or curatorship
- Refusal to participate
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| biological and radiological examinationsThe TRAUM-IMPACT study designed to assess the feasibility of establishing a long-term cohort study to monitor war casualties and will be carried out in parallel with the usual care provided. | Other | War wounded repatriated and treated at the Percy National Institute of Military Medicine |
Primary outcome
The primary outcome is the feasibility of a standardized multidisciplinary follow-up strategy, assessed by patient recruitment rate, retention rate during follow-up, completion
Time frame: 2 years
Health event reported during visits over the course of the study and type of injury at inclusion (multiple trauma, limb trauma, head trauma).
9 secondary outcomes
Longitudinal evolution of quality of life according to type of injury
Time frame: 2 years
Longitudinal changes in gait performance
Time frame: 2 yaers
Define predictive factors for the occurrence of a new diagnosis or new treatment (psychiatric illness, chronic illness, cardiovascular disease, neoplasia, or any relevant medical event).
Time frame: 2 yaers
Level of generic pain
Time frame: 2 years
Level of anxiety and depression
Time frame: 2 years
Sleep quality
Time frame: 2 years
Level of physical inactivity
Time frame: 2 years
Addictive behaviours
Time frame: 2 years
Incidence of Post-Traumatic Stress Disorder
Time frame: 2 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Aug 2026.
- Background: PubMed 33127630Bennett AN, Dyball DM, Boos CJ, Fear NT, Schofield S, Bull AMJ, Cullinan P; ADVANCE Study. Study protocol for a prospective, longitudinal cohort study investigating the medical and psychosocial outcomes of UK combat casualties from the Afghanistan war: the ADVANCE Study. BMJ Open. 2020 Oct 30;10(10):e037850. doi: 10.1136/bmjopen-2020-037850.
- BackgroundHoffmann C. Blessés de guerre français en Afghanistan: de la blessure à la réinsertion [Thèse d'exercice]. [France]: Université Pierre et Marie Curie (Paris). UFR de médecine Pierre et Marie Curie; 2014.
- Background: PubMed 34458905Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Back M, Benetos A, Biffi A, Boavida JM, Capodanno D, Cosyns B, Crawford C, Davos CH, Desormais I, Di Angelantonio E, Franco OH, Halvorsen S, Hobbs FDR, Hollander M, Jankowska EA, Michal M, Sacco S, Sattar N, Tokgozoglu L, Tonstad S, Tsioufis KP, van Dis I, van Gelder IC, Wanner C, Williams B; ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021 Sep 7;42(34):3227-3337. doi: 10.1093/eurheartj/ehab484. No abstract available.
- Background: PubMed 16139129Taylor AJ, Bindeman J, Feuerstein I, Cao F, Brazaitis M, O'Malley PG. Coronary calcium independently predicts incident premature coronary heart disease over measured cardiovascular risk factors: mean three-year outcomes in the Prospective Army Coronary Calcium (PACC) project. J Am Coll Cardiol. 2005 Sep 6;46(5):807-14. doi: 10.1016/j.jacc.2005.05.049.
- Individual participant dataSharing planned: No. The conditions for the transfer of all or part of the research database will be decided by the Central Directorate of the Armed Forces Health Service (research sponsor) and will be set out in a written contract.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing biological and radiological examinations in people with War Injury and Physical Injury, run by Direction Centrale du Service de Santé des Armées.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Caroline DOUTRELON, Chief Medical Officer (0033141466272, caroline.doutrelon@intradef.gouv.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The primary outcome is the feasibility of a standardized multidisciplinary follow-up strategy, assessed by patient recruitment rate, retention rate during follow-up, completion (time frame: 2 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07766447, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Aug 2026.