PeriodontitisNCT07772115
Occlusal Force and Chewing After Periodontal Therapy
A study testing Non-Surgical Periodontal Therapy in people with Periodontitis, run by Mohammed Bin Rashid University of Medicine and Health Sciences.
Trial summary
Stage III and Stage IV periodontitis are associated with loss of periodontal support, tooth mobility, and impaired oral function, which may affect occlusal force distribution and chewing performance. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Periodontitis
- What is being tested?
- Non-Surgical Periodontal Therapy
- Type of treatment
- Pill or oral medicine, Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- No sites listed yet
- Study dates
- 6 Oct 2026to 1 Feb 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18-70 years.
- Diagnosis of Stage III or Stage IV periodontitis (Grade A, B, or C) according to the 2018 World Workshop Classification.
- Presence of at least 20 natural teeth, including posterior occlusal support.
- No periodontal treatment within the preceding 12 months.
- Willing and able to attend all scheduled follow-up appointments
Who cannot join
- Systemic conditions known to impair periodontal healing, including:
- Uncontrolled diabetes mellitus (HbA1c >7%)
- Immunosuppressive therapy
- Bisphosphonate therapy
- Removable prostheses replacing multiple posterior teeth.
- Pregnancy or breastfeeding.
Show all 12Show fewer
- Current occlusal splint wearers.
- Planned dental treatment other than periodontal therapy during the study period.
- Heavy smokers (>20 cigarettes/day).
- Stage I or Stage II periodontitis, gingivitis, or a healthy periodontium.
- Severe manual dexterity impairment preventing adequate oral hygiene.
- Currently undergoing periodontal treatment.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Digital Assessment of Occlusal Force Distribution and Chewing Cycles Before and After Periodontal Therapy in Patients With Stage III-IV Periodontitis
Stage III and Stage IV periodontitis are associated with loss of periodontal support, tooth mobility, and impaired oral function, which may affect occlusal force distribution and chewing performance. Although non-surgical periodontal therapy effectively improves periodontal health, its effect on functional occlusal parameters and mandibular movements has not been comprehensively evaluated using digital technologies.
This prospective interventional study will investigate changes in occlusal force distribution and chewing cycle characteristics in patients with Stage III or Stage IV periodontitis before and after non-surgical periodontal therapy. Participants will receive standardized periodontal treatment and will be assessed at baseline, 8-12 weeks after completion of active therapy, and 3 months following re-evaluation. The T-Scan digital occlusal analysis system will be used to record occlusal force distribution, occlusion time, disocclusion time, and force balance. The Modjaw jaw-tracking system will be used to look at chewing cycle characteristics and mandibular movements. The study aims to determine whether periodontal therapy leads to measurable improvements in oral function and to provide objective functional outcome measures that may support periodontal and prosthodontic treatment planning.
- Conditions
- Periodontitis
- Being tested
- Non-Surgical Periodontal Therapy
- Medical subject headings
- Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non-Surgical Periodontal TherapyProcedure or surgery
Standardized non-surgical periodontal therapy consisting of oral hygiene instruction, supragingival debridement, and full-mouth subgingival instrumentation using ultrasonic scalers and hand instruments according to the European Federation of Periodontology (EFP) S3-level clinical practice guideline for Stage III and Stage IV periodontitis.
| Study group | Role | What they receive |
|---|---|---|
| Non-Surgical Periodontal Therapy | Experimental | Not described Receives: Procedure: Non-Surgical Periodontal Therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Right-Left Occlusal Force Balance
Change in right-left occlusal force balance measured using the T-Scan digital occlusal analysis system.
Measured: Baseline, 8-12 weeks after completion of non-surgical periodontal therapy, and 3 months after re-evaluation.
Secondary outcomes (1)
Change in Chewing Cycle Characteristics
Assessment of changes in chewing cycle characteristics measured using the Modjaw jaw tracking system.
Measured: Baseline, 8-12 weeks after therapy, and 3 months after re-evaluation.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Aug 2026
- Study start6 Oct 2026 (estimated)
- Primary completion25 Jan 2028 (estimated)
- Study completion1 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for PeriodontitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mohammed Bin Rashid University of Medicine and Health Sciences
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Haitham Elbishari, Mohammed Bin Rashid University of Medicine and Health Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07772115
- Sponsor's protocol ID
- MBRU-2026
- Status last verified
- Aug 2026
- First submitted
- 26 Jun 2026
- Last updated
- 19 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Pereira LJ, Gazolla CM, Magalhaes IB, Dominguete MH, Vilela GR, Castelo PM, Marques LS, Van Der Bilt A. Influence of periodontal treatment on objective measurement of masticatory performance. J Oral Sci. 2012;54(2):151-7. doi: 10.2334/josnusd.54.151.
PubMed 22790407Palinkas M, Borges TF, Junior MT, Monteiro SAC, Bottacin FS, Mestriner-Junior W, Regalo IH, Siessere S, Semprini M, Regalo SCH. Alterations in masticatory cycle efficiency and bite force in individuals with periodontitis. Int J Health Sci (Qassim). 2019 Jan-Feb;13(1):25-29.
PubMed 30842715Olivieri Q, Maniewicz S, Chebib N, Mojon P, Muller F. The Preferred Chewing Side in Partially Edentulous Patients Is More Related to Residual Dentition Than Hemispheric Laterality. J Oral Rehabil. 2025 Jul;52(7):949-956. doi: 10.1111/joor.13955. Epub 2025 Feb 27.
PubMed 40013481Ikebe K, Matsuda K, Kagawa R, Enoki K, Okada T, Yoshida M, Maeda Y. Masticatory performance in older subjects with varying degrees of tooth loss. J Dent. 2012 Jan;40(1):71-6. doi: 10.1016/j.jdent.2011.10.007. Epub 2011 Oct 21.
PubMed 22037296Barbe AG, Javadian S, Rott T, Scharfenberg I, Deutscher HCD, Noack MJ, Derman SHM. Objective masticatory efficiency and subjective quality of masticatory function among patients with periodontal disease. J Clin Periodontol. 2020 Nov;47(11):1344-1353. doi: 10.1111/jcpe.13364. Epub 2020 Sep 23.
PubMed 32892357Ayuso-Montero R, Mariano-Hernandez Y, Khoury-Ribas L, Rovira-Lastra B, Willaert E, Martinez-Gomis J. Reliability and Validity of T-scan and 3D Intraoral Scanning for Measuring the Occlusal Contact Area. J Prosthodont. 2020 Jan;29(1):19-25. doi: 10.1111/jopr.13096. Epub 2019 Jul 21.
PubMed 31270888
Study at a glance
From the registry record, last updated by the sponsor on 19 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Digital Assessment of Occlusal Force Distribution and Chewing Cycles Before and After Periodontal Therapy in Patients With Stage III-IV Periodontitis
- ClinicalTrials.gov ID
- NCT07772115
- Acronym / sponsor ID
- MBRU-2026
- Conditions
- Periodontitis
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Mohammed Bin Rashid University of Medicine and Health SciencesUniversity, hospital or other
- Study start
- 6 Oct 2026 (estimated)
- Primary completion
- 25 Jan 2028 (estimated)
- Study completion
- 1 Feb 2028 (estimated)
- First posted
- 19 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Stage III and Stage IV periodontitis are associated with loss of periodontal support, tooth mobility, and impaired oral function, which may affect occlusal force distribution and chewing performance. Although non-surgical periodontal therapy effectively improves periodontal health, its effect on functional occlusal parameters and mandibular movements has not been comprehensively evaluated using digital technologies.
This prospective interventional study will investigate changes in occlusal force distribution and chewing cycle characteristics in patients with Stage III or Stage IV periodontitis before and after non-surgical periodontal therapy. Participants will receive standardized periodontal treatment and will be assessed at baseline, 8-12 weeks after completion of active therapy, and 3 months following re-evaluation. The T-Scan digital occlusal analysis system will be used to record occlusal force distribution, occlusion time, disocclusion time, and force balance. The Modjaw jaw-tracking system will be used to look at chewing cycle characteristics and mandibular movements. The study aims to determine whether periodontal therapy leads to measurable improvements in oral function and to provide objective functional outcome measures that may support periodontal and prosthodontic treatment planning.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Non-Surgical Periodontal Therapy | Experimental | Procedure: Non-Surgical Periodontal Therapy |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Adults aged 18-70 years.
- Diagnosis of Stage III or Stage IV periodontitis (Grade A, B, or C) according to the 2018 World Workshop Classification.
- Presence of at least 20 natural teeth, including posterior occlusal support.
- No periodontal treatment within the preceding 12 months.
- Willing and able to attend all scheduled follow-up appointments
Key exclusion criteria (12 listed)
- Systemic conditions known to impair periodontal healing, including:
- Removable prostheses replacing multiple posterior teeth.
- Pregnancy or breastfeeding.
- Current occlusal splint wearers.
- Planned dental treatment other than periodontal therapy during the study period.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non-Surgical Periodontal TherapyStandardized non-surgical periodontal therapy consisting of oral hygiene instruction, supragingival debridement, and full-mouth subgingival instrumentation using ultrasonic scalers and hand instruments according to the European Federation of Periodontology (EFP) S3-level clinical practice guideline for Stage III and Stage IV periodontitis. | Procedure or surgery | Non-Surgical Periodontal Therapy |
Primary outcome
Change in Right-Left Occlusal Force Balance
Time frame: Baseline, 8-12 weeks after completion of non-surgical periodontal therapy, and 3 months after re-evaluation.
Change in right-left occlusal force balance measured using the T-Scan digital occlusal analysis system.
1 secondary outcome
Change in Chewing Cycle Characteristics
Time frame: Baseline, 8-12 weeks after therapy, and 3 months after re-evaluation.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Aug 2026.
- Results publication: PubMed 22790407Pereira LJ, Gazolla CM, Magalhaes IB, Dominguete MH, Vilela GR, Castelo PM, Marques LS, Van Der Bilt A. Influence of periodontal treatment on objective measurement of masticatory performance. J Oral Sci. 2012;54(2):151-7. doi: 10.2334/josnusd.54.151.
- Results publication: PubMed 30842715Palinkas M, Borges TF, Junior MT, Monteiro SAC, Bottacin FS, Mestriner-Junior W, Regalo IH, Siessere S, Semprini M, Regalo SCH. Alterations in masticatory cycle efficiency and bite force in individuals with periodontitis. Int J Health Sci (Qassim). 2019 Jan-Feb;13(1):25-29.
- Results publication: PubMed 40013481Olivieri Q, Maniewicz S, Chebib N, Mojon P, Muller F. The Preferred Chewing Side in Partially Edentulous Patients Is More Related to Residual Dentition Than Hemispheric Laterality. J Oral Rehabil. 2025 Jul;52(7):949-956. doi: 10.1111/joor.13955. Epub 2025 Feb 27.
- Results publication: PubMed 22037296Ikebe K, Matsuda K, Kagawa R, Enoki K, Okada T, Yoshida M, Maeda Y. Masticatory performance in older subjects with varying degrees of tooth loss. J Dent. 2012 Jan;40(1):71-6. doi: 10.1016/j.jdent.2011.10.007. Epub 2011 Oct 21.
- Results publication: PubMed 32892357Barbe AG, Javadian S, Rott T, Scharfenberg I, Deutscher HCD, Noack MJ, Derman SHM. Objective masticatory efficiency and subjective quality of masticatory function among patients with periodontal disease. J Clin Periodontol. 2020 Nov;47(11):1344-1353. doi: 10.1111/jcpe.13364. Epub 2020 Sep 23.
- Results publication: PubMed 31270888Ayuso-Montero R, Mariano-Hernandez Y, Khoury-Ribas L, Rovira-Lastra B, Willaert E, Martinez-Gomis J. Reliability and Validity of T-scan and 3D Intraoral Scanning for Measuring the Occlusal Contact Area. J Prosthodont. 2020 Jan;29(1):19-25. doi: 10.1111/jopr.13096. Epub 2019 Jul 21.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Non-Surgical Periodontal Therapy in people with Periodontitis, run by Mohammed Bin Rashid University of Medicine and Health Sciences.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 19 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Haitham Elbishari, PhD (+971529131315, helbishari@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Right-Left Occlusal Force Balance (time frame: Baseline, 8-12 weeks after completion of non-surgical periodontal therapy, and 3 months after re-evaluation.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07772115, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Aug 2026.