Stage III PeriodontitisNCT07785115
Full-Mouth vs. Quadrant-Wise Scaling and Root Planing: Clinical Effectiveness, Environmental Sustainability, and Patient-Reported Outcomes
A study testing Full-Mouth Scaling and Root Planing and Quadrant-Wise Scaling and Root Planing in people with Stage III Periodontitis, run by Selcuk University at 1 site in Turkey (Türkiye).
Trial summary
This randomized clinical trial compares full-mouth and quadrant-wise scaling and root planing in patients with Stage III periodontitis. In addition to evaluating clinical effectiveness and patient-reported outcomes, the study investigates the environmental sustainability of both treatment protocols using life cycle… Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Stage III Periodontitis
- What is being tested?
- Full-Mouth Scaling and Root Planing and Quadrant-Wise Scaling and Root Planing
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Sep 2025to 1 Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥18 years. Diagnosis of Stage III periodontitis according to the 2017 World Workshop -Classification of Periodontal and Peri-Implant Diseases and Conditions.
- Presence of at least four teeth in each quadrant, including at least one molar, excluding third molars.
- Absence of any systemic disease. No regular use of systemic medications. No history of periodontal treatment within the previous 6 months. No use of antibiotics, anti-inflammatory agents, or any other medications that could affect periodontal tissues within the previous 6 months.
- Non-smokers or individuals who had ceased smoking for at least 1 year prior to enrollment.
- Not pregnant or breastfeeding.
Who cannot join
- Age <18 years. Presence of any systemic disease. Regular use of systemic medications. History of periodontal treatment within the previous 6 months. Failure to complete the treatment protocol or attend scheduled follow-up visits.
- Current smoking. Use of antibiotics, anti-inflammatory agents, or any other medications that could affect the periodontal tissues within the previous 6 months.
- Requirement for antibiotic prophylaxis prior to dental treatment.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Selcuk University Faculty of Dentistry
Konya, 42060
About this study
Official title: COMPARISON OF FULL-MOUTH AND QUADRANT-WISE SCALING AND ROOT PLANING IN TERMS OF CLINICAL EFFECTIVENESS, ENVIRONMENTAL SUSTAINABILITY, AND PATIENT-REPORTED OUTCOMES
This randomized clinical trial compares full-mouth and quadrant-wise scaling and root planing in patients with Stage III periodontitis. In addition to evaluating clinical effectiveness and patient-reported outcomes, the study investigates the environmental sustainability of both treatment protocols using life cycle assessment. The findings are expected to contribute to more sustainable and patient-centered periodontal treatment planning.
- Conditions
- Stage III Periodontitis
- Being tested
- Full-Mouth Scaling and Root Planing, Quadrant-Wise Scaling and Root Planing
- Keywords
- Periodontitis, scaling and root planing, life cycle assessment, patient-reported outcomes, environmental sustainability
- Medical subject headings
- Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Full-Mouth Scaling and Root PlaningProcedure or surgery
Full-mouth scaling and root planing was completed in a single treatment session using ultrasonic scalers and Gracey curettes. Standardized oral hygiene instructions were provided before treatment. Participants were re-evaluated at 1-, 3-, and 6-month follow-up visits, and additional non-surgical periodontal treatment was provided for sites requiring further therapy when clinically indicated.Clinical outcomes, patient-reported outcomes, and the environmental impact of the treatment protocol were assessed throughout the study.
Quadrant-Wise Scaling and Root PlaningProcedure or surgery
Quadrant-wise scaling and root planing was performed over four treatment sessions scheduled at one-week intervals using ultrasonic scalers and Gracey curettes. Standardized oral hygiene instructions were provided before treatment. Participants were re-evaluated at 1-, 3-, and 6-month follow-up visits, and additional non-surgical periodontal treatment was provided for sites requiring further therapy when clinically indicated. Clinical outcomes, patient-reported outcomes, and the environmental impact of the treatment protocol were assessed throughout the study.
| Study group | Role | What they receive |
|---|---|---|
| Full-Mouth Scaling and Root Planing (FM-SRP) | Active comparator | Participants received full-mouth scaling and root planing completed in a single treatment session. Periodontal clinical parameters, patient-reported outcomes, and environmental sustainability outcomes were evaluated during a 6-month follow-up period. Receives: Procedure: Full-Mouth Scaling and Root Planing |
| Quadrant-Wise Scaling and Root Planing (Q-SRP) | Active comparator | Participants received quadrant-wise scaling and root planing performed over four treatment sessions at one-week intervals. Clinical effectiveness, patient-reported outcomes, and environmental sustainability were evaluated during a 6-month follow-up period. Receives: Procedure: Quadrant-Wise Scaling and Root Planing |
What is being measured
The primary outcome is the main question the study is designed to answer.
Probing Pocket Depth (PPD)
Mean probing pocket depth (PPD) was measured at six sites per tooth using a manual periodontal probe and recorded in millimeters (mm). Lower PPD values indicate improved periodontal status.
Measured: Baseline, 1 month, 3 months, and 6 months
Secondary outcomes (11)
Clinical Attachment Level (CAL)
Mean clinical attachment level (CAL) was measured at six sites per tooth using a manual periodontal probe and recorded in millimeters (mm). Lower CAL values indicate improved periodontal attachment.
Measured: Baseline, 1 month, 3 months, and 6 months
Bleeding on Probing (BOP)
Bleeding on probing (BOP) was assessed by recording the presence or absence of bleeding within 30 seconds after gentle periodontal probing at the buccal, lingual/palatal, mesial, and distal surfaces of each tooth. Results were expressed as the percentage (%) of bleeding sites, with lower values indicating reduced gingival inflammation.
Measured: Baseline, 1 month, 3 months, and 6 months
Plaque Index (PI)
Plaque Index (PI) was assessed on all teeth according to the Silness and Löe index and recorded as a mean index score. Lower PI scores indicate better plaque control.
Measured: Baseline, 1 month, 3 months, and 6 months
Gingival Index (GI)
Gingival Index (GI) was assessed on all teeth according to the Löe and Silness index and recorded as a mean index score. Lower GI scores indicate reduced gingival inflammation.
Measured: Baseline, 1 month, 3 months, and 6 months
Periodontal Inflamed Surface Area (PISA)
Periodontal Inflamed Surface Area (PISA) was calculated using a validated method based on clinical attachment level, gingival recession, and bleeding on probing measurements and recorded in square millimeters (mm²). Lower PISA values indicate a reduced periodontal inflammatory burden.
Measured: Baseline, 1 month, 3 months, and 6 months
Periodontal Epithelial Surface Area (PESA)
Periodontal Epithelial Surface Area (PESA) was calculated from clinical attachment level and gingival recession measurements and recorded in square millimeters (mm²). Lower PESA values indicate a smaller periodontal epithelial surface area.
Measured: Baseline, 1 month, 3 months, and 6 months
Pain Intensity (Visual Analog Scale, VAS)
Pain intensity following periodontal treatment was assessed using a 10-cm Visual Analog Scale (VAS), where 0 represented no pain and 10 represented the worst imaginable pain. Lower VAS scores indicate lower perceived pain intensity.
Measured: At the 1-month follow-up visit
Oral Health-Related Quality of Life (OHIP-14)
Oral health-related quality of life was assessed using the Oral Health Impact Profile-14 (OHIP-14) questionnaire.
Measured: At the 1-month follow-up visit
Analgesic Use
The number of participants who reported using or not using analgesic medication following periodontal treatment was recorded for each treatment group.
Measured: At the 1-month follow-up visit
Preference for Future Periodontal Treatment
At the 6-month follow-up visit, participants were asked whether, based on their experience with the assigned treatment approach, they would prefer the alternative periodontal treatment approach if future periodontal treatment were needed. Responses were recorded for analysis.
Measured: At the 6-month follow-up visit
Environmental Impact of Periodontal Treatment Approaches
The environmental impacts of the periodontal treatment approaches were assessed using Life Cycle Assessment (LCA).
Measured: During the 6-month study period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Aug 2026
- Study start15 Sep 2025
- Primary completion1 Sep 2026 (estimated)
- Study completion1 Sep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Stage III PeriodontitisStudies of the same condition, open and under way.
- More trials run by Selcuk UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Lead sponsor
- Selcuk University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nida Kalaç, Selcuk University
- Investigators
- Sefa Aydındoğan, Principal investigator, Department of Periodontology, Faculty of Dentistry, Selcuk University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07785115
- Sponsor's protocol ID
- SelcukU-DHF-NK-01
- Status last verified
- Jul 2026
- First submitted
- 20 Aug 2026
- Last updated
- 25 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- COMPARISON OF FULL-MOUTH AND QUADRANT-WISE SCALING AND ROOT PLANING IN TERMS OF CLINICAL EFFECTIVENESS, ENVIRONMENTAL SUSTAINABILITY, AND PATIENT-REPORTED OUTCOMES
- ClinicalTrials.gov ID
- NCT07785115
- Acronym / sponsor ID
- SelcukU-DHF-NK-01
- Conditions
- Stage III Periodontitis
- Keywords
- Periodontitis, scaling and root planing, life cycle assessment, patient-reported outcomes, environmental sustainability
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 52 participants (actual)
- Lead sponsor
- Selcuk UniversityUniversity, hospital or other
- Study start
- 15 Sep 2025 (actual)
- Primary completion
- 1 Sep 2026 (estimated)
- Study completion
- 1 Sep 2026 (estimated)
- First posted
- 25 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical trial compares full-mouth and quadrant-wise scaling and root planing in patients with Stage III periodontitis. In addition to evaluating clinical effectiveness and patient-reported outcomes, the study investigates the environmental sustainability of both treatment protocols using life cycle assessment. The findings are expected to contribute to more sustainable and patient-centered periodontal treatment planning.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Full-Mouth Scaling and Root Planing (FM-SRP) | Active comparator | Procedure: Full-Mouth Scaling and Root PlaningParticipants received full-mouth scaling and root planing completed in a single treatment session. Periodontal clinical parameters, patient-reported outcomes, and environmental sustainability outcomes were evaluated during a 6-month follow-up period. |
| Quadrant-Wise Scaling and Root Planing (Q-SRP) | Active comparator | Procedure: Quadrant-Wise Scaling and Root PlaningParticipants received quadrant-wise scaling and root planing performed over four treatment sessions at one-week intervals. Clinical effectiveness, patient-reported outcomes, and environmental sustainability were evaluated during a 6-month follow-up period. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age ≥18 years. Diagnosis of Stage III periodontitis according to the 2017 World Workshop -Classification of Periodontal and Peri-Implant Diseases and Conditions.
- Presence of at least four teeth in each quadrant, including at least one molar, excluding third molars.
- Absence of any systemic disease. No regular use of systemic medications. No history of periodontal treatment within the previous 6 months. No use of antibiotics, anti-inflammatory agents, or any other medications that could affect periodontal tissues within the previous 6 months.
- Non-smokers or individuals who had ceased smoking for at least 1 year prior to enrollment.
- Not pregnant or breastfeeding.
Key exclusion criteria (3 listed)
- Age <18 years. Presence of any systemic disease. Regular use of systemic medications. History of periodontal treatment within the previous 6 months. Failure to complete the treatment protocol or attend scheduled follow-up visits.
- Current smoking. Use of antibiotics, anti-inflammatory agents, or any other medications that could affect the periodontal tissues within the previous 6 months.
- Requirement for antibiotic prophylaxis prior to dental treatment.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Full-Mouth Scaling and Root PlaningFull-mouth scaling and root planing was completed in a single treatment session using ultrasonic scalers and Gracey curettes. Standardized oral hygiene instructions were provided before treatment. Participants were re-evaluated at 1-, 3-, and 6-month follow-up visits, and additional non-surgical periodontal treatment was provided for sites requiring further therapy when clinically indicated.Clinical outcomes, patient-reported outcomes, and the environmental impact of the treatment protocol were assessed throughout the study. | Procedure or surgery | Full-Mouth Scaling and Root Planing (FM-SRP) |
| Quadrant-Wise Scaling and Root PlaningQuadrant-wise scaling and root planing was performed over four treatment sessions scheduled at one-week intervals using ultrasonic scalers and Gracey curettes. Standardized oral hygiene instructions were provided before treatment. Participants were re-evaluated at 1-, 3-, and 6-month follow-up visits, and additional non-surgical periodontal treatment was provided for sites requiring further therapy when clinically indicated. Clinical outcomes, patient-reported outcomes, and the environmental impact of the treatment protocol were assessed throughout the study. | Procedure or surgery | Quadrant-Wise Scaling and Root Planing (Q-SRP) |
Primary outcome
Probing Pocket Depth (PPD)
Time frame: Baseline, 1 month, 3 months, and 6 months
Mean probing pocket depth (PPD) was measured at six sites per tooth using a manual periodontal probe and recorded in millimeters (mm). Lower PPD values indicate improved periodontal status.
11 secondary outcomes
Clinical Attachment Level (CAL)
Time frame: Baseline, 1 month, 3 months, and 6 months
Bleeding on Probing (BOP)
Time frame: Baseline, 1 month, 3 months, and 6 months
Plaque Index (PI)
Time frame: Baseline, 1 month, 3 months, and 6 months
Gingival Index (GI)
Time frame: Baseline, 1 month, 3 months, and 6 months
Periodontal Inflamed Surface Area (PISA)
Time frame: Baseline, 1 month, 3 months, and 6 months
Periodontal Epithelial Surface Area (PESA)
Time frame: Baseline, 1 month, 3 months, and 6 months
Pain Intensity (Visual Analog Scale, VAS)
Time frame: At the 1-month follow-up visit
Oral Health-Related Quality of Life (OHIP-14)
Time frame: At the 1-month follow-up visit
Analgesic Use
Time frame: At the 1-month follow-up visit
Preference for Future Periodontal Treatment
Time frame: At the 6-month follow-up visit
Environmental Impact of Periodontal Treatment Approaches
Time frame: During the 6-month study period
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Sefa Aydındoğan principal investigator
Department of Periodontology, Faculty of Dentistry, Selcuk University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Full-Mouth Scaling and Root Planing and Quadrant-Wise Scaling and Root Planing in people with Stage III Periodontitis, run by Selcuk University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 25 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Probing Pocket Depth (PPD) (time frame: Baseline, 1 month, 3 months, and 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Aug 2026.