Pulmonary FibrosisMERcURYNCT07782060
Feasibility Randomised Controlled Trial Exploring Implementation of the Compassionate Mindful rEsilience pRogram for People With pUlmonaRY Fibrosis: The MERcURY Study
A study testing Compassionate mindful resilience in people with Pulmonary Fibrosis, run by Queen's University, Belfast at 1 site in United Kingdom.
Trial summary
Pulmonary fibrosis (PF) is a chronic lung condition in which scar tissue gradually forms, impairing oxygen transfer and causing breathlessness. Individuals with PF frequently experience anxiety and depression, yet supportive care remains underdeveloped, and few evidence-based psychological interventions exist for this… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Pulmonary Fibrosis
- What is being tested?
- Compassionate mindful resilience
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 21 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 1 Dec 2024to 18 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- have a confirmed diagnosis of PF
- be aged 18 years or older
- reside in the UK or Ireland
- have the capacity to provide informed consent
- demonstrate a commitment to attend all four CMR sessions (demonstrated through discussion with the mindfulness teacher during screening)
- have access to an internet-enabled device.
Who cannot join
- No diagnosis of PF
- under 18 years old
- live outside of UK or Ireland
- no capacity to provide informed consent
- not willing to attend all four CMR sessions
- no access to an internet-enabled device.
Trial locations and contacts
1 site in 1 country.
United Kingdom1 site
Queen's University Belfast
Belfast, Please Select, BT7 1NN
About this study
Pulmonary fibrosis (PF) is a chronic lung condition in which scar tissue gradually forms, impairing oxygen transfer and causing breathlessness. Individuals with PF frequently experience anxiety and depression, yet supportive care remains underdeveloped, and few evidence-based psychological interventions exist for this population, representing a critical gap in care.
This feasibility randomised controlled trial (RCT) evaluated the Compassionate Mindful Resilience (CMR) programme, a 4-week online, nurse-led mindfulness-based intervention designed to improve psychological outcomes in people living with PF.
Read the detailed description
Background: Pulmonary fibrosis is a progressive, irreversible fibrotic lung disease that requires long-term treatment. People with a diagnosis of pulmonary fibrosis are known to have reduced health-related quality of life, furthermore, it is common for such individuals to experience anxiety and depression. Therefore, interventions to support these individuals are essential to improve their psychological health. Mindfulness is increasing in popularity but retention in these programmes can be challenging. Condensed programmes have great potential but require statistical and individual evaluation. The Compassionate Mindful Resilience Program is a 4-week course that teaches simple, effective, evidence-based practices, skills and techniques.
Methods: This study aims to establish the feasibility of a randomised controlled trial to evaluate the effectiveness of the Compassionate Mindful Resilience Program in improving the psychosocial well-being of people with a diagnosis of pulmonary fibrosis. The trial will be conducted to test procedures, outcomes and validated tools; estimate recruitment and attrition rates; and calculate the sample size required for a future definitive multi-centre randomised controlled trial. The study will also utilise qualitative methods to explore the acceptability of the intervention to the study population. In keeping with CONSORT guidelines. The SPIRIT guidelines and checklist will be utilised to report the study.
Discussion: This study will implement a four-week mindfulness intervention and its utility for people with Pulmonary Fibrosis. The investigators aim to increase equitable access to evidence-based mindfulness practices with the potential to improve the lives of people impacted by this condition. If the study demonstrates the practicability of delivering the online 4-week Compassionate Mindful Resilience program with adequate recruitment, the investigators will be able to determine the feasibility of progression to a randomised controlled clinical trial to increase equitable access to evidence-based mindfulness practices with the potential to improve the lives of people impacted by Pulmonary Fibrosis.
- Conditions
- Pulmonary Fibrosis
- Being tested
- Compassionate mindful resilience
- Medical subject headings
- Pulmonary Fibrosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Compassionate mindful resilienceBehavioural
It is an internationally accredited 4-week programme with 2-hour online sessions delivered via Microsoft Teams
| Study group | Role | What they receive |
|---|---|---|
| Intervention group | Experimental | CMR is an internationally accredited 4-week programme with 2-hour online sessions delivered via Microsoft Teams Receives: Behavioral: Compassionate mindful resilience |
| Waitlist group | No intervention | This group did not receive the CMR intervention until all intervention groups had completed CMR. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Feasibility of the intervention
Adherence
Measured: From enrollment until the follow up interview was completed (up to 10 weeks)
Secondary outcomes (1)
The feasibility of collecting data on anxiety, depression, well-being, mindfulness, resilience, and self-compassion
These were measured via online surveys at baseline, post-CMR, and four-week follow-up
Measured: Baseline (week 1), post-CMR (week 4), and four-week follow-up (week 8)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Aug 2026
- Study start1 Dec 2024
- Primary completion21 Apr 2025
- Study completion18 Jul 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Pulmonary FibrosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 21 participants (actual)
Sponsor and investigators
- Lead sponsor
- Queen's University, Belfast
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Clare McVeigh, Queen's University, Belfast
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07782060
- Sponsor's protocol ID
- MHLS 24_139
- Other IDs
- SB\ZA\101010662\980079
- Acronym
- MERcURY
- Status last verified
- Mar 2026
- First submitted
- 12 Aug 2026
- Last updated
- 24 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Mc Veigh C, Reid J, Larkin P, Porter S, Hudson P. Palliative care for people with non-malignant respiratory disease and their carers: a review of the current evidence. J Res Nurs. 2019 Sep;24(6):420-430. doi: 10.1177/1744987119840066. Epub 2019 Apr 29.
PubMed 34394556Mc Veigh C, Reid J, Larkin P, Porter S, Hudson P. The experience of palliative care service provision for people with non-malignant respiratory disease and their family carers: An all-Ireland qualitative study. J Adv Nurs. 2018 Feb;74(2):383-394. doi: 10.1111/jan.13453. Epub 2017 Nov 27.
PubMed 28910509
Study at a glance
From the registry record, last updated by the sponsor on 24 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Feasibility Randomised Controlled Trial Exploring Implementation of the Compassionate Mindful rEsilience pRogram for People With pUlmonaRY Fibrosis: The MERcURY Study
- ClinicalTrials.gov ID
- NCT07782060
- Acronym / sponsor ID
- MERcURY / MHLS 24_139
- Conditions
- Pulmonary Fibrosis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 21 participants (actual)
- Lead sponsor
- Queen's University, BelfastUniversity, hospital or other
- Study start
- 1 Dec 2024 (actual)
- Primary completion
- 21 Apr 2025 (actual)
- Study completion
- 18 Jul 2025 (actual)
- First posted
- 24 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Pulmonary fibrosis (PF) is a chronic lung condition in which scar tissue gradually forms, impairing oxygen transfer and causing breathlessness. Individuals with PF frequently experience anxiety and depression, yet supportive care remains underdeveloped, and few evidence-based psychological interventions exist for this population, representing a critical gap in care.
This feasibility randomised controlled trial (RCT) evaluated the Compassionate Mindful Resilience (CMR) programme, a 4-week online, nurse-led mindfulness-based intervention designed to improve psychological outcomes in people living with PF.
Detailed description
Background: Pulmonary fibrosis is a progressive, irreversible fibrotic lung disease that requires long-term treatment. People with a diagnosis of pulmonary fibrosis are known to have reduced health-related quality of life, furthermore, it is common for such individuals to experience anxiety and depression. Therefore, interventions to support these individuals are essential to improve their psychological health. Mindfulness is increasing in popularity but retention in these programmes can be challenging. Condensed programmes have great potential but require statistical and individual evaluation. The Compassionate Mindful Resilience Program is a 4-week course that teaches simple, effective, evidence-based practices, skills and techniques.
Methods: This study aims to establish the feasibility of a randomised controlled trial to evaluate the effectiveness of the Compassionate Mindful Resilience Program in improving the psychosocial well-being of people with a diagnosis of pulmonary fibrosis. The trial will be conducted to test procedures, outcomes and validated tools; estimate recruitment and attrition rates; and calculate the sample size required for a future definitive multi-centre randomised controlled trial. The study will also utilise qualitative methods to explore the acceptability of the intervention to the study population. In keeping with CONSORT guidelines. The SPIRIT guidelines and checklist will be utilised to report the study.
Discussion: This study will implement a four-week mindfulness intervention and its utility for people with Pulmonary Fibrosis. The investigators aim to increase equitable access to evidence-based mindfulness practices with the potential to improve the lives of people impacted by this condition. If the study demonstrates the practicability of delivering the online 4-week Compassionate Mindful Resilience program with adequate recruitment, the investigators will be able to determine the feasibility of progression to a randomised controlled clinical trial to increase equitable access to evidence-based mindfulness practices with the potential to improve the lives of people impacted by Pulmonary Fibrosis.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Intervention group | Experimental | Behavioral: Compassionate mindful resilienceCMR is an internationally accredited 4-week programme with 2-hour online sessions delivered via Microsoft Teams |
| Waitlist group | No intervention | –This group did not receive the CMR intervention until all intervention groups had completed CMR. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- have a confirmed diagnosis of PF
- be aged 18 years or older
- reside in the UK or Ireland
- have the capacity to provide informed consent
- demonstrate a commitment to attend all four CMR sessions (demonstrated through discussion with the mindfulness teacher during screening)
Key exclusion criteria (6 listed)
- No diagnosis of PF
- under 18 years old
- live outside of UK or Ireland
- no capacity to provide informed consent
- not willing to attend all four CMR sessions
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Compassionate mindful resilienceIt is an internationally accredited 4-week programme with 2-hour online sessions delivered via Microsoft Teams | Behavioural | Intervention group |
Primary outcome
Feasibility of the intervention
Time frame: From enrollment until the follow up interview was completed (up to 10 weeks)
Adherence
1 secondary outcome
The feasibility of collecting data on anxiety, depression, well-being, mindfulness, resilience, and self-compassion
Time frame: Baseline (week 1), post-CMR (week 4), and four-week follow-up (week 8)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Aug 2026.
- Background: PubMed 34394556Mc Veigh C, Reid J, Larkin P, Porter S, Hudson P. Palliative care for people with non-malignant respiratory disease and their carers: a review of the current evidence. J Res Nurs. 2019 Sep;24(6):420-430. doi: 10.1177/1744987119840066. Epub 2019 Apr 29.
- Background: PubMed 28910509Mc Veigh C, Reid J, Larkin P, Porter S, Hudson P. The experience of palliative care service provision for people with non-malignant respiratory disease and their family carers: An all-Ireland qualitative study. J Adv Nurs. 2018 Feb;74(2):383-394. doi: 10.1111/jan.13453. Epub 2017 Nov 27.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Compassionate mindful resilience in people with Pulmonary Fibrosis, run by Queen's University, Belfast at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Feasibility of the intervention (time frame: From enrollment until the follow up interview was completed (up to 10 weeks)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07782060, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Aug 2026.