Semen Quality in Healthy Adult MenNCT07778576
Effects of 12-Week Combined Exercise on Semen Quality and Metabolic Health in Healthy Men
A study testing Combined Aerobic and Resistance Exercise Program in people with Semen Quality in Healthy Adult Men, run by Cumhuriyet University at 1 site in Turkey (Türkiye).
Trial summary
This study evaluated whether a 12-week combined aerobic and resistance exercise program could improve semen quality and metabolic health in healthy adult men. A total of 34 men aged 18-24 years participated in the study. Read more about this study
- Who is it for?
- Ages 18 to 24 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Semen Quality in Healthy Adult Men
- What is being tested?
- Combined Aerobic and Resistance Exercise Program
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 34 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 3 Mar 2025to 6 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 24 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male participants aged 18-24 years. Being generally healthy and able to participate safely in an aerobic and resistance exercise program.
- Voluntarily agreeing to participate and providing written informed consent. Being willing and able to provide semen and blood samples at baseline and after the 12-week study period.
- Being able to complete the study assessments and comply with the study procedures.
Who cannot join
- Presence of a diagnosed reproductive system disorder or a medical condition known to affect semen quality.
- Presence of a chronic, cardiovascular, metabolic, musculoskeletal, or other medical condition that could prevent safe participation in exercise.
- Current use of medication, hormonal treatment, or nutritional supplementation known to influence reproductive or metabolic outcomes.
- Presence of an acute illness or injury during the assessment or intervention period that prevented participation.
- Failure to complete the baseline or post-intervention assessments. Failure to comply with the prescribed exercise program or study procedures.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Semen Quality and Metabolic Biomarker Changes Following a 12-Week Combined Exercise Program in Healthy Adult Men
This study evaluated whether a 12-week combined aerobic and resistance exercise program could improve semen quality and metabolic health in healthy adult men. A total of 34 men aged 18-24 years participated in the study. Participants were assigned to either an exercise group or a passive control group based on their willingness and ability to attend the exercise program; assignment was not randomized.
Participants in the exercise group completed supervised combined exercise sessions three times per week for 12 weeks. Each session included aerobic and resistance exercises. Participants in the control group were asked to maintain their usual daily activities and not begin a structured exercise program during the study.
Semen quality, metabolic biomarkers, and body composition were assessed before and after the 12-week study period. Semen assessments included semen volume, pH, sperm concentration, motility, and normal sperm morphology. The study aimed to determine whether regular combined exercise was associated with changes in reproductive and metabolic health compared with no structured exercise program.
Read the detailed description
This completed, non-randomized, parallel-group interventional study investigated the effects of a 12-week supervised combined aerobic and resistance exercise program on semen quality, metabolic biomarkers, and body composition in healthy adult men.
A total of 34 men aged 18-24 years were enrolled. Participants were allocated to an exercise group or a passive control group according to their willingness and availability to participate in the supervised exercise program. Therefore, no random sequence generation or concealed allocation procedure was used.
Participants assigned to the exercise group completed a 12-week combined exercise program consisting of three supervised sessions per week. The program incorporated both aerobic and resistance exercise components. Exercise sessions were progressively organized over the intervention period to provide a structured training stimulus. Participants assigned to the passive control group continued their usual daily routines and were instructed not to participate in a new structured exercise program during the same period.
Assessments were conducted at baseline and after completion of the 12-week intervention. Semen samples were evaluated for semen volume, pH, sperm concentration, total motility, progressive motility, non-progressive motility, and normal sperm morphology. Metabolic biomarkers and body-composition measures were also evaluated at both time points.
Laboratory personnel responsible for outcome assessment were unaware of the participants' group assignments. Changes from baseline to the end of the intervention were compared between the exercise and control groups to examine whether combined exercise was associated with improvements in reproductive and metabolic health.
- Conditions
- Semen Quality in Healthy Adult Men
- Being tested
- Combined Aerobic and Resistance Exercise Program
- Keywords
- Combined Exercise, Aerobic Exercise, Resistance Exercise, Semen Quality, Sperm Concentration, Sperm Motility, Sperm Morphology, Male Reproductive Health, Metabolic Biomarkers, Body Composition, Healthy Adult Men
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Combined Aerobic and Resistance Exercise ProgramBehavioural
Participants completed a 12-week supervised combined exercise program performed three times per week. Each session included aerobic and resistance exercise components. The training program was progressively structured across the intervention period to provide an appropriate exercise stimulus. Exercise sessions were supervised to support adherence and the correct performance of the prescribed activities. Semen quality, metabolic biomarkers, and body composition were assessed before and after the intervention.
| Study group | Role | What they receive |
|---|---|---|
| Combined Exercise Group | Experimental | Participants completed a 12-week supervised combined exercise program consisting of aerobic and resistance exercises performed three times per week. The exercise program was progressively structured throughout the intervention period. Semen quality, metabolic biomarkers, and body composition were assessed at baseline and after the 12-week intervention. Receives: Behavioral: Combined Aerobic and Resistance Exercise Program |
| Passive Control Group | No intervention | Participants continued their usual daily routines during the 12-week study period and were instructed not to begin or participate in a structured exercise program. They underwent the same baseline and post-intervention assessments as the combined exercise group, including semen quality, metabolic biomarkers, and body composition measurements. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Sperm Concentration
Sperm concentration was determined through semen analysis and expressed as the number of spermatozoa per milliliter of semen. The change from baseline to the end of the 12-week study period was compared between the combined exercise and passive control groups.
Measured: Baseline and Week 12
Change in Total Sperm Motility
Total sperm motility was assessed by semen analysis and expressed as the percentage of progressively and non-progressively motile spermatozoa. Change from baseline was evaluated after the 12-week study period.
Measured: Baseline and Week 12
Change in Progressive Sperm Motility
Progressive sperm motility was assessed by semen analysis and expressed as the percentage of spermatozoa demonstrating progressive forward movement. Change from baseline was evaluated after the 12-week study period.
Measured: Baseline and Week 12
Change in Non-Progressive Sperm Motility
Non-progressive sperm motility was assessed by semen analysis and expressed as the percentage of motile spermatozoa that did not demonstrate progressive forward movement. Change from baseline was evaluated after the 12-week study period.
Measured: Baseline and Week 12
Change in Normal Sperm Morphology
Normal sperm morphology was assessed by semen analysis and expressed as the percentage of spermatozoa classified as having normal morphology. Change from baseline was evaluated after the 12-week study period.
Measured: Baseline and Week 12
Change in Semen Volume
Semen volume was measured during semen analysis and expressed in milliliters. Change from baseline was evaluated after the 12-week study period.
Measured: Baseline and Week 12
Change in Semen pH
Semen pH was measured during semen analysis using the laboratory procedure specified in the study protocol. Change from baseline was evaluated after the 12-week study period.
Measured: Baseline and Week 12
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Aug 2026
- Study start3 Mar 2025
- Primary completion6 Jun 2025
- Study completion6 Jul 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Semen Quality in Healthy Adult MenStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Participants were assigned to either a supervised combined exercise group or a passive control group based on their willingness and availability to attend the exercise program. The two groups were followed in parallel for 12 weeks. Group allocation was not randomized.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 34 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cumhuriyet University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Barış Sarıakçalı, Cumhuriyet University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07778576
- Sponsor's protocol ID
- 2024-03-02
- Status last verified
- Aug 2026
- First submitted
- 18 Aug 2026
- Last updated
- 24 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Semen Quality and Metabolic Biomarker Changes Following a 12-Week Combined Exercise Program in Healthy Adult Men
- ClinicalTrials.gov ID
- NCT07778576
- Acronym / sponsor ID
- 2024-03-02
- Conditions
- Semen Quality in Healthy Adult Men
- Keywords
- Combined Exercise, Aerobic Exercise, Resistance Exercise, Semen Quality, Sperm Concentration, Sperm Motility, Sperm Morphology, Male Reproductive Health
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 34 participants (actual)
- Lead sponsor
- Cumhuriyet UniversityUniversity, hospital or other
- Study start
- 3 Mar 2025 (actual)
- Primary completion
- 6 Jun 2025 (actual)
- Study completion
- 6 Jul 2025 (actual)
- First posted
- 21 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluated whether a 12-week combined aerobic and resistance exercise program could improve semen quality and metabolic health in healthy adult men. A total of 34 men aged 18-24 years participated in the study. Participants were assigned to either an exercise group or a passive control group based on their willingness and ability to attend the exercise program; assignment was not randomized.
Participants in the exercise group completed supervised combined exercise sessions three times per week for 12 weeks. Each session included aerobic and resistance exercises. Participants in the control group were asked to maintain their usual daily activities and not begin a structured exercise program during the study.
Semen quality, metabolic biomarkers, and body composition were assessed before and after the 12-week study period. Semen assessments included semen volume, pH, sperm concentration, motility, and normal sperm morphology. The study aimed to determine whether regular combined exercise was associated with changes in reproductive and metabolic health compared with no structured exercise program.
Detailed description
This completed, non-randomized, parallel-group interventional study investigated the effects of a 12-week supervised combined aerobic and resistance exercise program on semen quality, metabolic biomarkers, and body composition in healthy adult men.
A total of 34 men aged 18-24 years were enrolled. Participants were allocated to an exercise group or a passive control group according to their willingness and availability to participate in the supervised exercise program. Therefore, no random sequence generation or concealed allocation procedure was used.
Participants assigned to the exercise group completed a 12-week combined exercise program consisting of three supervised sessions per week. The program incorporated both aerobic and resistance exercise components. Exercise sessions were progressively organized over the intervention period to provide a structured training stimulus. Participants assigned to the passive control group continued their usual daily routines and were instructed not to participate in a new structured exercise program during the same period.
Assessments were conducted at baseline and after completion of the 12-week intervention. Semen samples were evaluated for semen volume, pH, sperm concentration, total motility, progressive motility, non-progressive motility, and normal sperm morphology. Metabolic biomarkers and body-composition measures were also evaluated at both time points.
Laboratory personnel responsible for outcome assessment were unaware of the participants' group assignments. Changes from baseline to the end of the intervention were compared between the exercise and control groups to examine whether combined exercise was associated with improvements in reproductive and metabolic health.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Participants were assigned to either a supervised combined exercise group or a passive control group based on their willingness and availability to attend the exercise program. The two groups were followed in parallel for 12 weeks. Group allocation was not randomized.
| Arm | Type | Receives |
|---|---|---|
| Combined Exercise Group | Experimental | Behavioral: Combined Aerobic and Resistance Exercise ProgramParticipants completed a 12-week supervised combined exercise program consisting of aerobic and resistance exercises performed three times per week. The exercise program was progressively structured throughout the intervention period. Semen quality, metabolic biomarkers, and body composition were assessed at baseline and after the 12-week intervention. |
| Passive Control Group | No intervention | –Participants continued their usual daily routines during the 12-week study period and were instructed not to begin or participate in a structured exercise program. They underwent the same baseline and post-intervention assessments as the combined exercise group, including semen quality, metabolic biomarkers, and body composition measurements. |
Who may qualify
- Ages
- 18 to 24 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Male participants aged 18-24 years. Being generally healthy and able to participate safely in an aerobic and resistance exercise program.
- Voluntarily agreeing to participate and providing written informed consent. Being willing and able to provide semen and blood samples at baseline and after the 12-week study period.
- Being able to complete the study assessments and comply with the study procedures.
Key exclusion criteria (5 listed)
- Presence of a diagnosed reproductive system disorder or a medical condition known to affect semen quality.
- Presence of a chronic, cardiovascular, metabolic, musculoskeletal, or other medical condition that could prevent safe participation in exercise.
- Current use of medication, hormonal treatment, or nutritional supplementation known to influence reproductive or metabolic outcomes.
- Presence of an acute illness or injury during the assessment or intervention period that prevented participation.
- Failure to complete the baseline or post-intervention assessments. Failure to comply with the prescribed exercise program or study procedures.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Combined Aerobic and Resistance Exercise ProgramParticipants completed a 12-week supervised combined exercise program performed three times per week. Each session included aerobic and resistance exercise components. The training program was progressively structured across the intervention period to provide an appropriate exercise stimulus. Exercise sessions were supervised to support adherence and the correct performance of the prescribed activities. Semen quality, metabolic biomarkers, and body composition were assessed before and after the intervention. | Behavioural | Combined Exercise Group |
Primary outcome
Change in Sperm Concentration
Time frame: Baseline and Week 12
Sperm concentration was determined through semen analysis and expressed as the number of spermatozoa per milliliter of semen. The change from baseline to the end of the 12-week study period was compared between the combined exercise and passive control groups.
Change in Total Sperm Motility
Time frame: Baseline and Week 12
Total sperm motility was assessed by semen analysis and expressed as the percentage of progressively and non-progressively motile spermatozoa. Change from baseline was evaluated after the 12-week study period.
Change in Progressive Sperm Motility
Time frame: Baseline and Week 12
Progressive sperm motility was assessed by semen analysis and expressed as the percentage of spermatozoa demonstrating progressive forward movement. Change from baseline was evaluated after the 12-week study period.
Change in Non-Progressive Sperm Motility
Time frame: Baseline and Week 12
Non-progressive sperm motility was assessed by semen analysis and expressed as the percentage of motile spermatozoa that did not demonstrate progressive forward movement. Change from baseline was evaluated after the 12-week study period.
Change in Normal Sperm Morphology
Time frame: Baseline and Week 12
Normal sperm morphology was assessed by semen analysis and expressed as the percentage of spermatozoa classified as having normal morphology. Change from baseline was evaluated after the 12-week study period.
Change in Semen Volume
Time frame: Baseline and Week 12
Semen volume was measured during semen analysis and expressed in milliliters. Change from baseline was evaluated after the 12-week study period.
Change in Semen pH
Time frame: Baseline and Week 12
Semen pH was measured during semen analysis using the laboratory procedure specified in the study protocol. Change from baseline was evaluated after the 12-week study period.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Aug 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Combined Aerobic and Resistance Exercise Program in people with Semen Quality in Healthy Adult Men, run by Cumhuriyet University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Sperm Concentration (time frame: Baseline and Week 12). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Aug 2026.