Acne AtrophicaPLLA-PRP PTASNCT07775092
Poly-L-Lactic Acid Threads Versus Platelet-Rich Plasma for Post-Traumatic Atrophic Scars
A study testing subcision and PLLA threads' insertion and PRP and subcision (PRP-S) in people with Acne Atrophica and PRP, run by Tanta University at 1 site in Egypt.
Trial summary
This study compares the efficacy and safety of poly-L-lactic acid (PLLA) threads versus platelet-rich plasma (PRP), both combined with subcision, in the treatment of post-traumatic atrophic scars. Read more about this study
- Who is it for?
- Ages 16 to 55 years
- Conditions the study is for
- Acne Atrophica, PRP
- What is being tested?
- subcision and PLLA threads' insertion and PRP and subcision (PRP-S)
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 48 participants
- Where
- 1 siteEgypt
- Study dates
- 6 Feb 2023to 31 Aug 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 to 55 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Patients with post-traumatic atrophic scars. Scar duration of at least 1 year. No treatment received during the previous 6 months.
Who cannot join
- Keloids Immunosuppression Coagulative disorders Thrombophilic disorders Any chronic diseases
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Comparative Study of Poly-L-Lactic Acid Threads Versus Platelet-Rich Plasma, Both Combined With Subcision, in the Treatment of Post-Traumatic Atrophic Scars
This study compares the efficacy and safety of poly-L-lactic acid (PLLA) threads versus platelet-rich plasma (PRP), both combined with subcision, in the treatment of post-traumatic atrophic scars. Patients with post-traumatic atrophic scars were allocated to either a single session of subcision followed by PLLA thread insertion or four monthly sessions of subcision combined with PRP injection. Clinical improvement, patient satisfaction, adverse effects, and histopathological changes were assessed during a 3-month follow-up period.
Read the detailed description
Post-traumatic atrophic scars result from abnormal healing following skin injury and may cause significant cosmetic and functional impairment. Subcision releases the fibrous bands tethering the scar to deeper tissues and may improve the response to additional treatments. PLLA threads are biodegradable materials that can stimulate collagen production, while PRP contains concentrated platelets and growth factors that may enhance tissue repair and remodeling.
This comparative study was conducted at the Dermatology and Venereology Department, Tanta University Hospital. Patients diagnosed with post-traumatic atrophic scars for at least one year and who had not received treatment during the preceding six months were enrolled. Patients with keloids, immunosuppression, coagulative or thrombophilic disorders, or chronic diseases were excluded.
Participants were divided into two equal treatment groups. Group A received a single session of subcision followed by insertion of poly-L-lactic acid threads. Group B received subcision combined with PRP injection for four sessions at one-month intervals. Clinical photographs were obtained before treatment and three months after treatment. Clinical improvement was assessed by two blinded dermatologists using the Global Aesthetic Improvement Scale, while patient satisfaction and treatment-related complaints or adverse effects were also recorded.
Skin biopsies were obtained from six patients before treatment and three months after treatment and evaluated using hematoxylin and eosin and trichrome staining to assess histopathological changes. All patients were followed for three months.
The study was approved by the Research Ethics Committee of the Faculty of Medicine, Tanta University, with approval number 32889/01/19, and informed consent was obtained from all participants.
- Conditions
- Acne Atrophica, PRP
- Being tested
- subcision and PLLA threads' insertion, PRP and subcision (PRP-S)
- Keywords
- acne scars, PRP, subscision, threads
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
subcision and PLLA threads' insertionProcedure or surgery
subcision and PLLA threads' insertion at the same session
PRP and subcision (PRP-S)Procedure or surgery
PRP and subcision (PRP-S) injection monthly for four sessions
| Study group | Role | What they receive |
|---|---|---|
| subcision and PLLA threads | Active comparator | subcision and PLLA threads' insertion at the same session Receives: Procedure: subcision and PLLA threads' insertion |
| PRP and subcision (PRP-S) injection | Active comparator | PRP and subcision (PRP-S) injection monthly for four sessions Receives: Procedure: PRP and subcision (PRP-S) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Global Aesthetic Improvement Scale (GAIS) score
Clinical improvement of post-traumatic atrophic scars was assessed using the Global Aesthetic Improvement Scale by two dermatologists blinded to the treatment group. The scale was graded from 1 to 4: Grade 1 = mild/no improvement (0-25%), Grade 2 = moderate improvement (26-50%), Grade 3 = marked improvement (51-75%), and Grade 4 = excellent improvement (>75%).
Measured: 3 months after treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Aug 2026
- Study start6 Feb 2023
- Primary completion21 Aug 2023
- Study completion31 Aug 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acne AtrophicaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 48 participants (actual)
Sponsor and investigators
- Lead sponsor
- Tanta University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nesrin Sabry, Tanta University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07775092
- Sponsor's protocol ID
- 32889/01/19
- Acronym
- PLLA-PRP PTAS
- Status last verified
- Aug 2026
- First submitted
- 15 Aug 2026
- Last updated
- 20 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Comparative Study of Poly-L-Lactic Acid Threads Versus Platelet-Rich Plasma, Both Combined With Subcision, in the Treatment of Post-Traumatic Atrophic Scars
- ClinicalTrials.gov ID
- NCT07775092
- Acronym / sponsor ID
- PLLA-PRP PTAS / 32889/01/19
- Conditions
- Acne Atrophica, PRP
- Keywords
- acne scars, PRP, subscision, threads
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 48 participants (actual)
- Lead sponsor
- Tanta UniversityUniversity, hospital or other
- Study start
- 6 Feb 2023 (actual)
- Primary completion
- 21 Aug 2023 (actual)
- Study completion
- 31 Aug 2024 (actual)
- First posted
- 20 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study compares the efficacy and safety of poly-L-lactic acid (PLLA) threads versus platelet-rich plasma (PRP), both combined with subcision, in the treatment of post-traumatic atrophic scars. Patients with post-traumatic atrophic scars were allocated to either a single session of subcision followed by PLLA thread insertion or four monthly sessions of subcision combined with PRP injection. Clinical improvement, patient satisfaction, adverse effects, and histopathological changes were assessed during a 3-month follow-up period.
Detailed description
Post-traumatic atrophic scars result from abnormal healing following skin injury and may cause significant cosmetic and functional impairment. Subcision releases the fibrous bands tethering the scar to deeper tissues and may improve the response to additional treatments. PLLA threads are biodegradable materials that can stimulate collagen production, while PRP contains concentrated platelets and growth factors that may enhance tissue repair and remodeling.
This comparative study was conducted at the Dermatology and Venereology Department, Tanta University Hospital. Patients diagnosed with post-traumatic atrophic scars for at least one year and who had not received treatment during the preceding six months were enrolled. Patients with keloids, immunosuppression, coagulative or thrombophilic disorders, or chronic diseases were excluded.
Participants were divided into two equal treatment groups. Group A received a single session of subcision followed by insertion of poly-L-lactic acid threads. Group B received subcision combined with PRP injection for four sessions at one-month intervals. Clinical photographs were obtained before treatment and three months after treatment. Clinical improvement was assessed by two blinded dermatologists using the Global Aesthetic Improvement Scale, while patient satisfaction and treatment-related complaints or adverse effects were also recorded.
Skin biopsies were obtained from six patients before treatment and three months after treatment and evaluated using hematoxylin and eosin and trichrome staining to assess histopathological changes. All patients were followed for three months.
The study was approved by the Research Ethics Committee of the Faculty of Medicine, Tanta University, with approval number 32889/01/19, and informed consent was obtained from all participants.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| subcision and PLLA threads | Active comparator | Procedure: subcision and PLLA threads' insertionsubcision and PLLA threads' insertion at the same session |
| PRP and subcision (PRP-S) injection | Active comparator | Procedure: PRP and subcision (PRP-S)PRP and subcision (PRP-S) injection monthly for four sessions |
Who may qualify
- Ages
- 16 to 55 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (1 listed)
- Patients with post-traumatic atrophic scars. Scar duration of at least 1 year. No treatment received during the previous 6 months.
Key exclusion criteria (1 listed)
- Keloids Immunosuppression Coagulative disorders Thrombophilic disorders Any chronic diseases
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| subcision and PLLA threads' insertionsubcision and PLLA threads' insertion at the same session | Procedure or surgery | subcision and PLLA threads |
| PRP and subcision (PRP-S)PRP and subcision (PRP-S) injection monthly for four sessions | Procedure or surgery | PRP and subcision (PRP-S) injection |
Primary outcome
Global Aesthetic Improvement Scale (GAIS) score
Time frame: 3 months after treatment
Clinical improvement of post-traumatic atrophic scars was assessed using the Global Aesthetic Improvement Scale by two dermatologists blinded to the treatment group. The scale was graded from 1 to 4: Grade 1 = mild/no improvement (0-25%), Grade 2 = moderate improvement (26-50%), Grade 3 = marked improvement (51-75%), and Grade 4 = excellent improvement (>75%).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Aug 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing subcision and PLLA threads' insertion and PRP and subcision (PRP-S) in people with Acne Atrophica and PRP, run by Tanta University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Global Aesthetic Improvement Scale (GAIS) score (time frame: 3 months after treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Aug 2026; AzTrials last refreshed its copy on 30 Oct 2026.