Coronary Artery DiseaseNCT07775742
Effect of High-Intensity Interval Training Versus Home-Based Rehabilitation Program On Patients Underwent Coronary Artery Bypass Graft Surgery
A study testing High Intensity Interval Training program and home-based cardiac rehabilitation intervention in people with Coronary Artery Disease and Coronary Graft Stenosis, run by Kafrelsheikh University at 1 site in Saudi Arabia.
Trial summary
1. To assess the effect of high-intensity interval training on peak metabolic equivalents in patients with coronary heart disease after the coronary artery bypass grafting surgery. 2. Read more about this study
- Who is it for?
- Ages 55 to 58 years
- Conditions the study is for
- Coronary Artery Disease, Coronary Graft Stenosis
- What is being tested?
- High Intensity Interval Training program and home-based cardiac rehabilitation intervention
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 84 participants
- Where
- 1 siteSaudi Arabia
- Study dates
- 1 Jul 2026to 1 Feb 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 55 to 58 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Participants will be eligible if they are clinically stable as defined by the American College of Cardiology/American Heart Association.
- Only Participants will be stratified as low to moderate risk as identified by the American College of Sport Medicine/
- Mean age ± standard deviation, 55 ± 3 years.
- All patients underwent coronary artery bypass graft surgery, rested at home for at least one month, and then returned to the center for a cardiac rehabilitation program
Who cannot join
- Patients will be excluded from this study if they had an ejection fraction of less than 40% at rest (high risk as defined by American Association of Cardiovascular and Pulmonary Rehabilitation Stratification).
- Mental health disorders (such an anxiety or depression).
- Any vision or hearing defects or any neurological, respiratory, or musculoskeletal conditions that have an impact on ambulation.
- Irreversible heart failure.
- Myocardial Infarction (MI) over the past month.
- Persistent ventricular arrhythmias or unstable angina.
- Any exercise restrictions.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Saudi Arabia1 site, 1 recruiting
- Recruiting
Medina Cardiac Center
Madinah
Mohammed Obaid Almuzaini, physical therapist, +966540044491, Pt.mohammedobaid@gmail.com
About this study
Official title: Effect of High-Intensity Interval Training Versus Home-Based Rehabilitation Program on Peak Metabolic Equivalents On Patients Underwent Coronary Artery Bypass Graft Surgery
- To assess the effect of high-intensity interval training on peak metabolic equivalents in patients with coronary heart disease after the coronary artery bypass grafting surgery.
- To assess the effect of a home-based cardiac rehabilitation program on peak metabolic equivalents in patients with coronary heart disease after coronary artery bypass grafting surgery.
- To compare functional outcomes between the different treatment approaches.
Read the detailed description
Cardiovascular disease (CVD), a leading cause of death in the U.S., is primarily driven by coronary artery disease (CAD), which accounts for 85% of related fatalities. The Coronary Artery Bypass Grafting (CABG) procedure, used to treat blocked arteries, can lead to complications like reduced cardiopulmonary function and decreased physical activity post-surgery. To combat these issues, cardiac rehabilitation (CR) is recommended, incorporating exercise, dietary changes, and stress reduction. Research indicates that CR, particularly high-intensity interval training (HIIT), is safe for coronary artery disease patients and effectively enhances cardiopulmonary fitness. Maintaining exercise capacity is critical as it significantly correlates with improved survival rates in Cardiovascular disease patients. Despite evidence supporting cardiac rehabilitation's benefits, participation rates remain low, highlighting a need for sustained exercise habits post-rehabilitation. Home-based CR has shown effectiveness comparable to outpatient programs, although long-term benefits remain uncertain due to insufficient follow-up studies.
- Conditions
- Coronary Artery Disease, Coronary Graft Stenosis
- Being tested
- High Intensity Interval Training program, home-based cardiac rehabilitation intervention, no intervention program
- Medical subject headings
- Coronary Artery Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High Intensity Interval Training programOther
High-Intensity Interval Training (HIIT) includes a 5-minute warm-up, followed by a 3-minute training session at 60% to 70% of heart rate reserve and four 4-minute high-intensity intervals at 80% to 90% of heart rate reserve. Each interval is followed by a 3-minute active recovery at 60% to 70% of heart rate reserve, concluding with a 4-minute cool-down. Subjects without balance or leg issues performed treadmill exercises, while those with such complaints used a leg ergo-cycle.
home-based cardiac rehabilitation interventionOther
The home-based cardiac rehabilitation program utilizes Physio-tools software for exercise management. Participants will receive a data sheet for exercise logging, a color-coded program, and a Polar watch. Weekly phone support will provide encouragement and answer questions. The program involves moderate-intensity exercises, 3 times a week, including circuit training for 45 minutes, with structured warm-up, aerobic, and cool-down phases.
no intervention programOther
The control group had no intervention program. Based on current standard practice, all participants will be given an instruction booklet that contains instructions and precautions about surgery, wound care and encouragement to be active.
| Study group | Role | What they receive |
|---|---|---|
| High Intensity Interval Training program | Experimental | Twenty-eight patients will receive a high-intensity interval training program for four weeks Receives: Other: High Intensity Interval Training program |
| home-based cardiac rehabilitation intervention | Experimental | Twenty-eight patients will receive a home-based cardiac rehabilitation intervention for four weeks Receives: Other: home-based cardiac rehabilitation intervention |
| no intervention | Active comparator | all participants will be given an instruction booklet that contains instructions and precautions about surgery, wound care and encouragement to be active. Receives: Other: no intervention program |
What is being measured
The primary outcome is the main question the study is designed to answer.
assessment of Exercise capacity
Exercise capacity will be evaluated through a symptom-limited graded treadmill exercise test following the Bruce protocol, starting at 1.7 mph and a 10% incline. The intensity will increase every 3 minutes until the participant reaches exhaustion or meets clinical termination criteria. Capacity will be measured in metabolic equivalents (METs), with peak metabolic equivalents calculated based on the highest workload achieved. Estimated oxygen consumption will be expressed in mL·kg-¹·min-¹ and converted to METs. The main outcome will be the change in peak metabolic equivalents from baseline to post-intervention assessment.
Measured: At baseline and after 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Aug 2026
- Study start1 Jul 2026
- Primary completion1 Dec 2026 (estimated)
- Study completion1 Feb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Coronary Artery DiseaseStudies of the same condition, open and under way.
- More trials run by Kafrelsheikh UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 84 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Kafrelsheikh University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohammed Obaid Almuzaini, Kafrelsheikh University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07775742
- Sponsor's protocol ID
- Mohamed_Msc
- Status last verified
- Aug 2026
- First submitted
- 28 Jul 2026
- Last updated
- 20 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of High-Intensity Interval Training Versus Home-Based Rehabilitation Program on Peak Metabolic Equivalents On Patients Underwent Coronary Artery Bypass Graft Surgery
- ClinicalTrials.gov ID
- NCT07775742
- Acronym / sponsor ID
- Mohamed_Msc
- Conditions
- Coronary Artery Disease, Coronary Graft Stenosis
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 84 participants (estimated)
- Lead sponsor
- Kafrelsheikh UniversityUniversity, hospital or other
- Study start
- 1 Jul 2026 (actual)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 1 Feb 2027 (estimated)
- First posted
- 20 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- To assess the effect of high-intensity interval training on peak metabolic equivalents in patients with coronary heart disease after the coronary artery bypass grafting surgery.
- To assess the effect of a home-based cardiac rehabilitation program on peak metabolic equivalents in patients with coronary heart disease after coronary artery bypass grafting surgery.
- To compare functional outcomes between the different treatment approaches.
Detailed description
Cardiovascular disease (CVD), a leading cause of death in the U.S., is primarily driven by coronary artery disease (CAD), which accounts for 85% of related fatalities. The Coronary Artery Bypass Grafting (CABG) procedure, used to treat blocked arteries, can lead to complications like reduced cardiopulmonary function and decreased physical activity post-surgery. To combat these issues, cardiac rehabilitation (CR) is recommended, incorporating exercise, dietary changes, and stress reduction. Research indicates that CR, particularly high-intensity interval training (HIIT), is safe for coronary artery disease patients and effectively enhances cardiopulmonary fitness. Maintaining exercise capacity is critical as it significantly correlates with improved survival rates in Cardiovascular disease patients. Despite evidence supporting cardiac rehabilitation's benefits, participation rates remain low, highlighting a need for sustained exercise habits post-rehabilitation. Home-based CR has shown effectiveness comparable to outpatient programs, although long-term benefits remain uncertain due to insufficient follow-up studies.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| High Intensity Interval Training program | Experimental | Other: High Intensity Interval Training programTwenty-eight patients will receive a high-intensity interval training program for four weeks |
| home-based cardiac rehabilitation intervention | Experimental | Other: home-based cardiac rehabilitation interventionTwenty-eight patients will receive a home-based cardiac rehabilitation intervention for four weeks |
| no intervention | Active comparator | Other: no intervention programall participants will be given an instruction booklet that contains instructions and precautions about surgery, wound care and encouragement to be active. |
Who may qualify
- Ages
- 55 to 58 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Participants will be eligible if they are clinically stable as defined by the American College of Cardiology/American Heart Association.
- Only Participants will be stratified as low to moderate risk as identified by the American College of Sport Medicine/
- Mean age ± standard deviation, 55 ± 3 years.
- All patients underwent coronary artery bypass graft surgery, rested at home for at least one month, and then returned to the center for a cardiac rehabilitation program
Key exclusion criteria (7 listed)
- Patients will be excluded from this study if they had an ejection fraction of less than 40% at rest (high risk as defined by American Association of Cardiovascular and Pulmonary Rehabilitation Stratification).
- Mental health disorders (such an anxiety or depression).
- Any vision or hearing defects or any neurological, respiratory, or musculoskeletal conditions that have an impact on ambulation.
- Irreversible heart failure.
- Myocardial Infarction (MI) over the past month.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High Intensity Interval Training programHigh-Intensity Interval Training (HIIT) includes a 5-minute warm-up, followed by a 3-minute training session at 60% to 70% of heart rate reserve and four 4-minute high-intensity intervals at 80% to 90% of heart rate reserve. Each interval is followed by a 3-minute active recovery at 60% to 70% of heart rate reserve, concluding with a 4-minute cool-down. Subjects without balance or leg issues performed treadmill exercises, while those with such complaints used a leg ergo-cycle. | Other | High Intensity Interval Training program |
| home-based cardiac rehabilitation interventionThe home-based cardiac rehabilitation program utilizes Physio-tools software for exercise management. Participants will receive a data sheet for exercise logging, a color-coded program, and a Polar watch. Weekly phone support will provide encouragement and answer questions. The program involves moderate-intensity exercises, 3 times a week, including circuit training for 45 minutes, with structured warm-up, aerobic, and cool-down phases. | Other | home-based cardiac rehabilitation intervention |
| no intervention programThe control group had no intervention program. Based on current standard practice, all participants will be given an instruction booklet that contains instructions and precautions about surgery, wound care and encouragement to be active. | Other | no intervention |
Primary outcome
assessment of Exercise capacity
Time frame: At baseline and after 4 weeks
Exercise capacity will be evaluated through a symptom-limited graded treadmill exercise test following the Bruce protocol, starting at 1.7 mph and a 10% incline. The intensity will increase every 3 minutes until the participant reaches exhaustion or meets clinical termination criteria. Capacity will be measured in metabolic equivalents (METs), with peak metabolic equivalents calculated based on the highest workload achieved. Estimated oxygen consumption will be expressed in mL·kg-¹·min-¹ and converted to METs. The main outcome will be the change in peak metabolic equivalents from baseline to post-intervention assessment.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High Intensity Interval Training program and home-based cardiac rehabilitation intervention in people with Coronary Artery Disease and Coronary Graft Stenosis, run by Kafrelsheikh University at 1 site in Saudi Arabia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Saudi Arabia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mohammed O Almuzaini, PT (+966540044491, Pt.mohammedobaid@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
assessment of Exercise capacity (time frame: At baseline and after 4 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Aug 2026.