PeriodontitisNCT07782736
Advanced Platelet-Rich Fibrin Plus in Nonsurgical Periodontal Therapy
A study testing Scaling and Root Planing and Advanced Platelet-Rich Fibrin Plus in people with Periodontitis, run by University of Medicine and Pharmacy at Ho Chi Minh City at 1 site in Vietnam.
Trial summary
The purpose of this randomized, controlled, split-mouth clinical trial was to determine whether adding advanced platelet-rich fibrin plus (A-PRF+), an autologous fibrin membrane prepared from the participant's own blood, to routine nonsurgical periodontal therapy could improve the healing of periodontal pockets. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Periodontitis
- What is being tested?
- Scaling and Root Planing and Advanced Platelet-Rich Fibrin Plus
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 14 participants
- Where
- 1 siteVietnam
- Study dates
- 3 Oct 2025to 24 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Participant-level criteria:
- Adults aged 18 years or older.
- Diagnosis of periodontitis according to the 2017 World Workshop criteria.
- At least one eligible periodontal tooth/site in each half-mouth.
- Provision of written informed consent and agreement to attend the scheduled follow-up visits.
- Site-level criteria:
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- Probing pocket depth of 5 mm or greater at baseline.
- Clinical attachment loss of 3 mm or greater at baseline.
- Positive bleeding on probing at baseline.
Who cannot join
- Participant-level criteria:
- Current use of tobacco or related products.
- Systemic conditions closely associated with periodontitis or treatment response, including diabetes mellitus, rheumatoid arthritis, or hematologic disease.
- Pregnancy or lactation.
- Periodontal surgery within the preceding 6 months.
- Use of medications affecting blood coagulation.
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- Abnormal preintervention complete blood count, prothrombin time, or activated partial thromboplastin time.
- Poor oral hygiene.
- Failure to attend protocol-specified visits.
- Tooth/site-level criteria:
- Untreated dental caries or pulpal disease.
- Teeth undergoing active orthodontic treatment.
- Teeth with defective restorations.
- Third molars.
- Teeth with mobility grade II or greater.
- Sites with a plaque index of 2 or greater during follow-up were excluded from the site-level analysis.
Trial locations and contacts
1 site in 1 country.
Vietnam1 site
Specialty Dental Clinic, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City
Ho Chi Minh City
About this study
Official title: Application of Advanced Platelet-Rich Fibrin Plus (A-PRF+) in Nonsurgical Periodontal Therapy
The purpose of this randomized, controlled, split-mouth clinical trial was to determine whether adding advanced platelet-rich fibrin plus (A-PRF+), an autologous fibrin membrane prepared from the participant's own blood, to routine nonsurgical periodontal therapy could improve the healing of periodontal pockets.
Adults with periodontitis and periodontal sites with a probing pocket depth of 5 mm or greater and bleeding on probing were enrolled. For each participant, one side of the mouth was randomly assigned to receive scaling and root planing plus A-PRF+ membrane placement, while the other side received scaling and root planing alone. Periodontal probing depth, clinical attachment level, gingival recession, gingival index, bleeding on probing, and plaque index were assessed at baseline and after 4 and 8 weeks.
Read the detailed description
This single-center study used a randomized split-mouth design, allowing each participant to serve as their own control. Each participant drew a random assignment to determine the intervention and control sides of the mouth.
Both sides received routine nonsurgical periodontal therapy consisting of scaling and root planing. On the intervention side, A-PRF+ membranes prepared from autologous venous blood without anticoagulants or additives were additionally placed in eligible periodontal pockets. The control side received scaling and root planing without A-PRF+ placement.
Clinical periodontal parameters were recorded at baseline, 4 weeks, and 8 weeks. The study evaluated the short-term adjunctive clinical effect of A-PRF+ on periodontal pocket healing compared with nonsurgical periodontal therapy alone.
- Conditions
- Periodontitis
- Being tested
- Scaling and Root Planing, Advanced Platelet-Rich Fibrin Plus
- Keywords
- Advanced Platelet-Rich Fibrin Plus, A-PRF+, Nonsurgical Periodontal Therapy, Split-Mouth Design
- Medical subject headings
- Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Scaling and Root PlaningProcedure or surgery
Nonsurgical mechanical periodontal treatment was performed to remove supra- and subgingival plaque and calculus and to debride the root surfaces.
Advanced Platelet-Rich Fibrin PlusBiological
The autologous A-PRF+ membrane was prepared from venous blood collected without anticoagulants or additives and centrifuged at 1,300 rpm for 8 minutes. Following mechanical debridement and routine pocket irrigation, intervention pockets were rinsed with sterile saline before A-PRF+ membrane placement. The membrane was placed into eligible periodontal pockets and stabilized using an adhesive periodontal patch.
| Study group | Role | What they receive |
|---|---|---|
| Intervention Side: Scaling and Root Planing Plus A-PRF+ | Experimental | Eligible periodontal pockets on the randomly assigned intervention side received scaling and root planing followed by placement of an autologous A-PRF+ membrane. Receives: Procedure: Scaling and Root Planing; Biological: Advanced Platelet-Rich Fibrin Plus |
| Control Side: Scaling and Root Planing Alone | Active comparator | Eligible periodontal pockets on the contralateral control side received scaling and root planing without A-PRF+ membrane placement. Receives: Procedure: Scaling and Root Planing |
What is being measured
The primary outcome is the main question the study is designed to answer.
Probing Pocket Depth
Probing pocket depth was measured in millimeters using a periodontal probe, from the gingival margin to the base of the periodontal pocket. Lower values indicate shallower periodontal pockets.
Measured: Baseline, 4 weeks, and 8 weeks after treatment
Clinical Attachment Level
Clinical attachment level was measured in millimeters using a periodontal probe, from the cementoenamel junction to the base of the periodontal pocket. Lower values indicate less clinical attachment loss.
Measured: Baseline, 4 weeks, and 8 weeks after treatment
Secondary outcomes (4)
Gingival Recession
Gingival recession was measured in millimeters from the cementoenamel junction to the gingival margin using a periodontal probe.
Measured: Baseline, 4 weeks, and 8 weeks after treatment
Gingival Index
Gingival inflammation was assessed at each periodontal site using an ordinal gingival index scored from 0 to 3, with higher scores indicating greater gingival inflammation.
Measured: Baseline, 4 weeks, and 8 weeks after treatment
Bleeding on Probing
Description: Bleeding on probing was recorded as present or absent after periodontal probing and reported as the number and percentage of sites with a positive bleeding response.
Measured: Baseline, 4 weeks, and 8 weeks after treatment
Plaque Index
Plaque accumulation at each periodontal site was assessed using an ordinal plaque index scored from 0 to 3, with higher scores indicating greater plaque accumulation.
Measured: Baseline, 4 weeks, and 8 weeks after treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Aug 2026
- Study start3 Oct 2025
- Primary completion24 Apr 2026
- Study completion24 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PeriodontitisStudies of the same condition, open and under way.
- More trials run by University of Medicine and Pharmacy at Ho Chi Minh CityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized within-participant split-mouth design. Each participant received both treatments concurrently: scaling and root planing plus A-PRF+ on the randomly assigned intervention side and scaling and root planing alone on the control side.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 14 participants (actual)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nguyễn Thị Thảo Anh, University of Medicine and Pharmacy at Ho Chi Minh City
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07782736
- Sponsor's protocol ID
- 3518/DHYD-HDDD
- Status last verified
- Aug 2026
- First submitted
- 20 Aug 2026
- Last updated
- 24 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared. Only aggregate study results will be reported in scientific publications.
Study at a glance
From the registry record, last updated by the sponsor on 24 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Application of Advanced Platelet-Rich Fibrin Plus (A-PRF+) in Nonsurgical Periodontal Therapy
- ClinicalTrials.gov ID
- NCT07782736
- Acronym / sponsor ID
- 3518/DHYD-HDDD
- Conditions
- Periodontitis
- Keywords
- Advanced Platelet-Rich Fibrin Plus, A-PRF+, Nonsurgical Periodontal Therapy, Split-Mouth Design
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 14 participants (actual)
- Lead sponsor
- University of Medicine and Pharmacy at Ho Chi Minh CityUniversity, hospital or other
- Study start
- 3 Oct 2025 (actual)
- Primary completion
- 24 Apr 2026 (actual)
- Study completion
- 24 Apr 2026 (actual)
- First posted
- 24 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this randomized, controlled, split-mouth clinical trial was to determine whether adding advanced platelet-rich fibrin plus (A-PRF+), an autologous fibrin membrane prepared from the participant's own blood, to routine nonsurgical periodontal therapy could improve the healing of periodontal pockets.
Adults with periodontitis and periodontal sites with a probing pocket depth of 5 mm or greater and bleeding on probing were enrolled. For each participant, one side of the mouth was randomly assigned to receive scaling and root planing plus A-PRF+ membrane placement, while the other side received scaling and root planing alone. Periodontal probing depth, clinical attachment level, gingival recession, gingival index, bleeding on probing, and plaque index were assessed at baseline and after 4 and 8 weeks.
Detailed description
This single-center study used a randomized split-mouth design, allowing each participant to serve as their own control. Each participant drew a random assignment to determine the intervention and control sides of the mouth.
Both sides received routine nonsurgical periodontal therapy consisting of scaling and root planing. On the intervention side, A-PRF+ membranes prepared from autologous venous blood without anticoagulants or additives were additionally placed in eligible periodontal pockets. The control side received scaling and root planing without A-PRF+ placement.
Clinical periodontal parameters were recorded at baseline, 4 weeks, and 8 weeks. The study evaluated the short-term adjunctive clinical effect of A-PRF+ on periodontal pocket healing compared with nonsurgical periodontal therapy alone.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Randomized within-participant split-mouth design. Each participant received both treatments concurrently: scaling and root planing plus A-PRF+ on the randomly assigned intervention side and scaling and root planing alone on the control side.
| Arm | Type | Receives |
|---|---|---|
| Intervention Side: Scaling and Root Planing Plus A-PRF+ | Experimental | Procedure: Scaling and Root Planing, Biological: Advanced Platelet-Rich Fibrin PlusEligible periodontal pockets on the randomly assigned intervention side received scaling and root planing followed by placement of an autologous A-PRF+ membrane. |
| Control Side: Scaling and Root Planing Alone | Active comparator | Procedure: Scaling and Root PlaningEligible periodontal pockets on the contralateral control side received scaling and root planing without A-PRF+ membrane placement. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- Adults aged 18 years or older.
- Diagnosis of periodontitis according to the 2017 World Workshop criteria.
- At least one eligible periodontal tooth/site in each half-mouth.
- Provision of written informed consent and agreement to attend the scheduled follow-up visits.
- Probing pocket depth of 5 mm or greater at baseline.
Key exclusion criteria (16 listed)
- Current use of tobacco or related products.
- Systemic conditions closely associated with periodontitis or treatment response, including diabetes mellitus, rheumatoid arthritis, or hematologic disease.
- Pregnancy or lactation.
- Periodontal surgery within the preceding 6 months.
- Use of medications affecting blood coagulation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Scaling and Root PlaningNonsurgical mechanical periodontal treatment was performed to remove supra- and subgingival plaque and calculus and to debride the root surfaces. | Procedure or surgery | Control Side: Scaling and Root Planing Alone, Intervention Side: Scaling and Root Planing Plus A-PRF+ |
| Advanced Platelet-Rich Fibrin PlusThe autologous A-PRF+ membrane was prepared from venous blood collected without anticoagulants or additives and centrifuged at 1,300 rpm for 8 minutes. Following mechanical debridement and routine pocket irrigation, intervention pockets were rinsed with sterile saline before A-PRF+ membrane placement. The membrane was placed into eligible periodontal pockets and stabilized using an adhesive periodontal patch. | Biological | Intervention Side: Scaling and Root Planing Plus A-PRF+ |
Primary outcome
Probing Pocket Depth
Time frame: Baseline, 4 weeks, and 8 weeks after treatment
Probing pocket depth was measured in millimeters using a periodontal probe, from the gingival margin to the base of the periodontal pocket. Lower values indicate shallower periodontal pockets.
Clinical Attachment Level
Time frame: Baseline, 4 weeks, and 8 weeks after treatment
Clinical attachment level was measured in millimeters using a periodontal probe, from the cementoenamel junction to the base of the periodontal pocket. Lower values indicate less clinical attachment loss.
4 secondary outcomes
Gingival Recession
Time frame: Baseline, 4 weeks, and 8 weeks after treatment
Gingival Index
Time frame: Baseline, 4 weeks, and 8 weeks after treatment
Bleeding on Probing
Time frame: Baseline, 4 weeks, and 8 weeks after treatment
Plaque Index
Time frame: Baseline, 4 weeks, and 8 weeks after treatment
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Aug 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared. Only aggregate study results will be reported in scientific publications.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Scaling and Root Planing and Advanced Platelet-Rich Fibrin Plus in people with Periodontitis, run by University of Medicine and Pharmacy at Ho Chi Minh City at 1 site in Vietnam.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 16 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Vietnam. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Probing Pocket Depth (time frame: Baseline, 4 weeks, and 8 weeks after treatment). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Aug 2026; AzTrials last refreshed its copy on 8 Nov 2026.