Pancreatic CystNCT07767227
Blood and Cystic Fluid From Patients Undergoing Surgery for Worrisome Pancreatic Cysts
An observational study of Pancreatic Cyst, run by Translational Genomics Research Institute at 2 sites in United States.
Trial summary
The goal of this study is to collect biospecimens (blood and cystic fluid) and data from participants who have a pancreatic cyst that requires surgical resection. The blood and fluid samples will be analyzed for research into DNA, RNA, and proteins. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Pancreatic Cyst
- How many people
- 30 participants
- Where
- 2 sitesUnited States
- Study dates
- 3 Feb 2025to Mar 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Participants will, primarily, be patients of the clinical Investigators at HOAG and Piedmont Healthcare hospitals who are or will be scheduled for surgical resection of their worrisome pancreatic cyst as part of their clinically indicated care.
Who may be able to join
- Voluntarily agree to participate by giving written informed consent prior to any study-specific procedures.
- Subject at least 18 years of age and able to provide consent. Subject is willing and able to comply with requirements of the protocol.
- Radiologically documented cyst of the pancreas for which surgical removal is clinically indicated.
- Patient will be undergoing a surgical resection of their pancreatic cystic neoplasm.
Who cannot join
- Patient who is pregnant at the time of study enrollment and sample collection.
- Patient will not be undergoing clinically indicated surgery for a pancreatic cystic neoplasm.
- Patient is unwilling or unable to provide informed consent or comply with study procedures.
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United States2 sites, 2 recruiting
- Recruiting
Piedmont HealthCare
Atlanta, Georgia, 30309
Andrew Page, MD, (404) 605-7100, andrew.page@piedmont.org
- Recruiting
Hoag Family Cancer Institute
Newport Beach, California, 92663
Michael Demeure, MD, 949-764-4577, clinicalresearch@hoag.org
About this study
Official title: Pilot Proof of Concept Study of miRNA and Protein Signatures in Exosomes From Blood and Cystic Fluid in Patients Undergoing Surgery for Worrisome Pancreatic Cysts
The goal of this study is to collect biospecimens (blood and cystic fluid) and data from participants who have a pancreatic cyst that requires surgical resection. The blood and fluid samples will be analyzed for research into DNA, RNA, and proteins.
- Conditions
- Pancreatic Cyst
- Medical subject headings
- Pancreatic Cyst
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Pancreatic cyst | Patients who are or will be scheduled for surgical resection of their worrisome pancreatic cyst as part of their clinically indicated care. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Characterize the miRNA and protein signatures in exosomes derived from blood and cyst fluids in patients with worrisome cystic pancreatic tumors
Measured: At enrollment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Aug 2026
- Study start3 Feb 2025
- Primary completionDec 2027 (estimated)
- Study completionMar 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pancreatic CystStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Translational Genomics Research Institute
- Sponsor type
- University, hospital or other
- Collaborators
- Hoag Memorial Hospital Presbyterian, City of Hope National Medical Center, Piedmont Healthcare
- Responsible party
- Sponsor
- Investigators
- Michael Demeure, MD, Principal investigator, Hoag Family Cancer Institute
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07767227
- Sponsor's protocol ID
- 102-24-CA
- Status last verified
- Jul 2026
- First submitted
- 11 Aug 2026
- Last updated
- 17 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Pilot Proof of Concept Study of miRNA and Protein Signatures in Exosomes From Blood and Cystic Fluid in Patients Undergoing Surgery for Worrisome Pancreatic Cysts
- ClinicalTrials.gov ID
- NCT07767227
- Acronym / sponsor ID
- 102-24-CA
- Conditions
- Pancreatic Cyst
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Translational Genomics Research InstituteUniversity, hospital or other
- Collaborators
- Hoag Memorial Hospital Presbyterian, City of Hope National Medical Center, Piedmont Healthcare
- Study start
- 3 Feb 2025 (actual)
- Primary completion
- Dec 2027 (estimated)
- Study completion
- Mar 2028 (estimated)
- First posted
- 17 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to collect biospecimens (blood and cystic fluid) and data from participants who have a pancreatic cyst that requires surgical resection. The blood and fluid samples will be analyzed for research into DNA, RNA, and proteins.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Pancreatic cyst | – | –Patients who are or will be scheduled for surgical resection of their worrisome pancreatic cyst as part of their clinically indicated care. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Participants will, primarily, be patients of the clinical Investigators at HOAG and Piedmont Healthcare hospitals who are or will be scheduled for surgical resection of their worrisome pancreatic cyst as part of their clinically indicated care.
Key inclusion criteria (4 listed)
- Voluntarily agree to participate by giving written informed consent prior to any study-specific procedures.
- Subject at least 18 years of age and able to provide consent. Subject is willing and able to comply with requirements of the protocol.
- Radiologically documented cyst of the pancreas for which surgical removal is clinically indicated.
- Patient will be undergoing a surgical resection of their pancreatic cystic neoplasm.
Key exclusion criteria (3 listed)
- Patient who is pregnant at the time of study enrollment and sample collection.
- Patient will not be undergoing clinically indicated surgery for a pancreatic cystic neoplasm.
- Patient is unwilling or unable to provide informed consent or comply with study procedures.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Characterize the miRNA and protein signatures in exosomes derived from blood and cyst fluids in patients with worrisome cystic pancreatic tumors
Time frame: At enrollment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Michael Demeure, MD principal investigator
Hoag Family Cancer Institute
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Pancreatic Cyst, run by Translational Genomics Research Institute at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Michael Demeure, MD (949-764-4577, clinicalresearch@hoag.org), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Characterize the miRNA and protein signatures in exosomes derived from blood and cyst fluids in patients with worrisome cystic pancreatic tumors (time frame: At enrollment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2026.