Postoperative Troponin ElevationNCT07786753
Impact of Intraoperative Perfusion Variability on Postoperative Troponin Elevation in Geriatric Patients Undergoing Major Oncologic Surgery
An observational study of Postoperative Troponin Elevation and Intraoperative Perfusion, run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This prospective observational study aims to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation in geriatric patients undergoing major oncologic surgery. Read more about this study
- Who is it for?
- Ages 65 years and older
- Conditions the study is for
- Postoperative Troponin Elevation, Intraoperative Perfusion
- How many people
- 70 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Sep 2026to 2 Nov 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- No healthy volunteers
- Older adult
Study population: Geriatric patients aged 65 years or older undergoing major abdominal oncologic surgery who meet the predefined eligibility criteria and have preoperative and 24-hour postoperative troponin measurements. Intraoperative hemodynamic and perfusion parameters, including PI, PVI, and cerebral oxygen saturation measured by NIRS, will be monitored throughout surgery and recorded at 15-minute intervals.
Who may be able to join
- Age 65 years or older
- Undergoing major abdominal oncologic surgery
- Availability of preoperative and 24-hour postoperative troponin measurements
- Complete intraoperative and postoperative patient monitoring records
- Provision of written informed consent
Who cannot join
- Age younger than 65 years
- Absence of preoperative or 24-hour postoperative troponin measurements
- Incomplete intraoperative or postoperative patient monitoring records
- Undergoing emergency surgery
- Advanced heart failure
- ASA Physical Status IV
- Pulmonary artery pressure >40 mmHg
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
Ankara Dr. Abdurrahman Yurtaslan Oncolgy Training and Research Hospital
Yenimahalle, Ankara, 06200
About this study
This prospective observational study aims to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation in geriatric patients undergoing major oncologic surgery. Intraoperative hemodynamic and perfusion-related parameters will be recorded, and postoperative troponin levels will be assessed to investigate whether intraoperative perfusion changes are associated with myocardial injury. Troponin measurements will be obtained preoperatively and at 24 hours after surgery
- Keywords
- Postoperative Troponin Elevation, Geriatric Patients, Major Oncologic Surgery, Intraoperative Perfusion, Troponin, Hemodynamic Variability
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Geriatric Patients Undergoing Major Oncologic Surgery | Geriatric patients undergoing elective major oncolojic surgery will be prospectively observed.Intraoperative hemodynamic and perfusion-related parameters will be recorded, and serum troponin levels will be measured preoperatively and 24 hours after surgery to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Serum Troponin Concentration From Preoperative Baseline to 24 Hours After Surgery
Postoperative troponin elevation will be assessed by comparing serum troponin levels measured preoperatively and 24 hours after surgery. Its association with intraoperative perfusion variability will be evaluated.
Measured: Preoperatively and 24 hours after surgery
Secondary outcomes (3)
Association Between Intraoperative Perfusion Index and Postoperative Troponin Elevation
Perfusion Index (PI) will be continuously monitored intraoperatively and recorded at 15-minute intervals. The association between intraoperative PI values and postoperative troponin elevation at 24 hours after surgery will be evaluated.
Measured: Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively
Association Between Intraoperative Pleth Variability Index and Postoperative Troponin Elevation
Pleth Variability Index (PVI) will be continuously monitored intraoperatively and recorded at 15-minute intervals. The association between intraoperative PVI values and postoperative troponin elevation at 24 hours after surgery will be evaluated.
Measured: Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively.
Association Between Intraoperative Cerebral Oxygen Saturation and Postoperative Troponin Elevation
Cerebral oxygen saturation measured by near-infrared spectroscopy (NIRS) will be continuously monitored intraoperatively and recorded at 15-minute intervals. The association between intraoperative cerebral oxygen saturation values and postoperative troponin elevation at 24 hours after surgery will be evaluated.
Measured: Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2026
- Study start1 Sep 2026 (estimated)
- Primary completion2 Nov 2026 (estimated)
- Study completion2 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Postoperative Troponin ElevationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Özlem Kapusuz, Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07786753
- Sponsor's protocol ID
- AOH2026-05/89
- Status last verified
- Sep 2026
- First submitted
- 21 Aug 2026
- Last updated
- 16 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Intraoperative Perfusion Variability on Postoperative Troponin Elevation in Geriatric Patients Undergoing Major Oncologic Surgery
- ClinicalTrials.gov ID
- NCT07786753
- Acronym / sponsor ID
- AOH2026-05/89
- Keywords
- Postoperative Troponin Elevation, Geriatric Patients, Major Oncologic Surgery, Intraoperative Perfusion, Troponin, Hemodynamic Variability
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalUniversity, hospital or other
- Study start
- 1 Sep 2026 (estimated)
- Primary completion
- 2 Nov 2026 (estimated)
- Study completion
- 2 Nov 2026 (estimated)
- First posted
- 26 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective observational study aims to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation in geriatric patients undergoing major oncologic surgery. Intraoperative hemodynamic and perfusion-related parameters will be recorded, and postoperative troponin levels will be assessed to investigate whether intraoperative perfusion changes are associated with myocardial injury. Troponin measurements will be obtained preoperatively and at 24 hours after surgery
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Geriatric Patients Undergoing Major Oncologic Surgery | – | –Geriatric patients undergoing elective major oncolojic surgery will be prospectively observed.Intraoperative hemodynamic and perfusion-related parameters will be recorded, and serum troponin levels will be measured preoperatively and 24 hours after surgery to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation. |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Older adult
- Study population
- Geriatric patients aged 65 years or older undergoing major abdominal oncologic surgery who meet the predefined eligibility criteria and have preoperative and 24-hour postoperative troponin measurements. Intraoperative hemodynamic and perfusion parameters, including PI, PVI, and cerebral oxygen saturation measured by NIRS, will be monitored throughout surgery and recorded at 15-minute intervals.
Key inclusion criteria (5 listed)
- Age 65 years or older
- Undergoing major abdominal oncologic surgery
- Availability of preoperative and 24-hour postoperative troponin measurements
- Complete intraoperative and postoperative patient monitoring records
- Provision of written informed consent
Key exclusion criteria (7 listed)
- Age younger than 65 years
- Absence of preoperative or 24-hour postoperative troponin measurements
- Incomplete intraoperative or postoperative patient monitoring records
- Undergoing emergency surgery
- Advanced heart failure
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Change in Serum Troponin Concentration From Preoperative Baseline to 24 Hours After Surgery
Time frame: Preoperatively and 24 hours after surgery
Postoperative troponin elevation will be assessed by comparing serum troponin levels measured preoperatively and 24 hours after surgery. Its association with intraoperative perfusion variability will be evaluated.
3 secondary outcomes
Association Between Intraoperative Perfusion Index and Postoperative Troponin Elevation
Time frame: Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively
Association Between Intraoperative Pleth Variability Index and Postoperative Troponin Elevation
Time frame: Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively.
Association Between Intraoperative Cerebral Oxygen Saturation and Postoperative Troponin Elevation
Time frame: Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Postoperative Troponin Elevation and Intraoperative Perfusion, run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 16 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Serum Troponin Concentration From Preoperative Baseline to 24 Hours After Surgery (time frame: Preoperatively and 24 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Sep 2026.