HypertansionGenAI-HYPERNCT07776834
Generative AI-Supported Personalized Education Compared With Printed Material for Adults With Hypertension
A study testing Standard Hypertension Education and Generative AI-Supported Personalized Hypertension Education in people with Hypertansion, run by Akdeniz University at 1 site in Turkey (Türkiye).
Trial summary
This study evaluates whether generative artificial intelligence-supported personalized education can improve hypertension knowledge and medication adherence in adults with hypertension compared with standard printed educational material. A total of 88 adults with hypertension are included in the study. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Hypertansion
- What is being tested?
- Standard Hypertension Education and Generative AI-Supported Personalized Hypertension Education
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 88 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jun 2026to 20 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Voluntary agreement to participate in the study
- Diagnosis of hypertension
- Use of antihypertensive medication for at least 6 months
- Medication adherence self-efficacy score of 26 or lower
- Age 18 years or older
- Ability to read and write in Turkish
- General health status adequate for communication
- Ability to read SMS messages and use WhatsApp
Who cannot join
- Withdrawal from the study after enrollment
- Inability to be reached by telephone during the follow-up period
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Akdeniz University Hospital
Antalya, Antalya, 07070
About this study
Official title: The Effect of Generative Artificial Intelligence-Supported Personalized Education Compared With Printed Material on Hypertension Knowledge and Medication Adherence in Adults With Hypertension
This study evaluates whether generative artificial intelligence-supported personalized education can improve hypertension knowledge and medication adherence in adults with hypertension compared with standard printed educational material. A total of 88 adults with hypertension are included in the study. Participants are assigned to either an intervention group or a control group. The control group receives a printed hypertension education booklet. The intervention group receives personalized educational content prepared using generative artificial intelligence based on individual characteristics and needs, together with weekly WhatsApp or SMS messages, voice messages, and brief telephone follow-up. The intervention lasts four weeks, and final assessments are performed in the fifth week. Hypertension knowledge, medication adherence self-efficacy, and blood pressure are assessed before and after the intervention. It is expected that personalized education will improve hypertension knowledge and medication adherence compared with printed education.
- Conditions
- Hypertansion
- Being tested
- Standard Hypertension Education, Generative AI-Supported Personalized Hypertension Education
- Keywords
- generative artificial intelligence, medication adherence, hypertansion, self efficacy, blood pressure
- Medical subject headings
- Medication Adherence
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Standard Hypertension EducationBehavioural
Participants receive standard hypertension education including medication-related information and a printed hypertension education booklet developed based on expert recommendations.
Generative AI-Supported Personalized Hypertension EducationBehavioural
Participants receive personalized hypertension education generated using generative artificial intelligence based on individual characteristics, needs, baseline information, and standardized hypertension education content. The intervention is delivered over four weeks through weekly WhatsApp or SMS messages and voice messages. Brief structured telephone follow-up is provided in the first and fourth weeks.
| Study group | Role | What they receive |
|---|---|---|
| control group | Active comparator | Participants in this arm receive standard hypertension education and a printed hypertension education booklet. Baseline assessments and blood pressure measurements are performed in the first week. In the fifth week, post-intervention assessments and blood pressure measurements are repeated. Receives: Behavioral: Standard Hypertension Education |
| intervention group | Experimental | Participants in this arm receive generative artificial intelligence-supported personalized hypertension education based on their individual characteristics, needs, baseline information, and the standardized hypertension education content. The intervention is delivered over four weeks through weekly WhatsApp or SMS messages and voice messages. Brief structured telephone follow-up is conducted during the first and fourth weeks. In the fifth week, post-intervention assessments and blood pressure measurements are performed. Receives: Behavioral: Generative AI-Supported Personalized Hypertension Education |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean Change From Baseline in Medication Adherence Self-Efficacy Scale-Short Form (MASES-SF) Total Score at Week 5
Medication adherence self-efficacy will be assessed using the 13-item Medication Adherence Self-Efficacy Scale-Short Form (MASES-SF). Each item is scored from 1 (not at all sure) to 4 (very sure), resulting in a total score ranging from 13 to 52. Higher scores indicate greater self-efficacy for adhering to antihypertensive medication. The change in total score from baseline to Week 5 will be evaluated.
Measured: Baseline and Week 5
Mean Change From Baseline in Hypertension Knowledge-Level Scale (HK-LS) Total Score at Week 5
Hypertension knowledge will be assessed using the 22-item Hypertension Knowledge-Level Scale (HK-LS). The scale includes six domains: definition, medical treatment, medication adherence, lifestyle, diet, and complications. Responses are recorded as true, false, or do not know, and each correct response receives 1 point. Higher scores indicate greater hypertension knowledge, and a score of 16 or above indicates a high level of hypertension knowledge. The change in total score from baseline to Week 5 will be evaluated.
Measured: Baseline and Week 5
Secondary outcomes (2)
Mean Change From Baseline in Systolic Blood Pressure at Week 5
Systolic blood pressure will be measured in mmHg at baseline and Week 5. The change in systolic blood pressure from baseline to Week 5 will be evaluated.
Measured: Baseline and Week 5
Mean Change From Baseline in Diastolic Blood Pressure at Week 5
Diastolic blood pressure will be measured in mmHg at baseline and Week 5. The change in diastolic blood pressure from baseline to Week 5 will be evaluated.
Measured: Baseline and Week 5
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Aug 2026
- Study start1 Jun 2026
- Primary completion20 Dec 2026 (estimated)
- Study completion20 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HypertansionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Participants are assigned nonrandomly to two parallel groups in a 1:1 ratio. The control group receives standard printed hypertension education, while the intervention group receives generative artificial intelligence-supported personalized education in addition to the printed material. Both groups are assessed at baseline and again in the fifth week.
- Masking
- None (open label)
- Enrolment
- 88 participants (actual)
Sponsor and investigators
- Lead sponsor
- Akdeniz University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Yasemin DEMİR AVCI, PhD, Principal investigator, Akdeniz University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07776834
- Sponsor's protocol ID
- AKDENIZU-TBAEK-711
- Acronym
- GenAI-HYPER
- Status last verified
- Aug 2026
- First submitted
- 18 Aug 2026
- Last updated
- 20 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Generative Artificial Intelligence-Supported Personalized Education Compared With Printed Material on Hypertension Knowledge and Medication Adherence in Adults With Hypertension
- ClinicalTrials.gov ID
- NCT07776834
- Acronym / sponsor ID
- GenAI-HYPER / AKDENIZU-TBAEK-711
- Conditions
- Hypertansion
- Keywords
- generative artificial intelligence, medication adherence, hypertansion, self efficacy, blood pressure
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 88 participants (actual)
- Lead sponsor
- Akdeniz UniversityUniversity, hospital or other
- Study start
- 1 Jun 2026 (actual)
- Primary completion
- 20 Dec 2026 (estimated)
- Study completion
- 20 Dec 2026 (estimated)
- First posted
- 20 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluates whether generative artificial intelligence-supported personalized education can improve hypertension knowledge and medication adherence in adults with hypertension compared with standard printed educational material. A total of 88 adults with hypertension are included in the study. Participants are assigned to either an intervention group or a control group. The control group receives a printed hypertension education booklet. The intervention group receives personalized educational content prepared using generative artificial intelligence based on individual characteristics and needs, together with weekly WhatsApp or SMS messages, voice messages, and brief telephone follow-up. The intervention lasts four weeks, and final assessments are performed in the fifth week. Hypertension knowledge, medication adherence self-efficacy, and blood pressure are assessed before and after the intervention. It is expected that personalized education will improve hypertension knowledge and medication adherence compared with printed education.
Study design
- Primary purpose
- Health services research
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants are assigned nonrandomly to two parallel groups in a 1:1 ratio. The control group receives standard printed hypertension education, while the intervention group receives generative artificial intelligence-supported personalized education in addition to the printed material. Both groups are assessed at baseline and again in the fifth week.
| Arm | Type | Receives |
|---|---|---|
| control group | Active comparator | Behavioral: Standard Hypertension EducationParticipants in this arm receive standard hypertension education and a printed hypertension education booklet. Baseline assessments and blood pressure measurements are performed in the first week. In the fifth week, post-intervention assessments and blood pressure measurements are repeated. |
| intervention group | Experimental | Behavioral: Generative AI-Supported Personalized Hypertension EducationParticipants in this arm receive generative artificial intelligence-supported personalized hypertension education based on their individual characteristics, needs, baseline information, and the standardized hypertension education content. The intervention is delivered over four weeks through weekly WhatsApp or SMS messages and voice messages. Brief structured telephone follow-up is conducted during the first and fourth weeks. In the fifth week, post-intervention assessments and blood pressure measurements are performed. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Voluntary agreement to participate in the study
- Diagnosis of hypertension
- Use of antihypertensive medication for at least 6 months
- Medication adherence self-efficacy score of 26 or lower
- Age 18 years or older
Key exclusion criteria (2 listed)
- Withdrawal from the study after enrollment
- Inability to be reached by telephone during the follow-up period
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Standard Hypertension EducationParticipants receive standard hypertension education including medication-related information and a printed hypertension education booklet developed based on expert recommendations. | Behavioural | control group |
| Generative AI-Supported Personalized Hypertension EducationParticipants receive personalized hypertension education generated using generative artificial intelligence based on individual characteristics, needs, baseline information, and standardized hypertension education content. The intervention is delivered over four weeks through weekly WhatsApp or SMS messages and voice messages. Brief structured telephone follow-up is provided in the first and fourth weeks. | Behavioural | intervention group |
Primary outcome
Mean Change From Baseline in Medication Adherence Self-Efficacy Scale-Short Form (MASES-SF) Total Score at Week 5
Time frame: Baseline and Week 5
Medication adherence self-efficacy will be assessed using the 13-item Medication Adherence Self-Efficacy Scale-Short Form (MASES-SF). Each item is scored from 1 (not at all sure) to 4 (very sure), resulting in a total score ranging from 13 to 52. Higher scores indicate greater self-efficacy for adhering to antihypertensive medication. The change in total score from baseline to Week 5 will be evaluated.
Mean Change From Baseline in Hypertension Knowledge-Level Scale (HK-LS) Total Score at Week 5
Time frame: Baseline and Week 5
Hypertension knowledge will be assessed using the 22-item Hypertension Knowledge-Level Scale (HK-LS). The scale includes six domains: definition, medical treatment, medication adherence, lifestyle, diet, and complications. Responses are recorded as true, false, or do not know, and each correct response receives 1 point. Higher scores indicate greater hypertension knowledge, and a score of 16 or above indicates a high level of hypertension knowledge. The change in total score from baseline to Week 5 will be evaluated.
2 secondary outcomes
Mean Change From Baseline in Systolic Blood Pressure at Week 5
Time frame: Baseline and Week 5
Mean Change From Baseline in Diastolic Blood Pressure at Week 5
Time frame: Baseline and Week 5
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Aug 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Yasemin DEMİR AVCI, PhD principal investigator
Akdeniz University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Standard Hypertension Education and Generative AI-Supported Personalized Hypertension Education in people with Hypertansion, run by Akdeniz University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 20 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean Change From Baseline in Medication Adherence Self-Efficacy Scale-Short Form (MASES-SF) Total Score at Week 5 (time frame: Baseline and Week 5). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Aug 2026.