Acute Heart Failure (AHF)NCT07785531
Risk Factors, Etiology and Predictable Outcomes With Risk Stratification Scores in Acute Heart Failure Patients
An observational study of Acute Heart Failure (AHF), run by Assiut University at 1 site in Egypt.
Trial summary
Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Acute Heart Failure Patients Presenting to Assiut University Heart Hospital. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Heart Failure (AHF)
- What is being tested?
- Echo, Ecg and Creatinine
- How many people
- 350 participants
- Where
- 1 siteEgypt
- Study dates
- Aug 2026to Sep 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Acute heart failure patients presenting to Emergency Department and Cardiology Department, Assiut University Hospitals, Egypt.
Who may be able to join
- Age more than 18yrs
- Clinical diagnosis of acute heart failure according to current ESC guideline criteria.
Who cannot join
- Age below than 18
- Refusal to participate.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Heart Failure Patients Presenting to Assiut University Heart Hospital.
Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Acute Heart Failure Patients Presenting to Assiut University Heart Hospital.
Read the detailed description
Primary Aim To characterize the demographic and clinical characteristics, etiological spectrum, precipitating factors, management, and short-term outcomes, including length of stay, ICU admission, organ failure, and 30-day rehospitalization, of patients presenting with acute heart failure at Assiut University Heart Hospital
.Secondary Aim To evaluate the prognostic performance of the HEARTRISK6 score by externally validating its ability to predict short-term adverse outcomes, including in-hospital mortality.
- Conditions
- Acute Heart Failure (AHF)
- Being tested
- Echo, Ecg, Creatinine, Troponin
- Keywords
- Risk stratification scores
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EchoDiagnostic test
Echo for clinical assessment
EcgDiagnostic test
Twelve leads ECG to detect any ischemic changes
CreatinineDiagnostic test
To detect renal function test
TroponinDiagnostic test
Ischemic changes
What is being measured
The primary outcome is the main question the study is designed to answer.
Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Acute Heart Failure Patients Presenting to Assiut University Heart Hospital.
To externally validate the HEARTRISK6 score and evaluate its predictive performance for short-term adverse outcomes in patients with acute heart failure.
History of moderate/severe valvular heart disease_Yes. 1 Heart rate >100 to ≤120 bpm. 2 >120 bpm. 3 Non-invasive ventilation (NIV)BiPAP/NIV within first hour 2 Creatinine >150 to ≤300 µmol/L 2 >300 µmol/L. 3 Troponin >3-5 × upper reference limit (URL) 1 >5 × URL. 2 Failed reassessment / 3-minute walk test ifFailed1 comp0 High score means worse
Measured: Follow up patients for 30 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Aug 2026
- Study startAug 2026 (estimated)
- Primary completionAug 2028 (estimated)
- Study completionSep 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Acute Heart Failure (AHF)Studies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 350 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Remoon Hana Henein Mansour, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07785531
- Sponsor's protocol ID
- Outcomes in AHF
- Status last verified
- Jul 2026
- First submitted
- 8 Aug 2026
- Last updated
- 25 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Publications
McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, Burri H, Butler J, Celutkiene J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A; ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-3726. doi: 10.1093/eurheartj/ehab368. No abstract available.
PubMed 34447992
Study at a glance
From the registry record, last updated by the sponsor on 25 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Heart Failure Patients Presenting to Assiut University Heart Hospital.
- ClinicalTrials.gov ID
- NCT07785531
- Acronym / sponsor ID
- Outcomes in AHF
- Conditions
- Acute Heart Failure (AHF)
- Keywords
- Risk stratification scores
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 350 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- Aug 2026 (estimated)
- Primary completion
- Aug 2028 (estimated)
- Study completion
- Sep 2028 (estimated)
- First posted
- 25 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Acute Heart Failure Patients Presenting to Assiut University Heart Hospital.
Detailed description
Primary Aim To characterize the demographic and clinical characteristics, etiological spectrum, precipitating factors, management, and short-term outcomes, including length of stay, ICU admission, organ failure, and 30-day rehospitalization, of patients presenting with acute heart failure at Assiut University Heart Hospital
.Secondary Aim To evaluate the prognostic performance of the HEARTRISK6 score by externally validating its ability to predict short-term adverse outcomes, including in-hospital mortality.
Study design
- Observational model
- Other
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Acute heart failure patients presenting to Emergency Department and Cardiology Department, Assiut University Hospitals, Egypt.
Key inclusion criteria (2 listed)
- Age more than 18yrs
- Clinical diagnosis of acute heart failure according to current ESC guideline criteria.
Key exclusion criteria (2 listed)
- Age below than 18
- Refusal to participate.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EchoEcho for clinical assessment | Diagnostic test | – |
| EcgTwelve leads ECG to detect any ischemic changes | Diagnostic test | – |
| CreatinineTo detect renal function test | Diagnostic test | – |
| TroponinIschemic changes | Diagnostic test | – |
Primary outcome
Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Acute Heart Failure Patients Presenting to Assiut University Heart Hospital.
Time frame: Follow up patients for 30 days
To externally validate the HEARTRISK6 score and evaluate its predictive performance for short-term adverse outcomes in patients with acute heart failure. History of moderate/severe valvular heart disease_Yes. 1 Heart rate >100 to ≤120 bpm. 2 >120 bpm. 3 Non-invasive ventilation (NIV)BiPAP/NIV within first hour 2 Creatinine >150 to ≤300 µmol/L 2 >300 µmol/L. 3 Troponin >3-5 × upper reference limit (URL) 1 >5 × URL. 2 Failed reassessment / 3-minute walk test ifFailed1 comp0 High score means worse
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Aug 2026.
- Results publication: PubMed 34447992McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, Burri H, Butler J, Celutkiene J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A; ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-3726. doi: 10.1093/eurheartj/ehab368. No abstract available.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Heart Failure (AHF), run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 25 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Remoon hana Mansour (+201284555676, Remon.18313629@med.aun.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Clinical Characteristics, Etiology, Short-Term Outcomes, and Performance of Contemporary Risk Stratification Scores in Acute Heart Failure Patients Presenting to Assiut University Heart Hospital. (time frame: Follow up patients for 30 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07785531, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Aug 2026.