Asthma (Diagnosis)ArsEIBNCT07771608
Respiratory Admittance by Oscillometry in Children
An observational study of Asthma (Diagnosis), run by Central Hospital, Nancy, France.
Trial summary
Oscillometry is a pulmonary function testing technique suited for children because it does not require specific respiratory maneuvers like spirometry. Oscillometry provides a measure of respiratory impedance (Zrs) that is underestimated when the oscillatory signal is applied at the subject's mouth particularly during… Read more about this study
- Who is it for?
- Ages 5 to 16 years
- Conditions the study is for
- Asthma (Diagnosis)
- How many people
- 144 participants
- Where
- No sites listed yet
- Study dates
- 25 Aug 2026to 1 Sep 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 5 to 16 years
- All sexes
- No healthy volunteers
- Child
Study population: Data of children aged 5 to 16 years addressed by the pediatric pulmonologist to an exercise challenge test between January 2023 and April 2026 to the Pediatric Function Testing Department who have oscillometric and spirometric interpretable and reproducible measurements
Who may be able to join
- Children aged 5 to 16 years
- Children addressed by the pediatric pulmonologist to an exercise challenge test between January 2023 and April 2026
- Children with interpretable and reproducible oscillometric measurements
- Children with interpretable and reproducible spirometric measurements
Who cannot join
- Children who performed only spirometric measurements
- Children who performed only oscillometric measurements
- Children whose oscillometric and spirometric measurements are non-interpretable
- Children whose oscillometric and spirometric measurements are non-reproducible
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Respiratory Admittance Response to Exercise Challenge Test in Children
Oscillometry is a pulmonary function testing technique suited for children because it does not require specific respiratory maneuvers like spirometry. Oscillometry provides a measure of respiratory impedance (Zrs) that is underestimated when the oscillatory signal is applied at the subject's mouth particularly during bronchoconstriction induced by an exercise challenge test (ECT). This limitation may be overcome by calculating respiratory admittance (Ars), the inverse of respiratory impedance during an ECT.
Read the detailed description
Oscillometry is a pulmonary function testing technique that is well suited to children who have difficulty cooperating with conventional tests such as spirometry, as it is performed during spontaneous breathing and does not require specific respiratory maneuvers. In contrast, spirometry requires a deep inspiration followed by a forced and complete expiration.
Oscillometry provides a measure of respiratory impedance, which is the complex sum of respiratory resistance (Rrs) and respiratory reactance (Xrs). However, when the oscillatory signal is applied directly at the subject's airway opening, part of the flow signal may be lost due to cheek wall vibrations, resulting in an underestimation of Rrs. This underestimation may be more pronounced during bronchoconstriction, such as that induced by an exercise challenge test (ECT). This limitation may be overcome by calculating respiratory admittance (Ars), the inverse of respiratory impedance. When calculating the response to ECT, cheek wall admittance is cancelled out, potentially allowing a more accurate assessment of changes in respiratory mechanics during an ECT.
The hypothesis was that calculating Ars provides a more accurate assessment of changes in airway mechanics during an ECT.
- Conditions
- Asthma (Diagnosis)
- Keywords
- lung function testing, oscillometry, asthma
- Medical subject headings
- Asthma, Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Children with positive response to exercise challenge test | Children aged 5 to 16 years old who performed an exercise challenge test and had a decrease of ≥ 10% in FEV1 after test (FEV1 = forced expiratory volume in 1 sec obtained by forced spirometry) | |
| Children with NEGATIVEresponse to exercise challenge test | Children aged 5 to 16 years old who performed an exercise challenge test and had a decrease of < 10% in FEV1 after test (FEV1 = forced expiratory volume in 1 sec obtained by forced spirometry) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Diagnostic performance of Ars
Area under the ROC curves (AUC) for response to exercise challenge of Ars (computed from oscillometric parameters) compared with AUC of respiratory resistance to identify children with a positive challenge test and children with a negative challenge test
Measured: Through study completion, an average of 1 month
Secondary outcomes (2)
Sensitivity of Ars
Sensitivity of the response to exercise challenge of Ars (computed from oscillometric parameters) compared with the sensitivity of respiratory resistance to identify children with a positive challenge test
Measured: Through study completion, an average of 1 month
Specificity of Ars
Specificity of the response to exercise challenge of Ars (computed from oscillometric parameters) compared with the specificity of respiratory resistance to identify children with a positive challenge test
Measured: Through study completion, an average of 1 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Aug 2026
- Study start25 Aug 2026 (estimated)
- Primary completion25 Aug 2026 (estimated)
- Study completion1 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Asthma (Diagnosis)Studies of the same condition, open and under way.
- More trials run by Central Hospital, Nancy, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 144 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Central Hospital, Nancy, France
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr. Iulia IOAN, Central Hospital, Nancy, France
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07771608
- Sponsor's protocol ID
- 2026PI185
- Acronym
- ArsEIB
- Status last verified
- Aug 2026
- First submitted
- 12 Aug 2026
- Last updated
- 19 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Farre R. Measuring intra-subject changes in respiratory mechanics by oscillometry: impedance versus admittance. Eur Respir J. 2022 Oct 6;60(4):2201198. doi: 10.1183/13993003.01198-2022. Print 2022 Oct. No abstract available.
PubMed 36028252Nguyen YT, Demoulin B, Schweitzer C, Bonabel-Chone C, Marchal F. Identification of bronchodilator responsiveness by forced oscillation admittance in children. Pediatr Res. 2007 Sep;62(3):348-52. doi: 10.1203/PDR.0b013e3180db2933.
PubMed 17622963Ioan I, Coutier L, Bonabel C, Albrecht J, Demoulin B, Marchal F, Schweitzer C, Varechova S. Airway obstruction, upper airway artifact and response to bronchodilator in asthmatic and healthy children. Pediatr Pulmonol. 2015 Nov;50(11):1053-9. doi: 10.1002/ppul.23131. Epub 2014 Nov 10.
PubMed 25384559
Study at a glance
From the registry record, last updated by the sponsor on 19 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Respiratory Admittance Response to Exercise Challenge Test in Children
- ClinicalTrials.gov ID
- NCT07771608
- Acronym / sponsor ID
- ArsEIB / 2026PI185
- Conditions
- Asthma (Diagnosis)
- Keywords
- lung function testing, oscillometry, asthma
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 144 participants (estimated)
- Lead sponsor
- Central Hospital, Nancy, FranceUniversity, hospital or other
- Study start
- 25 Aug 2026 (estimated)
- Primary completion
- 25 Aug 2026 (estimated)
- Study completion
- 1 Sep 2026 (estimated)
- First posted
- 18 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Oscillometry is a pulmonary function testing technique suited for children because it does not require specific respiratory maneuvers like spirometry. Oscillometry provides a measure of respiratory impedance (Zrs) that is underestimated when the oscillatory signal is applied at the subject's mouth particularly during bronchoconstriction induced by an exercise challenge test (ECT). This limitation may be overcome by calculating respiratory admittance (Ars), the inverse of respiratory impedance during an ECT.
Detailed description
Oscillometry is a pulmonary function testing technique that is well suited to children who have difficulty cooperating with conventional tests such as spirometry, as it is performed during spontaneous breathing and does not require specific respiratory maneuvers. In contrast, spirometry requires a deep inspiration followed by a forced and complete expiration.
Oscillometry provides a measure of respiratory impedance, which is the complex sum of respiratory resistance (Rrs) and respiratory reactance (Xrs). However, when the oscillatory signal is applied directly at the subject's airway opening, part of the flow signal may be lost due to cheek wall vibrations, resulting in an underestimation of Rrs. This underestimation may be more pronounced during bronchoconstriction, such as that induced by an exercise challenge test (ECT). This limitation may be overcome by calculating respiratory admittance (Ars), the inverse of respiratory impedance. When calculating the response to ECT, cheek wall admittance is cancelled out, potentially allowing a more accurate assessment of changes in respiratory mechanics during an ECT.
The hypothesis was that calculating Ars provides a more accurate assessment of changes in airway mechanics during an ECT.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Children with positive response to exercise challenge test | – | –Children aged 5 to 16 years old who performed an exercise challenge test and had a decrease of ≥ 10% in FEV1 after test (FEV1 = forced expiratory volume in 1 sec obtained by forced spirometry) |
| Children with NEGATIVEresponse to exercise challenge test | – | –Children aged 5 to 16 years old who performed an exercise challenge test and had a decrease of < 10% in FEV1 after test (FEV1 = forced expiratory volume in 1 sec obtained by forced spirometry) |
Who may qualify
- Ages
- 5 to 16 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
- Study population
- Data of children aged 5 to 16 years addressed by the pediatric pulmonologist to an exercise challenge test between January 2023 and April 2026 to the Pediatric Function Testing Department who have oscillometric and spirometric interpretable and reproducible measurements
Key inclusion criteria (4 listed)
- Children aged 5 to 16 years
- Children addressed by the pediatric pulmonologist to an exercise challenge test between January 2023 and April 2026
- Children with interpretable and reproducible oscillometric measurements
- Children with interpretable and reproducible spirometric measurements
Key exclusion criteria (4 listed)
- Children who performed only spirometric measurements
- Children who performed only oscillometric measurements
- Children whose oscillometric and spirometric measurements are non-interpretable
- Children whose oscillometric and spirometric measurements are non-reproducible
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Diagnostic performance of Ars
Time frame: Through study completion, an average of 1 month
Area under the ROC curves (AUC) for response to exercise challenge of Ars (computed from oscillometric parameters) compared with AUC of respiratory resistance to identify children with a positive challenge test and children with a negative challenge test
2 secondary outcomes
Sensitivity of Ars
Time frame: Through study completion, an average of 1 month
Specificity of Ars
Time frame: Through study completion, an average of 1 month
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Aug 2026.
- Background: PubMed 36028252Farre R. Measuring intra-subject changes in respiratory mechanics by oscillometry: impedance versus admittance. Eur Respir J. 2022 Oct 6;60(4):2201198. doi: 10.1183/13993003.01198-2022. Print 2022 Oct. No abstract available.
- Background: PubMed 17622963Nguyen YT, Demoulin B, Schweitzer C, Bonabel-Chone C, Marchal F. Identification of bronchodilator responsiveness by forced oscillation admittance in children. Pediatr Res. 2007 Sep;62(3):348-52. doi: 10.1203/PDR.0b013e3180db2933.
- Background: PubMed 25384559Ioan I, Coutier L, Bonabel C, Albrecht J, Demoulin B, Marchal F, Schweitzer C, Varechova S. Airway obstruction, upper airway artifact and response to bronchodilator in asthmatic and healthy children. Pediatr Pulmonol. 2015 Nov;50(11):1053-9. doi: 10.1002/ppul.23131. Epub 2014 Nov 10.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Asthma (Diagnosis), run by Central Hospital, Nancy, France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 19 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Iulia Ioan, MD PhD (+33 3 83 15 47 94, ic.ioan@chru-nancy.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Diagnostic performance of Ars (time frame: Through study completion, an average of 1 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07771608, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Aug 2026.