ArthritisNCT07767669
A Controlled Study to Evaluate the Effects of a Topical Cream on Symptoms of Arthritis, Joint, and Muscle Pain
A study testing Intervention (Saje Pain Release Joint & Arthritis Cream) in people with Arthritis and Joint Pain, run by Saie Beauty at 1 site in United States.
Trial summary
This is a randomized, triple-blind, controlled clinical trial evaluating the effects of Saje Pain Release Joint \& Arthritis Cream on symptoms of arthritis, joint pain, and muscle pain in adults aged 20-65. Read more about this study
- Who is it for?
- Ages 20 to 65 years
- Conditions the study is for
- Arthritis, Joint Pain, Muscle Pain
- What is being tested?
- Intervention (Saje Pain Release Joint & Arthritis Cream)
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 80 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Feb 2026to 31 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Be male or female
- Be aged 20-65
- Has experienced issues regarding all of the following in the past four weeks: symptoms of arthritis of the knees, elbows, wrists, or ankles
- joint pain and stiffness
- Self-reported issues must be at least 3 out of 10 in severity, with 1 being the least severe and 10 being the most
- Generally healthy - does not live with any uncontrolled chronic disease
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- If taking oral over-the-counter supplements or herbal remedies targeted at symptoms of arthritis, joint and muscle pain, has been consistently taking these for at least 3 months prior to starting the study, and is willing to maintain this routine for the study duration
- Willing to avoid introducing any new forms of prescription medication or supplements that target symptoms of arthritis, joint and muscle pain for the study duration
- Resides in the United States
- Willing to maintain their current diet, sleep pattern, and activity levels for the duration of the trial
Who cannot join
- Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
- Anyone with any allergies or sensitivities to any of the study product ingredients
- Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period)
- Symptoms occurring in a joint that has been surgically repaired
- Anyone unwilling to follow the study protocol
- Anyone who identifies as having sensitive skin
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- Anyone with any history of skin cancer or any pre-cancerous lesions on their skin
- Anyone with a history of substance abuse
- Anyone who is currently a smoker or has been a smoker in the past 3 months
- Currently partaking in another research study or will be partaking in any other research study at any point during this study's duration
- Anyone with chronic skin conditions (e.g., dermatitis, eczema, psoriasis)
- Anyone who currently takes prescription pain relief to manage their symptoms
Trial locations and contacts
1 site in 1 country.
About this study
This is a randomized, triple-blind, controlled clinical trial evaluating the effects of Saje Pain Release Joint \& Arthritis Cream on symptoms of arthritis, joint pain, and muscle pain in adults aged 20-65. The trial is conducted virtually over seven days, with 80 participants randomized equally into an intervention arm (active topical cream) and a control arm (matched control product).
Participants apply their assigned product three times daily to affected areas (knees, elbows, wrists, or ankles) and complete questionnaires at Baseline, 30 minutes after the first application, and at the end of Day 7. The primary objective is to assess changes in arthritis and musculoskeletal pain symptoms, while secondary objectives assess participants' perceptions of joint pain, stiffness, function, comfort, flexibility, mobility, and overall quality of life.
- Conditions
- Arthritis, Joint Pain, Muscle Pain, Musculoskeletal Pain, Joint Stiffness
- Being tested
- Intervention (Saje Pain Release Joint & Arthritis Cream), Placebo Comparator
- Medical subject headings
- Arthritis, Arthralgia, Myalgia, Musculoskeletal Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Intervention (Saje Pain Release Joint & Arthritis Cream)Dietary supplement
40 participants apply a thin layer of the Saje Pain Release Joint \& Arthritis Cream to arthritis-affected areas (knees, elbows, wrists, ankles) three times daily (morning, afternoon, and evening) for seven days
Placebo ComparatorDietary supplement
40 participants apply a matched control product (identical in appearance and consistency to the active product but without active ingredients such as L-menthol and balsam copaiba oil) to arthritis-affected areas three times daily (morning, afternoon, and evening) for seven days
| Study group | Role | What they receive |
|---|---|---|
| Intervention (Saje Pain Release Joint & Arthritis Cream) | Experimental | Not described Receives: Dietary Supplement: Intervention (Saje Pain Release Joint & Arthritis Cream) |
| Placebo Comparator | Placebo comparator | Not described Receives: Dietary Supplement: Placebo Comparator |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in symptoms of arthritis
Assessed via self-reported numerical pain rating scale and the Musculoskeletal Health Questionnaire (MSK-HQ) validated questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Change in symptoms of joint pain
Assessed via self-reported numerical pain rating scale and the Musculoskeletal Health Questionnaire (MSK-HQ) validated questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Change in symptoms of muscle pain
Assessed via self-reported numerical pain rating scale and the Musculoskeletal Health Questionnaire (MSK-HQ) validated questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Secondary outcomes (8)
Change in self-reported joint pain
Assessed via self-reported questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Change in self-reported joint stiffness
Assessed via self-reported questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Change in self-reported joint function
Assessed via self-reported questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Change in self-reported joint comfort
Assessed via self-reported questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Change in self-reported flexibility
Assessed via self-reported questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Change in self-reported mobility
Assessed via self-reported questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Change in self-reported quality of life
Assessed via self-reported questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Change in self-reported overall health
Assessed via self-reported questionnaire
Measured: Baseline, 30 minutes after first application, and Day 7
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Aug 2026
- Study start1 Feb 2026
- Primary completion31 May 2026
- Study completion31 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ArthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Saie Beauty
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07767669
- Sponsor's protocol ID
- 20831
- Status last verified
- Aug 2026
- First submitted
- 11 Aug 2026
- Last updated
- 17 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Controlled Study to Evaluate the Effects of a Topical Cream on Symptoms of Arthritis, Joint, and Muscle Pain
- ClinicalTrials.gov ID
- NCT07767669
- Acronym / sponsor ID
- 20831
- Conditions
- Arthritis, Joint Pain, Muscle Pain, Musculoskeletal Pain, Joint Stiffness
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Saie BeautyIndustry (pharma, biotech, devices)
- Collaborators
- Citruslabs
- Study start
- 1 Feb 2026 (actual)
- Primary completion
- 31 May 2026 (actual)
- Study completion
- 31 May 2026 (actual)
- First posted
- 17 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a randomized, triple-blind, controlled clinical trial evaluating the effects of Saje Pain Release Joint \& Arthritis Cream on symptoms of arthritis, joint pain, and muscle pain in adults aged 20-65. The trial is conducted virtually over seven days, with 80 participants randomized equally into an intervention arm (active topical cream) and a control arm (matched control product).
Participants apply their assigned product three times daily to affected areas (knees, elbows, wrists, or ankles) and complete questionnaires at Baseline, 30 minutes after the first application, and at the end of Day 7. The primary objective is to assess changes in arthritis and musculoskeletal pain symptoms, while secondary objectives assess participants' perceptions of joint pain, stiffness, function, comfort, flexibility, mobility, and overall quality of life.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Intervention (Saje Pain Release Joint & Arthritis Cream) | Experimental | Dietary Supplement: Intervention (Saje Pain Release Joint & Arthritis Cream) |
| Placebo Comparator | Placebo comparator | Dietary Supplement: Placebo Comparator |
Who may qualify
- Ages
- 20 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (10 listed)
- Be male or female
- Be aged 20-65
- Has experienced issues regarding all of the following in the past four weeks: symptoms of arthritis of the knees, elbows, wrists, or ankles
- joint pain and stiffness
- Self-reported issues must be at least 3 out of 10 in severity, with 1 being the least severe and 10 being the most
Key exclusion criteria (12 listed)
- Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
- Anyone with any allergies or sensitivities to any of the study product ingredients
- Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period)
- Symptoms occurring in a joint that has been surgically repaired
- Anyone unwilling to follow the study protocol
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Intervention (Saje Pain Release Joint & Arthritis Cream)40 participants apply a thin layer of the Saje Pain Release Joint \& Arthritis Cream to arthritis-affected areas (knees, elbows, wrists, ankles) three times daily (morning, afternoon, and evening) for seven days | Dietary supplement | Intervention (Saje Pain Release Joint & Arthritis Cream) |
| Placebo Comparator40 participants apply a matched control product (identical in appearance and consistency to the active product but without active ingredients such as L-menthol and balsam copaiba oil) to arthritis-affected areas three times daily (morning, afternoon, and evening) for seven days | Dietary supplement | Placebo Comparator |
Primary outcome
Change in symptoms of arthritis
Time frame: Baseline, 30 minutes after first application, and Day 7
Assessed via self-reported numerical pain rating scale and the Musculoskeletal Health Questionnaire (MSK-HQ) validated questionnaire
Change in symptoms of joint pain
Time frame: Baseline, 30 minutes after first application, and Day 7
Assessed via self-reported numerical pain rating scale and the Musculoskeletal Health Questionnaire (MSK-HQ) validated questionnaire
Change in symptoms of muscle pain
Time frame: Baseline, 30 minutes after first application, and Day 7
Assessed via self-reported numerical pain rating scale and the Musculoskeletal Health Questionnaire (MSK-HQ) validated questionnaire
8 secondary outcomes
Change in self-reported joint pain
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported joint stiffness
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported joint function
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported joint comfort
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported flexibility
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported mobility
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported quality of life
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported overall health
Time frame: Baseline, 30 minutes after first application, and Day 7
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Intervention (Saje Pain Release Joint & Arthritis Cream) in people with Arthritis and Joint Pain, run by Saie Beauty at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in symptoms of arthritis (time frame: Baseline, 30 minutes after first application, and Day 7). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2026.