Vascular AccessNCT07773506
Ultrasound Assessment of Internal Jugular Vein for Cannulation and Venous Pressure Prediction
An observational study of Vascular Access and Elevated Jugular Venous Pressure, run by Assiut University.
Trial summary
This prospective observational study aims to evaluate the diagnostic utility of vascular ultrasound for internal jugular vein (IJV) assessment in adult patients undergoing clinically indicated IJV cannulation. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Vascular Access, Elevated Jugular Venous Pressure, Hemodynamic Instability
- How many people
- 100 participants
- Where
- No sites listed yet
- Study dates
- Sep 2026to Oct 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: Adult patients aged 18 years or older admitted to the Intensive Care Unit (ICU), Emergency Department, or Operating Theatres at Assiut University Hospitals who require ultrasound-guided right internal jugular vein (IJV) cannulation and hemodynamic assessment for clinical indications.
Who may be able to join
- Adult patients aged 18 years or older.
- Patients admitted to the Intensive Care Unit (ICU), Emergency Department, or Operating Theatres who require internal jugular vein (IJV) cannulation for clinical indications.
- Patients in whom ultrasound-guided right internal jugular vein cannulation is planned.
- Patients who are hemodynamically stable enough to undergo ultrasound examination before cannulation.
- Patients able to undergo vascular ultrasound examination in the supine position (0-30° head elevation according to the study protocol).
- Patients in whom complete ultrasound assessment of the internal jugular vein can be performed (including maximum diameter, minimum diameter, cross-sectional area, and collapsibility/distensibility index).
- Patients with a clinically indicated assessment of central venous pressure (CVP) or jugular venous pressure (JVP) allowing comparison with ultrasound measurements.
- Patients providing written informed consent, or consent obtained from a legally authorized representative when applicable.
Who cannot join
- Patients younger than 18 years of age.
- Previous surgery, radiotherapy, or significant trauma involving the neck.
- Known thrombosis, stenosis, or congenital anomalies of the internal jugular vein.
- Local infection, cellulitis, burn, or hematoma at the intended cannulation site.
- Large neck masses, thyroid enlargement, or cervical pathology causing distortion of neck anatomy.
- Severe coagulopathy or uncontrolled bleeding disorders contraindicating internal jugular vein cannulation.
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- Patients with cervical spine instability or those in whom proper positioning for ultrasound examination is not possible.
- Inadequate ultrasound visualization of the internal jugular vein.
- Severe tricuspid valve disease or conditions causing marked alterations in central venous hemodynamics that interfere with accurate interpretation of IJV measurements.
- Refusal of the patient or legally authorized representative to provide informed consent.
About this study
Official title: Ultrasound Guidance for Internal Jugular Vein Cannulation: Can Doppler Ultrasound Predict Jugular Venous Pressure Changes by Assessment of Internal Jugular Vein Diameter and Collapsibility?
This prospective observational study aims to evaluate the diagnostic utility of vascular ultrasound for internal jugular vein (IJV) assessment in adult patients undergoing clinically indicated IJV cannulation.
Traditionally, bedside clinical assessment of jugular venous pressure (JVP) is challenging and frequently imprecise in critically ill or obese individuals. This study investigates whether non-invasive ultrasound parameters, specifically IJV diameter, collapsibility index, and Doppler flow patterns, can reliably estimate central venous pressure (CVP) and identify elevated JVP.
Participants admitted to the Intensive Care Unit, Emergency Department, or Operating Theatres who require right IJV catheterization will receive a standardized pre-procedural vascular ultrasound evaluation in a supine position (0-30° head elevation) prior to routine, ultrasound-guided cannulation. Ultrasound measurements will then be compared to direct central venous pressure readings to assess diagnostic accuracy and correlation.
- Keywords
- Internal Jugular Vein, Vascular Ultrasound, Ultrasound Guidance, Central Venous Catheterization, Jugular Venous Pressure, Central Venous Pressure, Collapsibility Index, Doppler Flow
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Ultrasound-Guided IJV Cannulation Cohort | Adult patients in the Intensive Care Unit, Emergency Department, or Operating Theatres requiring ultrasound-guided right internal jugular vein (IJV) cannulation for clinical indications. Participants undergo pre-procedural vascular ultrasound to assess IJV diameter, collapsibility index, and Doppler flow characteristics in the supine position (0-30° head elevation), followed by ultrasound-guided catheterization and comparison with central venous pressure measurements. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Internal Jugular Vein Collapsibility Index Percentage
The Internal Jugular Vein (IJV) collapsibility index is evaluated by bedside vascular ultrasound and calculated using the formula: [(maximum anterior-posterior diameter during expiration - minimum anterior-posterior diameter during inspiration) / maximum anterior-posterior diameter during expiration] * 100. The outcome is reported as a continuous percentage from 0% to 100%, where higher values indicate greater vein collapsibility
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Aug 2026
- Study startSep 2026 (estimated)
- Primary completionSep 2027 (estimated)
- Study completionOct 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Vascular AccessStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Safaa Zayn El-Abden Zareh Hassan, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07773506
- Sponsor's protocol ID
- US-Guided IJV Access and JVP
- Status last verified
- Aug 2026
- First submitted
- 15 Aug 2026
- Last updated
- 19 Aug 2026
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 19 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ultrasound Guidance for Internal Jugular Vein Cannulation: Can Doppler Ultrasound Predict Jugular Venous Pressure Changes by Assessment of Internal Jugular Vein Diameter and Collapsibility?
- ClinicalTrials.gov ID
- NCT07773506
- Acronym / sponsor ID
- US-Guided IJV Access and JVP
- Keywords
- Internal Jugular Vein, Vascular Ultrasound, Ultrasound Guidance, Central Venous Catheterization, Jugular Venous Pressure, Central Venous Pressure, Collapsibility Index, Doppler Flow
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- Sep 2026 (estimated)
- Primary completion
- Sep 2027 (estimated)
- Study completion
- Oct 2027 (estimated)
- First posted
- 19 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective observational study aims to evaluate the diagnostic utility of vascular ultrasound for internal jugular vein (IJV) assessment in adult patients undergoing clinically indicated IJV cannulation.
Traditionally, bedside clinical assessment of jugular venous pressure (JVP) is challenging and frequently imprecise in critically ill or obese individuals. This study investigates whether non-invasive ultrasound parameters, specifically IJV diameter, collapsibility index, and Doppler flow patterns, can reliably estimate central venous pressure (CVP) and identify elevated JVP.
Participants admitted to the Intensive Care Unit, Emergency Department, or Operating Theatres who require right IJV catheterization will receive a standardized pre-procedural vascular ultrasound evaluation in a supine position (0-30° head elevation) prior to routine, ultrasound-guided cannulation. Ultrasound measurements will then be compared to direct central venous pressure readings to assess diagnostic accuracy and correlation.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Ultrasound-Guided IJV Cannulation Cohort | – | –Adult patients in the Intensive Care Unit, Emergency Department, or Operating Theatres requiring ultrasound-guided right internal jugular vein (IJV) cannulation for clinical indications. Participants undergo pre-procedural vascular ultrasound to assess IJV diameter, collapsibility index, and Doppler flow characteristics in the supine position (0-30° head elevation), followed by ultrasound-guided catheterization and comparison with central venous pressure measurements. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- Adult patients aged 18 years or older admitted to the Intensive Care Unit (ICU), Emergency Department, or Operating Theatres at Assiut University Hospitals who require ultrasound-guided right internal jugular vein (IJV) cannulation and hemodynamic assessment for clinical indications.
Key inclusion criteria (8 listed)
- Adult patients aged 18 years or older.
- Patients admitted to the Intensive Care Unit (ICU), Emergency Department, or Operating Theatres who require internal jugular vein (IJV) cannulation for clinical indications.
- Patients in whom ultrasound-guided right internal jugular vein cannulation is planned.
- Patients who are hemodynamically stable enough to undergo ultrasound examination before cannulation.
- Patients able to undergo vascular ultrasound examination in the supine position (0-30° head elevation according to the study protocol).
Key exclusion criteria (10 listed)
- Patients younger than 18 years of age.
- Previous surgery, radiotherapy, or significant trauma involving the neck.
- Known thrombosis, stenosis, or congenital anomalies of the internal jugular vein.
- Local infection, cellulitis, burn, or hematoma at the intended cannulation site.
- Large neck masses, thyroid enlargement, or cervical pathology causing distortion of neck anatomy.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Internal Jugular Vein Collapsibility Index Percentage
Time frame: Baseline
The Internal Jugular Vein (IJV) collapsibility index is evaluated by bedside vascular ultrasound and calculated using the formula: [(maximum anterior-posterior diameter during expiration - minimum anterior-posterior diameter during inspiration) / maximum anterior-posterior diameter during expiration] * 100. The outcome is reported as a continuous percentage from 0% to 100%, where higher values indicate greater vein collapsibility
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Vascular Access and Elevated Jugular Venous Pressure, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 19 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Internal Jugular Vein Collapsibility Index Percentage (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Aug 2026.