Non-surgical RetreatmentNiTi-RETREATNCT07783945
Effects of Different NiTi Systems on Postoperative Pain and Operation Time in Nonsurgical Endodontic Retreatment
A study testing ProTaper Universal Retreatment System, MicroMega REMOVER and ProTaper Next in people with Non-surgical Retreatment, run by Aydin Adnan Menderes University at 1 site in Turkey (Türkiye).
Trial summary
This prospective, randomized, single-center, single-blind clinical trial evaluated the effects of different nickel-titanium retreatment and final shaping systems on postoperative pain and operation time during single-visit nonsurgical endodontic retreatment of mandibular first molars. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Non-surgical Retreatment
- What is being tested?
- ProTaper Universal Retreatment System, MicroMega REMOVER and ProTaper Next
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 109 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 10 Mar 2023to 17 Mar 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Patients between 18- 65 years of ages
- Patients who agree to participate this study
- Patients had not used analgesic or antibiotics in last 7 days
- Mandibular molar teeth that have been endodontically treated only once
- Asymptomatic teeth with previous endodontic treatment but exhibiting inadequate root canal filling on radiographic examination.
- Teeth, although asymptomatic, but with newly developed periapical radiolucency within two years compared to the radiographic findings present 2 years ago at the time of root canal treatment was done.
- Teeth with periapical radiolucency, but with increased or unchanged according to pre-treatment radiography.
- Absence of a history of allergy to local anesthetics, medications, resin-based restorative materials or nickel.
Who cannot join
- Pregnant patients and patients in lactation period
- Having used corticosteroids in the last 6 months.
- Individuals with systemic diseases (endocarditis, immune system diseases, etc.) requiring antibiotic prophylaxis
- Having received immunosuppressive therapy within the last week
- Gingival recession exceeding 3 mm, deep periodontal pocketing, tooth mobility, or progressive periodontal disease
- The presence of a foreign body in the root canal that prevents entry (broken file, post, etc.)
Show all 11Show fewer
- Fracture or crack in the root
- Teeth that cannot reach the working length due to calcification in the root canal and step formation
- Teeth that cannot be restored due to excessive loss of material in the coronal structure
- The presence of more than one adjacent tooth requiring endodontic treatment that may cause reflected pain in the same patient.
- Teeth that develop any complications (breakage of endodontic file, perforation, inability to determine the working length with the apex finder) during the removal of the canal filling material.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Aydın Adnan Menderes University, Faculty of Dentistiry
Aydin, Ege, 09000
About this study
Official title: Evaluation of the Effect of Different Ni-Ti Shaping Systems on Postoperative Pain and Operation Time in Single-Visit Non-Surgical Retreatment: A Randomized Clinical Trial
This prospective, randomized, single-center, single-blind clinical trial evaluated the effects of different nickel-titanium retreatment and final shaping systems on postoperative pain and operation time during single-visit nonsurgical endodontic retreatment of mandibular first molars. Participants were allocated to four groups according to the combination of the retreatment system used for root canal filling removal and the rotary or reciprocating system used for final root canal shaping. Postoperative pain, analgesic consumption, and operation time were assessed and compared among the groups.
Read the detailed description
Postoperative pain is a common complication following nonsurgical endodontic retreatment and may be influenced by the instrumentation system used during root canal filling removal and final root canal shaping. This prospective, single-center, single-blind, randomized clinical trial was designed to compare the effects of different nickel-titanium instrumentation protocols on postoperative pain and operation time in mandibular first molar teeth requiring nonsurgical endodontic retreatment.
Adult participants aged 18-65 years with previously endodontically treated mandibular first molars meeting the eligibility criteria were included. All retreatment procedures were performed in a single visit by one endodontist. Participants were randomly allocated to one of four parallel treatment groups. Existing root canal filling materials were removed using either the ProTaper Universal Retreatment system or the MicroMega REMOVER system. Final root canal shaping was then performed using either the ProTaper Next rotary system or the MicroMega One RECI reciprocating system. Thus, the four intervention groups consisted of ProTaper Universal Retreatment plus ProTaper Next, ProTaper Universal Retreatment plus MicroMega One RECI, MicroMega REMOVER plus ProTaper Next, and MicroMega REMOVER plus MicroMega One RECI.
Postoperative pain intensity was assessed using a 100-mm visual analog scale, in which 0 represented no pain and 100 represented unbearable pain. Participants recorded their pain levels at 6 and 12 hours and on postoperative days 1, 2, 3, 4, 5, 6, and 7. The use and frequency of rescue analgesic medication were also recorded during the seven-day follow-up period. Clinical evaluations were performed at 48 hours and seven days to assess pain, tenderness to percussion, spontaneous pain, swelling, and the need for antibiotic treatment.
Operation time was recorded using a digital stopwatch. The recorded period included the time from the initial penetration into the existing root canal filling material until working length was reached and final root canal shaping was completed. Postoperative pain scores, analgesic consumption, and operation time were compared among the four instrumentation groups.
- Conditions
- Non-surgical Retreatment
- Being tested
- ProTaper Universal Retreatment System, MicroMega REMOVER, ProTaper Next, One RECI
- Keywords
- Non-surgical retreatment, Operation time, Postoperative pain, Visual analog scale
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ProTaper Universal Retreatment SystemDevice
A nickel-titanium rotary retreatment system used for the removal of existing root canal filling materials during nonsurgical endodontic retreatment.
MicroMega REMOVERDevice
A nickel-titanium rotary retreatment instrument used for the removal of existing root canal filling materials during nonsurgical endodontic retreatment.
ProTaper NextDevice
A nickel-titanium rotary instrumentation system used for final root canal shaping following the removal of existing root canal filling materials.
One RECIDevice
A nickel-titanium reciprocating instrumentation system used for final root canal shaping following the removal of existing root canal filling materials.
| Study group | Role | What they receive |
|---|---|---|
| PTUR + ProTaper Next | Experimental | Root canal filling materials were removed using the ProTaper Universal Retreatment system. Final root canal shaping was performed using the ProTaper Next rotary instrumentation system. Receives: Device: ProTaper Universal Retreatment System; Device: ProTaper Next |
| PTUR + One RECI | Experimental | Root canal filling materials were removed using the ProTaper Universal Retreatment system. Final root canal shaping was performed using the One RECI reciprocating instrumentation system. Receives: Device: ProTaper Universal Retreatment System; Device: One RECI |
| REMOVER + ProTaper Next | Experimental | Root canal filling materials were removed using the MicroMega REMOVER system. Final root canal shaping was performed using the ProTaper Next rotary instrumentation system. Receives: Device: MicroMega REMOVER; Device: ProTaper Next |
| REMOVER + One RECI | Experimental | Root canal filling materials were removed using the MicroMega REMOVER system. Final root canal shaping was performed using the One RECI reciprocating instrumentation system. Receives: Device: MicroMega REMOVER; Device: One RECI |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative Pain Intensity
Postoperative pain intensity was assessed using a 100-mm visual analog scale, where 0 indicated no pain and 100 indicated the worst imaginable pain. Pain scores were compared among the four instrumentation groups.
Measured: At 6, 12, 24, and 48 hours and on postoperative days 3, 4, 5, 6, and 7 after treatment.
Secondary outcomes (1)
Operation Time
The total time required to remove the existing root canal filling material and complete final root canal shaping was recorded in minutes for each participant and compared among the four instrumentation groups.
Measured: During the single-visit nonsurgical endodontic retreatment procedure.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Aug 2026
- Study start10 Mar 2023
- Primary completion17 Mar 2024
- Study completion17 Mar 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Non-surgical RetreatmentStudies of the same condition, open and under way.
- More trials run by Aydin Adnan Menderes UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 109 participants (actual)
Sponsor and investigators
- Lead sponsor
- Aydin Adnan Menderes University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hicran Dönmez Özkan, Aydin Adnan Menderes University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07783945
- Sponsor's protocol ID
- ADUDHF2023/05
- Acronym
- NiTi-RETREAT
- Status last verified
- Aug 2026
- First submitted
- 19 Aug 2026
- Last updated
- 25 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared because participant consent did not include provisions for sharing individual-level data with external researchers.
Publications
Nagendrababu V, Duncan HF, Bjorndal L, Kvist T, Priya E, Jayaraman J, Pulikkotil SJ, Pigg M, Rechenberg DK, Vaeth M, Dummer PMH. PRIRATE 2020 guidelines for reporting randomized trials in Endodontics: a consensus-based development. Int Endod J. 2020 Jun;53(6):764-773. doi: 10.1111/iej.13294. Epub 2020 Apr 23.
PubMed 32196696Shahi S, Asghari V, Rahimi S, Lotfi M, Samiei M, Yavari H, Shakouie S, Nezafati S. Postoperative Pain after Endodontic Treatment of Asymptomatic Teeth Using Rotary Instruments: A Randomized Clinical Trial. Iran Endod J. 2016 Winter;11(1):38-43. doi: 10.7508/iej.2016.01.008. Epub 2015 Dec 24.
PubMed 26843876Rahbani Nobar B, Dianat O, Rahbani Nobar B, Shirvani A, Zargar N, Kazem M, Tordik P. Effect of Rotary and Reciprocating Instrumentation Motions on Postoperative Pain Incidence in Non-Surgical Endodontic Treatments: A Systematic Review and Meta-Analysis. Eur Endod J. 2021 Apr;6(1):3-14. doi: 10.14744/eej.2020.51523. Epub 2021 Feb 2.
PubMed 33609019Canakci BC, Er O, Genc Sen O, Sut N. The effect of two rotary and two reciprocating NiTi systems on postoperative pain after root canal retreatment on single-rooted incisor teeth: A randomized controlled trial. Int Endod J. 2021 Nov;54(11):2016-2024. doi: 10.1111/iej.13609. Epub 2021 Aug 29.
PubMed 34383324Eyuboglu TF, Ozcan M. Postoperative pain intensity associated with the use of different nickel-titanium shaping systems during single-appointment endodontic retreatment: a randomized clinical trial. Quintessence Int. 2019;50(8):624-634. doi: 10.3290/j.qi.a42693.
PubMed 31286116Comparin D, Moreira EJL, Souza EM, De-Deus G, Arias A, Silva EJNL. Postoperative Pain after Endodontic Retreatment Using Rotary or Reciprocating Instruments: A Randomized Clinical Trial. J Endod. 2017 Jul;43(7):1084-1088. doi: 10.1016/j.joen.2017.02.010. Epub 2017 May 3.
PubMed 28477995
Study at a glance
From the registry record, last updated by the sponsor on 25 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Effect of Different Ni-Ti Shaping Systems on Postoperative Pain and Operation Time in Single-Visit Non-Surgical Retreatment: A Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07783945
- Acronym / sponsor ID
- NiTi-RETREAT / ADUDHF2023/05
- Conditions
- Non-surgical Retreatment
- Keywords
- Non-surgical retreatment, Operation time, Postoperative pain, Visual analog scale
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 109 participants (actual)
- Lead sponsor
- Aydin Adnan Menderes UniversityUniversity, hospital or other
- Study start
- 10 Mar 2023 (actual)
- Primary completion
- 17 Mar 2024 (actual)
- Study completion
- 17 Mar 2024 (actual)
- First posted
- 25 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective, randomized, single-center, single-blind clinical trial evaluated the effects of different nickel-titanium retreatment and final shaping systems on postoperative pain and operation time during single-visit nonsurgical endodontic retreatment of mandibular first molars. Participants were allocated to four groups according to the combination of the retreatment system used for root canal filling removal and the rotary or reciprocating system used for final root canal shaping. Postoperative pain, analgesic consumption, and operation time were assessed and compared among the groups.
Detailed description
Postoperative pain is a common complication following nonsurgical endodontic retreatment and may be influenced by the instrumentation system used during root canal filling removal and final root canal shaping. This prospective, single-center, single-blind, randomized clinical trial was designed to compare the effects of different nickel-titanium instrumentation protocols on postoperative pain and operation time in mandibular first molar teeth requiring nonsurgical endodontic retreatment.
Adult participants aged 18-65 years with previously endodontically treated mandibular first molars meeting the eligibility criteria were included. All retreatment procedures were performed in a single visit by one endodontist. Participants were randomly allocated to one of four parallel treatment groups. Existing root canal filling materials were removed using either the ProTaper Universal Retreatment system or the MicroMega REMOVER system. Final root canal shaping was then performed using either the ProTaper Next rotary system or the MicroMega One RECI reciprocating system. Thus, the four intervention groups consisted of ProTaper Universal Retreatment plus ProTaper Next, ProTaper Universal Retreatment plus MicroMega One RECI, MicroMega REMOVER plus ProTaper Next, and MicroMega REMOVER plus MicroMega One RECI.
Postoperative pain intensity was assessed using a 100-mm visual analog scale, in which 0 represented no pain and 100 represented unbearable pain. Participants recorded their pain levels at 6 and 12 hours and on postoperative days 1, 2, 3, 4, 5, 6, and 7. The use and frequency of rescue analgesic medication were also recorded during the seven-day follow-up period. Clinical evaluations were performed at 48 hours and seven days to assess pain, tenderness to percussion, spontaneous pain, swelling, and the need for antibiotic treatment.
Operation time was recorded using a digital stopwatch. The recorded period included the time from the initial penetration into the existing root canal filling material until working length was reached and final root canal shaping was completed. Postoperative pain scores, analgesic consumption, and operation time were compared among the four instrumentation groups.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| PTUR + ProTaper Next | Experimental | Device: ProTaper Universal Retreatment System, Device: ProTaper NextRoot canal filling materials were removed using the ProTaper Universal Retreatment system. Final root canal shaping was performed using the ProTaper Next rotary instrumentation system. |
| PTUR + One RECI | Experimental | Device: ProTaper Universal Retreatment System, Device: One RECIRoot canal filling materials were removed using the ProTaper Universal Retreatment system. Final root canal shaping was performed using the One RECI reciprocating instrumentation system. |
| REMOVER + ProTaper Next | Experimental | Device: MicroMega REMOVER, Device: ProTaper NextRoot canal filling materials were removed using the MicroMega REMOVER system. Final root canal shaping was performed using the ProTaper Next rotary instrumentation system. |
| REMOVER + One RECI | Experimental | Device: MicroMega REMOVER, Device: One RECIRoot canal filling materials were removed using the MicroMega REMOVER system. Final root canal shaping was performed using the One RECI reciprocating instrumentation system. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Patients between 18- 65 years of ages
- Patients who agree to participate this study
- Patients had not used analgesic or antibiotics in last 7 days
- Mandibular molar teeth that have been endodontically treated only once
- Asymptomatic teeth with previous endodontic treatment but exhibiting inadequate root canal filling on radiographic examination.
Key exclusion criteria (11 listed)
- Pregnant patients and patients in lactation period
- Having used corticosteroids in the last 6 months.
- Individuals with systemic diseases (endocarditis, immune system diseases, etc.) requiring antibiotic prophylaxis
- Having received immunosuppressive therapy within the last week
- Gingival recession exceeding 3 mm, deep periodontal pocketing, tooth mobility, or progressive periodontal disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ProTaper Universal Retreatment SystemA nickel-titanium rotary retreatment system used for the removal of existing root canal filling materials during nonsurgical endodontic retreatment. | Device | PTUR + One RECI, PTUR + ProTaper Next |
| MicroMega REMOVERA nickel-titanium rotary retreatment instrument used for the removal of existing root canal filling materials during nonsurgical endodontic retreatment. | Device | REMOVER + One RECI, REMOVER + ProTaper Next |
| ProTaper NextA nickel-titanium rotary instrumentation system used for final root canal shaping following the removal of existing root canal filling materials. | Device | PTUR + ProTaper Next, REMOVER + ProTaper Next |
| One RECIA nickel-titanium reciprocating instrumentation system used for final root canal shaping following the removal of existing root canal filling materials. | Device | PTUR + One RECI, REMOVER + One RECI |
Primary outcome
Postoperative Pain Intensity
Time frame: At 6, 12, 24, and 48 hours and on postoperative days 3, 4, 5, 6, and 7 after treatment.
Postoperative pain intensity was assessed using a 100-mm visual analog scale, where 0 indicated no pain and 100 indicated the worst imaginable pain. Pain scores were compared among the four instrumentation groups.
1 secondary outcome
Operation Time
Time frame: During the single-visit nonsurgical endodontic retreatment procedure.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Aug 2026.
- Background: PubMed 32196696Nagendrababu V, Duncan HF, Bjorndal L, Kvist T, Priya E, Jayaraman J, Pulikkotil SJ, Pigg M, Rechenberg DK, Vaeth M, Dummer PMH. PRIRATE 2020 guidelines for reporting randomized trials in Endodontics: a consensus-based development. Int Endod J. 2020 Jun;53(6):764-773. doi: 10.1111/iej.13294. Epub 2020 Apr 23.
- Background: PubMed 26843876Shahi S, Asghari V, Rahimi S, Lotfi M, Samiei M, Yavari H, Shakouie S, Nezafati S. Postoperative Pain after Endodontic Treatment of Asymptomatic Teeth Using Rotary Instruments: A Randomized Clinical Trial. Iran Endod J. 2016 Winter;11(1):38-43. doi: 10.7508/iej.2016.01.008. Epub 2015 Dec 24.
- Background: PubMed 33609019Rahbani Nobar B, Dianat O, Rahbani Nobar B, Shirvani A, Zargar N, Kazem M, Tordik P. Effect of Rotary and Reciprocating Instrumentation Motions on Postoperative Pain Incidence in Non-Surgical Endodontic Treatments: A Systematic Review and Meta-Analysis. Eur Endod J. 2021 Apr;6(1):3-14. doi: 10.14744/eej.2020.51523. Epub 2021 Feb 2.
- Background: PubMed 34383324Canakci BC, Er O, Genc Sen O, Sut N. The effect of two rotary and two reciprocating NiTi systems on postoperative pain after root canal retreatment on single-rooted incisor teeth: A randomized controlled trial. Int Endod J. 2021 Nov;54(11):2016-2024. doi: 10.1111/iej.13609. Epub 2021 Aug 29.
- Background: PubMed 31286116Eyuboglu TF, Ozcan M. Postoperative pain intensity associated with the use of different nickel-titanium shaping systems during single-appointment endodontic retreatment: a randomized clinical trial. Quintessence Int. 2019;50(8):624-634. doi: 10.3290/j.qi.a42693.
- Background: PubMed 28477995Comparin D, Moreira EJL, Souza EM, De-Deus G, Arias A, Silva EJNL. Postoperative Pain after Endodontic Retreatment Using Rotary or Reciprocating Instruments: A Randomized Clinical Trial. J Endod. 2017 Jul;43(7):1084-1088. doi: 10.1016/j.joen.2017.02.010. Epub 2017 May 3.
- Individual participant dataSharing planned: No. Individual participant data will not be shared because participant consent did not include provisions for sharing individual-level data with external researchers.
Related trials for Non-surgical Retreatment
Active, not recruiting
THE EFFECT OF FILLING MATERIAL AND PLACEMENT TECHNIQUE ON POSTOPERATIVE PAIN IN NON-SURGICAL ENDODONTIC RETREATMENT: A RANDOMIZED CLINICAL TRIAL
Retreatment, Endodontic Diseases
Recruiting
Efficacy of a Novel Nanoparticle -Augmented Disinfection Protocol
Post Operative Pain
Active, not recruiting
Non-Surgical Single Visit Endodontic Retreatment in Cases With Asymptomatic Apical Periodontitis Using Bioceramic Sealer
Asymptomatic Apical Periodontitis, Root Canal Retreatment
Not yet recruiting
Development and Validation of a Deep Learning Model to Predict Endodontic Retreatment Difficulty From Periapical Radiographs
Endodontic Retreatment, Non-surgical Retreatment
Not yet recruiting
Effect of a Herbal Intracanal Medication On Postoperative Pain And Flare up Incidence In Non Surgical Root Canal Retreatment
Postoperative Pain, Flare Up, Symptom
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ProTaper Universal Retreatment System, MicroMega REMOVER and ProTaper Next in people with Non-surgical Retreatment, run by Aydin Adnan Menderes University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative Pain Intensity (time frame: At 6, 12, 24, and 48 hours and on postoperative days 3, 4, 5, 6, and 7 after treatment.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07783945, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Aug 2026.