Menthol CigarettesNCT07782879
DoubleTake: Effect of Message Exposure Via a Discrete Choice Experiment With Eye-Tracking on Quit Attempts Among Adults Who Smoke Menthol Cigarettes
A study testing Message Exposure via Discrete Choice Experiment in people with Menthol Cigarettes and Smoking Behavior, run by Georgia State University at 2 sites in United States.
Trial summary
<p>The goal of this clinical trial is to learn how exposure to anti-smoking social media messages affects quitting-related behaviors. Eligible participants will be adults aged 21 or older who have used menthol cigarettes on at least 4 days during the past 30 days.</p> <br> <p>The main question this study aims to… Read more about this study
- Who is it for?
- Ages 21 years and olderHealthy volunteers can take part
- Conditions the study is for
- Menthol Cigarettes, Smoking Behavior, Cigarette Use
- What is being tested?
- Message Exposure via Discrete Choice Experiment
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 200 participants
- Where
- 2 sitesUnited States
- Study dates
- 21 Sep 2026to Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age 21+ years
- Smoked menthol cigarettes at least once a week in the past 30 days
- Can speak, read, and write in English
- Willing to participate in an in-person study
Who cannot join
- Eye conditions affecting fixation, ocular motility, or central acuity (e.g., strabismus, nystagmus, ptosis, aniridia, maculopathy, advanced cataracts, or other conditions affecting macular fixation or central visual acuity).
- Multifocal or near-infrared-blocking/heavily tinted corrective lenses: bifocal, trifocal, or progressive/varifocal lenses, or coatings that impair eye-tracking. (Single-vision glasses and contact lenses are eligible.)
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United States2 sites, 2 recruiting
- Recruiting
Georgia State University
Atlanta, Georgia, 30303
Lyudmila Popova, Ph.D., 404-413-9338, lpopova1@gsu.edu
- Not yet recruiting
University of California, Santa Barbara
Santa Barbara, California, 93106
Jiyaing Liu, Ph.D., (805) 893-8000, jiaying-liu@ucsb.edu
About this study
Official title: The DoubleTake Study: A Randomized, Waitlist-Controlled Trial of Message Exposure Delivered Via a Discrete Choice Experiment With Eye-Tracking on Quit Attempts Among Adults Who Smoke Menthol Cigarettes
<p>The goal of this clinical trial is to learn how exposure to anti-smoking social media messages affects quitting-related behaviors. Eligible participants will be adults aged 21 or older who have used menthol cigarettes on at least 4 days during the past 30 days.</p> <br> <p>The main question this study aims to answer is: Does exposure to anti-smoking messages (in the context of a discrete choice experiment [DCE] with eye-tracking study) increase quitting-related behaviors over the following 2 weeks?</p> <br> <p>Participants will be randomly assigned to view the messages either immediately or after a 2-week waiting period, allowing researchers to compare quitting-related behaviors between the two groups. The primary outcome is whether participants report making a quit attempt in the 2 weeks following randomization.</p> <br> <p>Participants will:</p> <ul> <li>Complete eligibility screening and baseline questions about demographics and tobacco use.</li> <li>Be randomly assigned to view the messages immediately or after a 2-week waiting period.</li> <li>Attend a 1-hour in-person study visit at Georgia State University or the University of California, Santa Barbara.</li> <li>View 64 anti-smoking social media messages presented in 16 choice sets while their eye movements and pupil dilation are measured using a screen-based eye-tracking device.</li> <li>Select which messages most attract their attention, which they would be most likely to share, and which would most motivate them to quit smoking.</li> <li>Complete questions about quitting-related behaviors either during the study visit (waitlist control condition) or through an online questionnaire 2 weeks later (immediate condition).</li> </ul>
Read the detailed description
<p>Discrete choice experiments (DCEs) are increasingly used in tobacco research to understand which message features people perceive as most effective. However, DCE studies are typically designed to assess message preferences and are not designed to test whether exposure to these messages has any downstream effect on actual behavior. Because DCEs expose participants to a large number of messages in a single session, a much higher dose of message exposure than in typical single- or few-message studies, it is possible that this cumulative exposure itself influences quitting-related outcomes such as making a quit attempt. This study (DoubleTake) is a randomized controlled trial designed to address this gap by testing whether exposure to multiple messages in the context of a DCE with concurrent eye-tracking affects quitting-related behaviors among adults who smoke menthol cigarettes, a population disproportionately affected by tobacco-related health disparities.</p> <br> <p>The study is a two-arm, randomized, waitlist-controlled trial with a planned total enrollment of approximately 200 participants (approximately 100 per arm). After completing eligibility screening and baseline questions on demographics and tobacco use, eligible participants will be randomly assigned to one of two conditions:</p>
<ul> <li><b>Immediate condition:</b> Participants complete the in-person DCE/eye-tracking study visit right away and then complete an online questionnaire assessing quitting-related behaviors 2 weeks later.</li> <li><b>Waitlist control condition:</b> Participants wait 2 weeks and then attend an in-person visit, at the start of which they answer questions about quitting-related behaviors covering the preceding 2-week waiting period, and then complete the DCE/eye-tracking study.</li> </ul>
<p>This design allows researchers to isolate the effect of message exposure on quitting-related behaviors by comparing outcomes reported by the immediate condition (after exposure) to those reported by the waitlist condition (before exposure, over an equivalent 2-week window).</p> <br> <p>All participants will attend a 1-hour in-person study visit at one of two sites (Georgia State University or the University of California, Santa Barbara). During this visit, participants will view 64 anti-smoking social media messages, presented across 16 choice sets, while an eye-tracking device records their eye movements and pupil dilation. Within each choice set, participants will indicate which message most attracts their attention, which they would be most likely to share, and which would most motivate them to quit smoking.</p> <br> <p>The primary outcome is a self-reported quit attempt within 2 weeks following randomization. Secondary outcome is intentions to quit smoking.</p>
- Conditions
- Menthol Cigarettes, Smoking Behavior, Cigarette Use
- Being tested
- Message Exposure via Discrete Choice Experiment
- Keywords
- smoking, menthol cigarettes, menthol, health communication
- Medical subject headings
- Smoking
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Message Exposure via Discrete Choice ExperimentBehavioural
Participants will view 64 anti-smoking social media messages, presented across 16 choice sets, in a discrete choice experiment (DCE) with eye-tracking. Within each choice set, participants indicate which message most attracts their attention, which they would be most likely to share or repost, and which would most motivate them to quit smoking.
| Study group | Role | What they receive |
|---|---|---|
| DCE exposure | Experimental | Participants complete the in-person discrete choice experiment (DCE) with eye-tracking study visit immediately after randomization. During this visit, participants view 64 anti-smoking social media messages presented in 16 choice sets while their eye movements are recorded. Participants then complete an online questionnaire assessing quitting-related behaviors 2 weeks later. Receives: Behavioral: Message Exposure via Discrete Choice Experiment |
| Waitlist Control | No intervention | Participants wait 2 weeks following randomization. At the start of an in-person visit conducted at the end of this waiting period, participants answer questions about quitting-related behaviors covering the preceding 2-week waiting period. Participants then complete the discrete choice experiment (DCE) with eye-tracking study. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Quit attempts
Self-reported quit attempt:
Participants will be asked, "Have you made an attempt to quit smoking cigarettes in the past 2 weeks?" Response options will include yes, no, and don't know. Participants who report a quit attempt will be asked, "How long did you stop smoking?" with responses recorded as the number of days, ranging from less than 1 day to 14 days. Participants who report stopping smoking for 1 day or more will be classified as having made a quit attempt for the primary outcome analysis.
Measured: 2 weeks after message exposure for the immediate intervention arm and 2 weeks before message exposure for the waitlist control arm.
Secondary outcomes (1)
Intention to Quit
Intention to quit smoking is assessed by asking participants the following questions, where 1 is not at all, and 5 is extremely: 1. How interested are you in quitting smoking in the next month? 2. How much do you plan to quit smoking in the next month and 3. How likely are you to quit smoking in the next month?
Measured: 2 weeks after message exposure for the immediate intervention arm and 2 weeks before message exposure for the waitlist control arm.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Aug 2026
- Study start21 Sep 2026
- Primary completionAug 2027 (estimated)
- Study completionAug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Menthol CigarettesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Georgia State University
- Sponsor type
- University, hospital or other
- Collaborators
- University of California, Santa Barbara, National Cancer Institute (NCI)
- Responsible party
- Principal investigator, Lyudmila Popova, Georgia State University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07782879
- Sponsor's protocol ID
- H26621
- Other IDs
- R01CA289552
- Status last verified
- Sep 2026
- First submitted
- 30 Jul 2026
- Last updated
- 25 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The DoubleTake Study: A Randomized, Waitlist-Controlled Trial of Message Exposure Delivered Via a Discrete Choice Experiment With Eye-Tracking on Quit Attempts Among Adults Who Smoke Menthol Cigarettes
- ClinicalTrials.gov ID
- NCT07782879
- Acronym / sponsor ID
- H26621
- Conditions
- Menthol Cigarettes, Smoking Behavior, Cigarette Use
- Keywords
- smoking, menthol cigarettes, menthol, health communication
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Georgia State UniversityUniversity, hospital or other
- Collaborators
- University of California, Santa Barbara, National Cancer Institute (NCI)
- Study start
- 21 Sep 2026 (actual)
- Primary completion
- Aug 2027 (estimated)
- Study completion
- Aug 2027 (estimated)
- First posted
- 24 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
<p>The goal of this clinical trial is to learn how exposure to anti-smoking social media messages affects quitting-related behaviors. Eligible participants will be adults aged 21 or older who have used menthol cigarettes on at least 4 days during the past 30 days.</p> <br> <p>The main question this study aims to answer is: Does exposure to anti-smoking messages (in the context of a discrete choice experiment [DCE] with eye-tracking study) increase quitting-related behaviors over the following 2 weeks?</p> <br> <p>Participants will be randomly assigned to view the messages either immediately or after a 2-week waiting period, allowing researchers to compare quitting-related behaviors between the two groups. The primary outcome is whether participants report making a quit attempt in the 2 weeks following randomization.</p> <br> <p>Participants will:</p> <ul> <li>Complete eligibility screening and baseline questions about demographics and tobacco use.</li> <li>Be randomly assigned to view the messages immediately or after a 2-week waiting period.</li> <li>Attend a 1-hour in-person study visit at Georgia State University or the University of California, Santa Barbara.</li> <li>View 64 anti-smoking social media messages presented in 16 choice sets while their eye movements and pupil dilation are measured using a screen-based eye-tracking device.</li> <li>Select which messages most attract their attention, which they would be most likely to share, and which would most motivate them to quit smoking.</li> <li>Complete questions about quitting-related behaviors either during the study visit (waitlist control condition) or through an online questionnaire 2 weeks later (immediate condition).</li> </ul>
Detailed description
<p>Discrete choice experiments (DCEs) are increasingly used in tobacco research to understand which message features people perceive as most effective. However, DCE studies are typically designed to assess message preferences and are not designed to test whether exposure to these messages has any downstream effect on actual behavior. Because DCEs expose participants to a large number of messages in a single session, a much higher dose of message exposure than in typical single- or few-message studies, it is possible that this cumulative exposure itself influences quitting-related outcomes such as making a quit attempt. This study (DoubleTake) is a randomized controlled trial designed to address this gap by testing whether exposure to multiple messages in the context of a DCE with concurrent eye-tracking affects quitting-related behaviors among adults who smoke menthol cigarettes, a population disproportionately affected by tobacco-related health disparities.</p> <br> <p>The study is a two-arm, randomized, waitlist-controlled trial with a planned total enrollment of approximately 200 participants (approximately 100 per arm). After completing eligibility screening and baseline questions on demographics and tobacco use, eligible participants will be randomly assigned to one of two conditions:</p>
<ul> <li><b>Immediate condition:</b> Participants complete the in-person DCE/eye-tracking study visit right away and then complete an online questionnaire assessing quitting-related behaviors 2 weeks later.</li> <li><b>Waitlist control condition:</b> Participants wait 2 weeks and then attend an in-person visit, at the start of which they answer questions about quitting-related behaviors covering the preceding 2-week waiting period, and then complete the DCE/eye-tracking study.</li> </ul>
<p>This design allows researchers to isolate the effect of message exposure on quitting-related behaviors by comparing outcomes reported by the immediate condition (after exposure) to those reported by the waitlist condition (before exposure, over an equivalent 2-week window).</p> <br> <p>All participants will attend a 1-hour in-person study visit at one of two sites (Georgia State University or the University of California, Santa Barbara). During this visit, participants will view 64 anti-smoking social media messages, presented across 16 choice sets, while an eye-tracking device records their eye movements and pupil dilation. Within each choice set, participants will indicate which message most attracts their attention, which they would be most likely to share, and which would most motivate them to quit smoking.</p> <br> <p>The primary outcome is a self-reported quit attempt within 2 weeks following randomization. Secondary outcome is intentions to quit smoking.</p>
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| DCE exposure | Experimental | Behavioral: Message Exposure via Discrete Choice ExperimentParticipants complete the in-person discrete choice experiment (DCE) with eye-tracking study visit immediately after randomization. During this visit, participants view 64 anti-smoking social media messages presented in 16 choice sets while their eye movements are recorded. Participants then complete an online questionnaire assessing quitting-related behaviors 2 weeks later. |
| Waitlist Control | No intervention | –Participants wait 2 weeks following randomization. At the start of an in-person visit conducted at the end of this waiting period, participants answer questions about quitting-related behaviors covering the preceding 2-week waiting period. Participants then complete the discrete choice experiment (DCE) with eye-tracking study. |
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age 21+ years
- Smoked menthol cigarettes at least once a week in the past 30 days
- Can speak, read, and write in English
- Willing to participate in an in-person study
Key exclusion criteria (2 listed)
- Eye conditions affecting fixation, ocular motility, or central acuity (e.g., strabismus, nystagmus, ptosis, aniridia, maculopathy, advanced cataracts, or other conditions affecting macular fixation or central visual acuity).
- Multifocal or near-infrared-blocking/heavily tinted corrective lenses: bifocal, trifocal, or progressive/varifocal lenses, or coatings that impair eye-tracking. (Single-vision glasses and contact lenses are eligible.)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Message Exposure via Discrete Choice ExperimentParticipants will view 64 anti-smoking social media messages, presented across 16 choice sets, in a discrete choice experiment (DCE) with eye-tracking. Within each choice set, participants indicate which message most attracts their attention, which they would be most likely to share or repost, and which would most motivate them to quit smoking. | Behavioural | DCE exposure |
Primary outcome
Quit attempts
Time frame: 2 weeks after message exposure for the immediate intervention arm and 2 weeks before message exposure for the waitlist control arm.
Self-reported quit attempt: Participants will be asked, "Have you made an attempt to quit smoking cigarettes in the past 2 weeks?" Response options will include yes, no, and don't know. Participants who report a quit attempt will be asked, "How long did you stop smoking?" with responses recorded as the number of days, ranging from less than 1 day to 14 days. Participants who report stopping smoking for 1 day or more will be classified as having made a quit attempt for the primary outcome analysis.
1 secondary outcome
Intention to Quit
Time frame: 2 weeks after message exposure for the immediate intervention arm and 2 weeks before message exposure for the waitlist control arm.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Message Exposure via Discrete Choice Experiment in people with Menthol Cigarettes and Smoking Behavior, run by Georgia State University at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 25 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Lyudmila Popova, Ph.D (404-413-9338, lpopova1@gsu.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Quit attempts (time frame: 2 weeks after message exposure for the immediate intervention arm and 2 weeks before message exposure for the waitlist control arm.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2026.