Plaque Induced Gingivitischx oilpullingNCT07769112
Comparative Efficacy of Oil Pulling and Chlorhexidine on Plaque Induced Gingivitis
A study testing Chlorhexidine mouthwash (0.12%) and coconut oil pulling in people with Plaque Induced Gingivitis, run by Liaquat College of Medicine and Dentistry at 1 site in Pakistan.
Trial summary
This randomized clinical trial aims to compare the efficacy of chlorhexidine and coconut oil in plaque-induced gingivitis patients. The study seeks to determine whether coconut oil pulling can provide comparable anti-plaque and anti-inflammatory effects to chlorhexidine mouthwash while producing fewer side effects. Read more about this study
- Who is it for?
- Ages 20 to 60 years
- Conditions the study is for
- Plaque Induced Gingivitis
- What is being tested?
- Chlorhexidine mouthwash (0.12%) and coconut oil pulling
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 sitePakistan
- Study dates
- 12 Aug 2024to 12 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Individual aged between 22-60years.
- Individual who have retained 28 no of teeth in the mouth.
- Individuals who have diagnosed as plaque induced gingivitis along with mild to moderate gingival inflammation.
Who cannot join
- Individual who have any systemic medical illness
- Multiple extractions, overhang restoration, wearing any appliance
- Periodontal problem with pocket depth more than 3mm
- Current or recent history of antibiotic consumption
- Non compliance that is unable to maintain their hygiene -
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Efficacy of Oil Pulling and Chlorhexidine on Plaque Induced Gingivitis: Randomized Clinical Trial
This randomized clinical trial aims to compare the efficacy of chlorhexidine and coconut oil in plaque-induced gingivitis patients. The study seeks to determine whether coconut oil pulling can provide comparable anti-plaque and anti-inflammatory effects to chlorhexidine mouthwash while producing fewer side effects. A total of 80 participants who diagnosed as plaque induced gingivitis will be randomly allocated into two equal groups (coconut and chlorhexidine). Clinical parameters, including Plaque Index and Gingival Index, will be assessed at baseline, day 7, day 14, and day 21 to evaluate changes in plaque and gingival inflammation following the interventions.
- Conditions
- Plaque Induced Gingivitis
- Being tested
- Chlorhexidine mouthwash (0.12%), coconut oil pulling
- Keywords
- gingivitis, chlorhexidine, coconut oil, dental plaque , oral hygiene, periodontal diseases
- Medical subject headings
- Gingivitis, Dental Plaque, Periodontal Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Chlorhexidine mouthwash (0.12%)Other
Participants will use 0.12% chlorhexidine mouthwash twice daily for 21 days.
coconut oil pullingOther
Participants will rinse with coconut oil once daily for 10-15 minutes for 21 days.
| Study group | Role | What they receive |
|---|---|---|
| chlorhexidine mouthwash group | Experimental | Participants will use 0.12% chlorhexidine mouthwash twice daily for 21 days. Receives: Other: Chlorhexidine mouthwash (0.12%) |
| coconut oil pulling group | Experimental | Participants will rinse with coconut oil once daily for 10-15 minutes for 21 days. Receives: Other: coconut oil pulling |
What is being measured
The primary outcome is the main question the study is designed to answer.
Reduction in Gingival Inflammation
To assess the gingival inflammation using Gingival Index scores in participants receiving chlorhexidine mouthwash and coconut oil pulling therapy
Measured: Baseline, Day 7, Day 14, and Day 21
Secondary outcomes (1)
Reduction in Dental Plaque
Evaluation of dental plaque accumulation using Plaque Index scores among study participants.
Measured: Baseline, Day 7, Day 14, and Day 21
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Aug 2026
- Study start12 Aug 2024
- Primary completion23 Feb 2025
- Study completion12 Jul 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Plaque Induced GingivitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Group A: CONTROL GROUP Participants will receive a 420ml(10 x42) ml opaque plastic bottle containing 0.12% chlorhexidine (CHX). They will be instructed to rinse 30sec with 10ml of the solution after brushing twice daily (morning after toothbrush and at night after tooth brush) for 3 weeks . Group B: TEST GROUP Participants will receive a 210 ml(10x21) ml opaque plastic bottle with a solution for cold pressed 100% original coconut oil pulling. They will be advised to rinse with two teaspoons(5ml each) until their mouth is half-filled, then swish the oil left to right and front to back until it turns milky white and thin before spitting it out. This procedure will be done on an empty stomach in the morning for 3 weeks.
- Masking
- None (open label)
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Liaquat College of Medicine and Dentistry
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07769112
- Sponsor's protocol ID
- irb/D-000111/25
- Other IDs
- LCMD
- Acronym
- chx oilpulling
- Status last verified
- Aug 2025
- First submitted
- 4 Apr 2026
- Last updated
- 17 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Protecting participant confidentiality in a small sample size. No infrastructure for secure data storage and distribution onsent obtained does not cover future data sharing.
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Efficacy of Oil Pulling and Chlorhexidine on Plaque Induced Gingivitis: Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07769112
- Acronym / sponsor ID
- chx oilpulling / irb/D-000111/25
- Conditions
- Plaque Induced Gingivitis
- Keywords
- gingivitis, chlorhexidine, coconut oil, dental plaque , oral hygiene, periodontal diseases
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Liaquat College of Medicine and DentistryUniversity, hospital or other
- Study start
- 12 Aug 2024 (actual)
- Primary completion
- 23 Feb 2025 (actual)
- Study completion
- 12 Jul 2025 (actual)
- First posted
- 17 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical trial aims to compare the efficacy of chlorhexidine and coconut oil in plaque-induced gingivitis patients. The study seeks to determine whether coconut oil pulling can provide comparable anti-plaque and anti-inflammatory effects to chlorhexidine mouthwash while producing fewer side effects. A total of 80 participants who diagnosed as plaque induced gingivitis will be randomly allocated into two equal groups (coconut and chlorhexidine). Clinical parameters, including Plaque Index and Gingival Index, will be assessed at baseline, day 7, day 14, and day 21 to evaluate changes in plaque and gingival inflammation following the interventions.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Group A: CONTROL GROUP Participants will receive a 420ml(10 x42) ml opaque plastic bottle containing 0.12% chlorhexidine (CHX). They will be instructed to rinse 30sec with 10ml of the solution after brushing twice daily (morning after toothbrush and at night after tooth brush) for 3 weeks . Group B: TEST GROUP Participants will receive a 210 ml(10x21) ml opaque plastic bottle with a solution for cold pressed 100% original coconut oil pulling. They will be advised to rinse with two teaspoons(5ml each) until their mouth is half-filled, then swish the oil left to right and front to back until it turns milky white and thin before spitting it out. This procedure will be done on an empty stomach in the morning for 3 weeks.
| Arm | Type | Receives |
|---|---|---|
| chlorhexidine mouthwash group | Experimental | Other: Chlorhexidine mouthwash (0.12%)Participants will use 0.12% chlorhexidine mouthwash twice daily for 21 days. |
| coconut oil pulling group | Experimental | Other: coconut oil pullingParticipants will rinse with coconut oil once daily for 10-15 minutes for 21 days. |
Who may qualify
- Ages
- 20 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Individual aged between 22-60years.
- Individual who have retained 28 no of teeth in the mouth.
- Individuals who have diagnosed as plaque induced gingivitis along with mild to moderate gingival inflammation.
Key exclusion criteria (5 listed)
- Individual who have any systemic medical illness
- Multiple extractions, overhang restoration, wearing any appliance
- Periodontal problem with pocket depth more than 3mm
- Current or recent history of antibiotic consumption
- Non compliance that is unable to maintain their hygiene -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Chlorhexidine mouthwash (0.12%)Participants will use 0.12% chlorhexidine mouthwash twice daily for 21 days. | Other | chlorhexidine mouthwash group |
| coconut oil pullingParticipants will rinse with coconut oil once daily for 10-15 minutes for 21 days. | Other | coconut oil pulling group |
Primary outcome
Reduction in Gingival Inflammation
Time frame: Baseline, Day 7, Day 14, and Day 21
To assess the gingival inflammation using Gingival Index scores in participants receiving chlorhexidine mouthwash and coconut oil pulling therapy
1 secondary outcome
Reduction in Dental Plaque
Time frame: Baseline, Day 7, Day 14, and Day 21
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2026.
- Individual participant dataSharing planned: No. Protecting participant confidentiality in a small sample size. No infrastructure for secure data storage and distribution onsent obtained does not cover future data sharing.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Chlorhexidine mouthwash (0.12%) and coconut oil pulling in people with Plaque Induced Gingivitis, run by Liaquat College of Medicine and Dentistry at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Reduction in Gingival Inflammation (time frame: Baseline, Day 7, Day 14, and Day 21). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2026.